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Seismic-induced surficial failure of cohesive slopes using three-dimensional limit analysis:A case study of the Wangjiayan landslide in Beichuan, China

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Earthquake Engineering and Engineering Vibration 2024年第3期23卷 537-545页

作者： Gao Yufeng Liu Yang Geng weijuan Zhang Fei Key Laboratory of the Ministry of Education for Geomechanics and Embankment Engineering College of Civil and Transportation EngineeringHohai UniversityNanjing 210098China Department of Civil Engineering Faculty of Civil Engineering and MechanicsJiangsu UniversityZhenjiang 212013China

A seismic-induced landslide is a common geological catastrophe that occurs in *** Wangjiayan landslide,which was triggered by the Wenchuan earthquake,is a typical case in *** Wanjiayan landslide caused many casualties and resulted in enormous property *** study constructs a simple surficial failure model based on the upper bound approach of three-dimensional(3D)limit analysis to evaluate the slope stability of the Wangjiayan case,while a traditional two-dimensional(2D)analysis is also conducted as a reference for comparison with the results of the 3D analysis.A quasi-static calculation is used to study the effect of the earthquake in terms of horizontal ground acceleration,while a parametric study is conducted to evaluate the critical cohesion of *** than employing a 3D analysis,using the 2D analysis yields an underestimation regarding the safety *** the Wangjiayan landslide,the difference in the factors of safety between the 3D and 2D analyses can reach 20%.The sliding surface morphology as determined by the 3D method is similar to actual morphology,and the parameters of both are also compared to analyze the reliability of the proposed 3D method.

关键词： landslide Wenchuan earthquake surficial failure limit analysis stability quasi-static

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Maps Preserving Semi-Fredholm Operators with Fixed Nullity

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Journal of Mathematical Research with Applications 2024年第4期44卷 533-540页

作者： Mengran NI weijuan SHI Department of Mathematics Shaanxi Normal University

Let X be an infinite-dimensional complex Banach space, and B(X) the algebra of all bounded linear operators on X. Given an integer n ≥ 1, we characterize all the bijective maps on B(X) preserving the difference of semi-Fredholm operators with nullity equal to n in both directions, and establish the structure of the given maps.

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Sanhua Tang(三化汤) protects against ischemic stroke by preventing blood-brain barrier injury: a network pharmacology and in vivo experiments

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Journal of Traditional Chinese Medicine 2024年第4期44卷 794-803页

作者： LUO Shan YANG Fan CheN Yuanchun ZHAO Ruoxi LIU Haiye GAO Fei MA Wencan GAO weijuan YU Wentao College of Basic Medicine Hebei University of Chinese Medicine Graduate School Hebei University of Chinese Medicine College of Acupuncture and Massage Hebei University of Chinese Medicine hebei Key Laboratory of Chinese Medicine Research on Cardio-Cerebrovascular Diseases hebei International Joint Research Centre for Acupuncture and Moxibustion of Traditional Chinese Medicine

OBJECTIVE: To assess the effect and mechanism of Sanhua Tang(三化汤, SHT) in treating ischemic stroke(IS) through the "Kaitong Xuanfu" theory by using network pharmacology and animal experiments. METHODS: The active ingredients and targets of SHT and IS were screened by public databases such as Traditional Chinese Medicine systems pharmacology, GeneCards, and online mendelian inheritance in man. Visual network topographies were constructed using R, Cytoscape 3.6.0, AutoDockTools, a user-sponsored molecular visualization system on an open-source foundation, and other software to analyze the correlation between targets and active ingredients. The middle cerebral artery occlusion(MCAO) model was established by operation. Animals were divided into the Sham group, MCAO group(M group), aloe-emodin(AE) group(MCAO rats treated with aloe-emodin), SHT at low dosage(SL group)(MCAO rats treated with SL), SHT at medium dosage(SM group), and SHT at high dosage(SH group). 2,3,5-triphenyl tetrazolium chloride staining was used to detect the volume of cerebral infarction; Nissl staining was used to observe the morphology of neuronal cells; transmission electron microscopy was used to observe the integrity of the blood-brain barrier(BBB); enzymelinked immunosorbent assay was used to detect the content of interleukin-6(IL-6), IL-10, tumor necrosis factor α(TNF-α) in serum. Western blot was used to detect the expression of vascular endothelial growth factor A(VEGFA) protein in the cerebral ischemic penumbra. RESULTS: Using network pharmacology and molecular docking validation, four active ingredients(lignan, naringenin, aloe-rhodopsin, and β-sitosterol), seven target proteins(protein kinase b 1, IL-6, TNF, VEGFA, TP53, jun proto-oncogene, and cysteinyl aspartate specific proteinase 3), and inflammatory signaling pathways were identified. Animal experiments showed that the SH and AE groups had fewer neurological deficits, reduced brain infarct volumes, decreased serum inflammatory factor l

关键词： Sanhua Tang blood-brain barrier inflammatory reactions ischemic stroke network pharmacology

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MPZL1 as an HGF/MET signaling amplifier promotes cell migration and invasion in glioblastoma

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Genes & Diseases 2024年第5期11卷 70-73页

作者： Haimin Song Bowen Ni Xuetao Peng weijuan Xu Shaochun Yang Runwei Yang Ziyu Wang Kaishu Li Rui Lin Yunxiao Zhang Jinglin Guo Kezhi Wu Guangwei Shi Jichao Sun Chunming he Yawei Liu Department of Neurosurgery The First Affiliated Hospital of Gannan Medical UniversityGanzhouJiangxi 341000China Department of Neurosurgery&Medical Research Center Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)FoshanGuangdong 528300China Medical Research Center Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)FoshanGuangdong 528300China Bidding and Procurement Office Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)FoshanGuangdong 528300China Department of Neurosurgery Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China Department of Neurosurgery The Sixth Affiliated Hospital of Guangzhou Medical UniversityQingyuanGuangdong 511518China Department of Neurosurgery The First Affiliated Hospital of Shantou University Medical CollegeShantouGuangdong 515041China Department of Geriatrics Shenzhen People’s Hospital(The Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and Technology)ShenzhenGuangdong 518020China

The extremely poor prognosis of patients is largely due to hepatocyte growth factor(HGF)/MET signaling,which promotes migration and invasion of glioblastoma(IDH wildtype;GBM;WHO grade 4).1,2 Clinical trials targeting MET,the only receptor of HGF,have yielded unimpressive results in GBM.3,4 here we found that HGF induced strong chemotaxis on GBM cells,but MET expression was extremely ***,therefore,used single-cell RNA sequencing(scRNA-seq)coupled with label-free proteome profiling to identify membrane proteins associated with HGF/MET signaling amplification in GBM and to provide a novel modulator,MPZL1,for HGF/MET-targeted therapy.

关键词： invasion prognosis Clinical

Chemical composition evaluation and pyrolysis behavior of biomass tar:Pyrolysis experiment and kinetic studies

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International Journal of Agricultural and Biological Engineering 2024年第3期17卷 230-234页

作者： weijuan Lan Yunlong Zhou Jiaxin Liu Yingxian Wang Dongxue Yin Jiangtao Ji Xin Jin School of Agricultural Equipment Engineering Henan University of Science and TechnologyLuoyang 471003HenanChina

Biomass gasification process generates the residual tar,which in turn exerts some negative influence on biomass gasification *** reduce this harmful influence,an evaluation of the tar properties during the biomass gasification was *** chemical composition and pyrolysis behavior of biomass tar were *** complex chemical composition of the tar,which includes phenol derivatives,naphthalene derivatives,other macromolecular aromatic compounds,furans,and other compounds(carbon number from 7 to 14),was established by gas chromatography-mass spectrometry *** analysis was performed with two heating rates(10℃/min and 20℃/min),and Coats-Redfern method was applied to assess the kinetic parameters,i.e.,the activation energy(E)and pre-exponential factor(A)of tar thermochemical *** results showed that the main degradation of tar is a two-step process,including a volatilization step at lower temperatures(her temperatures(105℃-380℃).The application of the Coats-Redfern method revealed a variation trend of the activation energy during the decomposition of tar in a non-isothermal *** shows that high temperature is more conducive to tar *** adjusting the temperature to control the generation and removal of tar,new approaches are provided for designing and optimizing biomass gasification systems.

关键词： biomass tar chemical components thermogravimetric analysis kinetics

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青藏高原东北缘基于W2度量的全波形成像

地球物理学报 2024年第3期67卷 843-854页

作者：董兴朋杨顶辉蒙伟娟中国地震局地质研究所北京100029 清华大学数学科学系北京100084

本研究收集青藏高原东北缘区域114个宽频带地震台站记录到的50个区域地震事件波形数据,采用基于二次Wasserstein(W2)度量的全波形成像方法,获得了10~100 s频带下该区域的高分辨率壳幔结构图像.结果显示,秦岭造山带中下地壳呈高速特征,... 详细信息

本研究收集青藏高原东北缘区域114个宽频带地震台站记录到的50个区域地震事件波形数据,采用基于二次Wasserstein(W2)度量的全波形成像方法,获得了10~100 s频带下该区域的高分辨率壳幔结构图像.结果显示,秦岭造山带中下地壳呈高速特征,表明高原内部弱物质未流入此处;而从松潘—甘孜地块跨过昆仑断裂至秦祁地块内的中下地壳呈现低S波速、正径向各向异性(V_(SH)>V_(SV))和高泊松比异常,暗示深部地壳物质存在水平流动.在秦祁地块中部,深部地壳高速特性及负径向各向异性(V_(SH)

关键词：青藏高原东北缘 Wasserstein度量波形反演地壳流径向各向异性泊松比

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甲基丙烯酸原位改性丁腈橡胶/谷壳灰复合发泡涂层

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高分子材料科学与工程 2015年第4期31卷 174-179,185页

作者：郑楠刘杰邱祖民何维娟南昌大学环境与化学工程学院江西南昌330031 陕西理工学院化学与环境科学学院陕西理工学院材料科学与工程学院陕西汉中723001

以农业废弃物谷壳灰(RHA)为填料,采用液态共混工艺,即将有机溶剂溶解的NBR生胶、谷壳灰和其他助剂混合形成混合胶液制备丁腈橡胶(NBR)/RHA复合发泡涂层,在混合胶液中添加甲基丙烯酸(MAA)对NBR/RHA复合发泡涂层进行原位改性。研究了MAA... 详细信息

以农业废弃物谷壳灰(RHA)为填料,采用液态共混工艺,即将有机溶剂溶解的NBR生胶、谷壳灰和其他助剂混合形成混合胶液制备丁腈橡胶(NBR)/RHA复合发泡涂层,在混合胶液中添加甲基丙烯酸(MAA)对NBR/RHA复合发泡涂层进行原位改性。研究了MAA的用量对RHA分散性、RHA与NBR界面结合性、NBR/RHA复合发泡涂层泡孔形貌、力学性能、耐溶剂性能及热学性能的影响。结果表明,MAA作为界面改性剂,可改善RHA的分散性,增强RHA与NBR相的界面作用,改变NBR/RHA复合发泡涂层的泡孔形貌,对NBR/RHA复合发泡涂层具有补强效果。当MAA用量为10phr时,NBR/RHA复合发泡涂层的力学性能、耐流体性能、热学性能等较佳。

关键词：丁腈橡胶谷壳灰液态共混原位改性甲基丙烯酸复合发泡涂层

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LncRNA HAGLR靶向miR-625-5p对脂多糖诱导的视网膜色素上皮细胞凋亡和炎症因子表达的影响

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眼科新进展 2024年第3期44卷 178-182页

作者：李晶曾卫娟濮阳医学高等专科学校河南省濮阳市457000 武汉大学中南医院眼科湖北省武汉市430062

目的探讨长链非编码RNA HAGLR(LncRNA HAGLR)是否可通过靶向调控微小RNA-625-5p(miR-625-5p)表达而影响脂多糖(LPS)诱导的视网膜色素上皮(RPE)细胞凋亡、炎症因子表达,为揭示视网膜病变机制奠定实验基础。方法将LPS诱导人视网膜色素... 详细信息

目的探讨长链非编码RNA HAGLR(LncRNA HAGLR)是否可通过靶向调控微小RNA-625-5p(miR-625-5p)表达而影响脂多糖(LPS)诱导的视网膜色素上皮(RPE)细胞凋亡、炎症因子表达,为揭示视网膜病变机制奠定实验基础。方法将LPS诱导人视网膜色素上皮细胞(ARPE-19)设为LPS组,正常培养的ARPE-19细胞设为Con组。实时荧光定量聚合酶链反应(qRT-PCR)检测LncRNA HAGLR、miR-625-5p表达水平。根据转染物不同分为LPS+sh-NC组、LPS+sh-HAGLR组、LPS+miR-NC组、LPS+miR-625-5p组、LPS+sh-HAGLR+anti-miR-NC组、LPS+sh-HAGLR+anti-miR-625-5p组。采用流式细胞术检测细胞凋亡率;ELISA法检测白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)水平;验证LncRNA HAGLR、miR-625-5p靶向关系;Western blot检测活化的半胱氨酸天冬氨酸特异性蛋白酶3(cleaved-Caspase 3)、cleaved-Caspase 9蛋白水平。结果与Con组比较,LPS组LncRNA HAGLR表达水平升高,miR-625-5p表达水平降低(均为P<0.05),细胞凋亡率,cleaved-Caspase 3、cleaved-Caspase 9蛋白水平,IL-6、IL-1β水平均升高(均为P<0.05)。与LPS+sh-NC组比较,LPS+sh-HAGLR组细胞凋亡率,cleaved-Caspase 3、cleaved-Caspase 9蛋白水平,IL-6、IL-1β水平均降低(均为P<0.05);LncRNA HAGLR可负向调控miR-625-5p表达水平(P<0.05)。与LPS+miR-NC组比较,LPS+miR-625-5p组miR-625-5p表达水平升高,细胞凋亡率,cleaved-Caspase 3、cleaved-Caspase 9蛋白水平,IL-6、IL-1β水平均降低(均为P<0.05)。与LPS+sh-HAGLR+anti-miR-NC组比较,LPS+sh-HAGLR+anti-miR-625-5p组miR-625-5p表达水平降低,细胞凋亡率,cleaved-Caspase 3、cleaved-Caspase 9蛋白水平,IL-6、IL-1β水平均升高(均为P<0.05)。结论干扰LncRNA HAGLR表达可通过靶向调控miR-625-5p表达抑制细胞凋亡、炎症因子表达,以减轻LPS诱导的ARPE-19细胞损伤。

关键词：长链非编码RNA HAGLR 微小RNA-625-5p 脂多糖视网膜色素上皮细胞细胞凋亡炎症

Haplotype-based phylogenetic analysis and population genomics uncover the origin and domestication of sweetpotato

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Molecular Plant 2024年第2期17卷 277-296页

作者： Mengxiao Yan Ming Li Yunze Wang Xinyi Wang M-Hossein Moeinzadeh Dora G.Quispe-Huamanquispe weijuan Fan Yijie Fang Yuqin Wang Haozhen Nie Zhangying Wang Aiko Tanaka Bettina heider Jan F.Kreuze Godelieve Gheysen Hongxia Wang Martin Vingron Ralph Bock Jun Yang Shanghai Key Laboratory of Plant Functional Genomics and Resources Shanghai Chenshan Botanical GardenShanghai 201602China College of Life Sciences Chongqing Normal UniversityChongqing 401331China Biotechnology and Nuclear Technology Research Institute Sichuan Academy of Agricultural SciencesChengdu 610061China College of Life Sciences Shanghai Normal UniversityShanghai 200234China Department of Computational Molecular Biology Max Planck Institute for Molecular GeneticsIhnestraBe 63-7314195 BerlinGermany Department of Biotechnology Ghent University9000 GhentBelgium Guangdong Provincial Key Laboratory of Crops Genetics and Improvement Crop Research InstituteGuangdong Academy of Agricultural SciencesGuangzhou 510640China Graduate School of Bioagricultural Sciences Nagoya UniversityChikusaNagoya 464-8601Japan international Potato Center(CIP) LimaPeru CAS Center for Excellence of Molecular Plant Sciences Institute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200233China Max-Planck-Institut fur Molekulare Pflanzenphysiologie Am Muhlenberg 114476 Potsdam-GolmGermany

The hexaploid sweetpotato(lpomoea batatas)is one of the most important root crops ***,its genetic origin remains controversial,and its domestication history remains *** this study,we used a range of genetic evidence and a newly developed haplotype-based phylogenetic analysis to identify two probable progenitors of *** diploid progenitor was likely closely related to lpomoea ae-quatoriensis and contributed the B,subgenome,IbT-DNA2,and the lineage 1 type of chloroplast genome to *** tetraploid progenitor of sweetpotato was most likely *** 4x,which donated the B2 subgenome,IbT-DNA1,and the lineage 2 type of chloroplast *** most likely originated from reciprocal crosses between the diploid and tetraploid progenitors,followed by a subsequent whole-genome *** addition,we detected biased gene exchanges between the subgenomes;the rate of B,to B2 subgenome conversions was nearly three times higher than that of B2 to B subgenome *** analyses revealed that genes involved in storage root formation,maintenance of genome stabil-ity,biotic resistance,sugar transport,and potassium uptake were selected during the speciation and domestication of *** study sheds light on the evolution of sweetpotato and paves the way forimprovementofthiscrop.

关键词： sweetpotato origin gene conversion domestication IbT-DNA HPA