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Coordination and Optimization of Multi-controller Parameters in Power System Based on a Sphere Artificial Immune Algorithm

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Coordination and Optimization of Multi-controller Parameters...

A self-powered and sensitive terahertz photodetection based on PdSe_(2)

第40届中国控制会议

作者： Yu Miao du weijie Li Jinglin School of Mechanical-electronic and Automobile Engineering Beijing University of Civil Engineering and Architecture Beijing Engineering Research Center of Monitoring for Construction Safety State Key Laboratory of Control and Simulation of Power System and Generation Equipment Tsinghua University

Interconnected power system is becoming more and more complex, in order to improve the performance of power system, the number and type of controllers are increasing. The interaction among controllers may be detrimental to the performance of power system, which would weak the performance of controllers. The purpose of this paper is to solve the problem of coordination control among controllers, firstly, a multi-controller parameter coordination model is given. Then, a spherical artificial immune algorithm is proposed to coordinate and optimize parameters among multi-damping controllers. This algorithm can reduce the computational complexity and optimize parameters globally. Finally, this algorithm is verified by the simulation of the four-machine two-area system. Compared with one similar method, simulation results show that this algorithm can effectively realize the coordination control among multi-damping controllers.

关键词： Sphere artificial immune system power system coordination control parameter optimization

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Chinese Physics B 2022年第5期31卷 219-224页

作者： Jie Zhou Xueyan Wang Zhiqingzi Chen Libo Zhang Chenyu Yao weijie du Jiazhen Zhang Huaizhong Xing Nanxin Fu Gang Chen Lin Wang Mathematics and Science College Shanghai Normal UniversityShanghai 200233China Shanghai Institute of Technical Physics State Key Laboratory of Infrared PhysicsChinese Academy of SciencesShanghai 200083China

With the rapid development of terahertz technology,terahertz detectors are expected to play a key role in diverse areas such as homeland security and imaging,materials diagnostics,biology,medical sciences,and *** self-powered,rapid response,and room temperature terahertz photodetectors are confronted with huge ***,we report a novel rapid response and self-powered terahertz photothermoelectronic(PTE)photodetector based on a lowdimensional material:palladium selenide(Pd Se_(2)).An order of magnitude performance enhancement was observed in photodetection based on PdSe_(2)/graphene heterojunction that resulted from the integration of graphene and enhanced the Seebeck *** 0.1-THz and 0.3-THz irradiations,the device displays a stable and repeatable photoresponse at room temperature without ***,rapid rise(5.0μs)and decay(5.4μs)times are recorded under 0.1-THz *** results demonstrate the promising prospect of the detector based on Pd Se2 in terms of air-stable,suitable sensitivity and speed,which may have great application in terahertz detection.

关键词： two-dimensional material terahertz photodetector photothermoelectric(PTE)effect

MicroRNA-328,a Potential Anti-Fibrotic Target in Cardiac Interstitial Fibrosis

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MicroRNA-328,a Potential Anti-Fibrotic Target in Cardiac Int...

Mettl13 protects against cardiac contractile dysfunction by negatively regulating C-Cbl-mediated ubiquitination of SERCA2a in ischemic heart failure

第十一届海峡两岸心血管科学研讨会、2017年全国心脑血管药理学术会议、中国卒中学会第一次新药研讨会

作者： du weijie Liang Haihai Ye Yuan Shan Hongli Lu Yanjie Harbin Medical University

Background:Deregulated myocardial fibrosis is associated with a wide spectrum of cardiac conditions,being considered one of the major causes for heart *** study was designed to investigate the role of microRNA-328(miR-328) in regulating cardiac ***:We induced cardiac fibrosis following MI by occlusion of the left coronary artery in

关键词： miRNA Target MicroRNA-328,a Potential Anti-Fibrotic Target in Cardiac Interstitial Fibrosis

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Science China(Life Sciences) 2023年第12期66卷 2786-2804页

作者： Shuting Yu ZhiYong Sun Xiuzhu Wang Tiantian Ju Changhao Wang Yingqi Liu Zhezhe Qu KuiWu Liu Zhongting Mei Na Li Meixi Lu Fan Wu Min Huang Xiaochen Pang Yingqiong Jia Ying Li Yaozhi Zhang Shunkang Dou Jianhao Jiang Xin Li Baofeng Yang weijie du Department of Pharmacology(The State-Province Key Laboratories of Biomedicine Pharmaceutics of China Key Laboratory of Cardiovascular ResearchMinistry of Education)College of PharmacyHarbin Medical UniversityHarbin 150081China Northern Translational Medicine Research and Cooperation Center Heilongjiang Academy of Medical SciencesHarbin Medical UniversityHarbin 150081China Research Unit of Noninfectious Chronic Diseases in Frigid Zone Chinese Academy of Medical Sciences2019RU070Harbin 150081China Traditional Chinese Medicine School Beijing University of Chinese MedicineBeijing 100029China

Ischemic heart failure(HF)remains a leading cause of morbidity and *** homeostasis of cardiac function and preventing cardiac remodeling deterioration are critical to halting HF ***-like protein 13(Mettl13)has been shown to regulate protein translation efficiency by acting as a protein lysine methyltransferase,but its role in cardiac pathology remains *** study aims to characterize the roles and mechanisms of Mettl13 in cardiac contractile function and *** found that Mettl13 was downregulated in the failing hearts of mice post-myocardial infarction(MI)and in a cellular model of oxidative ***-specific overexpression of Mettl13 mediated by AAV9-Mettl13 attenuated cardiac contractile dysfunction and fibrosis in response to MI,while silencing of Mettl13 impaired cardiac function in normal ***,Mettl13 overexpression abrogated the reduction in cell shortening,Ca^(2+)transient amplitude and SERCA2a protein levels in the cardiomyocytes of adult mice with ***,knockdown of Mettl13 impaired the contractility of cardiomyocytes,and decreased Ca^(2+)transient amplitude and SERCA2a protein expression in vivo and in ***,Mettl13 impaired the stability of c-Cbl by inducing lysine methylation of c-Cbl,which in turn inhibited ubiquitination-dependent degradation of ***,the inhibitory effects of knocking down Mettl13 on SERCA2a protein expression and Ca^(2+)transients were partially rescued by silencing c-Cbl in H_(2)O_(2)-treated *** conclusion,our study uncovers a novel mechanism that involves the Mettl13/c-Cbl/SERCA2a axis in regulating cardiac contractile function and remodeling,and identifies Mettl13 as a novel therapeutic target for ischemic HF.

关键词： heart failure Mettl13 SERCA2a c-Cbl ubiquitination

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阿肯弹唱会体育文化研究

体育文化导刊 2008年第8期 113-114页

作者：王萍杜卫杰新疆教育学院新疆师范大学

通过对新疆草原阿肯弹唱会发展现状的问卷调查,重点分析了阿肯弹唱会体育比赛具有的五个功能:娱乐功能、亲和功能、美育功能、教育功能、传承少数民族体育文化功能。

关键词：体育文化民族体育新疆草原阿肯弹唱会体育文化功能

CPAL, as a New Mediator of Cardiomyocyte Metabolic Alterations and Pyroptosis, Regulates Myocardial Infarction Injury in Mice

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Engineering 2023年第1期20卷 49-62页

作者： Jiamin Li Hongru Xue Ning Xu Liling Gong Ming Li Sijia Li Di Huang Qingwei Zhang Pengyu Li Qingsui Li Hang Yu Yining Liu Yadong Xue Haixin Chen Jiali Liu Wanyu Zhang Mingbin Liu Siyu Chang Xianzhi Lang Xingmiao Zhao weijie du Benzhi Cai Ning Wang Baofeng Yang State-Province Key Laboratories of Biomedicine-Pharmaceutics of China&Key Laboratory of Cardiovascular Medicine Research(Ministry of Education of the People’s Republic of China) Department of PharmacologyCollege of PharmacyHarbin Medical UniversityHarbin 150081China Institute of Clinical Pharmacy The University Key Laboratory of Drug ResearchHeilongjiang Higher Education InstitutionsDepartment of Pharmacythe Second Affiliated Hospital of Harbin Medical UniversityHarbin 150081China Research Unit of Noninfectious Chronic Diseases in Frigid Zones(2019RU070) Chinese Academy of Medical SciencesHarbin 150081China Northern Translational Medicine Research and Cooperation Center Heilongjiang Academy of Medical SciencesHarbin Medical UniversityHarbin 150081China

Myocardial infarction (MI), the most serious of the ischemic heart diseases, is accompanied by myocardial metabolic disorders and the loss of cardiomyocytes. Increasing evidence has shown that long noncoding RNAs (lncRNAs) are involved in various pathological conditions such as cancer and cardiovascular diseases (CVDs), and are emerging as a novel biomarker for these disorders. This study aims to investigate the regulatory role and mechanisms of lncRNAs in myocardial remodeling in the setting of MI. We find that post-infarcted hearts exhibit a reduction of adenosine triphosphate (ATP) and an alteration of the glucose and lipid metabolism genes cluster of differentiation 36 (CD36), hexokinase 1 (HK1), and clucose transporter 4 (GLUT4), accompanied by cardiomyocyte pyroptosis. We then identify a previously unknown conserved lncRNA, AK009126 (cardiomyocyte pyroptosis-associated lncRNA, CPAL), which is remarkably upregulated in the myocardial border zone of MI mice. Importantly, the adeno-associated virus 9 (AAV9)-mediated silencing of endogenous CPAL by its short hairpin RNA (shRNA) partially abrogates myocardial metabolic alterations and cardiomyocyte pyroptosis during MI in mice. Mechanistically, CPAL is shown to bind directly to nuclear factor kappa B (NFκB) and to act as an activator of NFκB to induce NFκB phosphorylation in cardiomyocytes. We also find that CPAL upregulates caspase-1 expression at the transcriptional level and consequently promotes the release of interleukin (IL)-18 and IL-1β from cardiomyocytes. Collectively, our findings reveal the conserved lncRNA CPAL as a new regulator of cardiac metabolic abnormalities and cardiomyocyte pyroptosis in the setting of MI and suggest CPAL as a new therapeutic target to protect cardiomyocytes against ischemic injury in infarcted hearts.

关键词： Myocar dial infarction Pyroptosis CPAL NFkB Inflammation

血清β-人绒毛膜促性腺激素、孕酮、癌抗原125及子宫内膜厚度用于早期异位妊娠诊断的价值

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实用妇产科杂志 2010年第10期26卷 759-762页

作者：李武杜炜杰浙江省人民医院浙江杭州310014

目的:评价血β-人绒毛膜促性腺激素(β-HCG)、孕酮(P)、癌抗原125(CA125)及子宫内膜厚度(EST)对异位妊娠的诊断价值。方法:回顾性分析2006年6月至2009年5月在我院门诊或住院拟诊为异位妊娠并且资料齐全的患者152例的临床资料,所有患者... 详细信息

目的:评价血β-人绒毛膜促性腺激素(β-HCG)、孕酮(P)、癌抗原125(CA125)及子宫内膜厚度(EST)对异位妊娠的诊断价值。方法:回顾性分析2006年6月至2009年5月在我院门诊或住院拟诊为异位妊娠并且资料齐全的患者152例的临床资料,所有患者均于就诊当天检测血β-HCG、P及CA125,并经阴道超声检测EST,48小时后再次检测血β-HCG,通过资料计算ROC曲线下面积(AUC)并确定各检测指标的最佳工作点(OOP)。结果:89例确诊为异位妊娠,24例为宫内早孕,27例为宫内早孕流产,12例为难免流产。ROC工作曲线显示,血β-HCG48h/0h的诊断准确度最高(AUC=0.85),其次为P(AUC=0.81),再次为EST(AUC=0.79),CA125的诊断准确度最低(AUC=0.76)。ROC曲线确定检测的OOP显示,血β-HCG48h/0h为0.55,P为36.25nmol/L,EST为10.50mm,CA125为30.05KU/L临界值时具有较好的异位妊娠诊断灵敏度和特异度。结论:各检测指标用于诊断异位妊娠的灵敏度和特异度有所差异,在诊断时可结合使用。

关键词：异位妊娠 β-人绒毛膜促性腺激素孕酮癌抗原125 子宫内膜厚度

Exosomes secreted from cardiomyocytes suppress the sensitivity of tumor ferroptosis in ischemic heart failure

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Signal Transduction and Targeted Therapy 2023年第4期8卷 2007-2021页

作者： Ye Yuan Zhongting Mei Zhezhe Qu Guanghui Li Shuting Yu Yingqi Liu Kuiwu Liu Zhihua Shen Jiaying Pu Yanquan Wang Changhao Wang Zhiyong Sun Qian Liu Xiaochen Pang Ao Wang Zijing Ren Tong Wang Ying Liu Jinhuan Hong Jiajie Xie Xin Li Zhonghua Wang weijie du Baofeng Yang Department of Pharmacology(The State-Province Key Laboratories of Biomedicine Pharmaceutics of China Key Laboratory of Cardiovascular ResearchMinistry of Education)College of PharmacyHarbin Medical UniversityHarbinChina Department of Pharmacy(The University Key Laboratory of Drug Research Heilongjiang Province)The Second Affiliated Hospital of Harbin Medical UniversityHarbinChina Research Unit of Noninfectious Chronic Diseases in Frigid Zone Chinese Academy of Medical Sciences2019RU070 HarbinChina Department of Clinical Pharmacology College of PharmacyHarbin Medical UniversityHarbinChina Department of Cardiology The First Affiliated Hospital of Harbin Medical UniversityHarbinChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinChina

Heart failure(HF)patients in general have a higher risk of developing *** animal studies have indicated that cardiac remodeling and HF remarkably accelerate tumor progression,highlighting a cause-and-effect relationship between these two disease *** ferroptosis,a prevailing form of non-apoptotic cell death,has been considered a promising therapeutic strategy for human *** critically contribute to proximal and distant organ-organ communications and play crucial roles in regulating diseases in a paracrine ***,whether exosomes control the sensitivity of cancer to ferroptosis via regulating the cardiomyocyte-tumor cell crosstalk in ischemic HF has not yet been ***,we demonstrate that myocardial infarction(MI)decreased the sensitivity of cancer cells to the canonical ferroptosis activator erastin or imidazole ketone erastin in a mouse model of xenograft ***-MI plasma exosomes potently blunted the sensitivity of tumor cells to ferroptosis inducers both in vitro in mouse Lewis lung carcinoma cell line LLC and osteosarcoma cell line K7M2 and in vivo with xenograft tumorigenesis *** expression of miR-22-3p in cardiomyocytes and plasma-exosomes was significantly upregulated in the failing hearts of mice with chronic MI and of HF patients as *** of tumor cells with the exosomes isolated from post-MI mouse plasma or overexpression of miR-22-3p alone abrogated erastin-induced ferroptotic cell death in ***-enriched miR-22-3p was packaged in exosomes and transferred into tumor *** of cardiomyocyte-specific miR-22-3p by AAV9 sponge increased the sensitivity of cancer cells to ***4,a pro-ferroptotic gene,was experimentally established as a target of miR-22-3p in tumor *** together,our findings uncovered for the first time that MI suppresses erastin-induced ferroptosis through releasing miR-22-3p-enriched exosomes derived from ***

关键词： Exosomes enriched prevailing

大型集装箱船大风浪时靠、离泊安全分析与探讨

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港口科技 2011年第3期 20-24页

作者：杜伟杰宁波引航站浙江宁波315040

大型集装箱船因为受风面积大,大风浪对大型集装箱船安全靠离泊带来极大的事故隐患和风险,需要认真加以防范。分别分析了风、浪、流等对大型集装箱船舶靠、离泊的影响。并结合引航实际,大型集装箱船靠泊、离泊时应注意的事项。

关键词：港口引航大型集装箱船大风浪靠、离泊安全注意事项