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“翻转课堂”在微生物学实验“细菌鉴定中常用的生理生化反应”教学中的应用与体会

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微生物学通报 2024年第4期51卷 1314-1320页

作者：靳永新魏东盛陈容容徐欣欣李明春喻其林吴卫辉南开大学生命科学学院微生物学系天津300071

微生物学实验是高等学校微生物学课程的重要组成部分。开展微生物学实验的目的不仅是对微生物学基本技能的传授、理论的验证与拓展,也是对高年级本科生走向毕业设计及进一步开展研究生科研工作的训练。为了训练学生的科研思维,在已掌握... 详细信息

微生物学实验是高等学校微生物学课程的重要组成部分。开展微生物学实验的目的不仅是对微生物学基本技能的传授、理论的验证与拓展,也是对高年级本科生走向毕业设计及进一步开展研究生科研工作的训练。为了训练学生的科研思维,在已掌握微生物基本操作与实验技术的基础上,将最后一个实验“细菌鉴定中常用的生理生化反应”设计为“翻转课堂”形式。学生通过课前查阅资料,课上讲解实验原理、预期实验结果、观察与修正实验结果、分析与讨论实验结果完成该实验。“翻转课堂”的教学形式活跃了课堂气氛,使学生们能够更好地查阅资料进行预习,结果分析及实验结论的修订训练了学生细致观察、深入分析和严谨结论的科学素养。

关键词：微生物学实验翻转课堂细菌生理生化实验科研思维

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An Occupational Dimethylacetamide Poisoning Incident Responded Efficiently in Health Emergency Response Network—Zhuhai City,Guangdong Province,China,August 2023

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China CDC weekly 2024年第34期6卷 872-875页

作者： Jiaxin Jiang Jian Huang Jintong He Chudong Zhang weihui Liang Qifeng wu Weifeng Rong Xiaoyong Liu Guangdong Province Hospital for Occupational Disease Prevention and Treatment(GDHOD) Guangzhou CityGuangdong ProvinceChina The Third People’s Hospital of Zhuhai(Zhuhai Hospital for Occupational Disease Prevention and Treatment ZHHOD)Zhuhai CityGuangdong ProvinceChina

Summary What is already known about this topic?Dimethylacetamide(DMA),a colorless liquid with low toxicity,is commonly used as a solvent in the production of synthetic materials,petroleum processing,and pharmaceutical *** comparison to substances of higher toxicity,occupational exposure to DMA presents a deceptive risk due to its insidious and subacute progression,increasing the likelihood of escalating into major incidents.

关键词： Dimethyl Guangdong manufacture

A novel preimplantation genetic testing strategy for a subtelomeric genetic disorder:A case study

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Genes & Diseases 2024年第4期11卷 13-15页

作者： Songchang Chen Li Wanng Luting Chen weihui Shi Junyu Zhang Yuting Hu Yinyu Wang Li Jin Jianzhong Sheng Feng Zhang Yanting wu Hefeng Huang Chenming Xu Obstetrics and Gynecology Hospital Institute of Reproduction and DevelopmentFudan UniversityShanghai 200090China The International Peace Maternity and Child Health Hospital School of MedicineShanghai Jiao Tong UniversityShanghai 200030China Research Units of Embryo Original Diseases Chinese Academy of Medical SciencesShanghai 200030China Key Laboratory of Reproductive Genetics(Ministry of Education) Department of Reproductive EndocrinologyWomen's HospitalZhejiang University School of MedicineHangzhouZhejiang 310058China Shanghai Key Laboratory of Embryo Original Diseases Shanghai 200030China Shanghai First Maternity and Infant Hospital Tongji University School of MedicineShanghai 200030China

Preimplantation genetic testing(PGT)is a precise and effective technique for detecting inherited pathogenic mutations to prevent birth ***,there are few reports on PGT for pseudo-autosomal genetic diseases.

关键词： implantation testing precise

绿叶对根的情意——景德镇陶瓷文化多元化叙事的“胡辛范式”

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景德镇陶瓷 2022年第5期32卷 58-62页

作者：吴维惠景德镇学院

在中国文学史上,一位作家因为一个地方的人文滋养而茁壮成长并卓有建树者不在少数。比如鲁迅与鲁镇、巴金与成都、沈从文与湘西、孙犁与白洋淀、莫言与高密、陈忠实与白鹿原,如此等等,不一而足。在中国当代文坛,尤其是女性文坛,胡辛先... 详细信息

在中国文学史上,一位作家因为一个地方的人文滋养而茁壮成长并卓有建树者不在少数。比如鲁迅与鲁镇、巴金与成都、沈从文与湘西、孙犁与白洋淀、莫言与高密、陈忠实与白鹿原,如此等等,不一而足。在中国当代文坛,尤其是女性文坛,胡辛先生是一位德高望重的长者,是一位著作等身的重量级作家。在我看来,她的重量,不仅来自那四十多部文采斐然、散发着独特思想光芒的皇皇巨著,还来自包括铁凝.

关键词：胡辛中国文学史铁凝沈从文白鹿原莫言陈忠实孙犁

窑火谱丹心铁血铸瓷魂——创建“景德镇抗战瓷博物馆”的目标与路径浅探

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景德镇陶瓷 2023年第6期51卷 14-16页

作者：吴冕吴维惠中共景德镇市委党校景德镇学院

抗日战争时期,国土沦丧,山河破碎,偏居一隅的景德镇也未能幸免,遭到日寇的狂轰滥炸;窑业倒闭,民生凋敝,古镇的瓷业遭到重创。面对敌人的累累罪行,义愤填膺的陶瓷艺人纷纷拿起画笔,在瓷器上发出救亡图存的呐喊。抗战胜利后,景德镇陶艺名... 详细信息

抗日战争时期,国土沦丧,山河破碎,偏居一隅的景德镇也未能幸免,遭到日寇的狂轰滥炸;窑业倒闭,民生凋敝,古镇的瓷业遭到重创。面对敌人的累累罪行,义愤填膺的陶瓷艺人纷纷拿起画笔,在瓷器上发出救亡图存的呐喊。抗战胜利后,景德镇陶艺名家受命绘制了一批精美的抗战胜利瓷,表达正义战胜邪恶的喜悦。

关键词：抗日战争时期瓷业抗战胜利后偏居一隅山河破碎民生凋敝景德镇救亡图存

Emergence of hypervirulent Pseudomonas aeruginosa pathotypically armed with co-expressed T3SS effectors ExoS and ExoU

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hLife 2023年第1期1卷 44-56页

作者： Yuqin Song Yongqi Mu Nai-Kei Wong Zhuo Yue Juan Li Min Yuan Xiong Zhu Jinshu Hu Gang Zhang Dawei Wei Chao Wang weihui wu Fang Bai Jie Feng State Key Laboratory of Microbial Resources Institute of MicrobiologyChinese Academy of SciencesBeijingChina Clinical Pharmacology Section Department of PharmacologyShantou University Medical CollegeGuangdongChina State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Molecular Microbiology and Technology of the Ministry of EducationCollege of Life SciencesNankai UniversityTianjinChina State Key Laboratory for Infectious Diseases Prevention and Control Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseaseNational Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Department of Clinical Laboratory People’s Hospital of SanyaHainanChina Cangzhou Central Hospital HebeiChina College of Life Science University of Chinese Academy of SciencesBeijingChina

Pseudomonas aeruginosa is a significant pathogen mainly causing healthcare-associated infections(HAIs).Newly emerging high-risk clones of *** with elevated virulence profiles furtherly cause severe community-acquired infections(CAIs).Usually,it is not common for *** to co-carry exoU and exoS genes,encoding two type III secretion system(T3SS)*** pathogenicity mechanism of exoS+/exoU+strains of *** remains ***,we provide detailed evidence for a subset of hypervirulent *** strains,which abundantly co-express and secrete the T3SS effectors ExoS and *** exoS+/exoU+*** strains were available to cause both HAIs and *** CAI-associated strains could elicit severe inflammation and hemorrhage,leading to higher death rates in a murine acute pneumonia model,and had great virulence potential in establishing chronic infections,demonstrating hypervirulence when compared to PAO1(exoS+/exoU-)and PA14(exoS-/exoU+).Both ExoS and ExoU were co-expressed and co-secreted in abundance in exoS+/exoU+*** abundant protein secretion could boost exoS+/exoU+strains’potentials for cytotoxicity in vitro and pathogenicity in *** evidence indicates that exoU acquisition is likely mediated by horizontal gene transfer(HGT)of the pathogenicity island PAPI-2,while deletion of exoU was sufficient to mitigate virulence in the exoS+/exoU+***,bioinformatics analysis showed that such exoS+/exoU+*** strains turned out to be widely distributed across the ***,the research provide detailed evidence for the high virulence and epidemicity of exoS+/exoU+strains of ***,highlighting an urgent need for surveillance against these high-risk hypervirulent strains.

关键词： Hypervirulent Pseudomonas aeruginosa community-acquired infection type III secretion system(T3SS) co-expressed ExoS and ExoU pathogen surveillance

Ballistic performances of the hourglass lattice sandwich structures under high-velocity fragments

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Defence Technology（防务技术） 2024年第1期31卷 312-325页

作者： He-xiang wu Jia Qu Lin-zhi wu Key Laboratory of Advanced Ship Materials and Mechanics College of Aerospace and Civil EngineeringHarbin Engineering UniversityHarbin150001China School of Civil Engineering Northeast Forestry UniversityHarbin150040China

In this paper,the numerical simulation method is used to study the ballistic performances of hourglass lattice sandwich structures with the same mass under the vertical incidence of *** is paid to elucidating the influences of rod cross-section dimensions,structure height,structure layer,and rod inclination angle on the deformation mode,ballistic performances,and ability to change the ballistic direction of *** results show that the ballistic performances of hourglass lattice sandwich structures are mainly affected by their structural *** this respect,structural parameters optimization of the hourglass lattice sandwich structures enable one to effectively improve their ballistic limit velocity and,consequently,ballistic performances.

关键词： Hourglass lattice sandwich structures Ballistic performances high-velocity Finite element analysis

Resilience-incorporated seismic risk assessment of precast concrete frames with“dry”connections

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Earthquake Engineering and Engineering Vibration 2024年第2期23卷 403-425页

作者： wu Chenhao Tang Yuchuan Cao Xuyang wu Gang Key Laboratory of Concrete and Prestressed Concrete Structures of the Ministry of Education Nanjing 211102China Department of Civil and Environmental Engineering University of CaliforniaLos AngelesCA 90095USA School of Civil Engineering Southeast UniversityNanjing 211102China College of Civil and Transportation Engineering Hohai UniversityNanjing 210024China

A resilience-incorporated risk assessment framework is proposed and demonstrated in this study to manifest the advantageous seismic resilience of precast concrete frame(PCF)structures with“dry”connections in terms of their low damage and rapid *** framework integrates various uncertainties in the seismic hazard,fragility,capacity,demand,loss functions,and post-earthquake *** this study,the PCF structures are distinguished from ordinary reinforced concrete frame(RCF)structures by characterizing multiple limit states for the PCF based on its unique damage ***,probabilistic story-wise pushover analyses are performed to yield story-wise capacities for the predefined limit *** the seismic resilience analysis,a step-wise recovery model is proposed to idealize the functionality recovery process,with separate considerations of the repair and non-repair *** recovery model leverages the economic loss and downtime to delineate the stochastic post-earthquake recovery curves for the resilience loss *** such,contingencies in the probabilistic post-earthquake repairs are incorporated and the empirical judgments on the recovery parameters are largely *** proposed framework is demonstrated through a comparative study between two“dry”connected PCFs and one RCF designed as alternative structural systems for a prototype *** results from the risk quantification indicate that the PCFs show reduced loss hazards and lower expected losses relative to the ***,the PCF equipped with energy dissipation devices at the“dry”connections largely reduces the expected economic loss,downtime,and resilience loss by 29%,56%,and 60%,respectively,compared to the RCF.

关键词： precast concrete frame non-emulative precast system seismic resilience seismic risk functional recovery

New findings on the influence of El Nino events on tropical cyclone formation

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Science China Earth Sciences 2024年第3期67卷 892-893页

作者： Liguang wu Department of Atmospheric and Oceanic Sciences Institute of Atmospheric SciencesFudan UniversityShanghai 200438China

Tropical cyclones typically form over warm tropical and subtropical ocean surfaces, as their formation and intensification rely primarily on the energy provided by the ocean. Pioneering research by Gray (1968) revealed that the formation of tropical cyclones requires the sea surface temperature (SST) to be no less than 26.5℃. Consequently, SST is commonly recognized as a crucial parameter among the environmental factors influencing tropical cyclone formation(Gray, 1979;Emanuel and Nolan, 2004).

关键词： tropical cyclone ocean