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Effect of valproic acid on endogenous neural stem cell proliferation in a rat model of spinal cord injury

Neural Regeneration Research 2009年第7期4卷 513-517页

作者： Guoxin Nan Ming Li weihong liao Jiaqiang Qin Yujiang Cao Youqiong Lu Department of Orthopedics Children's Hospital Chongqing Medical University Chongqing 400014 China Research Institute of Surgery Daping Hospital Third Military Medical University of Chinese PLA National Key Laboratory of TraumaBurning and Combined Injury Chongqing 400042 China

BACKGROUND： Valproic acid has been reported to decrease apoptosis, promote neuronal differentiation of brain-derived neural stem cells, and inhibit glial differentiation of brain-derived neural stem cells. OBJECTIVE： To investigate the effects of valproic acid on proliferation of endogenous neural stem cells in a rat model of spinal cord injury. DESIGN, TIME AND SETTING： A randomized, controlled, neuropathological study was performed at Key Laboratory of Trauma, Buming, and Combined Injury, Research Institute of Surgery, Daping Hospital, the Third Military Medical University of Chinese PLA between November 2005 and February 2007. MATERIALS： A total of 45 adult, Wistar rats were randomly divided into sham surgery （n = 5）, injury （n = 20）, and valproic acid （n = 20） groups. Valproic acid was provided by Sigma, USA. METHODS： Injury was induced to the T10 segment in the injury and valproic acid groups using the metal weight-dropping method. The spinal cord was exposed without contusion in the sham surgery group. Rats in the valproic acid group were intraperitoneally injected with 150 mg/kg valproic acid every 12 hours （twice in total）.MAIN OUTCOME MEASURES： Nestin expression （5 mm from injured center） was detected using immunohistochemistry at 1,3 days, 1, 4, and 8 weeks post-injury. RESULTS： Low expression of nestin was observed in the cytoplasm, but rarely in the white matter of the spinal cord in the sham surgery group. In the injury group, nestin expression was observed in the ependyma and pia mater one day after injury, and expression reached a peak at 1 week （P 〈 0.05）. Expression was primarily observed in the ependymal cells, which expanded towards the white and gray matter of the spinal cord. Nestin expression rapidly decreased by 4 weeks post-injury, and had almost completely disappeared by 8 weeks. At 24 hours after spinal cord injury, there was no significant difference in nestin expression between the valproic acid and injury groups. At 1 week, the

关键词： spinal cord injury nestin endogenous neural stem cells valproic acid rats

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STUDIES ON THE REACTIONS OF HIPPOCAMPAL FORMATION IN PAIN MODULATION AND ACUPUNCTURE ANALGESIA

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针刺研究 1989年第Z1期 45-46页

作者： Liu Zuozhou liao weihong Department of Physiology, The Third Military Medical University, Chongqing, China

It has been proved that the hippocampal formation is closely related tosome behaviour reactions (such as learning and memory), visceraI activities,and neuro-endocrine regulations. However, what roles the hippocampus mayplay in pain modulation and analgesic mechanism still need further *** we have done some works in this field. The blood pressure increased accompanying hippocampal EEG's slowrhythmic activity (SRA or theta rhythm) which had a higher amplitude and alonger time course. This EEG wave was specific and could be used as one ofindexes of nociceptive response. Our experiments also demonstrated that theblood pressure increase could be induced by peripheral somatic noxious stimu-

关键词： EEG STUDIES ON THE REACTIONS OF HIPPOCAMPAL FORMATION IN PAIN MODULATION AND ACUPUNCTURE ANALGESIA

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EFFECTS OF MICROIONTOPHORETIC APPLICATION OF SEROTONIN AND METHYSERGIDE ON HIPPOCAMPALNOCICEPTIVE UNITS RESPONDING TO NOXIOUS STIMULATION OF SAPHENOUS NERVE IN THE RAT

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针刺研究 1989年第Z1期 47-48页

作者： liao weihong Feng Zhengzhi Bi Xiaoning Liu Zuozhou Department of Physiology, The Third Military Medical University, Chongqing

In this study an attempt was made to observe the effects of iontophoreticapplication of 5-HT and methysergide on the nociceptive units. CA1 area ofhippocampus (HPC). Experiments were performed on 50 rats anaesthetizedwith choralose and urethane. The animals were immobilized with d-tubocura-rine. Stimulation of the sephenous nerve with a train of electric pulses wasused as a noxious stimulus. Single units were recorded extracellularly by the6-barrelled micropipett with stereotaxic techenique.

关键词： HPC HT CAI area EFFECTS OF MICROIONTOPHORETIC APPLICATION OF SEROTONIN AND METHYSERGIDE ON HIPPOCAMPALNOCICEPTIVE UNITS RESPONDING TO NOXIOUS STIMULATION OF SAPHENOUS NERVE IN THE RAT RAT

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EFFECTS OF ELECTROACUPUNCTURE ON EPILEPTIFORM HIPPOCAMPAL UNIT ACTIVITY INDUCED BY INTRACERE-BROVENTRICUILAR INJECTION OF CORIARIA LACTONE

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针刺研究 1989年第Z1期 49-50页

作者： Gao Chong liao weihong Yang Jizeng Department of Physiology, Chengdu Traditional Chinese Medicine College, Chengdu Department of Physiology, The Third Military Medical University, Chongqing

In our present study we build up a new experimental model in the rat forepilepsy and examine the effects of electroacupuncture on epileptiform hippo-campal unit activity. Experiments were carried out on conscious immobilized male rats, CoriariaLactone at a concentration of 30μg/10μl in saline was injected intracerebrove-ntricularly. Electrocorticography (ECoG) and hippocampal unit activity wererecorded simultaneously on the side of brain which received the drug *** some cases, the hippocampal EEG was also recorded. Acupuncture of Da-zhui, Shenzhu, Taichong and Kunlun were stumulated respectively.

关键词： In EFFECTS OF ELECTROACUPUNCTURE ON EPILEPTIFORM HIPPOCAMPAL UNIT ACTIVITY INDUCED BY INTRACERE-BROVENTRICUILAR INJECTION OF CORIARIA LACTONE

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移动互联网环境下消费者行为研究

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科技管理研究 2013年第14期33卷 179-183页

作者：廖卫红湖南机电职业技术学院湖南长沙410151

比较传统市场环境和传统互联网环境下消费者行为特征、影响因素、决策过程与行为模式,根据移动互联网环境下电子商务精准互动、个性化超强等特征,归纳、总结、构建出移动互联网环境下消费者行为特点、影响因素、消费决策过程模型与消费... 详细信息

比较传统市场环境和传统互联网环境下消费者行为特征、影响因素、决策过程与行为模式,根据移动互联网环境下电子商务精准互动、个性化超强等特征,归纳、总结、构建出移动互联网环境下消费者行为特点、影响因素、消费决策过程模型与消费行为模型。

关键词：互联网移动互联网消费者行为

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Tobacco as a promising crop for low-carbon biorefinery

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The Innovation 2024年第5期5卷 111-118,110页

作者： Fan Wang Xinglin Jiang Yuchen Liu Ge Zhang Yao Zhang Yongming Jin Sujuan Shi Xiao Men Lijuan Liu Lei Wang weihong liao Xiaona Chen Guoqiang Chen Haobao Liu Manzoor Ahmad Chunxiang Fu Qian Wang Haibo Zhang Sang Yup Lee Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of SciencesQingdao 266101China Tobacco Research Institute Chinese Academy of Agricultural SciencesQingdao 266101China Department of Chemical and Biomolecular Engineering(BK21 four) Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea The Novo Nordisk Foundation Center for Biosustainability Technical University of Denmark2800 Kongens LyngbyDenmark Shandong Energy Institute Qingdao 266101China Qingdao New Energy Shandong Laboratory Qingdao 266101China Sino-Danish College University of Chinese Academy of SciencesBeijing 100049China School of Life Science and Engineering Lanzhou University of TechnologyLanzhou 730050China Zhengzhou Tobacco Research Institute Zhengzhou 450001China

Energy crops play a vital role in meeting future energy and chemical demands while addressing climate ***,the idealization of lowcarbon workflows and careful consideration of cost-benefit equations are crucial for their more sustainable ***,we propose tobacco as a promising energy crop because of its exceptional water solubility,mainly attributed to a high proportion of water-soluble carbohydrates and nitrogen,less lignocellulose,and the presence of *** then designed a strategy that maximizes biomass conversion into bio-based products while minimizing energy and material *** autoclaving tobacco leaves in water,we obtained a nutrient-rich medium capable of supporting the growth of microorganisms and the production of bioproducts without the need for extensive pretreatment,hydrolysis,or additional ***,cultivating tobacco on barren lands can generate sufficient biomass to produce approximately 573 billion gallons of ethanol per *** approach also leads to a reduction of greenhouse gas emissions by approximately 76%compared to traditional corn stover during biorefinery ***,our study presents a novel and direct strategy that could significantly contribute to the goal of reducing carbon emissions and global sustainable development compared to traditional methods.

关键词： exceptional crops supporting

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基于Fourier描绘子的脑部切片匹配方法

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生物医学工程学杂志 2000年第4期17卷 437-439页

作者：吴宝明陈和晏廖维宏第三军医大学大坪医院野战外科研究所五室重庆400042 香港大学电机电子工程系

本文提出一种基于Fourier描绘子匹配脑部切片的算法 ,用于汇聚组合来自不同动物的生理数据。首先 ,将大鼠中脑组织切片数字化 ,用三条封闭特征轮廓表示 ,一组大鼠中脑 38张的连续切片被作为与其它任何切片匹配的标准模板。然后 ,将每一... 详细信息

本文提出一种基于Fourier描绘子匹配脑部切片的算法 ,用于汇聚组合来自不同动物的生理数据。首先 ,将大鼠中脑组织切片数字化 ,用三条封闭特征轮廓表示 ,一组大鼠中脑 38张的连续切片被作为与其它任何切片匹配的标准模板。然后 ,将每一切片的轮廓作Fourier展开 ,通过计算两切片对应轮廓的尤拉距离 ,结合三轮廓的权重 ,定义两切片间的“相似函数”。最后 ,根据实验组切片与标准模板切片之间相似函数的大小实现两者的匹配。本算法已成功应用于调幅声敏感听觉细胞功能组织的研究。

关键词：脑部切片匹配 Fourier描绘子电生理

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移动电子商务中消费者购买行为决策影响因素分析及实证研究

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改革与战略 2016年第8期32卷 113-118页

作者：廖卫红徐选华湖南机电职业技术学院湖南长沙410151 中南大学湖南长沙410083

文章以无线购物复杂程度、无线购物网站质量、无线网络系统的服务稳定性和可靠性等作为影响因素构建研究模型,通过发放调研问卷取得数据,利用SPSS22.0和结构方程模型(SEM)软件Lisrel8.7对问卷的信度、效度和模型建设进行分析检验,结果表... 详细信息

文章以无线购物复杂程度、无线购物网站质量、无线网络系统的服务稳定性和可靠性等作为影响因素构建研究模型,通过发放调研问卷取得数据,利用SPSS22.0和结构方程模型(SEM)软件Lisrel8.7对问卷的信度、效度和模型建设进行分析检验,结果表明,无线购物网站质量、无线网络系统的服务稳定性和可靠性、无线商家的品牌知名度和活动促销力度、同伴群体的影响、消费者的敢于创新的个性特征等五个因素对消费者的购买行为决策有正向显著影响,而感知的移动支付安全风险负向显著影响消费者购买行为决策。文章最后建议商家建设好网站、塑造品牌形象、加大促销力度、收集客户信息和加强信息基础设施建设等,以吸引更多的消费者通过移动电子商务进行消费,促进电子服务的发展。

关键词：移动电子商务消费者行为移动购物无线购物网站

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随机游动法在环状河网计算中的应用研究

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系统工程理论与实践 2016年第8期36卷 2169-2176页

作者：王家彪雷晓辉廖卫红王浩中国水利水电科学研究院流域水循环模拟与调控国家重点实验室北京100038

环状河网求解不同于树状河网,在采用三级解法进行环状河网非恒定流计算时常面临求解大型矩阵的难题.针对这一问题,从水流质点游动角度出发,研究将随机游动方法应用于环状河网水位计算,实现随机游动方法与三级解法相结合.在三级解法得到... 详细信息

环状河网求解不同于树状河网,在采用三级解法进行环状河网非恒定流计算时常面临求解大型矩阵的难题.针对这一问题,从水流质点游动角度出发,研究将随机游动方法应用于环状河网水位计算,实现随机游动方法与三级解法相结合.在三级解法得到节点水位方程组基础上,给出节点水位的随机显式求解新方法,然后采用追赶法完成整个河网水位流量计算.与常规三级解法相比,该方法求解原理简单,避免了大型矩阵的直接求解.将新方法建立模型运用于西江下游河网计算,结果表明,该方法较常规方法在简化运算的同时提高了计算效率,并且与常规三级解法具有同样的精度.模型计算结果也量化了各节点水位之间的相对联系情况.

关键词：环状河网节点水位计算随机游动转移概率计算效率

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胚胎脊髓移植联合应用神经生长因子、尼莫地平对成鼠损伤脊髓功能的影响

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第三军医大学学报 1999年第7期21卷 479-481页

作者：邓少丽袁涛廖维宏第三军医大学附属大坪医院野战外科研究所第三研究室重庆400042

目的：研究胚胎脊髓移植联合应用神经生长因子（NGF）及尼莫地平（ND）对脊髓损伤的修复作用。方法：72只大鼠半切洞脊髓损伤后，随机分为单纯胚胎脊髓移植组，移植＋NGF组，移植＋NGF＋ND组，并观察了脊髓血流量（SCBF），运动诱发电位... 详细信息

目的：研究胚胎脊髓移植联合应用神经生长因子（NGF）及尼莫地平（ND）对脊髓损伤的修复作用。方法：72只大鼠半切洞脊髓损伤后，随机分为单纯胚胎脊髓移植组，移植＋NGF组，移植＋NGF＋ND组，并观察了脊髓血流量（SCBF），运动诱发电位（MEP）及行为学变化。结果：NGF与ND可明显增加损伤移植部位的血流量，缩短MEP潜伏期，且显著提高后肢运动功能的Tarlov评分。结论；胚胎脊髓移植与NGF、ND联用，可促进大鼠损损伤脊髓功能恢复。

关键词：神经生长因子尼莫地平脊髓损伤胚胎脊髓移植

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