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The First-in-Human Whole-Body Dynamic Pharmacokinetics Study of Aptamer

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Research 2024年第1期2023卷 119-130页

作者： Ding Ding Haitao Zhao Dali Wei Qinglai Yang Cai Yang Ruowen Wang Yumei Chen Lianghua Li Shuxian An Qian Xia Gang huang Jianjun Liu Zeyu Xiao weihong Tan Institute of Molecular Medicine(IMM) Renji HospitalState Key Laboratory of Oncogenes and Related GenesShanghai Jiao Tong University School of Medicineand College of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Nuclear Medicine Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Center for Molecular Imaging Probes Cancer Research InstituteUniversity of South ChinaHengyangHunan 421001China The Key Laboratory of Zhejiang Province for Aptamers and Theranostics Zhejiang Cancer HospitalHangzhou Institute of Medicine(HIM)Chinese Academy of SciencesHangzhouZhejiang 310022China Molecular Science and Biomedicine Laboratory(MBL) State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringHunan UniversityChangshaHunan 410082China Shanghai Key Laboratory of Molecular Imaging Shanghai University of Medicine and Health SciencesShanghai 201318China Department of Pharmacology and Chemical Biology Shanghai Jiao Tong University School of MedicineShanghai200127China

Serving as targeting ligands,aptamers have shown promise in precision ***,the lack of knowledge of the biosafety and metabolism patterns in the human body largely impeded aptamers’clinical *** bridge this gap,here we report the first-in-human pharmacokinetics study of protein tyrosine kinase 7 targeted SGC8 aptamer via in vivo PET tracking of gallium-68(^(68)Ga)radiolabeled *** specificity and binding affinity of a radiolabeled aptamer,named ^(68)Ga[Ga]-NOTA-SGC8,were maintained as proven in *** preclinical biosafety and biodistribution evaluation confirmed that aptamers have no biotoxicity,potential mutation risks,or genotoxicity at high dosage(40 mg/kg).Based on this result,a first-in-human clinical trial was approved and carried out to evaluate the circulation and metabolism profiles,as well as biosafety,of the radiolabeled SGC8 aptamer in the human *** advantage of the cutting-edge total-body PET,the aptamers’distribution pattern in the human body was acquired in a dynamic fashion.

关键词： metabolism dosage Whole

Optimized NPK fertilizer recommendations based on topsoil available nutrient criteria for wheat in drylands of China

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Journal of Integrative Agriculture 2024年第7期23卷 2421-2433页

作者： Wenjie Yang Jie Yu Yanhang Li Bingli Jia Longgang Jiang Aijing Yuan Yue Ma Ming huang Hanbing Cao Jinshan Liu weihong Qiu Zhaohui Wang Key Laboratory of Plant Nutrition and Agri-environment in Northwest China Ministry of Agriculture and Rural Affairs/College of Natural Resources and EnvironmentNorthwest A&F UniversityYangling 712100China

The optimized management of crop fertilization is very important for improving crop yield and reducing the consumption of chemical *** nutrient values can be used for evaluating the nutritional status of a crop,and they reflect the nutrient concentrations above which the plant is sufficiently supplied for achieving the maximum potential *** on on-farm surveys of 504 farmers and 60 field experimental sites in the drylands of China,we proposed a recommended fertilization method to determine nitrogen(N),phosphorus(P),and potassium(K)fertilizer input rates for wheat production,and then validated the method by a field experiment at 66 different sites in northern *** results showed that wheat grain yield varied from 1.1 to 9.2 t ha^(-1),averaging 4.6 t ha^(-1),and it had a quadratic relationship with the topsoil(0-20 cm)nitrate N and soil available P contents at ***,yield was not correlated with the inputs of N,P,and K *** on the relationship(exponential decay model)between 95–105%of the relative yield and topsoil nitrate N,available P,and available K contents at wheat harvest from 60 field experiments,the topsoil critical nutrient values were determined as 34.6,15.6,and 150 mg kg^(-1)for soil nitrate N,available P,and available K,***,based on five groups of relative yield(>125%,115–125%,105–115%,95–105%,and<95%)and the model,the five groups of topsoil critical nutrient levels and fertilization coefficients(Fc)were ***,we proposed a new method for calculating the recommended fertilizer input rate as:Fr=Gy×Nr×Fc,where Fr is the recommended fertilizer(N/P/K)input rate;Gy is the potential grain yield;Nr is the N(N_(rN)),P(N_(rP)),and K(N_(rK))nutrient requirements for wheat to produce 1,000 kg of grain;and Fc is a coefficient for N(N_c)/P(P_c)/K(K_c)fertilizer.A 2-year validated experiment confirmed that the new method reduced N fertilizer input by 17.5%(38.5 kg N ha^(-1))and P fertilizer i

关键词： fertilization method dryland wheat soil nutrient critical value soil nitrogen topsoil nutrients

基于ARCnet/Ethernet的MMS集成通信系统

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计算机工程 1998年第4期24卷 43-45页

作者：黄伟红吴介一东南大学CIMS研究中心南京210096

在CIMS产业化的过程中，制造报文规范（MMS）成为CIMS网络集成的关键之一。文中探讨了从原有的MAP／TOP体系结构向面向实际应用型的ARCnet／Ethernet体系结构转变的问题，并在对MMS作系统分析之后，提出了基于ARCnet／Ethernet的MMS集... 详细信息

在CIMS产业化的过程中，制造报文规范（MMS）成为CIMS网络集成的关键之一。文中探讨了从原有的MAP／TOP体系结构向面向实际应用型的ARCnet／Ethernet体系结构转变的问题，并在对MMS作系统分析之后，提出了基于ARCnet／Ethernet的MMS集成通信系统的实现策服。

关键词：制造报文规范集成通信系统 CIMS MMS 局域网

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我国农业实行适度规模经营的条件分析

安徽农业科学 2006年第11期34卷 2578-2579,2588页

作者：黄卫红仲恺农业技术学院经济与管理学院广东广州510225

农业实行适度规模经营对我国实现农业现代化、解决农村一些深层次矛盾极为重要,但我国实施农业适度规模经营必须具备:农业适度规模经营必须进行土地制度创新,农业适度规模经营必须实行农村剩余劳动力的转移,农业适度规模经营必须大力发... 详细信息

农业实行适度规模经营对我国实现农业现代化、解决农村一些深层次矛盾极为重要,但我国实施农业适度规模经营必须具备:农业适度规模经营必须进行土地制度创新,农业适度规模经营必须实行农村剩余劳动力的转移,农业适度规模经营必须大力发展农村教育,农业适度规模经营必须坚持家庭联产承包责任制不动摇。

关键词：农业适度规模经营条件分析

Operation Efficiency and Influencing Factors of Listed Companies of Swine Industry:Empirical Analysis Based on Data of 16 Listed Companies in 2010-2014

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Asian Agricultural Research 2017年第3期9卷 14-19,23页

作者： Mengqi YOU Zhenhong QI Ai’e WANG Xinrui LI weihong huang Wenbin WAN College of Economics and Management Huazhong Agricultural UniversityWuhan 430070China Hubei Rural Development Research Center Wuhan 430070China

Listed companies of the swine industry,as an important form of agricultural industrialized operation,are typical representatives of large-scale production and the level of their operation efficiency exerts a direct influence on the healthy development of the swine *** the DEA-based Malmquist method,this paper made a static and dynamic evaluation of the operation efficiency of 16 listed companies in China's swine industry in 2010-2014. It obtained following results:( i) The overall efficiency of listed companies of China's swine industry remained at high level and the development trend was excellent.( ii) Different types of enterprises had difference in the overall efficiency,pure technical efficiency and scale efficiency. In general,pig feed processing companies had the best performance,followed by slaughtering and deep processing companies,and swine breeding companies were the worst.( iii) The total factor productivity characterized by the Malmquist index declined year by year in 2010-2013 and was improved in 2014,mainly due to technological progress.( iv) The total asset turnover ratio,equity concentration,and R & D management level had a significantly positive impact on the operation efficiency of listed companies in the swine industry,while the human capital had a significantly negative impact.

关键词： Operation efficiency Influencing factor Listed companies of swine industry DEA-based Malmquist DEA-Tobit

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我国粮食流通体制改革若干问题研究

安徽农业科学 2006年第8期34卷 1696-1697页

作者：黄卫红仲恺农业技术学院经济与管理学院广东广州510225

分析了我国粮食流通体制的现状及其形成原因,从价值取向、改革目标与改革手段3个方面深入探讨了粮食流通体制的改革。

关键词：粮食流通体制改革

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南水北调崇青隧洞施工涌水条件及涌水量研究

人民黄河 2016年第8期38卷 118-120,124页

作者：黄卫红北京市水利规划设计研究院北京100048

基于前期勘察成果、施工地质资料,对南水北调中线北京段崇青隧洞的工程地质条件进行了详细介绍,并对隧洞施工涌水地质条件进行了分析,在此基础上采用大井法和集水廊道法分别对隧洞涌水量进行计算,并与实测涌水量进行对比研究。结果表明... 详细信息

基于前期勘察成果、施工地质资料,对南水北调中线北京段崇青隧洞的工程地质条件进行了详细介绍,并对隧洞施工涌水地质条件进行了分析,在此基础上采用大井法和集水廊道法分别对隧洞涌水量进行计算,并与实测涌水量进行对比研究。结果表明:大井法估算涌水量为433 L/min,总体比实测值偏大;而集水廊道法估算涌水量为288 L/min,总体接近实测值;隧洞工程涌水量计算应有可靠的地质资料作为支撑,以避免计算失真,保证计算结果的可靠性。

关键词：隧洞涌水量大井法集水廊道法南水北调中线

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我国农村土地纠纷成因透析

安徽农业科学 2007年第5期35卷 1473-1474页

作者：黄卫红仲恺农业技术学院经济与管理学院广东广州510225

从静态角度分析了我国农村土地纠纷的现状,对我国农村土地纠纷原因作了细致剖析。

关键词：农村土地纠纷成因

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浅析农民合作经济组织发展中的政府行为

安徽农业科学 2006年第9期34卷 1969-1970页

作者：黄卫红仲恺农业技术学院经济与管理学院广东广州510225

政府主导的农民合作经济组织存在着产权不清、政企不分等特点,阻碍了合作经济组织的规范发展。政府在农民合作经济组织的发展中应有所为、有所不为,为合作经济的健康、规范发展创造良好的政策环境和法制环境。

关键词：规范政府行为农民合作经济