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Homer1a reduces inflammatory response after retinal ischemia/reperfusion injury

Neural Regeneration Research 2024年第7期19卷 1608-1617页

作者： Yanan Dou Xiaowei Fei Xin He Yu Huan Jialiang Wei Xiuquan Wu weihao lyu Zhou Fei Xia Li Fei Fei Department of Neurosurgery Xijing HospitalAir Force Military Medical UniversityXi’anShaanxi ProvinceChina Department of Ophthalmology Xijing HospitalAir Force Military Medical UniversityXi’anShaanxi ProvinceChina

Elevated intraocular pressure(IOP)is one of the causes of retinal ischemia/reperfusion injury,which results in NRP3 inflammasome activation and leads to visual *** is repo rted to play a protective role in neuroinflammation in the ***,the effects of Homerla on NLRP3inflammasomes in retinal ischemia/reperfusion injury caused by elevated IOP remain *** our study,animal models we re constructed using C57BL/6J and Homer1^(flox/-)/Homerla^(+/-)/Nestin-Cre^(+/-)mice with elevated IOP-induced retinal ischemia/repe rfusion *** in vitro expe riments,the oxygen-glucose deprivation/repe rfusion injury model was constructed with M uller *** found that Homerla ove rexpression amelio rated the decreases in retinal thickness and Muller cell viability after ischemia/reperfusion ***,Homerla knockdown promoted NF-κB P65^(Ser536)activation via caspase-8,NF-κB P65 nuclear translocation,NLRP3 inflammasome formation,and the production and processing of interleukin-1βand inte *** opposite results we re observed with Homerla ove ***,the combined administration of Homerla protein and JSH-23 significantly inhibited the reduction in retinal thickness in Homer1^(flox/-)Homer1a^(+/-)/Nestin-Cre^(+/-)mice and apoptosis in M uller cells after ischemia/reperfusion *** together,these studies demonstrate that Homer1a exerts protective effects on retinal tissue and M uller cells via the caspase-8/NF-KB P65/NLRP3 pathway after I/R injury.

关键词： caspase-8 Homer1a interleukin-18 interleukin-1β intraocular pressure ischemia/reperfusion injury JSH-23 Müller cells NLRP3 nuclear factor-kB p65 retina

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防护风镜对眼爆震伤诱导视网膜病理损伤和自噬变化的有效改善

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爆炸与冲击 2024年第12期44卷 159-177页

作者：晁望舒费晓炜李伟萍豆雅楠王俊龙何鑫吕伟豪武秀权陈红庆陈雷颖马天费舟庄茁康越费霏空军军医大学基础医学院陕西西安710032 空军军医大学西京医院陕西西安710032 军事医学科学院系统工程研究院北京100010 清华大学航天航空学院北京100084

首先基于头部动态测试系统与激波管和外场实弹实爆测试环境,验证了眼部装备(护目镜和风镜)的防护性能。研究结果表明,风镜防护性能更优,建议给执勤人员配发兼容防紫外、强光、烟雾和防破片功能的风镜产品,以提高相关人员眼部防护能力。... 详细信息

首先基于头部动态测试系统与激波管和外场实弹实爆测试环境,验证了眼部装备(护目镜和风镜)的防护性能。研究结果表明,风镜防护性能更优,建议给执勤人员配发兼容防紫外、强光、烟雾和防破片功能的风镜产品,以提高相关人员眼部防护能力。此后,研究眼部爆震伤后组织损伤、功能改变及市售风镜动物实验版的防护作用与机制,为防治眼部爆震伤及风镜后续的设计改进提供理论依据。选用比格犬和C57小鼠进行相关动物实验,通过HE、Tunel、Nissl染色、视觉电生理检查等检测方法,发现随着冲击波强度的提高和伤后时间的延长,视网膜损伤程度和细胞凋亡程度均提高,其中神经节细胞层(ganglion cell layer,GCL)和光感受器内外节交界处(layer of photoreceptor inner/outer segments,IS/OS)受到的损伤最严重;进一步研究分子变化发现,自噬相关调节蛋白SQSTM1/p62(P<0.0001)和LC3-Ⅱ(P=0.8437)、LC3-Ⅰ(P=0.003)的表达量明显增高,说明视网膜损伤一定程度上是由爆震伤后自噬增强这一机制导致的。市售风镜的动物实验版能够有效减轻冲击波对视网膜的损伤,保护RNFL、INL/ONL、GCL和IS/OS的结构。同时,与其他组相比,3.5 MPa组防护组与损伤组视网膜损伤和细胞凋亡程度差异最显著,推测该强度下防护风镜发挥了最大的保护作用,保护机制与防护降低视网膜细胞自噬相关。

关键词：比格犬眼部爆震伤防护风镜视网膜线粒体自噬

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重型颅脑损伤后钠钾紊乱等二次脑损伤因素对伤情的影响

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空军军医大学学报 2022年第4期43卷 424-427,431页

作者：吕伟豪武秀权郇宇吴霜何鑫费晓炜费舟张磊空军军医大学西京医院神经外科陕西西安710032

目的探讨重型颅脑损伤(sTBI)患者住院期间血钠、血钾紊乱频次与其早期伤情改变的关系。方法回顾性分析2013年10月至2019年6月空军军医大学西京医院神经外科重症监护室收治的454例sTBI患者临床资料。根据患者出院时的格拉斯哥预后评分(G... 详细信息

目的探讨重型颅脑损伤(sTBI)患者住院期间血钠、血钾紊乱频次与其早期伤情改变的关系。方法回顾性分析2013年10月至2019年6月空军军医大学西京医院神经外科重症监护室收治的454例sTBI患者临床资料。根据患者出院时的格拉斯哥预后评分(GOS)将其分为两组:转归良好组,GOS>3分;转归不良组,GOS≤3分。统计患者年龄,性别,住院期间血钠、血钾离子紊乱的频次等,采用单因素和多因素logistic回归分析判断影响伤情加重的危险因素,并通过绘制受试者工作(ROC)曲线评价伤情加重危险因素的诊断效能。结果在纳入人群中,伤情转归不良313例,伤情转归良好141例。单因素分析显示,年龄,住院期间血钠、血钾异常总频次与颅脑损伤(TBI)伤情改变相关(P<0.05)。多因素logistic回归分析显示,患者住院期间血钠、血钾发生异常总频次为加重TBI伤情的危险因素,ROC曲线提示住院期间血钠、血钾异常发生总频次可能具备一定的诊断效能。结论患者住院期间发生血钠、血钾异常总频次是TBI患者伤情加重的危险因素之一,其有可能成为一个简便的判断患者伤情改变情况的指标。

关键词：重型颅脑损伤二次脑损伤电解质紊乱早期伤情转归

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In situ generated layered NiFe-LDH/MOF heterostructure nanosheet arrays with abundant defects for efficient alkaline and seawater oxidation

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Nano Research 2023年第7期16卷 8945-8952页

作者： Manjie Xiao Can Wu Jiawei Zhu Chengtian Zhang Yan Li Jiahui lyu weihao Zeng Haiwen Li Lei Chen Shichun Mu State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Foshan Xianhu Laboratory Foshan 528200China Science and Technology Institute of Advanced Technology Wuhan 430051China Hefei General Machinery Research Institute Hefei 230031China

As the main limiting step of overall water splitting,oxygen evolution reaction(OER)is urgent to be enhanced by developing efficient catalysts to promote the process of electrolytic *** on theoretical analysis,the Ni-metal-organic framework(Ni-MOF)and NiFe-layered double hydroxide(NiFe-LDH)(NiFe-LDH/MOF)heterostructure can optimize the energy barrier of the OER process and decrease the adsorption energy of oxygen-containing intermediates,effectively accelerating the OER ***,layered NiFe-LDH/MOF heterostructures are in situ constructed through a facile two-step reaction process,with substantial oxygen defects and lattice defects that further improve the catalytic *** a result,only 208 and 275 mV OER overpotentials are needed for NiFe-LDH/MOF to drive the current densities of 20 and 100 mA·cm^(-2)in 1 M KOH solutions,and even maintain catalytic stability of 100 h at 20 mA·cm^(-2).When applied to seawater oxidation,only 235 and 307 mV OER overpotentials are required to achieve the current densities of 20 and 100 mA·cm^(-2),respectively,with almost no attenuation for 100 h stability test at 20 mA·cm^(-2),all better than commercial RuO_(2).This work provides the theoretical and experimental basis and a new idea for efficiently driving fresh water and seawater cracking by heterostructure and defect coupling design toward catalysts.

关键词： oxygen evolution reaction defects seawater electrolysis catalyst

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An uncertainty investigation for liner impedance eduction methods

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Chinese Journal of Aeronautics 2024年第3期37卷 49-59页

作者： weihao SHI Xiaodong JING School of Energy and Power Engineering Beihang UniversityBeijing 100191China

Impedance eduction methods have been developed for decades to meet the increasing need for high-quality impedance data in the design and optimization of acoustic *** this end,it is important to fully investigate the uncertainty problem,to which only limited attention has been devoted so *** paper considers the possibility of acoustically-induced structural vibration as a nonnegligible uncertainty or error source in impedance eduction *** the frequency moves away from the resonant frequency,with the increase in the value of cavity reactance,the acoustic particle velocity inside liner orifices possibly decreases to the extent comparable to the vibration velocity of liner facing ***,the acoustically-induced vibration,although generally being weak except at the inherent structural frequencies,may considerably affect the impedance eduction results near the anti-resonant frequency where the liner has poor *** demonstrate the effect of structural vibration,the vibration velocity of liner facing sheet is estimated from the experimentally educed admittance of the liner samples whose orifices are sealed with ***,a three-dimensional numerical model is set up,in which normal particle velocity is introduced over the solid portion of liner facing sheet to imitate structural vibration,rather than directly solving the acoustic-structural coupling *** shown by the results,the vibration of liner facing sheet,whose velocity is as small as estimated by the experiment,can result in anomalous deviation of the educed impedance from the impedance model near the anti-resonant *** trend that the anomalous deviation varies with frequency is numerically captured.

关键词： Impedance eduction Uncertainty analysis Acoustically-induced structural vibration Anti-resonant frequency Perforated liner

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Learning layout generation for virtual worlds

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Computational Visual Media 2024年第3期10卷 577-592页

作者： weihao Cheng Ying Shan ARC Lab TencentShenzhen 518057China

The emergence of the metaverse has ledto the rapidly increasing demand for the generation ofextensive 3D worlds. We consider that an engagingworld is built upon a rational layout of multiple landuse areas (e.g., forest, meadow, and farmland). Tothis end, we propose a generative model of landuse distribution that learns from geographic *** model is based on a transformer architecturethat generates a 2D map of the land-use layout,which can be conditioned on spatial and semanticcontrols, depending on whether either one or bothare provided. This model enables diverse layoutgeneration with user control and layout expansion byextending borders with partial inputs. To generatehigh-quality and satisfactory layouts, we devise ageometric objective function that supervises the modelto perceive layout shapes and regularize generationsusing geometric priors. Additionally, we devise aplanning objective function that supervises the modelto perceive progressive composition demands andsuppress generations deviating from controls. Toevaluate the spatial distribution of the generations, wetrain an autoencoder to embed land-use layouts intovectors to enable comparison between the real andgenerated data using the Wasserstein metric, which isinspired by the Fr´echet inception distance.

关键词： layout generation virtual worlds Transformer land-use

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重型颅脑损伤合并应激性高血糖患者血糖水平与预后的关系

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中华神经创伤外科电子杂志 2023年第6期9卷 338-342页

作者：吕伟豪费晓炜武秀权何鑫郇宇吴霜豆雅楠费舟胡世颉空军军医大学第一附属医院神经外科西安710032

目的探讨入院伴随应激性高血糖(SH)的重型颅脑损伤(sTBI)患者住院期间随机血糖水平与预后的关系。方法回顾性分析空军军医大学第一附属医院神经外科重症监护室自2013年10月至2022年6月收治的85例sTBI且入院首次随机血糖>11.1 mmol/L患... 详细信息

目的探讨入院伴随应激性高血糖(SH)的重型颅脑损伤(sTBI)患者住院期间随机血糖水平与预后的关系。方法回顾性分析空军军医大学第一附属医院神经外科重症监护室自2013年10月至2022年6月收治的85例sTBI且入院首次随机血糖>11.1 mmol/L患者的住院期间病历资料。根据出院时的GOS评分将患者分为预后良好组(GOS>3分)和预后不良组(GOS≤3分)。比较2组患者的一般资料,采用多因素Logistic回归分析法判断影响患者预后的独立危险因素,分析患者住院期间随机血糖水平与预后的关系。结果纳入的85例患者中预后不良组67例,预后良好组18例。2组患者住院期间的随机血糖水平比较差异有统计学意义(P11.1 mmol/L是sTBI患者预后的独立危险因素。26例患者住院期间并发感染,其中预后良好组3例,预后不良组23例,2组患者的感染率比较,差异无统计学意义(P>0.05)。随机血糖水平>11.1 mmol/L的患者均较≤11.1 mmol/L的感染率升高,但差异均无统计学意义(P>0.05)。结论sTBI合并SH患者住院期间的随机血糖水平与预后有关,且血糖>11.1 mmol/L是sTBI患者预后的独立危险因素。

关键词：重型颅脑损伤二次脑损伤应激性高血糖预后

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Parkin通过抑制神经元内铁死亡信号减轻机械性神经元损伤

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空军军医大学学报 2022年第4期43卷 410-414页

作者：武秀权吕伟豪费晓炜吴霜何鑫豆雅楠郇宇贾博费舟空军军医大学西京医院神经外科陕西西安710032

目的通过建立原代皮层神经元机械性损伤模型,研究Parkin在创伤性脑损伤后铁死亡信号激活中的作用及调控机制。方法建立原代皮层神经元机械性损伤模型,首先采用免疫荧光和Western blotting观察Parkin在损伤后的表达变化,然后采用Parkin... 详细信息

目的通过建立原代皮层神经元机械性损伤模型,研究Parkin在创伤性脑损伤后铁死亡信号激活中的作用及调控机制。方法建立原代皮层神经元机械性损伤模型,首先采用免疫荧光和Western blotting观察Parkin在损伤后的表达变化,然后采用Parkin过表达慢病毒转染神经元,将实验分为对照组、损伤组、损伤+Parkin过表达慢病毒组及损伤+对照病毒组。分别采用CCK-8法检测细胞活力;2,7二氯二氢荧光素乙酰乙酸法检测神经元内活性氧(ROS)水平;丙二醛、4羟基壬烯醛含量测定评价细胞内脂质过氧化(LPO)水平;Fe^(2+)比色法、总谷胱甘肽(GSH)试剂盒检测细胞内Fe^(2+)及GSH含量。Western blotting检测GPX4和ACSL4蛋白水平。结果与对照组比较,损伤组神经元活力显著降低(P<0.05);细胞内发生ROS、LPO及Fe^(2+)积累(P<0.05),GSH合成减少(P<0.05),且GPX4蛋白表达减少、ACSL4蛋白表达增加(P<0.05)。与损伤+对照病毒组比较,损伤+Parkin过表达慢病毒组细胞活力升高;细胞内ROS、LPO、Fe^(2+)含量明显减少(P<0.05),GSH合成增加(P<0.05),而GPX4蛋白表达增加、ACSL4蛋白表达减少(P<0.05)。结论Parkin可能是通过GPX4/ACSL4途径抑制铁死亡发生,从而减轻机械性神经元损伤。

关键词： Parkin 神经元创伤性脑损伤机械性损伤铁死亡神经保护作用

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Tribological properties of TiAlN-coated cermets

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Rare Metals 2009年第1期28卷 57-62页

作者： ZHENG Liyun ZHAO Lixin XIONG weihao Key Laboratory of Resource Explore Research of Hebei Province Hebei University of Engineering Handan 056038 China College of Materials Science and Engineering Huazhong University of Science and Technology Wuhan 430074 China

Ti（C,N）-based cermets were coated with TiAlN using multi-arc ion plating technology. Sliding wear tests were performed on the coated cermets. The microstructure and morphologies of the coated cermets before and after friction and wear tests were characterized. The results show that the TiAlN coating surface was smooth and its root mean square roughness was 16.6 nm. The hardness （HK） of TiAlN coating layers reached approximately 3200 and the critical load （Lc） under which the coating failure occurred was 59 N. The sliding wear test results show that the friction coefficients of the TiAlN-coated cermets were lower than that of the cermets without any coating. Under the same load, the adhesion phenomenon of the counterpart materials on the specimens was improved and the mean friction coefficient increased with increasing sliding velocity. When the sliding velocity was 0.26 m·s^-1, the mass of the coated cermets reduced. At the same sliding velocity, the average friction coefficient of the TiAlN-coated cerrnets was lower under a higher load. The wear mechanisms of the TiAlN-coated cermets were mainly adhesive and abrasive wear.

关键词： cermets tribological properties wear TiAIN coating

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Numerical simulation of the temperature field within new type of monolayer freezing-shaft lining

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Mining Science and Technology 2010年第2期20卷 198-203页

作者： CHEN, Xiaoxiang YANG, weihao school of energy science and engineering henan polytechnic universityjiaozuo 454000china state key laboratory of geomechanics and deep underground engineering china university of mining & technology state key laboratory of geomechanics and deep underground engineering china university of mining & technologyxuzhou 221008china

Numerical simulation was used to estimate the temperature field within a poured concrete,mono-layer freezing-shaft *** affects from various factors were *** maximum temperature within the lining increases as the lining thickness increases,decreases as the soil-side wall temperature decreases,decreases as the air temperature inside the shaft decreases and decreases as the air velocity inside the shaft *** compression speed of an insulating foam layer affects the maximum temperature difference between the interior and the *** maximum temperature difference between the interior and the sidewalls approaches or exceeds the maximum allowable for the curing of poured concrete *** should be paid to the question of the lining cracking during the curing *** temperature gradient in the vertical direction may be minimized by preventing air contact against the steel connection board supporting the base of the freshly poured section.

关键词： new type monolayer freezing shaft lining temperature field numerical simulation

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