检索结果-南通市图书馆

Heterogeneous information phase space reconstruction and stability prediction of filling body–surrounding rock combination

引用

International Journal of Minerals,Metallurgy and Materials 2024年第7期31卷 1500-1511页

作者： Dapeng Chen Shenghua Yin weiguo long Rongfu Yan Yufei Zhang Zepeng Yan Leiming Wang Wei Chen School of Civil and Resources Engineering University of Science and Technology of BeijingBeijing 100083China Production Technology Department Longshou MineJinchuan Group Co.Ltd.Jinchang 737100China School of Civil Engineering and Architecture East China Jiaotong UniversityNanchang 330013China

Traditional research believes that the filling body can effectively control stress concentration while ignoring the problems of unknown stability and the complex and changeable stress distribution of the filling body–surrounding rock combination under high-stress *** monitoring data processing methods cannot fully consider the complexity of monitoring objects,the diversity of monitoring methods,and the dynamics of monitoring *** solve this problem,this paper proposes a phase space reconstruction and stability prediction method to process heterogeneous information of backfill–surrounding rock *** three-dimensional monitoring system of a large-area filling body–surrounding rock combination in longshou Mine was constructed by using drilling stress,multipoint displacement meter,and *** information,such as the stress and displacement of the filling body–surrounding rock combination,was continuously *** with the average mutual information method and the false nearest neighbor point method,the phase space of the heterogeneous information of the filling body–surrounding rock combination was then *** this paper,the distance between the phase point and its nearest point was used as the index evaluation distance to evaluate the stability of the filling body–surrounding rock *** evaluated distances(ED)revealed a high sensitivity to the stability of the filling body–surrounding rock *** new method was then applied to calculate the time series of historically ED for 12 measuring points located at longshou *** moments of mutation in these time series were at least 3 months ahead of the roadway return *** the ED prediction experiments,the autoregressive integrated moving average model showed a higher prediction accuracy than the deep learning models(long short-term memory and Transformer).Furthermore,the root-mean-square error distribution of the prediction results peaked at 0

关键词： deep mining filling body–surrounding rock combination phase space reconstruction multiple time series stability prediction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

低级别嗜酸性肾肿瘤1例并文献复习

引用

肿瘤研究与临床 2024年第4期36卷 304-306页

作者：王文欣史圆圆钟安菁龙卫国庄莹高芸江苏大学附属医院病理科镇江212001

目的探讨低级别嗜酸性肾肿瘤(LOT)的临床病理特征和鉴别诊断。方法回顾性分析江苏大学附属医院2023年5月收治的1例LOT患者的诊治过程,并复习相关文献。结果患者为47岁女性,全身麻醉下行左肾部分切除术。显微镜下可见肿瘤大部分呈实性、... 详细信息

目的探讨低级别嗜酸性肾肿瘤(LOT)的临床病理特征和鉴别诊断。方法回顾性分析江苏大学附属医院2023年5月收治的1例LOT患者的诊治过程,并复习相关文献。结果患者为47岁女性,全身麻醉下行左肾部分切除术。显微镜下可见肿瘤大部分呈实性、片状生长,局灶呈小簇状、条索状排列;肿瘤由温和的嗜酸细胞构成,细胞核规则,呈卵圆形"低级别核"形态,有纤细的核周空晕,核仁不明显;间质中可见疏松水肿区及出血区;免疫组织化学结果显示CK7阳性,CD117阴性,综合诊断为LOT。患者术后恢复良好,生命体征平稳。结论LOT以胞质嗜酸、低级别核、低转移潜能为特征,CK7阳性,CD117阴性,常见活化性mTOR突变或TSC1/2突变。LOT需与嗜酸细胞瘤、嫌色性肾细胞癌等具有胞质嗜酸性特征的肾脏肿瘤相鉴别。

关键词：肾肿瘤嗜酸性细胞低级别诊断,鉴别

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

粗骨料纤维充填体的力学特性与能量损伤演变规律

引用

中国有色金属学报 2024年第7期34卷 2476-2490页

作者：薛希龙孙鹏程武拴军张晓龙卫国张元坤李佳乐顾元统胡瑞宁南华大学资源环境与安全工程学院衡阳421200 金川集团股份有限公司龙首矿金昌737100 镍钴共伴生资源开发与综合利用全国重点实验室金昌737100 中核韶关锦原铀业有限公司韶关512300

为提升充填体的抗拉性能、抗裂性能和韧性,通过抗压、巴西劈裂和落锤冲击试验研究了聚丙烯纤维对充填体强度特征、变形特征、抗冲击性能和能量演变的影响。结果表明:随着纤维掺量增加,充填体强度先增大后减小,弹性模量逐渐降低;掺入纤维... 详细信息

为提升充填体的抗拉性能、抗裂性能和韧性,通过抗压、巴西劈裂和落锤冲击试验研究了聚丙烯纤维对充填体强度特征、变形特征、抗冲击性能和能量演变的影响。结果表明:随着纤维掺量增加,充填体强度先增大后减小,弹性模量逐渐降低;掺入纤维后,充填体总耗能增加,达到峰值后释放动能减小,摩擦内能增加,可促进弹性应变能转变为耗散应变能;随着纤维掺量增加,充填体冲击耗能、延性比和韧性系数先增大后减小,终裂形态由“开裂即碎”演变为“裂而不碎”;掺入0.10%纤维的充填体抗拉强度、韧性和抗冲击等性能最优。强化机制主要是充填体内纤维“筋网结构”延缓裂纹产生、抑制裂纹扩展和提升能量吸收上限。研究成果有助于提升采场充填体顶板的稳定性,保障矿山生产作业安全。

关键词：混合粗骨料充填体纤维强度能量耗散落锤冲击试验

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of Nogo-neutralizing antibody and neurotrophin-3 on axonal regeneration following spinal cord injury in rats

引用

Neural Regeneration Research 2008年第12期3卷 1319-1323页

作者： Ruisen Zhan Shijie Chen weiguo Wang Haibin long Department of Orthopedics the Third Xiangya Hospital Central South University Changsha 410013 Hunan Province China

BACKGROUND： Recent studies have suggested that regeneration of the central nerve fiber following spinal cord injury occurs under specific conditions. OBJECTIVE： To study the effects of Nogo-neutralizing antibody （IN-1）, in combination with neurotrophin-3 （NT-3）, on axonal regeneration and motor function following spinal cord injury in the rat. DESIGN, TIME AND SETTING： A randomized, controlled, animal study combining immunohistochemistry was performed at the Laboratory of Neuroanatomy of Xiangya Medical College, and Central Laboratory of Xiangya the Third Hospital, Central South University from January 2006 to December 2007. MATERIALS： Eighteen healthy, Sprague Dawley rats were randomly divided into three groups, with six rats per group： control, IN-l, and IN-1/NT-3. Hemisectioned spinal cord injury models were established by cutting the posterior 2/3 of spinal cord, which is equivalent to the Ts level. METHODS： A polyethylene tubing was inserted through into subarachnoid cavity, equivalent to the superior margin at the T8 level. Saline, IN-1, and IN-1/NT-3 were respectively injected into control, IN-1, and IN-1/NT-3 groups, three times/day for seven consecutive days. MAIN OUTCOME MEASURES： At 2 weeks post-surgery, biotin dextran amine （10%） was injected into the right sensorimotor cortex area. At day 28 post-surgery, spinal cord tissue was prepared for frozen sections Positive astrocytic expression was observed with glial fibrillary acidic protein （GFAP） immunohistochemical staining whose proliferation level was represented by gray value, i.e. the higher the gray value was, the less the positive cells were, and growth of positive fibers was observed with a biotin dextran amine histological reaction. Motor function was measured according to BBB scores pre-operatively, as well as at days 1, 7, 14, 21, and 28 post-operatively. RESULTS： Three rats died during experimentation. By random supplement, a total of 18 rats were included. GFAP-positive astrocytes were observe

关键词： Nogo-neutralizing antibody neurotrophin-3 biotin dextran amine glial fibrillary acidic protein spinal cord

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Lateral shear performance of sheathed post-and-beam wooden structures with small panels

引用

Frontiers of Structural and Civil Engineering 2023年第7期17卷 1117-1131页

作者： weiguo long Wenfan LU Yifeng LIU Qiuji LI Jiajia OU Peng PAN China Southwest Architectural Design and Research Institute Co.Ltd. Chengdu 610042China Civil Engineering Department Tsinghua UniversityBeijing 100084China

Sheathed post-and-beam wooden structures are distinct from light-wood *** allow for using sheathing panels that are smaller(0.91 m×1.82 m)than standard-sized panels(1.22 m×2.44 m or 2.44 m×2.44 m).Evidence indicates that nail spacing and panel thickness determine the lateral capacity of the wood frame shear *** verify the lateral shear performance of wood frame shear walls with smaller panels,we subjected 13 shear walls,measuring 0.91 m in width and 2.925 m in height,to a low-cycle cyclic loading test with three kinds of nail spacing and three panel thicknesses.A nonlinear numerical simulation analysis of the wall was conducted using ABAQUS finite element(FE)software,where a custom nonlinear spring element was used to simulate the sheathing-frame *** results indicate that the hysteretic performance of the walls was mainly determined by the hysteretic performance of the sheathing-frame *** same nail specifications were adopted,the stiffness and bearing capacity of the walls were inversely related to the nail spacing and directly related to the panel *** shear wall remained in the elastic stage when the drift was 1/250 rad and ductility coefficients were all greater than 2.5,which satisfied the deformation requirements of residential *** on the test and FE analysis results,the shear strength of the post-and-beam wooden structures with sheathed walls was determined.

关键词： post-and-beam wooden structures with sheathed walls low reversed cyclic loading bearing capacity stiffness numerical simulation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

ONECUT2高表达介导胃癌复发患者5-FU化疗耐药

引用

江苏大学学报（医学版） 2024年第1期34卷 19-24页

作者：朱海峰陈述龙卫国王旭江苏大学附属医院化疗科江苏镇江212001 江苏大学附属医院肝胆外科江苏镇江212001 江苏大学附属医院病理科江苏镇江212001 江苏大学附属医院放疗科江苏镇江212001

目的:探究One cut结构域家族成员2(ONECUT2)是否可以作为对5-FU耐药的胃癌复发患者的治疗靶点。方法:利用癌症基因组图谱(TCGA)数据库分析ONECUT2基因在胃癌患者及胃癌复发患者的表达情况。利用基因集富集分析(GSEA)评估TCGA数据库中ONE... 详细信息

目的:探究One cut结构域家族成员2(ONECUT2)是否可以作为对5-FU耐药的胃癌复发患者的治疗靶点。方法:利用癌症基因组图谱(TCGA)数据库分析ONECUT2基因在胃癌患者及胃癌复发患者的表达情况。利用基因集富集分析(GSEA)评估TCGA数据库中ONECUT2表达量与药物代谢相关生物学过程的相关性。利用CCK-8细胞毒性实验评估胃癌细胞敲低或过表达ONECUT2对5-FU的耐药情况。分析30例胃癌术后复发患者ONECUT2表达量与5-FU治疗效果的相关性。结果:TCGA数据库分析显示,在经受过化疗且复发的胃癌患者中,ONECUT2高表达的患者无病间隔期(disease-free interval,DFI)更短。GSEA分析结果表明,ONECUT2高表达与异生药物代谢通路呈正相关,这提示可能与胃癌患者的耐药相关。体外实验中,敲低ONECUT2降低胃癌细胞对5-FU的半数抑制浓度(IC_(50))值;反之,过表达ONECUT2增加细胞对5-FU的IC_(50)值。30例胃癌复发患者对5-FU的药物敏感性与ONECUT2表达量相关。结论:胃癌复发患者的ONECUT2表达量更高,ONECUT2高表达与胃癌复发患者的5-FU耐药相关,可能是潜在的治疗靶点。

关键词： One cut结构域家族成员2 胃癌复发 5-FU耐药 GSEA 细胞毒性半数抑制浓度

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of combined application of Nogo-neutralizing antibody IN-1 and neurotrophin-3 on c-Fos and c-Jun expression in a rat model of hemisection spinal cord injury

引用

Neural Regeneration Research 2010年第6期5卷 461-465页

作者： Ruisen Zhan Xiongwu long weiguo Wang Shijie Chen Fengqi Huang Department of Orthopedics Third Xiangya Hospital Central South University Changsha 410013 Hunan Province China

BACKGROUND： Nogo-neutralizing antibody IN-1 accelerates axon growth and enhances recovery of spinal cord function by inhibiting growth inhibitory factors. Neurotrophin-3 （NT-3）contributes to regeneration of nerve fibers in the spinal cord and motor function recovery. The combination of Nogo-neutralizing antibody IN-1 and NT-3 is hypothesized to produce better outcomes and facilitate axonal regeneration by affecting c-Fos and c-Jun protein expression. OBJECTIVE： To investigate the combined effects of Nogo-neutralizing antibody IN-1 and NT-3 on c-Fos and c-Jun protein levels in the injured spinal cord. DESIGN, TIME AND SETTING： A randomized, controlled study was performed at the Laboratory of Neuroanatomy, Xiangya Medical College, Central South University and the Central Laboratory of Third Xiangya Hospital of China from June 2005 to December 2007. MATERIALS： NT-3 （Peprotech, USA） and Nogo-neutralizing antibody IN-1 （Santa Cruz Biotechnology, USA） were used in this study. METHODS： Hemisectioned spinal cord injury models were established by cutting the posterior 2/3 of rat spinal cord, which is equivalent to the T8 level in the human spine. A total of 120 rats were equally and randomly assigned to three groups： model （0.2 μL saline）, IN-1 （0.2 μL IN-1）, and IN-1/NT-3 （0.2 μL IN-1 ＋ 0.2 μL NT-3）. The compounds were separately infused into transection sites on the side of head. MAIN OUTCOME MEASURES： Western blot analysis was employed to measure c-Fos and c-Jun protein expression in the injured spinal cord at 15, 30 minutes, 1,2, 4, 6, 8, and 12 hours following surgery. RESULTS： Following spinal cord injury, c-Fos and c-Jun protein expression were increased and peaked at 4 6 hours. Following injection of IN-1 or the combination of IN-1 and NT-3, c-Fos protein expression was significantly reduced in the injured spinal cord （P 〈 0.05 or P 〈 0.01）（with the exception of the 15 minute time point）. However, c-Jun protein expression was significantly increased （P〈 0.05 or P〈 0

关键词： IN-1 neurotrophin-3 c-Fos c-Jun spinal cord injury neural regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

血小板内皮细胞黏附分子1和平滑肌肌动蛋白对瘢痕疙瘩综合治疗预后的影响

引用

江苏大学学报（医学版） 2024年第1期34卷 57-60页

作者：羊逸飞许辉龙卫国李遇梅江苏大学附属医院皮肤科江苏镇江212001 江苏大学再生医学研究院江苏镇江212001 江苏大学附属医院病理科江苏镇江212001

目的:探究瘢痕疙瘩血管内血小板内皮细胞黏附分子1(platelet endothelial cell adhesion molecule-1,PECAM-1)与平滑肌肌动蛋白(smooth muscle actin,SMA)的表达水平对瘢痕疙瘩综合治疗预后的影响。方法:回顾性分析2020年8月至2022年6... 详细信息

目的:探究瘢痕疙瘩血管内血小板内皮细胞黏附分子1(platelet endothelial cell adhesion molecule-1,PECAM-1)与平滑肌肌动蛋白(smooth muscle actin,SMA)的表达水平对瘢痕疙瘩综合治疗预后的影响。方法:回顾性分析2020年8月至2022年6月江苏大学附属医院皮肤科门诊收治的瘢痕疙瘩患者61例,共计69处瘢痕疙瘩,均接受手术切除与^(90)Sr同位素敷贴综合治疗,免疫组织化学染色检测手术切除瘢痕疙瘩标本血管内PECAM-1及SMA表达水平,电话及门诊随访6个月。结果:19处(27.5%)瘢痕疙瘩6个月内复发,11处(15.9%)在^(90)Sr同位素敷贴治疗后发生不良反应,复发组PECAM-1与SMA的高表达率均高于未复发组(χ^(2)=7.496,P=0.006;χ^(2)=5.197,P=0.023);治疗后不良反应发生率与PECAM-1及SMA的表达水平无明显关系(χ^(2)=0.172,P=0.935;χ^(2)=1.110,P=0.484)。结论:瘢痕疙瘩血管内PECAM-1及SMA的表达水平与综合治疗预后呈负相关,二者可能是判断瘢痕疙瘩预后的潜在指标。

关键词：瘢痕疙瘩放射性核素敷贴治疗免疫组织化学染色血小板内皮细胞黏附分子1 平滑肌肌动蛋白

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

三星堆古蜀文化遗址博物馆大型螺旋坡道结构减震设计与舒适度分析

引用

建筑结构 2024年第13期54卷 93-98页

作者：赖程钢杨文刘晓舟龙卫国肖克艰向新岸中国建筑西南设计研究院有限公司成都610042

三星堆古蜀文化遗址博物馆中庭的螺旋坡道采用钢箱梁结构体系,其最大半径为28.7m,水平投影长度为118.5m,宽度为4.5~14.5m。介绍了螺旋坡道结构减震(振)设计过程,通过设置黏滞阻尼器和调谐质量阻尼器减小坡道在地震作用和人行激励作用下... 详细信息

三星堆古蜀文化遗址博物馆中庭的螺旋坡道采用钢箱梁结构体系,其最大半径为28.7m,水平投影长度为118.5m,宽度为4.5~14.5m。介绍了螺旋坡道结构减震(振)设计过程,通过设置黏滞阻尼器和调谐质量阻尼器减小坡道在地震作用和人行激励作用下的结构响应,采用MIDAS Gen和ANSYS软件建立多尺度整体模型考虑螺旋坡道和主体结构的相互作用,进行了地震作用时程分析和人行激励舒适度分析。结果表明,各水准地震下黏滞阻尼器对螺旋坡道水平加速度减震效率约为45%~50%,水平位移的减震效率约为55%~70%。设置调谐质量阻尼器对螺旋坡道竖向振动加速度减振效率约为55%~60%,有效减小了坡道在人行激励作用下的结构响应。

关键词：三星堆古蜀文化遗址博物馆大型螺旋坡道消能减震人行激励舒适度分析黏滞阻尼器调谐质量阻尼器减震效率

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

三星堆古蜀文化遗址博物馆大型螺旋坡道结构设计与分析

引用

建筑结构 2024年第12期54卷 1-6页

作者：杨文赖程钢刘晓舟龙卫国肖克艰向新岸文见中国建筑西南设计研究院有限公司成都610042

三星堆古蜀文化遗址博物馆中庭的螺旋坡道采用钢箱梁结构体系,最大半径28.7m,水平投影长度118.5m。介绍了大型螺旋坡道结构体系选型和边界条件的对比过程,采用通用计算软件MIDAS Gen建立多尺度整体模型考虑螺旋坡道和主体结构的相互作用... 详细信息

三星堆古蜀文化遗址博物馆中庭的螺旋坡道采用钢箱梁结构体系,最大半径28.7m,水平投影长度118.5m。介绍了大型螺旋坡道结构体系选型和边界条件的对比过程,采用通用计算软件MIDAS Gen建立多尺度整体模型考虑螺旋坡道和主体结构的相互作用,通过静力分析和反应谱分析考察螺旋坡道在不同荷载作用下的承载能力和变形,并采用有限元软件ANSYS建立分析模型进行连续倒塌分析。结果表明,螺旋坡道采用钢箱梁结构具有较好的整体刚度,静力荷载和地震作用下坡道的应力和变形均满足规范要求,并具有较好的抗连续倒塌能力。

关键词：三星堆古蜀文化遗址博物馆大型螺旋坡道钢箱梁结构选型支座设计多尺度建模连续倒塌

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：