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Virologica Sinica 2023年第3期38卷 482-483页

作者： Sheng chen Xinheng Zhang Yu Nie Hongxin Li weiguo chen Wencheng Lin Feng chen Qingmei Xie College of Animal Science South China Agricultural University&Lingnan Guangdong Laboratory of Modern Agriculture&Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular BreedingGuangdongGuangzhou510642China South China Collaborative Innovation Center for Poultry Disease Control and Product Safety GuangdongGuangzhou510642China Key Laboratory of Animal Health Aquaculture and Environmental Control GuangdongGuangzhou510642China

Due to our negligence,the original version of this article,published online on April 08,2021,contained a mistake in Fig.1E.The lane ofβ-actin in Western blotting was misused.The correct Fig.1 is given below.We apologize for our oversight when preparing the figure and state that this does not change the scientific conclusions of the article in any way.

关键词： preparing mistake African

Semen extracellular vesicles mediate vertical transmission of subgroup J avian leukosis virus

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Virologica Sinica 2022年第2期37卷 284-294页

作者： Liqin Liao weiguo chen Xiangyu Zhang Huanmin Zhang Aijun Li Yiming Yan Zi Xie Hongxing Li Wencheng Lin Jingyun Ma Xinheng Zhang Qingmei Xie Heyuan Branch Guangdong Provincial Laboratory of Lingnan Modern Agricultural Science and TechnologyCollege of Animal ScienceSouth China Agricultural UniversityGuangzhou510642China Guangdong Provincial Key Lab of Agro Animal Genomics and Molecular Breeding Guangzhou510642China USDA Agriculture Research ServiceAvian Disease and Oncology LaboratoryEast LansingMI48823USA College of Science and Engineering Jinan UniversityGuangzhou510632China Key Laboratory of Animal Health Aquaculture and Environmental Control GuangdongGuangzhou510642China Guangdong Engineering Research Center for Vector Vaccine of Animal Virus Guangzhou510642China

Subgroup J avian leukosis virus(ALV-J) is a highly oncogenic retrovirus that has been devastating the global poultry industry since the late 1990s. The major infection model of ALV-J is vertical transmission, which is responsible for the congenital infection of progeny from generation to generation. Increasing evidence has suggested that extracellular vesicles(EVs) derived from virus-infected cells or biological fluids have been thought to be vehicles of transmission for viruses. However, the role of EVs in infection and transmission of ALV-J remains obscure. In the present study, semen extracellular vesicles(SE) were isolated and purified from ALV-J-infected rooster seminal plasma(SE-ALV-J), which was shown to contain ALV-J genomic RNA and partial viral proteins, as determined by RNA sequencing, reverse transcription-quantitative PCR and Western blotting. Furthermore, SE-ALV-J was proved to be able to transmit ALV-J infection to host cells and establish productive infection.More importantly, artificial insemination experiments showed that SE-ALV-J transmitted ALV-J infection to SPF hens, and subsequently mediated vertical transmission of ALV-J from the SPF hens to the progeny chicks. Taken together, the results of the present study suggested that ALV-J utilized host semen extracellular vesicles as a novel means for vertical transmission, enhancing our understanding on mechanisms underlying ALV-J transmission.

关键词： Semen extracellular vesicles(SE) Subgroup J avian leukosis virus(ALV-J) Infection Vertical transmission

基于镜像虚拟电阻技术的三相光伏逆变器直流电压波动抑制策略

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太阳能学报 2024年第3期45卷 555-564页

作者：刘淇伟曾江冯健磊陈伟国华南理工大学电力学院广州510641 广东省电网智能量测与先进计量企业重点实验室广州510663

针对光伏逆变器直流侧电容电压波动的问题,根据光伏逆变器直流电压波动的机理和其主要输出有功功率的特点,提出一种镜像虚拟电阻技术用以解决光伏逆变器直流电压波动的问题。该策略只需在逆变器正常工作的基础上增加少量计算,具有较高... 详细信息

针对光伏逆变器直流侧电容电压波动的问题,根据光伏逆变器直流电压波动的机理和其主要输出有功功率的特点,提出一种镜像虚拟电阻技术用以解决光伏逆变器直流电压波动的问题。该策略只需在逆变器正常工作的基础上增加少量计算,具有较高实用性。对于谐波分量,光伏逆变器等效为一个与基波等效电阻大小相等、方向相反的镜像虚拟电阻吸收电网谐波功率,同时可显著减小直流侧电压波动的问题。仿真和实物实验结果均验证了该策略的有效性。

关键词：直流电压波动瞬时无功功率虚拟电阻镜像虚拟电阻谐波抑制光伏逆变器

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African Swine Fever Virus Protein E199L Promotes Cell Autophagy through the Interaction of PYCR2

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Virologica Sinica 2021年第2期36卷 196-206页

作者： Sheng chen Xinheng Zhang Yu Nie Hongxin Li weiguo chen Wencheng Lin Feng chen Qingmei Xie College of Animal Science South China Agricultural University&Lingnan Guangdong Laboratory of Modern Agriculture&Guangdong Provincial Key Lab of AgroAnimal Genomics and Molecular BreedingGuangzhou 510642China South China Collaborative Innovation Center for Poultry Disease Control and Product Safety Guangzhou 510642China Key Laboratory of Animal Health Aquaculture and Environmental Control Guangzhou 510642China

African swine fever virus(ASFV),as a member of the large DNA viruses,may regulate autophagy and apoptosis by inhibiting programmed cell death.However,the function of ASFV proteins has not been fully elucidated,especially the role of autophagy in ASFV infection.One of three Pyrroline-5-carboxylate reductases(PYCR),is primarily involved in conversion of glutamate to proline.Previous studies have shown that depletion of PYCR2 was related to the induction of autophagy.In the present study,we found for the first time that ASFV E199 L protein induced a complete autophagy process in Vero and HEK-293 T cells.Through co-immunoprecipitation coupled with mass spectrometry(Co IP-MS)analysis,we firstly identified that E199 L interact with PYCR2 in vitro.Importantly,our work provides evidence that E199 L down-regulated the expression of PYCR2,resulting in autophagy activation.Overall,our results demonstrate that ASFV E199 L protein induces complete autophagy through interaction with PYCR2 and down-regulate the expression level of PYCR2,which provide a valuable reference for the role of autophagy during ASFV infection and contribute to the functional clues of PYCR2.

关键词： African swine fever virus(ASFV) E199L Pyrroline-5-carboxylate reductase 2(PYCR2) Autophagy

基于二维高斯核密度估计的有色纤维颜色特征提取方法

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纺织学报 2024年第5期45卷 85-93页

作者：裘柯槟陈维国张志强黄为忠嘉兴南湖学院时尚设计学院浙江嘉兴314001 浙江理工大学纺织科学与工程学院(国际丝绸学院) 浙江杭州310018 浙江理工大学桐乡研究院有限公司浙江嘉兴314500 浙江厚源纺织股份有限公司浙江嘉兴314511

为提高基于显微高光谱成像的有色纤维颜色测量的准确性和可重复性,研究了一种基于二维高斯核密度估计的有色纤维颜色特征提取方法。首先通过显微高光谱成像测色系统采集有色纤维的高光谱图像,选择400~700 nm、波段间隔为10 nm的光谱反射... 详细信息

为提高基于显微高光谱成像的有色纤维颜色测量的准确性和可重复性,研究了一种基于二维高斯核密度估计的有色纤维颜色特征提取方法。首先通过显微高光谱成像测色系统采集有色纤维的高光谱图像,选择400~700 nm、波段间隔为10 nm的光谱反射率,将其转换为色度值CIE L^(*)a^(*)b^(*),计算纤维区域中的颜色均值与每个像元颜色的色差ΔE_(00),建立色差ΔE_(00)与L^(*)相关联的二维数据;再基于二维高斯核密度估计方法计算像元的密度值,并确立了有色纤维的密度截断阈值估计方法,用于截断舍弃低密度的离散异常像元;最后根据像元的密度值计算加权光谱反射率并转换为相应的色度值。选取有色羊毛纤维进行实证分析,结果表明:影响颜色测量结果准确性和可重复性的离散异常像元主要存在于二维空间密度分布中的“尾部”区域,离散异常像元越多,“尾部”越长,对测量结果影响越严重;相比均值法和明度加权法,本文通过截断舍弃离散异常像元以减小其对测色结果影响的方式,提高了有色羊毛纤维颜色测量的准确性,且测量结果的可重复性最优,在有色羊毛纤维的染配色和混配色预测模型研究中具有实际应用价值。

关键词：有色纤维显微高光谱成像颜色测量核密度估计颜色特征提取

A Study of Multi-Scale Relationship Between Investor Sentiment and Stock Index Fluctuation Based on the Analysis of BEMD Spillover Index

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Journal of Systems Science and Information 2021年第4期9卷 399-420页

作者： weiguo chen Shufen ZHOU Yin ZHANG Yi SUN College of Economics and Management Beijing University of TechnologyBeijing 100124China China Post Group Corporation Limited Training Center Shijiazhuang 050021China School of Finance Anhui University of Finance and EconomicsBengbu 233000China

According to behavioral finance theory, investor sentiment generally exists in investors’ trading activities and influences financial market. In order to investigate the interaction between investor sentiment and stock market as well as financial industry, this study decomposed investor sentiment, stock price index and SWS index of financial industry into IMF components at different scales by using BEMD algorithm. Moreover, the fluctuation characteristics of time series at different time scales were extracted, and the IMF components were reconstructed into short-term high-frequency components, medium-term important event low-frequency components and long-term trend components. The short-term interaction between investor sentiment and Shanghai Composite Index, Shenzhen Component Index and financial industries represented by SWS index was investigated based on the spillover index. The time difference correlation coefficient was employed to determine the medium-term and long-term correlation among variables. Results demonstrate that investor sentiment has a strong correlation with Shanghai Composite Index, Shenzhen Component Index and different financial industries represented by SWS index at the original scale, and the change of investor sentiment is mainly influenced by external market information. The interaction between most markets at the short-term scale is weaker than that at the original scale. Investor sentiment is more significantly correlated with SWS Bond, SWS Diversified Finance and Shanghai Composite Index at the long-term scale than that at the medium-term scale.

关键词： investor sentiment spillover index BEMD algorithm

Study on the Measurement of Industrial Structure “Sophistication,Rationalization and Ecologicalization” Based on the Dynamic Analysis of Grey Relations——A Case Study of Beijing-Tianjin-Hebei

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Journal of Systems Science and Information 2020年第2期11卷 130-147页

作者： Shiyi YUAN Xiaopeng SUN weiguo chen Yongwu LI School of Economics and Management Beijing University of TechnologyBeijing 100124China

The Beijing-Tianjin-Hebei region is one of the regions with the most dynamic economies,highest degrees of openness,strongest innovation capacities and largest populations,as well as an important engine driving China’s economic development.Currently,the development of the BeijingTianjin-Hebei region faces many difficulties,including an inefficient distribution of regional functions,imbalance in industrial structure,low sophistication,and serious overburdening of resources and the environment.Promoting the overall coordinated development of the region has become an urgent challenge.In this paper,according to the conventions of industrial structure optimization,the three core indicators of regional industrial structure rationalization,sophistication and ecologicalization are constructed.With the help of the grey dynamic correlation model,the three indicators are coupled with the economic growth rate,and the industrial structure optimization index of the Beijing-Tianjin-Hebei region is comprehensively measured.The study shows that rationalization of the industrial structure in the Beijing-Tianjin-Hebei region is increasing but that this trend is not obvious;sophistication of the industrial structure is relatively high and has also been operating at a high level;however,the overall ecological level of the industrial structure in the Beijing-Tianjin-Hebei region is not high and presents the characteristics of high in the middle and low at both ends.In terms of the relationship between industrial structure and economic growth in the Beijing-Tianjin-Hebei region,ecologicalization of the industrial structure has the greatest influence on economic growth,followed by sophistication of the industrial structure,and rationalization of the industrial structure has the weakest influence.

关键词： ecologicalization grey dynamic analysis degrees industrial structure sophistication rationalization

The New Clinical Skills Training Module for the Master's Degree in Ophthalmology

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Eye Science 2013年第4期28卷 211-214页

作者： Meihua Le weiguo chen Aiting Yu State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen University

This article aims at the principle problems noticed in the process of training postgraduates in ophthalmology for clinical skills (POCs). Alteration of the training objectives and training curricula,.as well as the clinical department training plans,.will allow POCs to obtain a systematic and standardized education to establish their general attitude toward medical life and career plans. This will help to improve their clinical skills and establish professional ethics that will protect the interests of patients and promote the healthy and harmonious development of the Eye Hospital. Furthermore, the Ophthalmology Center could cultivate a number of outstanding postgraduate students that match its tier, to describe the quality of the training for the master's degree in Ophthalmology.

关键词：临床治疗试验硕士学位眼科训练模块职业生涯职业道德和谐发展研究生

Prognostic value of the 21-gene recurrence score in ER-positive,HER2-negative,node-positive breast cancer was similar in nodenegative diseases:a single-center study of 800 patients

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Frontiers of Medicine 2021年第4期15卷 621-628页

作者： Jiayi Wu Weiqi Gao Xiaosong chen Chunxiao Fei Lin Lin weiguo chen Ou Huang Siji Zhu Jianrong He Yafen Li Li Zhu Kunwei Shen Comprehensive Breast Health Center Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China

Multi-gene assays have emerged as crucial tools for risk stratification in early-stage breast cancer.This study aimed to evaluate the prognostic significance of the 21-gene recurrence score(RS)in Chinese patients with pN0-l,estrogen receptor-positive(ER+),human epidermal growth factor receptor 2-negative(HER2)breast cancer.Among 800 patients recruited between 2009 and 2016,the median RS was 24(0-69),with 27.4%,46.8%,and 25.9%patients classified into low-,intermediate-,and high-risk groups.Cox regression analysis demonstrated that the high-risk category was associated with significantly higher odds of invasive disease-free survival(IDFS)and distant disease-free survival(DDFS)events compared with the low-risk category(IDFS:HR=2.450,95%Cl 1.017-5.902,P=0.046;DDFS:HR=2.829,95%Cl 1.013-7.901,P=0.047).No significant association between RS category and overall survival(OS)was found(intermediate vs.low:HR=1.244,95%Cl 0.292-5.297,P=0.768;high vs.low:HR=2.933,95%Cl 0.759-11.327,P=0.119).RS,as a continuous variable,was a highly significant predictor for IDFS(HR=1.028,95%Cl 1.010-1.047,P=0.002),DDFS(HR=1.030,95%Cl 1.010-1.051,P=0.003),and OS(HR=1.034,95%Cl 1.007-1.063,P=0.014).Our findings suggested that RS may predict IDFS in Chinese patients with ER+/HER2 breast cancer with NO or N1 disease.

关键词： early breast cancer 21-gene assay recurrence score prognosis

The Cross-Correlation Relationship Between the Real Estate Industry and High-Quality Economic Development

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Journal of Systems Science and Information 2021年第6期9卷 704-720页

作者： Mengwan ZHANG Fengfeng GAO Jialin GAO weiguo chen Chong Aik LEE School of Economics and Management Beijing University of TechnologyBeijing 100124China School of Economics and Management Tsinghua UniversityBeijing 100084China College of Economics and Management Beijing University of TechnologyBeijing 100124China UCSI University Selangor 56000Malaysia

Based on China’s real estate investment(REI), commercial housing sales(CHS), and GDP data from 2001 to 2020, we studied the dependence, asymmetry, and transmission direction of China’s real estate and economy. Their cross-correlation is demonstrated through the deep crosscorrelation analysis(DCCA) algorithm, multifractal asymmetric detrended cross-correlation analysis(MF-ADCCA) algorithm and DCCA algorithm based on a time delay. Both REI and CHS have persistence with GDP. The real estate industry and economy have asymmetric multifractal characteristics.Meanwhile, real estate and the economy have different trends, and they can affect each other with the same length of time delay. This effect diminishes in a short period of time, and there are unsteady fluctuations in cross-correlation persistence in the long term.

关键词： real estate industry high-quality economic development cross-correlation relationship