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Journal of Environmental Sciences 2016年第7期28卷 215-223页

作者： weiguang sun Jun Nan Jia Xing Jiayu Tian State Key Laboratory of Urban Water Resource and Environment School of Municipal and Environmental EngineeringHarbin Institute of TechnologyHarbin 150090China Heilongjiang Environmental Protection Academy of Science Harbin 150056China

Three-dimensional fluorescence excitation–emission matrix（EEM） coupled with parallel factor analysis（PARAFAC） was performed for a total of 18 water samples taken from three water sources（two lakes and one wastewater treatment plant（WWTP） secondary effluent）,with the purpose of identifying the major ultrafiltration（UF） membrane foulants in different water sources. Three fluorescent components（C1, C2 and C3） were identified,which represented terrestrially derived humic-like substances（C1）, microbially derived humic-like substances（C2）, and protein-like substances（C3）. The correlations between the different fluorescent components and UF membrane fouling were analyzed. It was shown that for the WWTP secondary effluent, all three components（C1, C2 and C3） made a considerable contribution to the irreversible and total fouling of the UF ***, for the two lakes, only the C3 exhibited a strong correlation with membrane fouling, indicating that the protein-like substances were the major membrane foulants in the lake waters. Significant attachment of C1, C2 and C3 to the UF membrane was also confirmed by mass balance analyses for the WWTP secondary effluent; while the attachment of C1 and C2 was shown to be negligible for the two lakes. The results may provide basic formation for developing suitable fouling control strategies for sustainable UF processes.

关键词： Membrane fouling Organic substances Three-dimensional fluorescence matrix Parallel factor analysis Correlation analysis

Robust Fingerprint Localization Based on Massive MIMO Systems

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China Communications 2022年第11期19卷 148-159页

作者： Xiaojun Wang Yijie Ren weiguang sun Xiaoshu Chen National Mobile Communications Research Laboratory Southeast UniversityNanjing 210000China Purple Mountain Laboratories Nanjing 210000China Frontiers Science Center for Mobile Information Communication and Security Southeast UniversityNanjing 210000China

Location-based services have become an important part of the daily *** localization has been put forward to overcome the shortcomings of the traditional positioning algorithms in indoor scenario and rich scattering *** this paper,a single-site multiple-input multiple-output(MIMO)orthogonal frequency division multiplexing(OFDM)system is modeled,from which an angle delay channel power matrix(ADCPM)is *** the changing environment,auto encoders are used to generate new fingerprints based on ADCPM fingerprints to improve the robustness of the *** the scattering environment has changed beyond a certain extent,the robustness will not be able to make up for the positioning *** this circumstance,an updating of the fingerprint database is imperative.A new fingerprint database updating algorithm which combines a new clustering method and an updating rule based on probability is *** results show the desirable performance of the proposed methods.

关键词： massive multiple-input multiple-output fingerprint extraction robustness database updating

Natural products from untapped sources as a potent reserve against antimicrobial resistance crisis

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Chinese Journal of Natural Medicines 2024年第7期22卷 577-579页

作者： GU Xiaoxia sun weiguang HU Zhengxi Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation School of PharmacyTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Since the discovery of penicillin in 1928,antibiotics have revolutionized modern medicine by effectively treating infectious diseases and saving countless ***,the widespread development of antimicrobial resistance(AMR)now threatens the efficacy and longevity of these critical drugs.A study published in The Lancet reported that bacterial AMR contributed to approximately 4.95 million deaths globally in 2019,with 1.27 million directly attributable to AMR(Fig.1)[1].Natural products(NPs)continue to play a crucial role in discovering new antibiotics.

关键词： Natural products Untapped sources Antimicrobial resistance

Hybeanones A and B,Two Highly Modified Polycyclic Polyprenylated Acylphloroglucinols from Hypericum beanii

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Chinese Journal of Chemistry 2022年第1期40卷 53-58页

作者： Beiye Yang Changxing Qi Zeyu Yao Shuang Lin Fengli Li weiguang sun Zhengxi Hu Yonghui Zhang Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation School of PharmacyTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China

Hybeanones A and B(1 and 2),two highly oxygenated and rearranged polycyclic polyprenylated acylphloroglucinols(PPAPs),were isolated from the aerial parts of Hypericum *** structures comprising absolute configurations were elucidated by spectroscopic analysis,single-crystal X-ray diffraction,and quantum chemical *** 1 and 2 are defined by a newly assembled cyclopentanone unit fused to a tricyclic γ-lactone unit via a ketone *** breakage of C-1/C-2 linkage via retro-Claisen reaction,attack from C-1 to C-19,and Baeyer-Villiger oxidation at C-1/C-23 bond were presumed to be the key steps in the assembly of 1 and *** isolates 1 and 2 showed potential acetylcholinesterase(AchE)inhibitory activities,with IC50 values of 21.34±1.48 and 18.79±2.36μmol/L,respectively.

关键词： Hypericum beanii Natural products Structure elucidation Inhibitors Molecular docking

Polyaspers A and B,the First Ergosterol-Polyether Adducts with Unprecedented 6/6/6/5/5/6/6/6/6 Nonacyclic Architecture from Aspergillus ***507

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Chinese Journal of Chemistry 2024年第7期42卷 743-751页

作者： Hong Hu Lanqin Li Zhengyi Shi Xueqi Lan Yeting Zhang Xinye Huang Xincai Hao Qun Zhou weiguang sun Changxing Qi Yonghui Zhang Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China Institute of Organ Transplantation Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology Key Laboratory of Organ TransplantationMinistry of EducationNHC Key Laboratory of Organ TransplantationKey Laboratory of Organ TransplantationChinese Academy of Medical SciencesWuhanHubei 430030China Hubei Key Laboratory of Wudang Local Chinese Medicine Research Hubei Engineering Technology Center for Comprehensive Utilization of Medicinal PlantsCollege of PharmacyHubei University of MedicineShiyanHubei 442000China

Psoriasis is a chronic immune-mediated inflammatory skin disease and the TNF-αis an important therapeutic target of this *** our continuous study of bioactive natural products from fungi,the first ergosterol-polyether adducts,polyaspers A(1)and B(2),along with two known ergosterols,(36,5α,6α,22E)-5,6-epoxy-3-hydroxyergosta-8,22-dien-7-one(3)and calvasterol B(4),were iso-lated from Aspergillus *** elucidation was accomplished by extensive spectroscopic analysis and single-crystal X-ray diffraction *** A and B possessing an unequalled 6/6/6/5/5/6/6/6/6 nonacyclic system,and their biosynthetic path-ways were proposed to include intermolecular cyclization and Diels-Alder *** screen of these isolates showed that 1-3 could improve the cell viability in an actinomycin D/TNF-αinduced L929 cells death model,with the EC50 values of 49.85,46.75 and 4.99μmol/L,respectively,and the activity of 3 was even comparable with that of the positive control *** bioactive investigations discovered 3 could suppress the inflammatory response simulated with TNF-αin HaCaT *** an imiquimod-induced psoriasis murine model,3 significantly restrained the development of psoriasis symptoms and reduced the expression of IL-17 and IL-23,presenting an anti-psoriatic *** such,those ergosterol derivatives,might serve as lead compounds for the development of novel TNF-αinhibitory agents in the clinical treatment of psoriasis.

关键词： Psoriasis Aspergillus sp.TJ507 TNF-α Ergosterol-polyether adducts Inflammatory skin disease

Niduenes A-F,six functionalized sesterterpenoids with a pentacyclic 5/5/5/5/6 skeleton from endophytic fungus Aspergillus nidulans

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Chinese Chemical Letters 2024年第9期35卷 202-205页

作者： Aimin Fu Chunmei Chen Qin Li Nanjin Ding Jiaxin Dong Yu Chen Mengsha Wei weiguang sun Hucheng Zhu Yonghui Zhang Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation School of PharmacyTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Niduenes A-F(1-6),six novel sesterterpenoids with unprecedented 5/5/5/5/6 pentacyclic ring skeleton were isolated from endophytic fungus Aspergillus *** 1 and 2 represent the first examples of aromatic pentacyclic *** structures and configurations were elucidated by spectroscopic data and single-crystal X-ray diffraction *** 4 demonstrated potent resensitization of SW620/AD300 cells to paclitaxel(PTX).Rhodamine 123 accumulation assay and docking analysis further support that 4 inhibitory the efflux function of P-glycoprotein(P-gp).

关键词： Aspergillus nidulans Sesterterpenoids Aromatic sesterterpenoids Structure elucidation Single-crystal X-ray diffraction Biosynthetic pathways

Ten ring-B aromatized ergosterols from Aspergillus spectabilis

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Chinese Journal of Natural Medicines 2024年第7期22卷 654-662页

作者： WEI Mengsha sun weiguang LIU Linlin LI Yongqi LI Lanqin LI Qin CHEN Yu GUO Jieru GU Lianghu ZHU Hucheng CHEN Chunmei ZHANG Yonghui Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation School of PharmacyTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Tongji Hospital Affiliated to Tongji Medical College Huazhong University of Science and TechnologyWuhan 430030China

Spectasterols F−O(1−10),ten interesting ergosterols with an aromatized B ring,were obtained from Aspergillus *** structures and absolute configurations were determined using a combination of high-resolution electrospray ionization mass spectrometry(HR-ESI-MS),nuclear magnetic resonance(NMR)spectroscopy,single-crystal X-ray diffraction analyses,and electronic circular dichroism(ECD)***,these aromatic ergosterols feature versatile side ***,compound aromatic ergosterols featured versatile side chains,and compound 4 is an unusual C23 ergosterol characterized by a shorter side chain due to oxidative cleavage between C-23 and *** compounds were evaluated for their neuroprotective activities,with compound 8 showing a dose-dependent ability to reduce apoptosis and protect mitochondrial function in glutamate-induced SH-SY5Y cells.

关键词： Steroids Aspergillus spectabilis Aromatic ergosterols Neuroprotective activities Structure elucidation

Mulberry leaf flavonoids activate BAT and induce browning of WAT to improve type 2 diabetes via regulating the AMPK/SIRT1/PGC-1α signaling pathway

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Chinese Journal of Natural Medicines 2023年第11期21卷 812-829页

作者： CHENG Long SHI Lu HE Changhao WANG Chen LV Yinglan LI Huimin AN Yongcheng DUAN Yuhui DAI Hongyu ZHANG Huilin HUANG Yan FU Wanxin sun weiguang ZHAO Baosheng School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 102488China Department of Pharmacognosy School of PharmacyChina Medical UniversityShenyang 110122China College of Life Sciences Beijing University of Chinese MedicineBeijing 102488China GuangZhou Baiyunshan Xingqun Pharmaceutical Co. Ltd.Guangzhou 510288China Beijing Research Institute of Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China

Mulberry (Morus alba L.) leaf is a well-established traditional Chinese botanical and culinary resource. It has found widespread application in the management of diabetes. The bioactive constituents of mulberry leaf, specifically mulberry leaf flavonoids (MLFs), exhibit pronounced potential in the amelioration of type 2 diabetes (T2D). This potential is attributed to their ability to safeguard pancreatic β cells, enhance insulin resistance, and inhibit α-glucosidase activity. Our antecedent research findings underscore the substantial therapeutic efficacy of MLFs in treating T2D. However, the precise mechanistic underpinnings of MLF’s anti-T2D effects remain the subject of inquiry. Activation of brown/beige adipocytes is a novel and promising strategy for T2D treatment. In the present study, our primary objective was to elucidate the impact of MLFs on adipose tissue browning in db/db mice and 3T3-L1 cells and elucidate its underlying mechanism. The results manifested that MLFs reduced body weight and food intake, alleviated hepatic steatosis, improved insulin sensitivity, and increased lipolysis and thermogenesis in db/db mice. Moreover, MLFs activated brown adipose tissue (BAT) and induced the browning of inguinal white adipose tissue (IWAT) and 3T3-L1 adipocytes by increasing the expressions of brown adipocyte marker genes and proteins such as uncoupling protein 1 (UCP1) and beige adipocyte marker genes such as transmembrane protein 26 (Tmem26), thereby promoting mitochondrial biogenesis. Mechanistically, MLFs facilitated the activation of BAT and the induction of WAT browning to ameliorate T2D primarily through the activation of AMP-activated protein kinase (AMPK)/sirtuin 1 (SIRT1)/peroxisome proliferator-activated receptor-gamma coactivator 1α (PGC-1α) signaling pathway. These findings highlight the unique capacity of MLF to counteract T2D by enhancing BAT activation and inducing browning of IWAT, thereby ameliorating glucose and lipid metabolism disorders. As s

关键词： Mulberry leaf flavonoids Brown adipose tissue Browning of white adipose tissue Type 2 diabetes AMPK/SIRT1/PGC-1α

Research on the damage of the Great Wall of Ming Dynasty in Beijing by remote sensing

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Science China(Technological Sciences) 2008年第S1期51卷 195-202页

作者： LI XiaoJuan,GONG HuiLi,ZHANG Ou,ZHANG weiguang & sun YongHua The Key Lab of 3D Information Acquisition and Application,MOE,the Key Lab of Beijing Resource Envi-ronment and GIS,and College of Resource Environment & Tourism,Capital Normal University,Beijing 100037,China The Key Lab of 3D Information Acquisition and Application MOE the Key Lab of Beijing Resource Environment and GIS and College of Resource Environment & Tourism Capital Normal University Beijing China

Using aerial photos and high resolution satellite images of the year of 2004,this paper establishes remote sensing interpretation marks of the Great Wall of Ming Dynasty's damaged levels. Based on field survey and remote sensing survey in 1984,we analyzed present situation and changing characteristics being of the Great Wall of Ming Dynasty in Beijing. The results show that about 7.02% of the wall is well-preserved (about 25861 m); 31.5% of the wall is slightly or moderately dam-aged (about 115989 m); 61.5% of the wall is badly damaged (about 226379 m). This paper analyzes the dynamic change of the Great Wall of Ming Dynasty. It shows that the damaged situation of the Great Wall of Ming Dynasty in Beijing is serious. From 1984 to 2004,the well-preserved wall is decreased by 33206 m (decreased by 56%); badly damaged wall increased by 51207 m (increased by 67%). Finally,this paper analyzes the influence factors of damaging Great Wall. The conclusion is as follows: The damaged Great Wall is generally near the roads and villages,small slope,and easily arriving land.

关键词： the Great Wall of Ming Dynasty remote sensing interpreting damage dynamic change spatial analysis

基于单神经元自适应PID的光伏发电MPPT

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电力系统及其自动化学报 2017年第2期29卷 89-95页

作者：沈赋尹斌孙维广河海大学能源与电气学院南京211100

光伏电池的输出特性随着外部环境和负载的变化而变化,具有非线性特性。为了充分利用光伏电池,需对其进行最大功率点跟踪。利用Boost电路提升光伏电池输出电压,提出了单神经元自适应PID的控制方法来实现对其进行最大功率点跟踪。通过对... 详细信息

光伏电池的输出特性随着外部环境和负载的变化而变化,具有非线性特性。为了充分利用光伏电池,需对其进行最大功率点跟踪。利用Boost电路提升光伏电池输出电压,提出了单神经元自适应PID的控制方法来实现对其进行最大功率点跟踪。通过对目前常用光伏并网模糊控制和单神经元自适应PID控制两种方法的比较,在Matlab/Simulink的环境下进行了仿真研究。研究结果证明了使用单神经元自适应PID控制的优越性。

关键词：光伏电池最大功率点跟踪 Boost电路单神经元自适应PID控制单神经元