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Reductive lipid nanoparticles loaded with vinorelbine inhibit chemotherapy-induced invasion of cancer cells by modulating ENPP2

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Nano Research 2024年第4期17卷 2886-2898页

作者： Xiaoqi Zhao Xuemeng Guo Mei Pang weigen qiu Zhenyu Luo Qing Lin Yichao Lu Hang Yin Sijie Wang Huihui Liu Junlei Zhang Lihua Luo Jian You College of Pharmaceutical Sciences Zhejiang University866 Yuhangtang RoadHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China

Cancer is a predominant culprit behind worldwide death and accounts for up to 10 million deaths every *** is the primary therapeutic method employed for cancer in clinical settings and is essential in controlling tumor *** the advances in this field,tumor invasion and metastasis during treatment remain a significant cause of treatment ***,the underlying mechanisms involving such a disappointing phenomenon are still not fully ***(VNB)extends the lifespan of many cancer patients in the clinic as an emerging chemotherapy drug approved by Food and Drug Administration(FDA).However,VNB-induced tumor metastasis is still an intractable problem,which may be closely related to the abnormal oxidative stress generated during VNB-mediated ***,the study aims to construct a reductive nanosystem loaded with VNB,called VNB-VNP,to improve cancer cure rates and reduce tumor *** the reductive component vitamin E,VNB-VNP can effectively reduce oxidative stress and significantly outperform free VNB in preventing tumor *** transcriptome analysis shows that VNB-VNP can alleviate the over-expression of ectonucleotide pyrophosphatase/phosphodiesterase 2(ENPP2),which may be the main reason why VNB-VNP can inhibit tumor invasion and ***,the research designs a new platform for VNB treatment,which demonstrates promising efficacy in inhibiting neoplastic progression and identifies a new mechanism associated with VNB-induced tumor metastasis,which may offer several valuable references for enhancing chemotherapy efficacy in clinical anti-tumor therapy.

关键词： chemotherapy vinorelbine tumor Invasion lysophosphatidic acid ectonucleotide pyrophosphatase/phosphodiesterase 2(ENPP2)

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ASYMPTOTIC STABILITY OF A CLASS OF NONLINEAR GENERALIZED SYSTEMS

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Applied Mathematics(A Journal of Chinese Universities) 2000年第2期15卷 123-127页

作者： qiuweigen LiuYongqing ComputerDepartmentofGuangdongUniversityofTechnology Guangzhou510090. AutomationDepartmentofSouthChinaUniversityofTechnology Guangzhou510641

This paper is mainly used to determine the asymptotic stability of a class of nonlinear generalized systems through its slow subsystems under the assumption of *** example is given.

关键词： Singularity asymptoticstability impulse regularity

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An　Impulse　Weakly　Observability　of　Generalized　Linear　Systems

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Journal of Systems Engineering and Electronics 1998年第3期9卷 16-22页

作者： qiu weigen & Liu Yongqing(Department of Automatic Control Engineering, South China University of Technology,Guangzhou 510641, P. R. China ) Department of Automatic Control Engineering. South China University of Technology Guangzhou 510641. P. R. China

This paper mainly discusses the singular linear systems of distributional version. By using its matrices coefficients and some invariant subspaces, the distributionally weakly obseervability and the impulse observabil... 详细信息

关键词： Impulse Distributionally weakly unobservability Invariaot subspace

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Challenges and prospects for room temperature solid-state sodiumsulfur batteries

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Nano Research 2024年第3期17卷 1402-1426页

作者： Yashuang qiu Jing Xu Research Center of Grid Energy Storage and Battery Application School of Electrical and Information EngineeringZhengzhou UniversityZhengzhou 450001China

Room temperature sodium-sulfur(Na-S)batteries,known for their high energy density and low cost,are one of the most promising next-generation energy storage ***,the polysulfide shuttling and uncontrollable Na dendrite growth as well as safety issues caused by the use of organic liquid electrolytes in Na-S cells,have severely hindered their ***-state electrolytes instead of liquid electrolytes are considered to be the most direct and effective solution to solve the above ***,its practical application is still greatly challenged due to the poor interfacial compatibility between the all-solid-state electrolytes and the anode/cathode,ionic conductivity,and the shuttle effect caused by the presence of liquid phase in the quasi-solid-state *** paper presents a comprehensive review of solid-state Na-S batteries from the perspective of regulating interfacial compatibility and improving ionic conductivity as well as suppressing polysulfide *** to different components,solid-state electrolytes were divided into five categories:solid inorganic electrolytes,solid polymer electrolytes,polymer/inorganic solid hybrid electrolytes,gel polymer electrolytes,and liquid–solid inorganic hybrid ***,the prospect of developing high performance solid-state electrolytes to improve the cycling stability of room temperature Na-S cells is envisaged.

关键词： sodium-sulfur batteries solid-state electrolytes ionic conductivity polysulfide shuttling interfacial compatibility

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改进ShuffleNet V2的轻量级农作物病害识别方法

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计算机工程与应用 2022年第12期58卷 260-268页

作者：李好邱卫根张立臣广东工业大学计算机学院广州510006

针对目前有关深度学习的农作物病害识别方法中存在模型较为复杂,部署在计算资源有限的边缘设备和移动终端上适应性不强,实时准确识别作物病害较差的问题,提出一种改进ShuffleNet V2的轻量级农作物病害识别方法。以ShuffleNet V2单元为基... 详细信息

针对目前有关深度学习的农作物病害识别方法中存在模型较为复杂,部署在计算资源有限的边缘设备和移动终端上适应性不强,实时准确识别作物病害较差的问题,提出一种改进ShuffleNet V2的轻量级农作物病害识别方法。以ShuffleNet V2单元为基础,引入ECA(efficient channel attention)注意力模块,使用H-Swish激活函数以便减少网络结构每个Stage模块中ShuffleNet V2单元使用个数,使用轻量化网络设计组件深度可分离卷积。在PlantVillage病害数据集上进行实验。结果表明,模型的参数量约为2.95×10^(5),计算量为3.388×10^(7)(FLOPs)和6.674×10^(7)( MAdd),病害识别平均准确率达到了99.24%,为农作物病害识别方法在移动终端等资源受限设备上部署应用提供参考。

关键词：农作物病害识别 ShuffleNet V2 轻量级 ECA注意力模块

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Enhanced service stability and thermoelectric performance in Cu_(2)−δSebased composites

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Science China Materials 2024年第7期67卷 2369-2370页

作者： Pengfei qiu Xun Shi State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China

Thermoelectric(TE)materials can directly convert the industrial waste heat into useful electricity based on the Seebeck effect,providing a promising way to tackle the environmental pollution and global energy crisis[1].In the past several decades,many new high-performance TE materials have been discovered to enrich the TE *** them,Cu_(2)−δSe-based TE materials,which are in line with the“phonon-liquid electron-crystal”concept,have sparked widespread interest due to the high TE figure-of-merit(ZT)and the combination of elements that are nontoxic and earth-abundant[2].In 2012,Liu et al.[3]reported a ZT of 1.5 at 1000 K in the stoichiometric Cu_(2)*** alloying S at the Se-site,the ZT was enhanced to around 2.0 at 1000 K[4].Via incorporating carbon nanotubes,the ZT was further enhanced to 2.4 at 1000 K[5].Moreover,Yang et al.[6]and Zhou et al.[7]reported that the ZT of Cu_(2)Se/BiCuSeO composites can reach 2.7–2.8 around 1000 K.

关键词： composites BiCuSeO performance

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y-Tuning: an efficient tuning paradigm for large-scale pre-trained models via label representation learning

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Frontiers of Computer Science 2024年第4期18卷 107-116页

作者： Yitao LIU Chenxin AN Xipeng qiu School of Computer Science Fudan UniversityShanghai 200433China

With current success of large-scale pre-trained models(PTMs),how efficiently adapting PTMs to downstream tasks has attracted tremendous attention,especially for PTMs with billions of *** work focuses on designing parameter-efficient tuning paradigms but needs to save and compute the gradient of the whole computational *** this paper,we propose y-Tuning,an efficient yet effective paradigm to adapt frozen large-scale PTMs to specific downstream tasks.y-Tuning learns dense representations for labels y defined in a given task and aligns them to fixed feature *** computing the gradients of text encoder at training phrase,y-Tuning is not only parameterefficient but also *** results show that for DeBERTaxxL with 1.6 billion parameters,y-Tuning achieves performance more than 96%of full fine-tuning on GLUE Benchmark with only 2%tunable parameters and much fewer training costs.

关键词： pre-trained model lightweight fine-tuning paradigms label representation

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The First Five Years of a Phase Theory for Complex Systems and Networks

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IEEE/CAA Journal of Automatica Sinica 2024年第8期11卷 1728-1743页

作者： Dan Wang Wei Chen Li qiu Division of Decision and Control Systems KTH Royal Institute of TechnologyStockholm 10044Sweden Department of Mechanics and Engineering Science&the State Key Laboratory for Turbulence and Complex Systems Peking UniversityBeijing 100871China Hong Kong University of Science and Technology Hong KongChinaand also with the Southern University of Science and TechnologyShenzhen 518055China

In this paper,we review the development of a phase theory for systems and networks in its first five years,represented by a trilogy:Matrix phases and their properties;The MIMO LTI system phase response,its physical interpretations,the small phase theorem,and the sectored real lemma;The synchronization of a multi-agent network using phase *** the end,we also summarize a list of ongoing research on the phase theory and speculate what will happen in the next five years.

关键词： Consensus and synchronization matrix phases multi-agent systems phase theory sectored real lemma small phase theorem.

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基于多尺度UNet的肾脏CT图像分割

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计算机应用与软件 2023年第8期40卷 221-227,243页

作者：冯嘉钦邱卫根张立臣广东工业大学广东广州510000

肾脏图像分割对于肾脏疾病的评估以及临床诊断具有重要意义。但传统的肾脏图像分割方法难以对肾脏组织进行精准分割。为了解决上述问题,提出一种结合多尺度UNet模型和分水岭后处理的方法,用于肾脏CT图像的自动分割。多尺度UNet模型的下... 详细信息

肾脏图像分割对于肾脏疾病的评估以及临床诊断具有重要意义。但传统的肾脏图像分割方法难以对肾脏组织进行精准分割。为了解决上述问题,提出一种结合多尺度UNet模型和分水岭后处理的方法,用于肾脏CT图像的自动分割。多尺度UNet模型的下采样层融合了Inception模块,同时对采样层加入残差块,以有效提取和融合CT图像中多尺度特征,提高了分割准确度。同时,通过一系列分水岭后处理步骤,对模型分割结果进行优化。实验采用grand-challenge中的KITS19数据集。算法实验结果在MIoU(Mean Intersection over Union)和MDSC(Mean Dice Similarity Coefficient)评估指标上得到一定的提高,分别达到了93.37%和99.88%。该算法在与主流的6个方法对比中有一定的优势,能够为肾脏疾病的临床诊断提供更准确的肾脏结构组织信息。

关键词：肾脏图像分割深度学习数学形态学全卷积网络多尺度UNet

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Effect of Modulus Heterogeneity on the Equilibrium Shape and Stress Field ofαPrecipitate in Ti-6Al-4V

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 1017-1028页

作者： Di qiu Rongpei Shi Materials Genome Institute Shanghai UniversityShanghai200444China School of Materials Science and Engineering Harbin Institute of TechnologyShenzhen518055China Shanghai Frontier Science Center of Mechanoinformatics Shanghai UniversityShanghai200444China Zhejiang Laboratory Hangzhou311100China

For media with inclusions(e.g.,precipitates,voids,reinforcements,and others),the difference in lattice parameter and the elastic modulus between the matrix and inclusions cause stress concentration at the *** stress fields depend on the inclusions’size,shape,and distribution and will respond instantly to the evolving *** study develops a phase-field model concerningmodulus *** effect of modulus heterogeneity on the growth process and equilibrium state of theαplate in Ti-6Al-4V during precipitation is ***αprecipitate exhibits strong anisotropy in shape upon cooling due to the interplay of the elastic strain and interfacial *** calculated orientation of the habit plane using the homogeneous modulus ofαphase shows the smallest deviation fromthat of the habit plane observed in the experiment,compared to the case where the homogeneous modulus ofβphase is *** addition,the equilibrium volume ofαphase within the systemusing homogeneousβmodulus exhibits the largest dependency on the applied *** stress fields across theα/βinterface are further calculated under the assumption of modulus heterogeneity and compared to those using homogeneous modulus of eitherαorβ*** study provides an essential theoretical basis for developing mechanics models concerning systems with heterogeneous structures.

关键词： Elastic heterogeneity habit plane stress field titanium phase-field simulation

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