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全面推行规范化管理着力提升劳教场所整体水平

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中国司法 2011年第2期 40-43页

作者：李群忠张卫芬四川省眉山强戒所

随着劳教戒毒场所工作职能由单一的对劳教人员进行管理教育向强制隔离戒毒和劳教管理教育双重职能的转变,随着收容收治对象在人员数量和构成比例上发生的新变化和"多进宫"及感染HIV人数明显增加等新情况,随着管理教育方法手段由单纯的... 详细信息

随着劳教戒毒场所工作职能由单一的对劳教人员进行管理教育向强制隔离戒毒和劳教管理教育双重职能的转变,随着收容收治对象在人员数量和构成比例上发生的新变化和"多进宫"及感染HIV人数明显增加等新情况,随着管理教育方法手段由单纯的管理、教育矫治向管理、教育矫治和治

关键词：公正廉洁执法劳教工作戒毒工作劳教人员强戒人员戒毒康复劳教戒毒劳动教养人员教育矫治劳教场所

ICD和免疫激动剂协作的树形高分子纳米平台作为极简“原位”肿瘤疫苗用于高效化学免疫治疗

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Science China Materials 2024年第8期67卷 2700-2708页

作者：孙艳菊陈文强孙硕商洪才关秀文张维芬 College of Pharmacy Shandong Second Medical UniversityWeifang 261053China School of Clinical Medicine Shandong Second Medical UniversityWeifang 261053China Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing Dongzhimen Hospital Affiliated to Beijing University of Chinese MedicineBeijing 100700China

作为一种新兴的联合治疗策略,肿瘤化学免疫治疗拓展了传统化疗药物的潜在可能性,利用某些化疗药物诱发免疫原性细胞死亡(ICD)激活抗肿瘤免疫应答,提升肿瘤治疗效率.本文设计了一种ICD和免疫激动剂协作的树形高分子纳米平台作为极简“原... 详细信息

作为一种新兴的联合治疗策略,肿瘤化学免疫治疗拓展了传统化疗药物的潜在可能性,利用某些化疗药物诱发免疫原性细胞死亡(ICD)激活抗肿瘤免疫应答,提升肿瘤治疗效率.本文设计了一种ICD和免疫激动剂协作的树形高分子纳米平台作为极简“原位”肿瘤疫苗用于高效的化学免疫治疗.利用树状高分子PAMAM担载ICD引发药物DOX以及免疫激动剂CpG,该DOX@PAMAM/CpG(简称DPC)纳米粒子物理性能适宜,通过便捷的瘤内注射可在肿瘤组织良好蓄积和内化,并最大限度地降低全身毒性.在CpG的协助下该纳米粒子可引发强劲的ICD并激活全面的抗肿瘤免疫反应,体内动物实验证实该DPC纳米粒子对侵袭性黑色素瘤具有显著的抑制.本研究为肿瘤化学免疫治疗纳米递药平台的构建提供了一种切实可行的策略.

关键词：化学免疫治疗瘤内注射药物诱发全身毒性肿瘤疫苗激动剂黑色素瘤树状高分子

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小檗碱/壳聚糖季铵盐纳米粒的制备及其表征

锦州医科大学学报 2022年第6期43卷 21-25页

作者：单璐张维芬锦州医科大学附属第三医院药剂科辽宁锦州121000 潍坊医学院药学院山东潍坊261053

目的制备小檗碱/壳聚糖季铵盐纳米粒并考察其理化特性。方法采用离子交联法制备小檗碱/壳聚糖季铵盐纳米粒,通过紫外分光光度法(ultraviolet,UV)、傅立叶变换红外光谱(fourier transform infrared spectroscopy,FTIR)、透射电子显微镜(t... 详细信息

目的制备小檗碱/壳聚糖季铵盐纳米粒并考察其理化特性。方法采用离子交联法制备小檗碱/壳聚糖季铵盐纳米粒,通过紫外分光光度法(ultraviolet,UV)、傅立叶变换红外光谱(fourier transform infrared spectroscopy,FTIR)、透射电子显微镜(transmission electron microscopy,TEM)、动态光散射(dynamic light scattering,DLS)、动态透析法研究其特性。结果小檗碱纳米粒粒径为300 nm左右,多分散性指数(polydispersity index,PDI)为0.1~0.3,呈类球型,粒径较为均一,分布均匀,载药量为(14.27±0.017)%,包封率为(94.17±0.11)%,具有缓释作用,48 h累计释放量为55.46%。结论离子交联法成功构建小檗碱/壳聚糖季铵盐纳米粒,粒径均一,呈类球形,粒度均匀,分散性良好,具有缓释作用。

关键词：壳聚糖季铵盐小檗碱离子交联法纳米粒

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住院肺炎患儿家属心理反应及需求的调查

中华现代护理杂志 2018年第14期24卷 1711-1714页

作者：张伟芬潘巧琴浙江省丽水市人民医院儿科 323000

目的调查住院肺炎患儿家属心理反应、需求,以采取针对性护理措施.方法选择2015年5月—2016年4月浙江省丽水市人民医院收治的200例肺炎患儿及其家属,采用症状自评量表（SCL-90）和急危重患者家属需求量表中文版对患儿家属进行心理状态... 详细信息

目的调查住院肺炎患儿家属心理反应、需求,以采取针对性护理措施.方法选择2015年5月—2016年4月浙江省丽水市人民医院收治的200例肺炎患儿及其家属,采用症状自评量表（SCL-90）和急危重患者家属需求量表中文版对患儿家属进行心理状态及需求调查.结果 200名患儿家属均存在焦虑、抑郁、神经质、人际关系敏感、敌对等不良心理障碍反应,其中焦虑占85.5%.在需求量表中各领域得分由高到低分别为：病情保证领域（3.67±0.31）分、接近患儿领域（3.25±0.28）分、获取信息领域（3.12±0.25）分、获得支持领域（2.97±0.27）分、自身舒适领域（2.83±0.26）分;100%的患儿家属对其中＂患儿能够得到最佳治疗＂＂每天能够及时了解患儿身体状况＂2个条目认为重要或非常重要.结论医务工作人员应当重视患儿家属的心理状态和需求,同时应加强与患儿家属沟通和交流,有利于建立良好的医患关系,从而提高对护理工作的满意度.

关键词：肺炎家属心理反应需求

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北京地区莱姆病的发现及临床研究

中华流行病学杂志 1994年第1期15卷 10-13页

作者：冯方波张薇芬周国萍张首印袁玉民吴宜恕解放军第二六一医院临床实验科

作者报道北京地区存在莱姆病感染。应用ＩＦＡ法检测自然人群１３１４人抗ＢＢ螺旋体抗体，感染率１１．８７％；传播媒介为长角血蜱，应用改良ＢＳＫ培养液分别从蜱、人血液中分高培养出ＢＢ螺旋体６株；取３０例皮肤病变组织作病理检... 详细信息

作者报道北京地区存在莱姆病感染。应用ＩＦＡ法检测自然人群１３１４人抗ＢＢ螺旋体抗体，感染率１１．８７％；传播媒介为长角血蜱，应用改良ＢＳＫ培养液分别从蜱、人血液中分高培养出ＢＢ螺旋体６株；取３０例皮肤病变组织作病理检查，有５例查到ＢＢ螺旋体；莱姆病患者应用大剂量青霉素或头孢三嗪治疗，有效率分别为６４％及８８％。

关键词：莱姆病蜱螺旋体临床

Selenate oxyanion-intercalated NiFeOOH for stable water oxidation via lattice oxygen oxidation mechanism

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Journal of Energy Chemistry 2025年第2期101卷 676-684页

作者： Yijie zhang Weiyi zhang Xiaowen zhang Jinping Li Guang Liu Shanxi Key Laboratory of Gas Energy Efficient and Clean Utilization College of Chemical Engineering and Technology Taiyuan University of Technology Shanxi Research Institute of Huai Rou Laboratory

Transition metal-based compounds can serve as pre-catalysts to obtain genuine oxygen evolution reaction（OER） electrocatalysts in the form of oxyhydroxides through electrochemical ***,the role and existence form of leached oxygen anions are still ***,we selected iron selenite-wrapped hydrated nickel molybdate（denoted as NiMoO/FeSeO） as a pre-catalyst to study the oxyanion *** is surprising to find that SeO2-exists in the catalyst in the form of intercalation,which is different from previous studies that suggest that anions are doped with residual elements after electrochemical activation,or adsorbed on the catalyst *** experiment and theoretical calculations show that the existence of SeO42-intercalation effectively adjusts the electronic structure of NiFeOOH,promotes intramolecular electron transfer and O-O release,and thus lowers the reaction energy *** expected,the synthesized NiFeOOH-SeO only needs 202 and 285 mV to attain 100 and 1000 mA cm-2in 1 M ***,the anion exchange membrane water electrolyzer（AEMWE） consisting of NiFeOOHSeO anode and Pt/C cathode can reach 1 A cm-2at 1.70 V and no significant attenuation within 300 *** findings provide insights into the mechanism,by which the intercalated oxyanions enhance the OER performance of NiFeOOH,thereby facilitating large-scale hydrogen production through AEMWE.

关键词： Anion exchange membrane electrolyzer Industrial current densities Lattice oxygen oxidation Oxyanion intercalation Water splitting

How sediment dredging alters phosphorus dynamics in a lowland rural river?

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Journal of Environmental Sciences 2025年第1期147卷 189-199页

作者： Qimou zhang Jiacong Huang Yulai Ji Jing zhang Shuai zhang Junfeng Gao Key Laboratory of Watershed Geographic Sciences Nanjing Institute of Geography and LimnologyChinese Academy of SciencesNanjing 210008China University of Chinese Academy of Sciences Beijing 10094China

China’s lowland rural rivers are facing severe eutrophication problems due to excessive phosphorus(P)from anthropogenic ***,quantifying P dynamics in a lowland rural river is challenging due to its complex interaction with surrounding areas.A P dynamic model(River-P)was specifically designed for lowland rural rivers to address this *** modelwas coupled with the Environmental Fluid Dynamics Code(EFDC)and the Phosphorus Dynamic Model for lowland Polder systems(PDP)to characterize P dynamics under the impact of dredging in a lowland rural *** on a two-year(2020-2021)dataset from a representative lowland rural river in the Lake Taihu Basin,China,the coupled model was calibrated and achieved a model performance(R^(2)>0.59,RMSE<0.04 mg/L)for total P(TP)*** research in the study river revealed that(1)the time scale for the effectiveness of sediment dredging for P control was~300 days,with an increase in P retention capacity by 74.8 kg/year and a decrease in TP concentrations of 23%after dredging.(2)Dredging significantly reduced P release from sediment by 98%,while increased P resuspension and settling capacities by 16%and 46%,respectively.(3)The sediment-water interface(SWI)plays a critical role in P transfer within the river,as resuspension accounts for 16%of TP imports,and settling accounts for 47%of TP *** the large P retention capacity of lowland rural rivers,drainage ditches and ponds with macrophytes are promising approaches to enhance P retention *** study provides valuable insights for local environmental departments,allowing a comprehensive understanding of P dynamics in lowland rural *** enable the evaluation of the efficacy of sediment dredging in P control and the implementation of corresponding P control measures.

关键词： Lowland rural river Phosphorus Sediment dredging Model ensemble Retention capacity

Analyzing carbon emissions and influencing factors in Chengdu-Chongqing urban agglomeration counties

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Journal of Environmental Sciences 2025年第5期151卷 640-651页

作者： zhang Heng Lu Wenfu Peng Lindan zhang Key Laboratory of the Evaluation and Monitoring of Southwest Land Resources(Ministry of Education) Sichuan Normal UniversityChengdu 610068China The Institute of Geography and Resources Science Sichuan Normal UniversityChengdu 610068China

Majority of carbon emissions originate from fossil energy consumption,thus necessitating calculation and monitoring of carbon emissions from energy *** this study,we utilized energy consumption data from Sichuan Province and Chongqing Municipality for the years 2000 to 2019 to estimate their statistical carbon *** then employed nighttime light data to downscale and infer the spatial distribution of carbon emissions at the county level within the Chengdu-Chongqing urban ***,we analyzed the spatial pattern of carbon emissions at the county level using the coefficient of variation and spatial autocorrelation,and we used the Geographically and Temporally Weighted Regression(GTWR)model to analyze the influencing factors of carbon emissions at this *** results of this study are as follows:(1)from 2000 to 2019,the overall carbon emissions in the Chengdu-Chongqing urban agglomeration showed an increasing trend followed by a decrease,with an average annual growth rate of 4.24%.However,in recent years,it has stabilized,and 2012 was the peak year for carbon emissions in the Chengdu-Chongqing urban agglomeration;(2)carbon emissions exhibited significant spatial clustering,with high-high clustering observed in the core urban areas of Chengdu and Chongqing and low-low clustering in the southern counties of the Chengdu-Chongqing urban agglomeration;(3)factors such as GDP,population(Pop),urbanization rate(Ur),and industrialization structure(Ic)all showed a significant influence on carbon emissions;(4)the spatial heterogeneity of each influencing factor was evident.

关键词： Carbon emissions Chengdu-Chongqing urban agglomeration Spatial autocorrelation Geographically and temporally weighted regression

Automatic and Rapid Throughflow-Based Optimal Design Method for Multi-Stage Axial-Flow Compressors

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Journal of Thermal Science 2025年第1期34卷 77-91页

作者： LEI Fan zhang Xiawen JU Yaping zhang Chuhua Department of Fluid Machinery and Engineering School of Energy and Power EngineeringXi'an Jiaotong UniversityXi'an 710049China State Key Laboratory for Strength and Vibration of Mechanical Structures Xi'an Jiaotong UniversityXi'an 710049China Production and Environmental Department China Huaneng Group.Co.Ltd.Beijing 100031China

Throughflow design has the advantages of less time consumption and large optimization space,and thus is the corner stone of advanced design system of multi-stage axial-flow *** majority of relevant studies were limited to the throughflow inverse designs,and quite few works have been till now devoted to the throughflow optimal *** this work,an automatic and rapid throughflow-based optimal design method is proposed for axial-flow compressors in which a throughflow inverse design solver is embedded in optimal genetic algorithm to improve the design efficiency of axial-flow *** types of design parameters in the throughflow inverse design of axial-flow compressors,i.e.,swirl and shroud curve,are simultaneously used to optimize both the blade shape and flow *** proposed method is validated by the redesign optimization of the benchmark axial-flow compressor NASA Stage 35,and the CFD predictions show that the throughflow-based optimization leads to 1.18% efficiency benefit at design *** proposed method is then utilized to the two-dimensional throughflow optimal design of a large-scale 6.5-stage axial-flow industrial *** optimal design results are confirmed by CFD predictions,indicating that the proposed method can effectively improve the design adiabatic efficiency of the compressors by 1.09% within a few minutes on desk-top *** throughflow design implications are also obtained for advanced axial-flow industrial *** work could enhance the capability of throughflow design method and has engineering application value to explore the throughflow optimization space of multi-stage axial-flow compressors.

关键词： multi-stage axial-flow compressor throughflow design empirical correlations genetic algorithm aerodynamic optimization