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Unraveling the role of cancer-associated fibroblasts in colorectal cancer

World Journal of Gastrointestinal Oncology 2024年第12期16卷 4565-4578页

作者： Jia-Yu Cui Jing ma Xin-Xin Gao Zhi-Mei Sheng Zi-Xin Pan Li-Hong Shi Bao-Gang Zhang Affiliated Hospital of Shandong Second Medical University School of Clinical MedicineShandong Second Medical UniversityWeifang 261053Shandong ProvinceChina Affiliated Hospital of Shandong Second Medical University Department of PathologyShandong Second Medical UniversityWeifang 261053Shandong ProvinceChina School of Rehabilitation Medicine Shandong Second Medical UniversityWeifang 261053Shandong ProvinceChina Department of Pathology Shandong Second Medical UniversityWeifang 261053Shandong ProvinceChina

Within the intricate milieu of colorectal cancer(CRC)tissues,cancer-associated fibroblasts(CAFs)act as pivotal orchestrators,wielding considerable influence over tumor *** review endeavors to dissect the multifaceted functions of CAFs within the realm of CRC,thereby highlighting their indispensability in fostering CRC malignant microenvironment and indicating the development of CAFs-targeted therapeutic *** a comprehensive synthesis of current knowledge,this review delineates insights into CAFsmediated modulation of cancer cell proliferation,invasiveness,immune evasion,and neovascularization,elucidating the intricate web of interactions that sustain the pro-tumor metabolism and secretion of multiple ***,recognizing the high level of heterogeneity within CAFs is crucial,as they encompass a range of subtypes,including myofibroblastic CAFs,inflammatory CAFs,antigen-presenting CAFs,and vessel-associated ***,the symbiotic relationship between CAFs and the intestinal microbiota is explored,shedding light on a novel dimension of CRC *** remarkable progress,the orchestrated dynamic functions of CAFs remain incompletely deciphered,underscoring the need for continued research endeavors for therapeutic advancements in CRC management.

关键词： Colorectal cancer Cancer-associated fibroblasts Therapeutic strategies Microbiota Neovascularization

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急性心肌梗死患者APN和D-二聚体水平的观察

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中华全科医学 2009年第9期7卷 949-950页

作者：张艳红尹奎夫马香稳徐燕张建武山东省潍坊市妇幼保健院内科 261011

目的探讨血浆脂联素(APN)和D-二聚体在急性心肌梗死(AMI)患者中的变化及其临床意义。方法选择AMI患者50例,入院后均行超声心动图检查评价室壁运动和心功能,并设对照组(30例)进行比较。采用ELISA法测定APN,免疫比浊法测定D-二聚体水平。... 详细信息

目的探讨血浆脂联素(APN)和D-二聚体在急性心肌梗死(AMI)患者中的变化及其临床意义。方法选择AMI患者50例,入院后均行超声心动图检查评价室壁运动和心功能,并设对照组(30例)进行比较。采用ELISA法测定APN,免疫比浊法测定D-二聚体水平。结果AMI患者APN水平显著低于正常心功能对照组(P<0.01),D-二聚体水平显著高于正常心功能对照组(P<0.01)。AMI患者APN、D-二聚体水平与左心室射血分数(LVEF)呈负相关(r=-0.549,P<0.01)。结论血浆APN、D-二聚体水平与预后显著相关,对AMI的辅助诊断、疗效观察及预后判断具有重要价值。

关键词：急性心肌梗死脂联素 D-二聚体

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Highly Efficient White Organic Light-emitting Devices with Optimized Electron Transporting Layers

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Chemical Research in Chinese Universities 2017年第2期33卷 227-230页

作者： ZHANG Tianyu ZHENG Yu WANG Chengming ZHANG Yixin LIU Shihao ma Jian ZHANG Letian XIE Wenfa CHEN Ping LIN Jun LIU Yujuan Key Laboratory of Geo-exploration Instruments Ministry of Educanon College of Instrumentation and Electrical Engineering Jilin University Changchun 130061 P R. China State Key Laboratory on Integrated Optoelectronics College of Electronic Science and Engineering Jilin University Changchun 130012 P. R. China Changchun Institute of Optics Fine Mechanics and Physics Chinese Academy of Sciences Changchun 130033 P. R. China

We fabricated three phosphorescent blue organic light-emitting devices based on blue phosphor of iri-dium（Ⅲ） bis[（4,6-difluorophenyl）-pyridinato-N,C2＇]（Firpic） with different electron transporting layer（ETL） materialsBy analyzing efficiency curves and spectral characteristics, the significant effect of ETL on many aspects of deviceperformance was demonstrated. With optimized ETL, the characteristics of devices, such as voltage and efficiencywere significantly improved. Combined with a yellow phosphor of iridium（Ⅲ） bis（4-phenylthieno[3,2-c]pyridinato-N,C2＇） acetylacetonate（PO-01）, phosphorescent white organic light-emitting devices（PhWOLEDs） were ***, with an aim to promote the performance of the PhWOLEDs~ a thin layer of 4,4＇,4＂-tri（N-carbazolyl）-triphenylamine（TCTA） was introduced between two light emission layers, and the diffusion of excitons was *** outperformance device fabricated with 4,7-diphenyl-l,10-phenanthroline（Bphen） as the electron transportinglayer exhibited a peak current efficiency of 36.6 cd/A, a peak power efficiency of 19.2 lm/W, and the InternationalCommission on Illumination coordinates（0.37, 0.46）.

关键词： White organic light-emiRing device High efficiency Optimized electron transporting layer

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Differences and determinants in access to essential public health services in China： a case study with hypertension people and under-sixes as target population

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Chinese Medical Journal 2014年第9期127卷 1626-1632页

作者： Niu Hongli Tian Miaomiao ma Anning Wang Chunping Zhang Liang School of Medicine and Health management Huazhong University of Science and Technology Wuhan Hubei 430030 China Center for Policy and Health management Chinese Academy oI Medical Sciences Beijing 100020 China School of Public Health Weifang Medical University Weifang Shandong 261053 China

Background Since 2009, health reform had launched in China and essential public health services were provided for all residents to ensure service equity and accessibility, and to achieve sustained population-wide health improvement. This study aimed to investigate the differences and determinants among populations with different characteristics access to essential public health services in China, especially hypertension people and children aged 0-6 years. Methods A cross-sectional study with socio-demographic data analysis was undertaken to estimate distribution characteristics of receiving essential public health services of hypertension patients and children. Regular follow-ups and effective blood pressure control reflected the effective management for hypertension patients, and for children, public services provided were vaccination on schedule and regular physical check-up. Logistic regression was used to determine the predictors for effective management. Results A total of 1 505 hypertension patients and 749 children were involved; 39.14% of hypertension participants could control their blood pressure in the normal range, and the rate in urban areas （43.61%） was higher than that in rural （31.88%）. And 34.68% of them could receive more than 4 times follow-ups by the medical technician. Of 754 children, 79.84% could receive the periodic physical examination and 98.40% had vaccinated regularly. Children living in rural areas were more likely to have regular check-ups （83.96%） and regular vaccination （nearly 99%）. Overall, geographic location and education level were the determinants of people access to essential public health services. Conclusions Implementation of the health reform since 2009 has headed China＇s public health system in the right direction and promoted the improvement of public health system development. Our study highlights the growing needs for more public health services in China, and China＇s public health system needs to be greatly improved in

关键词： public health individual difference epidemiologic determinants

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彰武水库水质状态分析及评价

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贵州师范大学学报（自然科学版） 2022年第6期40卷 82-88页

作者：陈利粉陈龙宋盈马建茹杨卫芳河南省安阳生态环境监测中心河南安阳455000

运用主成分分析法(PCA)、综合营养状态指数法(TLI)和加拿大水质指数(CCME WQI)对2011—2020年彰武水库水质状态进行比较,发现3种分析方法对彰武水库水质状态分析具有较好的一致性。主成分分析结果显示:彰武水库水质变化的主要驱动因子... 详细信息

运用主成分分析法(PCA)、综合营养状态指数法(TLI)和加拿大水质指数(CCME WQI)对2011—2020年彰武水库水质状态进行比较,发现3种分析方法对彰武水库水质状态分析具有较好的一致性。主成分分析结果显示:彰武水库水质变化的主要驱动因子为总氮、生化需氧量、高锰酸盐指数、叶绿素a、pH值和总磷;不同水期,主要污染物不同;生化需氧量、总氮始终是水库水质污染的重要污染指标。由于污染主要来源于工业、生活污水及农业面源,建议进一步强化水库上游工、农业污染减排,加快周边农村环境综合整治,控制农业面源污染,以确保库区水环境质量得以改善。

关键词：彰武水库主成分分析法综合营养状态指数加拿大水质指数(CCME WQI) 相关性分析

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Comparison of ocular biometric parameters between two swept-source optical coherence tomography devices and Scheimpflug tomography in patients with cataract

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1437-1446页

作者： Shan ma Cheng Li Jing Sun Jun Yang Kai Wen Xi-Teng Chen Fang-Yu Zhao Rong-Yu Gao Fang Tian Tianjin Key Laboratory of Retinal Functions and Diseases Tianjin Branch of National Clinical Research Center for Ocular DiseaseEye Institute and School of OptometryTianjin Medical University Eye HospitalTianjin 300380China Zhengda Guangming Eye Group Weifang 261000Shandong ProvinceChina Binzhou Polytechnic Binzhou 256603Shandong ProvinceChina

AIM:To assess and compare the variations and agreements across different ocular biometric parameters using swept-source optical coherence tomography(SS-OCT)and Scheimpflug tomography in patients diagnosed with ***:This prospective case series was conducted at Tianjin Medical University Eye *** total,212 eyes from 212 patients scheduled for phacoemulsification were *** were evaluated preoperatively using two SSOCT devices(IOLmaster700 and CASIA2)and Scheimpflug tomography(Pentacam).Central corneal thickness(CCT),anterior chamber depth(ACD),aqueous depth(AQD),white-to-white distance(WTW),flat simulated keratometry(Kf),steep simulated keratometry(Ks),mean keratometry(Km),and total corneal keratometry(TKm)were *** correlation coefficient(ICC),95%confidence intervals(CI)and limits of agreement(LoA)widths were conducted to assess differences and correlations between ***:All parameters,except for Ks,were significantly *** comparison revealed no significant differences between keratometry obtained by IOLmaster 700 and *** widths of all paired comparisons for Ks were>0.80 *** for WTW between IOLmaster 700 and CASIA2 and between CASIA2 and Pentacam,other Pearson’s coefficients between devices showed a strong correlation(all r>0.95).The ICC of WTW(ICC=0.438,95%CI 0.167-0.625)showed poor *** reliability of CCT,ACD,and AQD was excellent(all ICC>0.95),whereas that of TKm was good(ICC=0.827,95%CI 0.221-0.939).A significant linear correlation was also observed among ***:The ocular parameters derived from the use of IOLmaster700,CASIA2,and Pentacam exhibit significant discrepancies;as such,measurements from these devices should not be deemed as interchangeable.

关键词： ocular parameters swept-source optical coherence tomography cataract

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Effect of an Ilex asprella root decoction on the related genes of lipid metabolism from chronic stress and hyperlipidemic fatty liver in rats

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Chinese Medical Journal 2012年第19期125卷 3539-3542页

作者： HU Xiang-yang SHU Xiao-chun GUO Ying ma Yi Department of Traditional Chinese Medicine Fifth Affiliated Hospital of Sun Yat-sen University Zhuhai Guangdong 519000 China Department of Endocrinology Affiliated Hospital of Weifang Medical University Weifang Shandong 261053 China Life Sciences College of Jinan University Guangzhou Guangdong 510632 China

Background The gradually increasing changes in a human hyperlipidemic diet along with chronic stress might play an important role in the increased numbers of fatty liver. This study investigated the effects of Ilex asprella root decoction on related genes of lipid metabolism in chronic stress in hyperlipidemic fatty liver in rats. Methods Forty-eight male Wistar rats were randomly divided into four groups： normal control group, model control group, simvastatin group, and Ilex asprella root group. To establish chronic stress and hyperlipidemic fatty liver models in rats, the levels of serum lipids, glucose, liver index, insulin （INS）, insulin resistant （IR） index, adiponectin, superoxide dismutase （SOD）, glutathione peroxidase （GSH-pX）, glutathione （GSH）, liver X receptor （LXR）, and sterol responsive element binding protein （$REBP）-lc in rats were measured. Results When compared to the normal control group, the levels of serum lipids, glucose, liver index, INS, IR index, and GSH in the model control group significantly increased （P 〈0.01）. The protein levels of LXRa and SREBP-lc increased （P 〈0.05）, and the serum adiponectin and the SOD and GSH-pX decreased significantly （P 〈0.01）. When compared to the model control group, the levels of serum lipids, glucose, liver index, INS, IR index, SOD, and GSH-pX in the simvastatin group and Ilex asprella root group increased in varying degrees （P 〈0.01 or 0.05）; the serum adiponectin and GSH decreased （P 〈0.05）, while the protein levels of LXRa and SREBP-lc decreased in varying degrees （P 〈0.01 or 0.05）. When compared to the simvastatin group, the IR index and protein levels of LXRa in the Ilex asprella root group decreased （P 〈0.05）, and the serum adiponectin and SOD increased （P 〈0.05）. Conclusion The Ilex asprella root decoction has some protective effects on regulating the related genes of lipid metabolism caused by chronic stress and hyperlipidemic fatty liver in rats.

关键词： roots of llex asprella chronic stress hyperlipidemic fatty liver genes of lipid metabolism

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Keap1在肾细胞癌中的表达及其作用

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山东大学学报（医学版） 2017年第3期55卷 94-99页

作者：史培堃曾贝妮吴伟芳胡晓燕马天加周亚滨山东大学医学院病原生物学系山东济南250012 山东大学第二医院泌尿外科山东济南250033

目的探讨Kelch样ECH相关蛋白-1(Keap1)在肾癌中的表达及其在肾癌发生发展中的作用。方法采用Q-PCR技术检测32例肾癌患者的肿瘤组织和肾癌旁组织中Keap1、核因子E2相关因子2(NFE2L2)的表达;免疫组织化学染色法检测上述肾癌患者肿瘤组织... 详细信息

目的探讨Kelch样ECH相关蛋白-1(Keap1)在肾癌中的表达及其在肾癌发生发展中的作用。方法采用Q-PCR技术检测32例肾癌患者的肿瘤组织和肾癌旁组织中Keap1、核因子E2相关因子2(NFE2L2)的表达;免疫组织化学染色法检测上述肾癌患者肿瘤组织和肾癌旁组织中Keap1、NFE2L2的表达;CCK-8法检测和克隆形成法检测过表达Keap1后对肾癌细胞系ACHN增殖活性以及克隆形成能力的影响。结果实时荧光定量PCR(Q-PCR)结果显示,75.00%患者Keap1 mRNA的表达癌旁组织高于肿瘤组织(P=0.000),62.50%患者NFE2L2mRNA的表达肿瘤组织高于癌旁组织(P=0.046)。免疫组化结果显示32例肾癌患者中,Keap1蛋白在癌旁组织(87.50%)的表达高于肿瘤组织(25.00%)(P=0.000),NFE2L2蛋白在肿瘤组织(81.25%)的表达高于癌旁组织(46.88%)(P=0.004)。高表达Keap1后,NFE2L2的表达降低,肾癌细胞系ACHN的增殖能力和克隆形成能力降低。结论 Keap1/NFE2L2通路在肾癌的发生和发展中可能发挥重要作用,Keap1的表达对肾癌可能起到抑制作用。

关键词：肾细胞癌 Kelch样ECH相关蛋白-1 核因子E2相关因子2 细胞增殖

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半腱肌半膜肌重建前交叉韧带术后早期康复

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中华物理医学与康复杂志 2002年第6期24卷 331-333页

作者：马燕红程安龙江澜王亚泉孙欣袁伟芳蒋垚赵金忠第六人民医院康复医学科上海200233 第六人民医院第六人民医院骨科

目的　观察自体多股半腱肌半膜肌 (STG)重建膝前交叉韧带术后早期快速进展康复治疗的安全性和对患者膝功能水平的影响。方法　单侧自体多股半腱肌半膜肌膝前交叉韧带重建术 48例 ,其中康复组 31例术后接受快速进展康复方法 ,对照组 1 7... 详细信息

目的　观察自体多股半腱肌半膜肌 (STG)重建膝前交叉韧带术后早期快速进展康复治疗的安全性和对患者膝功能水平的影响。方法　单侧自体多股半腱肌半膜肌膝前交叉韧带重建术 48例 ,其中康复组 31例术后接受快速进展康复方法 ,对照组 1 7例。比较两组术后 6月的关节活动度、肌力、Lysholm评分及关节稳定性检查。结果　术后 6月康复组与对照组伸展受限分别是 2 .63°±2 .50°和 4 .1 5°± 2 .65°,屈曲度减少分别是 4.1 5°± 2 .95°和 5.0 1°± 2 .41° ,P man和Pivotshift检查均阴性。结论　我们进行的术后快速进展早期康复方法能促进自体多股STG重建膝交叉韧带患者功能水平的恢复。

关键词：半腱肌半膜肌早期康复前交叉韧带重建术后

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基于AFDEX的45°斜三通挤压成形工艺数值模拟及试验研究

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锻压技术 2016年第4期41卷 60-64页

作者：赵恒良钟志平翟月雯马晓晖刘维坊师博王伟机械科学研究总院北京100083 河北宏润重工股份有限公司河北沧州061300 北京机电研究所北京100083

基于AFDEX有限元软件,建立了某规格45°斜三通挤压成形热力耦合有限元模型,揭示了成形过程中等效应变、载荷-时间曲线和模具应力的分布规律,得到了挤压该规格45°斜三通件挤压设备吨位。研究结果显示,高应变值主要集中在坯料金属流经垂... 详细信息

基于AFDEX有限元软件,建立了某规格45°斜三通挤压成形热力耦合有限元模型,揭示了成形过程中等效应变、载荷-时间曲线和模具应力的分布规律,得到了挤压该规格45°斜三通件挤压设备吨位。研究结果显示,高应变值主要集中在坯料金属流经垂直冲头的区域;由载荷-时间曲线可知,镦粗开始后,镦粗杆的载荷先缓慢上升,之后快速增大,直到镦粗结束,成形载荷为42410 k N;反挤压开始后,随着加载过程的进行,反挤压杆的载荷迅速增大至约23000 k N,之后一段时间内相对趋于稳定,最终,成形载荷为34920 k N。结合工艺试验,镦粗和穿孔的成形载荷分别为41520和34500 k N,与模拟结果非常接近,验证了工艺方案的合理性,模具结构满足要求。

关键词： 45°斜三通镦粗反挤压穿孔数值模拟

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