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2020年西藏自治区1-69岁人群乙型病毒性肝炎血清流行病学调查

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中国疫苗和免疫 2024年第2期30卷 174-178页

作者：田甜顿珠多吉胡永红赵伟栋琼珍次仁德吉晋美西藏自治区疾病预防控制中心西藏拉萨850000

目的了解西藏自治区2020年1-69岁人群乙型病毒性肝炎(乙肝)血清流行率。方法采用多阶段整群随机抽样法选取西藏自治区5个疾病监测点1-69岁人群采集血清标本。使用酶联免疫吸附试验检测乙肝表面抗原(Hepatitis B surface antigen,HBsAg)... 详细信息

目的了解西藏自治区2020年1-69岁人群乙型病毒性肝炎(乙肝)血清流行率。方法采用多阶段整群随机抽样法选取西藏自治区5个疾病监测点1-69岁人群采集血清标本。使用酶联免疫吸附试验检测乙肝表面抗原(Hepatitis B surface antigen,HBsAg)、表面抗体(Hepatitis B surface antibody,HBsAb)和核心抗体(Hepatitis B core antibody,HBcAb),使用微粒子酶联免疫法对HBsAg阳性标本检测乙肝e抗原(Hepatitis B e antigen,HBeAg)和e抗体(Hepatitis B e antibody,HBeAb),分析乙肝病毒(Hepatitis B virus,HBV)标志物阳性率和组合模式。结果在4912例调查对象中,HBsAg、HBsAb、HBcAb阳性率分别为9.20%、37.11%、32.76%(标化率:8.65%、37.30%、30.35%)。1-4岁、5-14岁、15-29岁、30-69岁HBsAg阳性率分别为2.23%、2.85%、6.87%、12.46%,HBsAb阳性率分别为52.79%、32.67%、37.71%、36.03%,HBcAb阳性率分别为4.19%、6.42%、21.09%、46.95%。共检出13种HBV标志物组合模式,其中五项标志物阴性、HBsAb单项阳性、HBsAg+HBcAb+HBeAb阳性、HBsAg+HBcAb+HBeAg阳性分别占总调查对象的43.79%、22.39%、6.15%、1.65%。结论2020年西藏自治区1-69岁人群特别是儿童HBsAg阳性率和HBV感染率显著下降,存在一定比例易感人群。仍需重点加强新生儿乙肝疫苗及时和全程接种工作。

关键词：乙型病毒性肝炎乙型肝炎病毒血清标志物血清流行率

Study of selective hydrogenation of biodiesel in a DBD plasma reactor

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Plasma Science and Technology 2021年第9期23卷 184-193页

作者： weidong zhao Chao HUA Xiaoyin ZHANG Xiaolong QI Kiatsiriroat TANONGKIAT Junfeng WANG School of Automotive and Traffic Engineering Jiangsu UniversityZhenjiang 212013People's Republic of China Department of Mechanical Engineering Faculty of EngineeringChiang Mai UniversityChiang Mai 50200Thailand School of Energy and Power Engineering Jiangsu UniversityZhenjiang 212013People's Republic of China

In order to achieve the selective hydrogenation of biodiesel at room temperature and under normal pressure,we researched the upgrading of soybean biodiesel using a dielectric-barrier discharge(DBD)reaction *** Raney-Ni as the hydrogenation catalyst,the effects of the operating parameters on the hydrogenation depth and the selectivity of biodiesel were systematically *** results show that the polyunsaturated components in soybean methyl ester were reduced by 57.04%,and that the polyunsaturated components were hydrogenated to monounsaturated components with a selectivity of 77.75%.Based on the gas chromatography and mass spectrometry(GC-MS)test results,we established a kinetic model for biodiesel hydrogenation.A comparison of the calculated and experimental results shows that the hydrogenation of the biodiesel can be described by a quasi first-order reaction *** calculated reaction rate constants indicate that under DBD plasma reaction conditions,the hydrogenation of biodiesel has high selectivity for the formation of monounsaturated components.

关键词： biodiesel selectivity hydrogenation dielectric-barrier discharge oxidation stability saturation

Colorimetric detection and efficient monitoring of a potential biomarker of lumbar disc herniation using carbon nanotube-based probe

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Science China Chemistry 2016年第4期59卷 493-496页

作者： Yufeng Huang Ju Liu Min Zou Qingzhi Zhang Jie Chao weidong zhao Desheng Wu Shao Su Lianhui Wang Department of Spine Surgery Shanghai East HospitalTongji UniversityShanghai 200120China Department of Orthopedic Surgery Shanghai Pudong New District Zhoupu HospitalShanghai 201318China Key Laboratory for Organic Electronics&Information Displays Institute of Advanced MaterialsNational Syngerstic Innovation Center for Advanced MaterialsNanjing University of Posts&TelecommunicationsNanjing 210023China

Herein, a multiwalled carbon nanotubes(MWNT)-based colorimetric probe was designed to discover and monitor the level of apolipoprotein-L1(Apo L1) in lumbar disc herniation(LDH) patients. Apo L1 could be easily found in human serum of the LDH group, but not obviously expressed in the normal control group(Ctrl), spine spondylolisthesis(SSP) group, spinal fracture(SFR) group, and spine scoliosis(SSC) group. Furthermore, the as-prepared MWNT-based probe was also used to track the recovery of LDH patients who have successful surgery operation. The P value of early diagnosis and recovery monitoring was 0.05 for the proposed method and a conventional enzyme-linked immunosorbent assay(ELISA), respectively, suggesting this detection strategy had significant differences compared with the traditional ELISA. All experimental results showed that Apo L1 might be a potential biomarker for early diagnosis of LDH. This proposed detection strategy has a potential application in discovering new biomarkers of diseases.

关键词： colorimetric probe apolipoprotein-L1 early diagnosis recovery monitoring

Porphyromonas gingivalis bacteremia increases the permeability of the blood-brain barrier via the Mfsd2a/Caveolin-1 mediated transcytosis pathway

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International Journal of Oral Science 2023年第1期15卷 136-147页

作者： Shuang Lei Jian Li Jingjun Yu Fulong Li Yaping Pan Xu Chen Chunliang Ma weidong zhao Xiaolin Tang Department of Periodontics School and Hospital of StomatologyLiaoning Provincial Key Laboratory of Oral DiseaseChina Medical UniversityShenyangChina Department of Pediatric Dentistry School and Hospital of StomatologyLiaoning Provincial Key Laboratory of Oral DiseaseChina Medical UniversityShenyangChina Department of Preventive Dentistry School and Hospital of StomatologyLiaoning Provincial Key Laboratory of Oral DiseaseChina Medical UniversityShenyangChina Department of Developmental Cell Biology Key Laboratory of Cell BiologyChina Medical UniversityShenyangChina

Bacteremia induced by periodontal infection is an important factor for periodontitis to threaten general health. P. gingivalis DNA/virulence factors have been found in the brain tissues from patients with Alzheimer’s disease(AD). The blood-brain barrier(BBB) is essential for keeping toxic substances from entering brain tissues. However, the effect of P. gingivalis bacteremia on BBB permeability and its underlying mechanism remains unclear. In the present study, rats were injected by tail vein with P. gingivalis three times a week for eight weeks to induce bacteremia. An in vitro BBB model infected with P. gingivalis was also established. We found that the infiltration of Evans blue dye and Albumin protein deposition in the rat brain tissues were increased in the rat brain tissues with P. gingivalis bacteremia and P. gingivalis could pass through the in vitro BBB model. Caveolae were detected after P. gingivalis infection in BMECs both in vivo and in vitro. Caveolin-1(Cav-1) expression was enhanced after P. gingivalis *** of Cav-1 rescued P. gingivalis-enhanced BMECs permeability. We further found P. gingivalis-gingipain could be colocalized with Cav-1 and the strong hydrogen bonding between Cav-1 and arg-specific-gingipain(RgpA) were ***, P. gingivalis significantly inhibited the major facilitator superfamily domain containing 2a(Mfsd2a) expression. Mfsd2a overexpression reversed P. gingivalis-increased BMECs permeability and Cav-1 expression. These results revealed that Mfsd2a/Cav-1 mediated transcytosis is a key pathway governing BBB BMECs permeability induced by P. gingivalis, which may contribute to P. gingivalis/virulence factors entrance and the subsequent neurological impairments.

关键词： gingivalis expression inhibited

A SPARSE-GRID METHOD FOR MULTI-DIMENSIONAL BACKWARD STOCHASTIC DIFFERENTIAL EQUATIONS

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Journal of Computational Mathematics 2013年第3期31卷 221-248页

作者： Guannan Zhang Max Gunzburger weidong zhao Department of Scientific Computing Florida State University Tallahassee FL 32306Computer Science and Mathematics Division Oak Ridge National Lab Oak Ridge TN 37831 Department of Scientific Computing Florida State University Tallahassee FL 32306 School of Mathematics Shandong University Jinan Shandong 250100 China

A sparse-grid method for solving multi-dimensional backward stochastic differential equations （BSDEs） based on a multi-step time discretization scheme [31] is presented. In the multi-dimensional spatial domain, i.e. the Brownian space, the conditional mathe- matical expectations derived from the original equation are approximated using sparse-grid Gauss-Hermite quadrature rule and （adaptive） hierarchical sparse-grid interpolation. Error estimates are proved for the proposed fully-discrete scheme for multi-dimensional BSDEs with certain types of simplified generator functions. Finally, several numerical examples are provided to illustrate the accuracy and efficiency of our scheme.

关键词： Backward stochastic differential equations Multi-step scheme Gauss-Hermite quadrature rule Adaptive hierarchical basis Sparse grids.

The influence of silica on reaction rates and molecular hydrogen(H_(2))generation during olivine hydrothermal alteration

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Science China Earth Sciences 2024年第1期67卷 222-233页

作者： Ruifang HUANG weidong SUN Xing DING Yusheng zhao Yibing LI Xiuqi SHANG CAS Key Laboratory of Ocean and Marginal Sea Geology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China SUSTech Academy for Advanced Interdisciplinary Studies Southern University of Science and TechnologyShenzhen 518055China Center of Deep Sea Research Institute of OceanologyChinese Academy of SciencesQingdao 266071China State Key Laboratory of Isotope Geochemistry Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China Institue of Geology Chinese Academy of Geological SciencesBeijing 100037China

Hydrothermal alteration of olivine greatly influences geodynamics and the recycling of volatiles(such as water and carbon)in subduction *** is an important component of geological fluids,and its influence on the hydrothermal alteration of olivine remains poorly *** this study,we performed experiments at 300–515℃ and 3.0 kbar(1 bar=10^(5)Pa)by reacting well homogenized mixtures of olivine and silica powders with saline solutions(0.5 mol L^(−1)NaCl).Silica greatly influences the reaction pathways,reaction rates,and molecular hydrogen(H_(2))formation during olivine hydrothermal *** experiments at 300℃ and 3.0 kbar with mixtures of olivine and 10 wt%silica,olivine was replaced by serpentine and *** proportions of serpentine and talc were determined according to standard curves based on infrared spectroscopy *** 6.5%serpentine and 12%talc were produced after an experimental duration of 7 days,which had no change after a longer period(14 days).Compared to the kinetics in silica-free systems,the rates of olivine hydrothermal alteration in experiments with 10 wt%silica are much *** overall reaction is:4.5Forsterite+5.5SiO_(2),aq+4H_(2)O=Serpentine+*** the addition of more silica(20 wt%and 40 wt%),olivine was transformed into *** rates of reaction were much faster,e.g.,for experiments with olivine and 20 wt%silica,43%of talc was produced after 14 days,which increased to 77%for experiments with 40 wt%silica over the same *** overall reaction is:3Forsterite+5SiO_(2),aq+2H_(2)O=*** experiments at 400–505℃ and 3.0 kbar,the promoting effect of silica on olivine hydrothermal alteration was also observed,which is closely associated with a decrease in Gibbs free energies of olivine hydrothermal *** 300℃ and 3.0 kbar,silica decreased H_(2)formed during olivine hydrothermal alteration by around an order of magnitude,resulting in an increase in oxygen *** on measured H_(2),we calibrated ox

关键词： Olivine hydrothermal alteration Silica Serpentinization Hydrogen Serpentine

加味柴胡疏肝散联合穴位贴敷治疗脑梗死后睡眠障碍(肝郁化火型)的临床疗效及其对血清5-羟色胺、5羟基吲哚乙酸水平的影响

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实用心脑肺血管病杂志 2024年第1期32卷 85-90页

作者：王爱卿高红赵伟东窦荣花张万辉河北省沧州中西医结合医院脑病科河北省沧州市061000

目的探讨加味柴胡疏肝散联合穴位贴敷治疗脑梗死后睡眠障碍(肝郁化火型)的临床疗效及其对血清5-羟色胺(5-HT)、5羟基吲哚乙酸(5-HIAA)水平的影响。方法选取2022年2月—2023年2月河北省沧州中西医结合医院收治的脑梗死后睡眠障碍(肝郁化... 详细信息

目的探讨加味柴胡疏肝散联合穴位贴敷治疗脑梗死后睡眠障碍(肝郁化火型)的临床疗效及其对血清5-羟色胺(5-HT)、5羟基吲哚乙酸(5-HIAA)水平的影响。方法选取2022年2月—2023年2月河北省沧州中西医结合医院收治的脑梗死后睡眠障碍(肝郁化火型)患者80例为研究对象,采用随机数字表法将其分为对照组和观察组,每组40例。对照组采用常规药物治疗,观察组在对照组治疗基础上采用加味柴胡疏肝散联合穴位贴敷治疗,两组均连续治疗4周。比较两组临床疗效,治疗前后中医主症积分、匹兹堡睡眠质量指数(PSQI)评分、睡眠状况自评量表(SRSS)评分、多导睡眠仪监测结果及血清5-HT、5-HIAA水平,治疗期间不良反应发生率。结果观察组临床疗效优于对照组(u=2.087,P=0.037)。治疗后对照组和观察组心烦不能入睡、烦躁易怒、胸闷胁痛、头痛面红积分分别低于本组治疗前,且观察组低于对照组(P<0.05)。治疗后对照组和观察组PSQI评分、SRSS评分分别低于本组治疗前,且观察组低于对照组(P<0.05)。治疗后,对照组和观察组睡眠潜伏期、觉醒时间分别短于本组治疗前,总睡眠时间分别长于本组治疗前,睡眠效率、快速眼动睡眠(REM)期比例分别高于本组治疗前(P<0.05);治疗后观察组睡眠潜伏期、觉醒时间短于对照组,总睡眠时间长于对照组,睡眠效率、REM期比例高于对照组(P<0.05)。治疗后对照组和观察组血清5-HT、5-HIAA水平分别高于本组治疗前,且观察组高于对照组(P<0.05)。观察组治疗期间不良反应发生率为12.5%(5/40),与对照组的17.5%(7/40)比较,差异无统计学意义(χ^(2)=0.392,P=0.531)。结论加味柴胡疏肝散联合穴位贴敷治疗脑梗死后睡眠障碍(肝郁化火型)的临床疗效确切,其能有效减轻患者临床症状和睡眠障碍,改善患者睡眠质量,提高患者血清5-HT、5-HIAA水平,且安全性较好。

关键词：脑梗死睡眠障碍加味柴胡疏肝散穴位贴敷疗法治疗结果 5-羟色胺 5羟吲哚乙酸

基于BOM的民用大飞机全生命周期业务贯通方法

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科技和产业 2024年第13期24卷 144-151页

作者：刘湘川王辉葛磊雷帅赵卫东李杰张颖瑶同济大学电子与信息工程学院上海201804 上海飞机制造有限公司上海201324 列维自动化系统(上海)有限公司上海201109

分析物料清单(BOM)在民用大飞机全生命周期业务活动中的关键作用。通过比较不同BOM数据结构的优势和劣势,研究民用大飞机设计、工艺、制造、服务业务下BOM之间的映射机制。在此基础上实现了民用大飞机全生命周期业务贯通,从而为突破民... 详细信息

分析物料清单(BOM)在民用大飞机全生命周期业务活动中的关键作用。通过比较不同BOM数据结构的优势和劣势,研究民用大飞机设计、工艺、制造、服务业务下BOM之间的映射机制。在此基础上实现了民用大飞机全生命周期业务贯通,从而为突破民用大飞机全生命周期业务壁垒、促进民用飞机运营商高效运作提供了新思路。

关键词：物料清单(BOM) 全生命周期业务贯通

Insights into Nano-and Micro-Structured Scaffolds for Advanced Electrochemical Energy Storage

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Nano-Micro Letters 2024年第7期16卷 187-230页

作者： Jiajia Qiu Yu Duan Shaoyuan Li Huaping zhao Wenhui Ma weidong Shi Yong Lei Fachgebiet Angewandte Nanophysik Institut Für Physik and IMN MacroNanoTechnische Universit.t Ilmenau98693 IlmenauGermany Key Laboratory of Complex Nonferrous Metal Resources Clean Utilization Faculty of Metallurgical and Energy EngineeringKunming University of Science and TechnologyKunming 650093People’s Republic of China School of Chemistry and Chemical Engineering Jiangsu UniversityZhenjiang 212013People’s Republic of China School of Science and Technology Pu’er UniversityPu’er 665000People’s Republic of China

Adopting a nano-and micro-structuring approach to fully unleashing the genuine potential of electrode active material benefits in-depth understandings and research progress toward higher energy density electrochemical energy stor-age devices at all technology readiness *** to various challenging issues,especially limited stability,nano-and micro-structured(NMS)electrodes undergo fast electrochemical performance *** emerging NMS scaffold design is a pivotal aspect of many electrodes as it endows them with both robustness and electrochemical performance enhancement,even though it only occupies comple-mentary and facilitating components for the main ***,extensive efforts are urgently needed toward optimizing the stereoscopic geometrical design of NMS scaffolds to minimize the volume ratio and maximize their functionality to fulfill the ever-increasing dependency and desire for energy power source *** review will aim at highlighting these NMS scaffold design strategies,summariz-ing their corresponding strengths and challenges,and thereby outlining the potential solutions to resolve these challenges,design principles,and key perspectives for future research in this ***,this review will be one of the earliest reviews from this viewpoint.

关键词： Nano-and micro-structured Interconnected porous Scaffolds Electrode design Electrochemical energy storage