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基于多特征信息的双层睡眠分期模型

华中科技大学学报（自然科学版） 2024年第5期52卷 64-69页

作者：张虹淼王梓廖肖剑李伟达苏州大学机电工程学院江苏省先进机器人技术重点实验室江苏苏州215021

针对睡眠相关疾病的诊断和治疗过程中睡眠分期的问题,使用ADASYN算法对睡眠样本进行类平衡,有效利用复合多尺度排列熵、样本熵和不同频段的能量值等一系列能够反映不同睡眠阶段信息的特征进行训练.为了提高分类中易混淆睡眠阶段的分类... 详细信息

针对睡眠相关疾病的诊断和治疗过程中睡眠分期的问题,使用ADASYN算法对睡眠样本进行类平衡,有效利用复合多尺度排列熵、样本熵和不同频段的能量值等一系列能够反映不同睡眠阶段信息的特征进行训练.为了提高分类中易混淆睡眠阶段的分类识别性能,构建了一种双层分类模型,使睡眠分期的五分类问题转化为两个三分类问题.将所提出的方法在Sleep-EDF数据集上进行验证,结果表明:所提出的模型对健康受试者的准确率可达到88.3%,较以往模型提高1%~3%,其中N1阶段的分类准确率可达69.5%,较以往模型提高约10%,证明本双层分类模型优于传统的睡眠分类模型.

关键词：睡眠分期脑电信号特征提取复合多尺度排列熵双层分类模型

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大数据背景下通信网络数字化建设分析

信息与电脑 2024年第9期36卷 171-173页

作者：李韦达天津国投新能源有限公司天津300142

文章探讨了大数据背景下通信网络数字化建设的驱动力、核心技术,并从数据驱动的网络优化、智能化网络运维及用户行为分析等方面,提出大数据驱动的通信网络数字化建设策略,通过案例研究深入剖析大数据在通信网络数字化建设中的应用。

关键词：大数据通信网络数字化建设

高校辅导员参与思政课教学的三重追问——基于协同育人的视角

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福建技术师范学院学报 2024年第1期42卷 100-108页

作者：李伟达福建师范大学马克思主义学院福建福州350117

辅导员是高校思想政治工作的骨干力量,肩负着对大学生进行思想理论教育和价值引领的职责使命,思政课是落实立德树人根本任务的关键课程。高校辅导员参与思政课教学是推进高校思政教育协同育人的势之所趋,带着“何以可能、何以可为、何... 详细信息

辅导员是高校思想政治工作的骨干力量,肩负着对大学生进行思想理论教育和价值引领的职责使命,思政课是落实立德树人根本任务的关键课程。高校辅导员参与思政课教学是推进高校思政教育协同育人的势之所趋,带着“何以可能、何以可为、何以实现”的三重追问,着力探究高校辅导员参与思政课教学的政策安排与理论基础、现实需要与自身优势、实践路径,旨在深化对高校辅导员参与思政课教学的认识,发挥辅导员队伍的独特优势,协同思政课教师合力育人,促进高校思政课教学提质增效。

关键词：高校辅导员参与思政课教学协同育人

Two-tier control structure design methodology applied to heat exchanger networks

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Chinese Journal of Chemical Engineering 2022年第7期35卷 231-244页

作者： Siwen Gu Lei Zhang Yu Zhuang weida li Jian Du Cheng Shao Institute of Chemical Process Systems Engineering School of Chemical EngineeringDalian University of TechnologyDalian 116024China Jiangsu Collaborative Innovation Center for Cultural Creativity School of Photoelectric EngineeringChangzhou Institute of TechnologyChangzhou 213032China Institute of Advanced Control Technology School of Control Science and EngineeringDalian University of TechnologyDalian 116024China

Because of its paramount importance in the successful industrial control strategy of a given heat exchanger network(HEN),the control structure designs for providing appropriate manipulated variable(MV)and controlled variable pairings have received considerable ***,quite frequently HENs with such control structures face the problem of hard constraints,typically holding the HENs at less controlled operating *** both the MV pairings and the above control pairings should be considered to design a control *** paper investigates the systematic incorporation of the two pairings,and presents a methodology for designing such two-tier control *** is developed based on the sequential strategy,coupling an indirect-tier with direct-tier control structure design,wherein the intention is realized in the former stage and the latter is implemented for further *** MV identification and pairing are achieved through variations in heat load of heat exchangers to design the indirect-tier control *** the direct-tier control structure is followed the relative gain array pairing *** the proposed methodology,on the one hand,it generates an explicit connection between the MV pairings and the HEN configuration,and the quantitative interaction measure is improved to avoid the multiple solutions to break the relationship among all the control pairings into individuals;on the other hand,a two-tier control structure reveals control potentials and control system design requirements,this may avoid complex and economically unfavourable control and HEN *** application of proposed framework is illustrated with two cases involving the dynamic simulation analysis,the quantitative assessment and the random test.

关键词： Heat exchanger networks(HENs) Controllability Two-tier control structure Manipulated variable pairing Control pairing

Single-cell RNA Sequencing Reveals Sexually Dimorphic Transcriptome and Type 2 Diabetes Genes in Mouse Islet β Cells

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Genomics, Proteomics & Bioinformatics 2021年第3期19卷 408-422页

作者： Gang liu Yana li Tengjiao Zhang Mushan li Sheng li Qing He Shuxin liu Minglu Xu Tinghui Xiao Zhen Shao Weiyang Shi weida li Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalFrontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China Tsingtao Advanced Research Institute Tongji UniversityQingdao 266073China CAS Key Laboratory of Computational Biology Shanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China University of Chinese Academy of Sciences Beijing 100049China Department of Statistics The Pennsylvania State UniversityUniversity ParkPA 16802USA Ministry of Education Key Laboratory of Marine Genetics and Breeding College of Marine Life SciencesOcean University of ChinaQingdao 266003China

Type 2 diabetes(T2D)is characterized by the malfunction of pancreaticβ*** and pathogenesis of T2D can be affected by multiple factors,including sex ***,the mechanisms underlying sex differences in T2D susceptibility and pathogenesis remain *** single-cell RNA sequencing(scRNA-seq),we demonstrate the presence of sexually dimorphic transcriptomes in mouseβ*** a high-fat diet-induced T2D mouse model,we identified sex-dependent T2D altered genes,suggesting sex-based differences in the pathological mechanisms of ***,based on islet transplantation experiments,we found that compared to mice with sexmatched islet transplants,sex-mismatched islet transplants in healthy mice showed down-regulation of genes involved in the longevity regulating pathway ofβ***,the diabetic mice with sex-mismatched islet transplants showed impaired glucose *** data suggest sexual dimorphism in T2D pathogenicity,indicating that sex should be considered when treating *** hope that our findings could provide new insights for the development of precision medicine in T2D.

关键词： Type 2 diabetes mellitus Pancreaticβcell Sex-biased gene expression Sex-dependent T2D altered genes Precision medicine

Micro-vibration suppression and compensation techniques for in-orbit satellite:A review

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Chinese Journal of Aeronautics 2024年第9期37卷 1-19页

作者： weida XING Weixiao TUO Xingfei li Tianyu WANG Chenxi YANG State Key Laboratory of Precision Measurement Technology and Instruments Tianjin UniversityTianjin 30072China Taihu Laboratory of Deepsea Technological Science Wuxi 214123China

Micro-vibration is an important factor affecting the imaging quality and pointing accu-racy of the in-orbit *** address the problem of micro-vibration compensation,a general summary for modeling,analysis,suppression,and compensation approach should be *** this review,micro-vibration characteristics and its impacts on the payloads are firstly ***,methods for micro-vibration measurement are *** detail,the principles and practical applications of these methods are ***,advanced technologies for micro-vibration suppression are summarized from micro-vibration source attenuation,transfer path opti-mization and sensitive load *** approaches have been found to be effective for micro-vibration *** one is the line-of-Sight(LOS)stabilization assisted with Inertial Ref-erence Unit(IRU).The other is using image restoration technology to remove the blur caused by platform *** compensation technique and research status of the two techniques are *** work will provide researchers with technical guidelines for micro-vibration suppression.

关键词： In-orbit Satellite Micro-vibration suppression Compensation technique Vibration isolation Path optimization

Development of a DFN-based probabilistic block theory approach for bench face angle design in open pit mining

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第8期16卷 3047-3062页

作者： Jianhua Yan Xiansen Xing Zhihai li weida Ni liuyuan Zhao Chun Zhu Yuanyuan He School of Earth Sciences and Engineering Hohai UniversityNanjing210098China POWERCHINA Huadong Engineering Corporation limited Hangzhou311122China Zhejiang Huadong Construction Corporation limited Hangzhou310004China The Seventh Geological Brigade of Hubei Geological Bureau Yichang443000China

In open pit mining,uncontrolled block instabilities have serious social,economic and regulatory consequences,such as casualties,disruption of operation and increased regulation *** this reason,bench face angle,as one of the controlling parameters associated with block instabilities,should be carefully designed for sustainable *** study introduces a discrete fracture network(DFN)-based probabilistic block theory approach for the fast design of the bench face angle.A major advantage is the explicit incorporation of discontinuity size and spatial distribution in the procedure of key blocks *** proposed approach was applied to a granite mine in ***,DFN models were generated from a multi-step modeling procedure to simulate the complex structural characteristics of pit ***,a modified key blocks searching method was applied to the slope faces modeled,and a cumulative probability of failure was obtained for each ***,a bench face angle was determined commensurate with an acceptable risk level of *** simulation results have shown that the number of hazardous traces exposed on the slope face can be significantly reduced when the suggested bench face angle is adopted,indicating an extremely low risk of uncontrolled block instabilities.

关键词： Open pit mine Bench face angle Block theory Probabilistic approach Discrete fracture network modeling Fractured rock slope

Dynamic gut microbiome-metabolome in cationic bovine serum albumin induced experimental immune-complex glomerulonephritis and effect of losartan and mycophenolate mofetil on microbiota modulation

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Journal of Pharmaceutical Analysis 2024年第4期14卷 562-577页

作者： Wenying Shi Zhaojun li weida Wang Xikun liu Haijie Wu Xiaoguang Chen Xunrong Zhou Sen Zhang State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100050China State Key Laboratory of Functions and Applications of Medicinal Plants College of PharmacyGuizhou Provincial Engineering Technology Research Center for Chemical Drug R&DGuizhou Medical UniversityGuiyang550004China Department of Medicine Solna Center for Molecular MedicineKarolinska University Hospital and Karolinska InstituteStockholm17176Sweden Department of Pharmacy The Second Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550001China

Dynamic changes in gut dysbiosis and metabolomic dysregulation are associated with immune-complex glomerulonephritis(ICGN).However,an in-depth study on this topic is currently ***,we report an ICGN model to address this *** was induced via the intravenous injection of cationized bovine serum albumin(c-BSA)into Sprague-Dawley(SD)rats for two weeks,after which mycophenolate mofetil(MMF)and losartan were administered *** and six weeks after ICGN establishment,fecal samples were collected and 16S ribosomal DNA(rDNA)sequencing and untargeted metabolomic were *** microbiota transplantation(FMT)was conducted to determine whether gut normali-zation caused by MMF and losartan contributed to their renal protective effects.A gradual decline in microbial diversity and richness was accompanied by a loss of renal *** 18 genera were found to have significantly different relative abundances between the early and later stages,and Marvinbryantia and Allobaculum were markedly upregulated in both *** metabolomics indicated that the tryptophan metabolism was enhanced in ICGN,characterized by the overproduction of indole and kynurenic acid,while the serotonin pathway was *** of losartan and MMF ameliorated microbial dysbiosis and reduced the accumulation of indoxyl conjugates in *** using feces from animals administered MMF and losartan improved gut dysbiosis by decreasing the Firmicutes/Bacteroidetes(F/B)ratio but did not improve renal *** findings indicate that ICGN induces serous gut dysbiosis,wherein an altered tryptophan metabolism may contribute to its *** and losartan significantly reversed the gut microbial and metabolomic dysbiosis,which partially contributed to their renoprotective effects.

关键词： Immune-complex glomerulonephritis Gut microbiome Metabolomics Fecal microbiota transplant Tryptophan metabolism

Potential impact of specific therapy on pregnant women with pulmonary arterial hypertension without cardiac shunt:a descriptive study in northern China

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Emergency and Critical Care Medicine 2024年第2期4卷 60-66页

作者： weida Lu Min li Fuqing Ji Hua Feng Guo li Qiushang Ji Hongyu Zhang Xiaopei Cui Department of Geriatric Medicine&Shandong Key Laboratory Cardiovascular Proteomics Qilu Hospital of Shandong UniversityJinanShandongChina Intensive Care Unit of Cardiac Surgery Shandong Provincial Qianfoshan Hospitalthe First Hospital Affiliated with Shandong First Medical UniversityAffiliated Hospital of Shandong UniversityJinanShandongChina Department of Cardiology Linyi Central HospitalLinyiShandongChina Department of Gastroenterology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinanShandongChina Department of Pulmonary and Critical Care Medicine the Affiliated Hospital of Qingdao UniversityQingdaoShandongChina Department of Cardiology Qilu Hospital of Shandong UniversityJinanShandongChina

Background:Pregnancy in women with pulmonary arterial hypertension(PAH)is a fatal condition,despite the effectiveness of PAH-specific *** coverage status and effect of specific therapies in pregnant patients with PAH without cardiac shunts in China remain *** investigate this issue,we conducted a multicenter retrospective study in northern ***:The study included 85 patients who were admitted to 4 clinical centers in Shandong Province between October 2010 and August *** endpoint events included(1)maternal death and/or(2)major adverse cardiac events,both occurring during pregnancy or within 6 weeks ***:Although the overall mortality rate was encouraging(11.8%),the number of patients receiving PAH-specific therapies was extremely low(28.2%).Moreover,only 15.3%of patients received adequate duration of PAH-specific therapy(≥4 weeks)before delivery,and this subgroup showed the lowest major adverse cardiac events rate(7.7%)compared with that in the untreated(19.7%)and short-time treated groups(lity ***-term PAH-specific therapy does not guarantee favorable maternal *** screening,early identification,and timely intervention are expected to improve maternal outcomes in pregnant women with PAH.

关键词： Major adverse cardiac events Maternal mortality Pregnancy outcome Pulmonary arterial hypertension Specific therapy