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A Novel Spacetime Collocation Meshless Method for Solving Two- Dimensional Backward Heat Conduction Problems

Computer Modeling in Engineering & Sciences 2019年第1期118卷 229-252页

作者： Chihyu Liu Chengyu Ku Jingen Xiao weichung yeih Department of Harbor and River Engineering National Taiwan Ocean UniversityKeelung20224Taiwan Center of Excellence for Ocean Engineering National Taiwan Ocean UniversityKeelung20224Taiwan.

In this article,a meshless method using the spacetime collocation for solving the two-dimensional backward heat conduction problem(BHCP)is *** spacetime collocation meshless method(SCMM)is to derive the general solutions as the basis functions for the two-dimensional transient heat equation using the separation of *** solutions of the heat conduction problem are expressed as a series using the addition *** the basis functions are the general solutions of the governing equation,the boundary points may be collocated on the spacetime boundary of the *** proposed method is verified by conducting several heat conduction *** also carry out numerical applications to compare the SCMM with other meshless *** results show that the SCMM is accurate and ***,it is found that the recovered boundary data on inaccessible boundary can be obtained with high accuracy even though the over specified data are provided only at a 1/6 portion of the spacetime boundary.

关键词： Spacetime collocation meshless method backward heat conduction problem basis functions.

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Hypertrophic cardiornyopathy: from gene defect to clinical disease

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Cell Research 2003年第1期 9-20页

作者： MAN-weichung,TATIANATSOUTSMAN,CHRISTOPHERSEMSARIAN Molecular Molecular Molecular Cardiology Group Centenary Institute and Cardiology Group Centenary Institute and Cardiology Group Centenary Institute and Department of Cardiology Royal Prince Alfred Hospital Sydney NSW Australia

Major advances have been made over the last decade in our understanding of the molecular basis of several cardiac conditions. Hypertrophic cardiomyopathy (HCM) was the first cardiac disorder in which a genetic basis was identified and as such, has acted as a paradigm for the study of an inherited cardiac disorder. HCM can result in clinical symptoms ranging from no symptoms to severe heart failure and premature sudden death. HCM is the commonest cause of sudden death in those aged less than 35 years, including competitive athletes. At least ten genes have now been identified, defects in which cause HCM. All of these genes encode proteins which comprise the basic contractile unit of the heart, i.e. the sarcomere. While much is now known about which genes cause disease and the various clinical presentations, very little is known about how these gene defects cause disease, and what factors modify the expression of the mutant genes. Studies in both cell culture and animal models of HCM are now beginning to

关键词： hypertrophy cardiomyopathy gene mutations signalling modifying factors.

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