检索结果-南通市图书馆

Ribavirin monotherapy increases sustained response rate in relapsers of end treatment virologic responders

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2005年第11期11卷 1663-1667页

作者： Cho-liYen Jia-JangChang Tsung-ShihLee Ching-Jungliu li-weichen liang-CheChang DivisionofHepatogastroenterology DepartmentofInternalMedicineKeelungChang-GungMemorialHospitalTaiwanChina DepartmentofPathology KeelungChang-GungMemorialHospitalTaiwanChina

AIM: To assess the efficacy of ribavirin monotherapy in patients with biochemical relapse after combination ***: Twenty-four weeks of ribavirin monotherapy was given to biochemical relapsers of end treatment biochemical responders within 6 mo after combination therapy, including non-responders with HCV-RNA level ≤0.2 Meq/mL and end treatment virologic responders (ETVRs) with or without reappearance of ***: Sixty-two chronic HCV-infected patients completed 24 wk of interferon-α plus ribavirin combination therapy. Fifty patients (80%) achieved end treatment biochemical response including 16 non-responders and 34 of 36 ETVRs. Twenty-six patients (41.9%) were nonresponders. Ribavirin monotherapy was given to 20biochemical relapsers including 12 non-responders with HCV-RNA levels ≤0.2 Meq/mL, four of eight HCV-RNA reappearing ETVRs, and four HCV-RNA negative *** 24 wk of ribavirin monotherapy, one of 12 nonresponders, two of four HCV-RNA reappearing ETVRs and all four RNA-negative biochemical relapsers of ETVRs showed sustained virologic response. Two of 12monotherapy treated non-responders showed persistent normalization of liver function test. In total, 50% (31/62)of patients achieved sustained virologic ***: Resumption of ribavirin monotherapy in ETVRs at signs of viral rebound and recurrent biochemical abnormalities rather than continuation of monotherapy appears to be the key to success of ribavirin monotherapy after interferon-related combination therapy.

关键词： Ribavirin monotherapy Interferon-α plus iribavirin combination therapy Relapser End treatment virologic responder

Effective inhibition of expression of hepatitis B virus genes by DNAzymes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2005年第23期11卷 3504-3507页

作者： Jian-ErWo Xiao-lingWu lin-FuZhou Hang-PingYao li-weichen ReinhardH.Dennin KeyLaboratoryofInfectiousDiseases MinistryofPublicHealthofChina InstituteofInfectiousDiseases FirstAffiliatedHospitalMedicalCollegeofZhejiangUniversityHangzhou310003ZhejiangProvinceChina MedicalSchool HangzhouNormalCollegeHangzhou310012ZhejiangProvinceChina InstituteofMedicalMicrobiologyandHygiene UniversityofLuebeckLuebeckD-23538Germany

AIM: To evaluate the inhibitory effects of DNAzymes on the expressions of hepatitis B virus (HBV) s (HBsAg) and e (HBeAg) in 2.2.15 cells, and to explore the potential therapeutic effects of DNAzymes on replication of HBV genome. METHODS: DNAzymes DrzBS and DrzBC specific to HBV (aywsubtype) s gene ORF A^157UG and e gene ORF A^1816UG, were designed and synthesized. Inhibitory effects of DrzBS or DrzBC on the expressions of HBV s and e genes as well as HBV DNA levels in culture supernatants were observed in 2.2.15 cells. RESULTS: After being treated with DrzBS or DrzBC, the expression of HBV s or e genes in 2.2.15 cells was depressed dramatically. The maximum inhibition rate was 94.2% and 91.8% for DrzBS and DrzBC, respectively. The concentration for effective inhibition of both DrzBS and DrzBC was within 0.1-2.5 μmol/L, showing a dosedependence. The efficiency of inhibiting HBsAg, HBeAg in 2.2.15 cells by DrzBS or DrzBC was higher than that of the same target genes by antisense oligonucleotides (ASON). The concentration for effective inhibition of DNAzymes was at least 10-fold lower compared with ASON controls. Neither inhibition on the replication of HBV DNA nor toxicity to 2.2.15 cells was observed. CONCLUSION: DrzBS and DrzBC can block the expression of HBV s- and e-genes in 2.2.15 cells and provide a specific and effective anti-HBV gene therapeutic means.

关键词： DNAzyme HBV Gene expression Inhibition

Vitreous Humor:A Review of Biochemical Constituents in Postmortem Interval Estimation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Forensic Science and Medicine 2018年第2期4卷 85-90页

作者： weichen li Yunfeng Chang Zijia Cheng Jiang ling Leiming Han Xingmei li Yanjun Ding Department of Forensic Science School of Basic Medical SciencesCentral South UniversityChangshaChina

Postmortem changes in the biochemical constituents of the vitreous humor have been widely used to estimate the postmortem interval(PMI)over the past several ***,few reviews have summarized the relationship between the postmortem vitreous biochemical constituents and time of ***,the relationship between PMI and single biochemical components,including vitreous potassium,hypoxanthine,and amino acids,as well as comparisons of each statistical parameter in the formula,is *** also discuss other compounds such as urea and uric acid,which have no direct relationship with *** of multiple constituent simultaneous analysis for estimating PMI is being increasingly *** promising idea of using simultaneous analysis of multiple constituents to determine PMI is proposed as a future research direction.

关键词： Biochemical constituents multiple constituent analysis postmortem changes postmortem interval vitreous humor

Aqueous Zn-CO_(2) batteries:a route towards sustainable energy storage

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Industrial Chemistry & Materials

Industrial Chemistry & Materials 2024年第4期2卷 514-532页

作者： Yanxiu liu Junjie Chen weichen li Yu Zhang Xianwei Fu Erling li Shangbin Jin li-Ming Yang Zhihong Tian Markus Antonietti Tianxi liu School of Mechanical and Power Engineering East China University of Science and TechnologyShanghai 200237China Engineering Research Center for Nanomaterials Henan UniversityKaifeng 475004P.R.China Department of Colloid Chemistry Max Planck Institute of Colloids and InterfacesPotsdam 14476Germany Key Laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan UniversityWuxi 214122P.R.China School of Chemical Engineering and Technology Xi'an Jiaotong University28 Xianning RoadXi'anShaanxi710049China School of Chemistry and Chemical Engineering Huazhong University of Science and TechnologyWuhan 430074China

In recent years,the concept of rechargeable aqueous Zn–CO_(2) batteries has attracted extensive attention owing to their dual functionality of power supply and simultaneous conversion of CO_(2) into value-added chemicals or *** state-of-the-art research has been mainly focused on the exploration of working mechanisms and catalytic cathodes but hardly applies an integrative *** numerous studies have proven the feasibility of rechargeable aqueous Zn–CO_(2) batteries,challenges remain including the low CO_(2) conversion efficiency,poor battery capacity,and low energy *** review systematically summarizes the working principles and devices,and the catalytic cathodes used for Zn–CO_(2) *** challenges and prospects in this field are also elaborated,providing insightful guidance for the future development of rechargeable aqueous Zn–CO_(2) batteries with high performance.

关键词： Zn-CO_(2)battery CO_(2)reduction reaction Working mechanism Electrocatalysts

Influence of introducing Zr,Ti,Nb and Ce elements on externally solidified crystals and mechanical properties of high-pressure die-casting Al–Si alloy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 147-153页

作者： Junjie li Wenbo Yu Zhenyu Sun weichen Zheng liangwei Zhang Yanling Xue Wenning liu Shoumei Xiong Center of Materials Science and Engineering School of Mechanical and Electronic Control EngineeringBeijing Jiaotong UniversityBeijing 100044China Traffic&Transportation Engineering Central South UniversityChangsha 410075China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China

High pressure die casting(HPDC)AlSi10Mn Mg alloy castings are widely used in the automobile *** can optimize the mechanical properties of castings through heat treatment,while the release of thermal stress arouses the deformation of large integrated ***,the development of non-heat treatment Al alloys is becoming the hot *** addition,HPDC contains externally solidified crystals(ESCs),which are detrimental to the mechanical properties of *** achieve high strength and toughness of non-heat treatment die-casting Al-Si alloy,we used AlSi9Mn alloy as matrix with the introduction of Zr,Ti,Nb,and *** influences on ESCs and mechanical properties were systematically investigated through three-dimensional reconstruction and thermodynamic *** results reveal that the addition of Ti increased ESCs'size and porosity,while the introduction of Nb refined ESCs and decreased ***,large-sized Al_3(Zr,Ti)phases formed and degraded the mechanical *** introduction of Ce resulted in the poisoning effect and reduced mechanical properties.

关键词： aluminium alloy high-pressure die-casting externally solidified crystals non-heat treatment

在线全文

学校读者我要写书评

暂无评论

渗铝管腐蚀性能研究

热加工工艺 2011年第14期40卷 57-58页

作者：李伟臣辽宁省产品质量监督检验院辽宁沈阳110032

选取10钢管进行固体粉末渗铝法渗铝,在其表面获得了不同铝含量的渗铝层,对渗铝钢、未渗铝钢进行高温氧化、硫化氢腐蚀以及环烷酸试验,通过实验数据论证了渗铝钢具有优越的耐高温氧化性能及耐酸腐蚀性能。

关键词：固体粉末渗铝腐蚀高温氧化

在线全文

学校读者我要写书评

暂无评论

工字形截面RC剪力墙变形指标限值研究

哈尔滨工程大学学报 2019年第2期40卷 285-291页

作者：季静曹源李伟琛韩小雷华南理工大学土木与交通学院广东广州510640 华南理工大学亚热带建筑科学国家重点实验室广东广州510640

为了研究工字形截面RC剪力墙在地震作用下的变形能力,采用ABAQUS分析了324个工字形RC剪力墙有限元模型,以剪跨比和弯剪比为参数确定了构件破坏形态的判断标准。结合我国规范提出了7个性能水准和6个性能水准限值,根据材料应变和荷载-位... 详细信息

为了研究工字形截面RC剪力墙在地震作用下的变形能力,采用ABAQUS分析了324个工字形RC剪力墙有限元模型,以剪跨比和弯剪比为参数确定了构件破坏形态的判断标准。结合我国规范提出了7个性能水准和6个性能水准限值,根据材料应变和荷载-位移曲线定义了6个性能水准限值的判断准则,并可得到所有模型的位移角。根据破坏形态、轴压比和弯剪比进行统计,得到工字形RC剪力墙的变形指标限值并与构件试验及ASCE41指标进行对比,分析结果表明:提出的破坏形态划分方法预测正确率达85%,能够满足工程需求;利用本文变形限值对试验构件破坏形态的判断结果与ASCE 41基本一致;试验得到的"比较严重破坏"位移角约为本文变形限值的3倍,指标限值具有足够的安全储备。

关键词：工字形截面 RC剪力墙破坏形态变形限值构件变形性能水准判定材料应变有限元模拟

在线全文

学校读者我要写书评

暂无评论

不同抗震等级RC梁抗震性能试验研究

建筑结构学报 2015年第S2期36卷 299-308页

作者：韩小雷崔济东龚涣钧李伟琛华南理工大学土木与交通学院广东广州510640 华南理工大学亚热带建筑科学国家重点实验室广东广州510640

通过9根钢筋混凝土梁的低周往复试验,对比研究不同抗震等级RC梁的破坏形态、延性、滞回性能、耗能能力及刚度退化等。结果表明:剪跨比为2.0的试件发生弯曲滑移破坏,剪跨比为3.0的试件和剪跨比为4.2的试件发生弯曲破坏;剪跨比为2.0的试... 详细信息

通过9根钢筋混凝土梁的低周往复试验,对比研究不同抗震等级RC梁的破坏形态、延性、滞回性能、耗能能力及刚度退化等。结果表明:剪跨比为2.0的试件发生弯曲滑移破坏,剪跨比为3.0的试件和剪跨比为4.2的试件发生弯曲破坏;剪跨比为2.0的试件抗震等级分别为二级和四级,表明满足规范抗震等级要求的RC梁试件无法避免发生弯曲滑移破坏;同组试件中,抗震等级越高(配箍率越大),试件的极限位移角越大。除去发生弯曲滑移破坏的试件,试件的极限位移角随抗震等级的提高呈线性增长趋势;抗震等级相同时,弯曲滑移破坏的试件刚度退化比弯曲和弯剪破坏试件严重;弯曲滑移破坏与弯曲破坏的RC梁试件其耗能分别集中在塑性阶段的前期和中后期。

关键词：钢筋混凝土梁抗震等级弯曲滑移破坏低周往复试验抗震性能

基于试验的ABAQUS混凝土塑性损伤参数取值方法

在线全文

学校读者我要写书评

暂无评论

结构工程师 2016年第2期32卷 64-69页

作者：李伟琛韩小雷崔济东华南理工大学土木与交通学院土木工程系广州510641

在ABAQUS的混凝土塑性损伤本构中,塑性损伤参数是影响钢筋混凝土构件行为的重要参数,其取值不仅影响卸载或反向加载的刚度,且直接对构件应变成分有很大影响。对国内外多组混凝土单轴往复压、拉试验数据进行统计分析及数据拟合,提出了一... 详细信息

在ABAQUS的混凝土塑性损伤本构中,塑性损伤参数是影响钢筋混凝土构件行为的重要参数,其取值不仅影响卸载或反向加载的刚度,且直接对构件应变成分有很大影响。对国内外多组混凝土单轴往复压、拉试验数据进行统计分析及数据拟合,提出了一种新的塑性损伤参数的取值方法。与其他方法的比较及数值试验均表明,该方法能较准确地反映真实的混凝土退化特性,并且相对于其他损伤参数取值方法形式更为简洁,便于使用。

关键词：混凝土塑性损伤本构损伤参数混凝土单轴试验曲线拟合