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Development and validation of a novel criterion of histologic healing in ulcerative colitis defined by inflammatory cell enumeration in lamina propria mucosa:A multicenter retrospective cohort in China

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Chinese Medical Journal 2024年第11期137卷 1316-1323页

作者： Han Gao Kangsheng Peng Yadi Shi Shenshen zhu Ruicong Sun Chunjin Xu Ping Liu Zhi Pang Lanxiang zhu weichang Chen Baisui Feng Huili Wu Guangxi Zhou Mingsong Li Junxiang Li Baijing Ding Zhanju Liu Center for IBD Research and Department of Gastroenterology Shanghai Tenth People’s HospitalTongji University School of MedicineShanghai 200085China Clinical Medicine Sanquan College of Xinxiang Medical UniversityXinxiangHenan 453003China Department of Gastroenterology The First People’s Hospital of Shangqiu City Affiliated to Xinxiang Medical UniversityShangqiuHenan 476100China Department of Gastroenterology Wuhu First People’s HospitalWuhuAnhui 241000China Department of Gastroenterology Suzhou Municipal Hospital Affiliated to Nanjing Medical UniversitySuzhouJiangsu 215008China Department of Gastroenterology The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu 251006China Department of Gastroenterology The Second Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450014China Department of Gastroenterology Zhengzhou Central Hospital Affiliated to Zhengzhou UniversityZhengzhouHenan 450000China Department of Gastroenterology The Affiliated Hospital of Jining Medical CollegeJiningShandong 272004China Department of Gastroenterology The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510140China Department of Gastroenterology Dongfang Hospital of Beijing University of Chinese MedicineBeijing 100078China

Background:Histological healing is closely associated with improved long-term clinical outcomes and lowered relapses in patients with ulcerative colitis(UC).Here,we developed a novel diagnostic criterion for assessing histological healing in UC ***:We conducted a retrospective cohort study in UC patients,whose treatment was iteratively optimized to achieve mucosal healing at Shanghai Tenth People’s Hospital of Tongji University from January 2017 to May *** identified an inflammatory cell enumeration index(ICEI)for assessing histological healing based on the proportions of eosinophils,CD177^(+)neutrophils,and CD40L^(+)T cells in the colonic lamina propria under high power field(HPF),and the outcomes(risks of symptomatic relapses)of achieving histological remission *** histological inflammation using Kaplan-Meier *** reliability and inter-reader reliability were evaluated by each *** relationships to the changes in the Nancy index and the Geboes score were also assessed for *** ICEI was further validated in a new cohort of UC patients from other nine university ***:We developed an ICEI for clinical diagnosis of histological healing,i.e.,Y=1.701X_(1)+0.758X_(2)+1.347X_(3)-7.745(X_(1),X_(2),and X_(3)represent the proportions of CD177^(+)neutrophils,eosinophils,and CD40L^(+)T cells,respectively,in the colonic lamina propria under HPF).The receiver operating characteristics curve(ROC)analysis revealed that Y1 was the cutoff value for the diagnosis of histological healing and that an area under the curve(AUC)was 0.942(95%confidence interval[CI]:0.905-0.979)with a sensitivity of 92.5%and a specificity of 83.6%(P1).The intraclass correlation coefficient(ICC)for the intrareader reliability was 0.855(95%CI:0.781-0.909),and ICEI had good inter-reader reliability of 0.832(95%CI:0.748-0.894).During an 18-month follow-up,patients with histological healing had a substantially better outcome com

关键词： Ulcerative colitis Histological healing Inflammatory cell enumeration index Prognosis

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中医综合疗法治疗颈肩腰腿痛的临床观察

中外医药研究 2024年第8期3卷 90-92页

作者：孔维昌江西省赣州市南康区孔维昌中医综合诊所江西赣州341400

目的:探讨中医综合疗法治疗颈肩腰腿痛的临床效果。方法:选取2020年1月—2023年8月江西省赣州市南康区孔维昌中医综合诊所收治的70例颈肩腰腿痛患者为研究对象,随机分为对照组与观察组,各35例。对照组采用常规治疗,观察组采用中医综合... 详细信息

目的:探讨中医综合疗法治疗颈肩腰腿痛的临床效果。方法:选取2020年1月—2023年8月江西省赣州市南康区孔维昌中医综合诊所收治的70例颈肩腰腿痛患者为研究对象,随机分为对照组与观察组,各35例。对照组采用常规治疗,观察组采用中医综合疗法。比较两组患者治疗效果。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者疼痛评分低于治疗前,日常生活能力评分高于治疗前,且观察组疼痛评分低于对照组,日常生活能力评分高于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者腰屈曲范围、腰椎曲度高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。结论:应用中医综合疗法治疗颈肩腰腿痛可显著减轻患者的疼痛程度,促进腰部功能恢复,提高日常活动能力,疗效显著。

关键词：颈肩腰腿痛中医综合疗法针灸中药外敷

液相ELISA法测定人血浆抗英夫利西单抗抗体及在克罗恩病患者中应用

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中国医院药学杂志 2024年第15期44卷 1744-1749页

作者：朱扣柱丁肖梁王燕陈卫昌缪丽燕苏州大学附属第一医院药学部江苏苏州215006 江南大学附属儿童医院(无锡市儿童医院)药学部江苏无锡214023 苏州大学附属第一医院消化内科江苏苏州215006

目的:建立人血浆抗英夫利西单抗抗体(antibodies to infliximab, ATI)免疫分析方法并进行方法学验证。方法:用甘氨酸酸解英夫利西单抗(infliximab, IFX)与ATI结合形成的复合物,然后用生物素标记IFX和辣根过氧化物酶(HRP)标记IFX结合ATI... 详细信息

目的:建立人血浆抗英夫利西单抗抗体(antibodies to infliximab, ATI)免疫分析方法并进行方法学验证。方法:用甘氨酸酸解英夫利西单抗(infliximab, IFX)与ATI结合形成的复合物,然后用生物素标记IFX和辣根过氧化物酶(HRP)标记IFX结合ATI形成桥联复合物,再将溶液转移到链霉亲和素包被的孔板上进行检测。方法建立后采用51例未曾使用过IFX的克罗恩病患者血浆进行验证。结果:检测ATI的ELISA方法经验证筛选临界值为1.16,确证临界值为17.21%,滴度临界值为1.34,批内和批间精密度均小于20%,灵敏度达50 ng·mL^(-1),当阳性对照抗体质量浓度为100 ng·mL^(-1)时,药物耐受水平为12.5μg·mL^(-1)。结论:成功建立并验证了检测人血浆ATI的免疫分析方法,适合临床开展治疗药物检测。

关键词：英夫利西单抗抗英夫利西单抗抗体克罗恩病酶联免疫吸附分析法

经尿道钬激光剜除术与经尿道等离子电切术治疗良性前列腺增生的疗效分析

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系统医学 2024年第10期9卷 123-126页

作者：张伟昌安徽省霍邱县第二人民医院外一科安徽霍邱237400

目的探讨良性前列腺增生采取经尿道钬激光剜除术与经尿道等离子电切术治疗的差异。方法选取2020年1月—2023年9月安徽省霍邱县第二人民医院收治的82例良性前列腺增生患者为研究对象,随机数表法分为两组,每组41例。对照组采用经尿道等离... 详细信息

目的探讨良性前列腺增生采取经尿道钬激光剜除术与经尿道等离子电切术治疗的差异。方法选取2020年1月—2023年9月安徽省霍邱县第二人民医院收治的82例良性前列腺增生患者为研究对象,随机数表法分为两组,每组41例。对照组采用经尿道等离子电切术治疗,观察组采用经尿道钬激光剜除术治疗,对比两组手术指标、并发症与预后情况。结果观察组手术用时(92.73±8.94)min长于对照组,术中出血量(51.36±5.48)mL少于对照组,膀胱冲洗、导尿管留置与住院时间分别为(26.62±2.11)h、(3.66±1.02)d、(6.27±1.12)d,均短于对照组,差异有统计学意义(t=12.775、23.628、31.350、6.774、8.989,P均0.05)。结论良性前列腺增生患者采取经尿道钬激光剜除术与经尿道等离子电切术的疗效相当,但经尿道钬激光剜除术的出血量和术后不良反应较少,患者恢复更快。

关键词：良性前列腺增生经尿道钬激光剜除术经尿道等离子电切术并发症

VUV luminescence properties of Y_(0.95)Eu_(0.05)PO_4 phosphor derived by a modified solid-state route

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Rare Metals 2008年第4期27卷 354-357页

作者： ZHENG Cuihong zhu weichang WANG Lu School of Materials Science and Engineering and Anhui Key Laboratory of Metal Materials and Processing Anhui University of Technology Ma ＇anshan 243002 China

A modified solid-state route was attempted to prepare Y0.95 Eu0.05PO4 PDP phosphor, involving milling a powdered mixture of YCl3, EuCl3, and （NH4）2HPO4 and calcining the milling-derived precursor. The thermal decomposition behavior of the milling-derived precursor was investigated by thermogravimetric analysis （TGA）. Phase compositions, morphologies, and luminescence properties of the prepared phosphor powder were characterized by X-ray diffraction （XRD）, scanning electron microscope （SEM）, and vacuum ultraviolet （VUV） emission spectra, respectively. The results indicated that the Y0.95Eu0.05PO4 phosphor powder obtained at a calcination temperature of 900℃ was xenotime-structured. The phosphor powder particles were uniform and spherical-shaped with a primary particle size of-200 um. In comparison with that derived by the conventional solid-state route, the phosphor powder prepared by the modified solid-state route exhibited a higher color purity, presenting a predominant emission peak at 619 nm under 147 um VUV excitation.

关键词： phosphor luminescence properties vacuum ultraviolet solid-state reaction

Cobalt-free Composite Ba_(0.5)Sr_(0.5)Fe_(0.9)Ni_(0.1)O_(3-δ)-Ce_(0.8)Sm_(0.2)O_(2-δ) as Cathode for Intermediate-Temperature Solid Oxide Fuel Cell

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Journal of Materials Science & Technology 2012年第9期28卷 828-832页

作者： Xiangfeng Chu Feng Liu weichang zhu Yongping Dong Mingfu Ye Wenqi Sun School of Chemistry and Chemical Engineering Anhui University of TechnologyMaanshan 243002China School of Materials Science and Engineering Anhui University of TechnologyMaanshan 243002China

New cobalt-free composites consisting of Ba0.5Sr0.5Fe0.9Ni0.1O3-δ （BSFN） and Ce0.8Sm0.2O2-δ （SDC） were investigated as possible cathode materials for intermediate-temperature solid oxide fuel cell （IT-SOFC）. BSFN, which was synthesized by auto ignition process, was chemically compatible with SDC up to 1100 ℃ as indicated by X-ray diffraction analysis. The electrical conductivity of BSFN reached the maximum value of 57 ***-1 at 450 ℃. The thermal expansion coefficient （TEC） value of BSFN was 30.9×10-6 K-1, much higher than that of typical electrolytes. The electrochemical behavior of the composites was analyzed via electrochemical impedance spectroscopy with symmetrical cells BSFN-SDC/SDC/BSFN-SDC. The area specific interracial polarization resistance （ASR） decreased with increasing SDC content of the composite. The area specific interracial polarization resistance （ASR） at 700 ℃ is only 0.49, 0.34 and 0.31 Ω.cm2 when 30, 40, and 50 wt% SDC was cooperated to BSFN, respectively. These results suggest that BSFN-SDC is a possible candidate for IT-SOFC cathode.

关键词： Ba0.5Sr0.5Fe0.9Ni0.1O3- δ Cathode Intermediate-temperature solid oxide fuel cell (IT-SOFC) Solid oxide fuel cell

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麦芽酚碳酸酯的合成及其裂解行为分析

轻工学报 2024年第4期39卷 50-56页

作者：庞登红白冰祝浩罗诚浩柯炜昌张璟黄龙毛多斌湖北中烟工业有限责任公司技术中心湖北武汉430000 郑州轻工业大学烟草科学与工程学院河南郑州450001

为开发适用于加热卷烟的麦芽酚潜香化合物,将不同种类的醇与麦芽酚通过缩合反应合成7种麦芽酚碳酸酯。利用核磁共振和高分辨质谱技术对产物结构进行确认,并通过热重分析和在线热裂解-气相色谱-质谱联用分析技术考查7种麦芽酚碳酸酯的裂... 详细信息

为开发适用于加热卷烟的麦芽酚潜香化合物,将不同种类的醇与麦芽酚通过缩合反应合成7种麦芽酚碳酸酯。利用核磁共振和高分辨质谱技术对产物结构进行确认,并通过热重分析和在线热裂解-气相色谱-质谱联用分析技术考查7种麦芽酚碳酸酯的裂解行为。结果表明:在优化的合成条件下,7种麦芽酚碳酸酯产率范围为83.0%~94.3%;合成的麦芽酚碳酸酯的热失重过程主要存在直接挥发和裂解两种模式;麦芽酚碳酸酯在加热时均可裂解生成麦芽酚,其裂解能力与原料醇的类型密切相关,其中麦芽酚叔丁醇碳酸酯和麦芽酚苯甲醇碳酸酯最易发生裂解,在200℃的较低温度下便可迅速裂解并释放麦芽酚,与加热卷烟烟丝受热温度相适应,相比之下,麦芽酚仲醇碳酸酯的裂解能力较弱,而麦芽酚伯醇碳酸酯则难以在低温条件下发生裂解。

关键词：麦芽酚碳酸酯潜香化合物裂解加热卷烟

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丁香酸对不同品种烟草苗期根系生长的影响

土壤 2024年第1期56卷 35-41页

作者：俞海冰陆玉芳汤利施卫明高维常郭亚利朱迪云南农业大学资源与环境学院昆明650500 土壤与农业可持续发展重点实验室(中国科学院) 南京210008 贵州省烟草科学研究院烟草行业山地烤烟品质与生态重点实验室贵阳550081 贵州省烟草公司黔西南州公司贵州兴义562400

为探究最新发现的植物源生物硝化抑制剂丁香酸对烟草品种K326和云烟85苗期根系生长的影响,通过基质培养试验,设置0、10、25、50、100、200 μmol/L 6个丁香酸浓度,研究了不同浓度丁香酸在不同时间(3 d和5 d)对K326和云烟85主根伸长量和... 详细信息

为探究最新发现的植物源生物硝化抑制剂丁香酸对烟草品种K326和云烟85苗期根系生长的影响,通过基质培养试验,设置0、10、25、50、100、200 μmol/L 6个丁香酸浓度,研究了不同浓度丁香酸在不同时间(3 d和5 d)对K326和云烟85主根伸长量和一级侧根发育的影响。结果表明:与对照(0 μmol/L)相比,25~100 μmol/L丁香酸能促进K326主根伸长,在3 d时促进率为13.33%~30.67%,在5 d时促进率降为8.54%~22.55%,最适浓度为50 μmol/L;10~50 μmol/L丁香酸促进云烟85主根伸长,在3 d时促进率为7.81%~18.75%,在5 d时促进率维持在4.10%~10.66%,最佳促进浓度25 μmol/L;丁香酸对两个烟草品种主根伸长的促进效果均为3 d优于5 d。在侧根发育方面,低浓度丁香酸能显著促进K326和云烟85一级侧根数,两个品种促进侧根发育的最适浓度均为25 μmol/L。相关性分析表明,丁香酸处理下两个烟草品种苗期的主根伸长变化率与侧根数变化率呈显著正相关。可见,适宜浓度的丁香酸对两个典型烟草品种苗期主根增长和侧根发育均为促进效应。生物硝化抑制剂丁香酸具有促进烟草根系生长的潜力,为研发烤烟新型专用肥提供了理论依据。

关键词：生物硝化抑制剂丁香酸主根伸长量一级侧根数量 K326 云烟85

一类基于克莱姆法则的避免求导的加权插值迭代算法

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宁夏师范学院学报 2024年第4期45卷 16-25页

作者：郭巧杨兵王伟昌安徽职业技术学院计算机与信息技术学院安徽合肥230611 安徽职业技术学院智能制造学院安徽合肥230611 安徽工布制造科技有限公司安徽合肥231500

用n次插值多项式拟合需要求导的迭代算法,构造含有n+1个未知量的线性方程组,其中前n个未知量通过加权插值的形式,并用克莱姆法则由第n+1个未知量表示,从而避免求导.收敛性分析和数值实例进一步验证该迭代算法优于牛顿迭代,在运动机器人... 详细信息

用n次插值多项式拟合需要求导的迭代算法,构造含有n+1个未知量的线性方程组,其中前n个未知量通过加权插值的形式,并用克莱姆法则由第n+1个未知量表示,从而避免求导.收敛性分析和数值实例进一步验证该迭代算法优于牛顿迭代,在运动机器人路径轨迹优化和非线性分数阶滑模时滞控制领域具有重要意义.

关键词：克莱姆法则避免求导加权插值迭代