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Development and validation of a novel criterion of histologic healing in ulcerative colitis defined by inflammatory cell enumeration in lamina propria mucosa: A multicenter retrospective cohort in China

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中华医学杂志(英文版) 2024年第11期137卷 2024 May 13页

作者： Gao Han Peng Kangsheng Shi Yadi Zhu Shenshen Sun Ruicong Xu Chunjin Liu Ping Pang Zhi Zhu Lanxiang chen weichang Feng Baisui Wu Huili Zhou Guangxi Li Mingsong Li Junxiang Ding Baijing Liu Zhanju Department of Gastroenterology The Third Affiliated Hospital of Guangzhou Medical University Guangzhou Guangdong China Department of Gastroenterology Dongfang Hospital of Beijing University of Chinese Medicine Beijing China Center for IBD Research and Department of Gastroenterology Shanghai Tenth People’s Hospital Tongji University School of Medicine Shanghai China Clinical Medicine Sanquan College of Xinxiang Medical University Xinxiang Henan China Department of Gastroenterology The First People’s Hospital of Shangqiu City Affiliated to Xinxiang Medical University Shangqiu Henan China Department of Gastroenterology Wuhu First People’s Hospital Wuhu Anhui China Department of Gastroenterology Suzhou Municipal Hospital Affiliated to Nanjing Medical University Suzhou Jiangsu China Department of Gastroenterology The First Affiliated Hospital of Soochow University Suzhou Jiangsu China Department of Gastroenterology The Second Affiliated Hospital of Zhengzhou University Zhengzhou Henan China Department of Gastroenterology Zhengzhou Central Hospital Affiliated to Zhengzhou University Zhengzhou Henan China Department of Gastroenterology The Affiliated Hospital of Jining Medical College Jining Shandong China

Background: Histological healing is closely associated with improved long-term clinical outcomes and lowered relapses in patients with ulcerative colitis (UC). Here, we developed a novel diagnostic criterion for assessing histological healing in UC patients.Methods: We conducted a retrospective cohort study in UC patients, whose treatment was iteratively optimized to achieve mucosal healing at Shanghai Tenth People’s Hospital of Tongji University from January 2017 to May 2022. We identified an inflammatory cell enumeration index (ICEI) for assessing histological healing based on the proportions of eosinophils, CD177+ neutrophils, and CD40L+ T cells in the colonic lamina propria under high power field (HPF), and the outcomes (risks of symptomatic relapses) of achieving histological remissionvs. persistent histological inflammation using Kaplan-Meier curves. Intrareader reliability and inter-reader reliability were evaluated by each reader. The relationships to the changes in the Nancy index and the Geboes score were also assessed for responsiveness. The ICEI was further validated in a new cohort of UC patients from other nine university hospitals.Results: We developed an ICEI for clinical diagnosis of histological healing, i.e., Y = 1.701X1 + 0.758X2 + 1.347X3 - 7.745 (X1, X2, and X3 represent the proportions of CD177+ neutrophils, eosinophils, and CD40L+ T cells, respectively, in the colonic lamina propria under HPF). The receiver operating characteristics curve (ROC) analysis revealed that Y <-0.391 was the cutoff value for the diagnosis of histological healing and that an area under the curve (AUC) was 0.942 (95% confidence interval [CI]: 0.905-0.979) with a sensitivity of 92.5% and a specificity of 83.6% (P <0.001). The intraclass correlation coefficient (ICC) for the intrareader reliability was 0.855 (95% CI: 0.781-0.909), and ICEI had good inter-reader reliability of 0.832 (95% CI: 0.748-0.894). During an 18-month follow-up, patients with histological healing had a substantially better outcome compared with

关键词： Ulcerative colitis Histological healing Inflammatory cell enumeration index Prognosis

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Sirt3 is critical for p53-mediated ferroptosis upon ROS-induced stress

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Journal of Molecular Cell Biology 2021年第2期13卷 151-154页

作者： Ying Jin Wei Gu weichang chen Department of Gastroenterology The First Affiliated Hospital of Soochow UniversitySuzhou 215006China Institute for Cancer Genetics and Department of Pathology and Cell Biologyand Herbert Irving Comprehensive Cancer CenterCollege of Physicians&SurgeonsColumbia UniversityNew YorkNY 10032USA Department of Gastroenterology Suzhou Ninth People’s HospitalSuzhou 215200China

Dear Editor,p53 acts as a transcription factor to modulate various types of cellular processes to suppress tumor development(Tackmann and Zhang,2017).The exquisite regulation of p53 functions is of vital importance for cell fate decisions.Although it is well accepted that p53-mediated cell-cycle arrest,senescence,and apoptosis serve as major tumor suppression mechanisms,recent studies suggest that other unconventional activities such as ferroptosis are also critically involved in its tumor suppressor function(Li et al.,2012).We and others found that p53 plays an important role in modulating ferroptotic responses through its metabolic targets(Jiang et al.,2015;Jennis et al.,2016;Wang et al.,2016).Ferroptosis is a regulated form of iron-dependent,non-apoptotic cell death characterized by excessive reactive oxygen species(ROS)generation and accumulation of lipid peroxidates(Stockwell et al.,2020).Lipid peroxides are normally eliminated by glutathione peroxidase 4(GPX4)and its co-factor glutathione(GSH),which convert lipid hydroperoxides to non-toxic lipid alcohols.Thus,ferroptosis can be artificially induced by pharmacological agents that disrupt this lipid repair system,allowing lethal accumulation of lipid peroxides.Such agents include direct GPX4 enzymatic inhibitors,as well as the small molecule erastin,which suppress glutathione synthesis and indirectly suppress GPX4 activation(Stockwell et al.,2020).Although activation of p53 expression is able to modulate ferroptosis induced by GPX4 inhibition in certain cell types(Jiang et al.,2015),p53-mediated ferroptotic responses are also observed upon ROS-induced stress,apparently through a GPX4-independent manner(Chu et al.,2019).Nevertheless,the molecular factors that modulate p53-dependent ferroptosis upon ROS stress need further elucidation.Sirt3 is a NAD-dependent deacetylase predominantly localized in mitochondria,which functions in multiple metabolic pathways,including electron transport chain,fatty acid oxidation,amino acid metabolism,redox balance,and the trica

关键词： metabolism Lipid stress

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家居摆设的皮革材料工艺技法与中国风的审美关系探讨

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皮革科学与工程 2024年第2期34卷 99-105页

作者：陈伟长柳周青泉州师范学院美术与设计学院福建泉州362000

旨在探讨皮革家居摆设的工艺技法与中国风题材的审美关系。运用文献研究和实地调查,首先介绍了中国风的概念与演变,并分析了其在家居摆设中的运用。对皮革材料的审美进行深入研究中,包括其应用历史和审美价值,结合家居摆设中皮革的应用... 详细信息

旨在探讨皮革家居摆设的工艺技法与中国风题材的审美关系。运用文献研究和实地调查,首先介绍了中国风的概念与演变,并分析了其在家居摆设中的运用。对皮革材料的审美进行深入研究中,包括其应用历史和审美价值,结合家居摆设中皮革的应用和质料特点。通过皮革材料的工艺技法与现代皮革家居摆设的分析,展望了中国风格皮革材料的发展前景。研究表明,皮革材料在家居摆设中的材质和技法特点能够为家居环境增添温暖和高雅的氛围,在中国风题材具有独特的审美叠加态下,能够体现中国传统文化的魅力。然而,皮革材料在现代生活中的应用也存在一些局限,未来的研究应该致力于解决这些问题,提高皮革功能与生活的应用性。

关键词：中国风家居摆设皮革材料工艺技法

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Mapping of de novo mutations in primary biliary cholangitis to a disease-specific co-expression network underlying homeostasis and metabolism

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Journal of Genetics and Genomics 2022年第2期49卷 145-154页

作者： Lu Wang Jinchen Li Chan Wang Ruqi Tang Jialong Liang Yuhua Gong Yaping Dai Ningling Ding Jian Wu Na Dai Lei Liu Yi Zhao Youlin Shao Weifeng Zhao Peng Jiang Xingjuan Shi weichang chen Ye Tian Xiangdong Liu Xiong Ma Zhongsheng Sun Key Laboratory of Developmental Genes and Human Diseases Institute of Life SciencesSoutheast University2 Sipailou RoadNanjingJiangsu 210096China Beijing Institutes of Life Science Chinese Academy of SciencesNo.1 West Beichen RoadChaoyang DistrictBeijing 100101China Department of Gastroenterology and Hepatology Shanghai Institute of Digestive DiseasesShanghai Jiao Tong University School of Medicine Afﬁliated Renji Hospital145 Shandong Middle RoadShanghai 200001China Department of Laboratory Medicine The Third People’s Hospital of Zhenjiang300 DaijiamenZhenjiangJiangsu 212021China Department of Laboratory Medicine The Fifth People’s Hospital of Wuxi1215 Guangrui RoadWuxiJiangsu 214000China Department of Hepatology The Fifth People’s Hospital of SuzhouSoochow University10 Guangqian RoadSuzhouJiangsu 215131China Department of Rheumatology First Afﬁliated Hospital of Soochow University188 Shizi RoadSuzhouJiangsu 215006China Department of Gastroenterology Jiangsu University Afﬁliated Kunshan Hospital91 Qianjin West RoadKunshanJiangsu 215300China Department of Gastroenterology Yixing People’s Hospital75 Tongzhenguan RoadYixinJiangsu 214200China Department of Gastrointestinal Endoscopy Eastern Hepatobiliary Surgery Hospital700 Moyu North RoadShanghai 201800China Department of Hepatology The Third People’s Hospital of Changzhou300 Lanling North RoadChangzhouJiangsu 213001China Department of Infectious Diseases First Afﬁliated Hospital of Soochow University188 Shizi RoadSuzhouJiangsu 215006China Department of Gastroenterology First Afﬁliated Hospital of Soochow University188 Shizi RoadSuzhouJiangsu 215006China Department of Radiology Second Afﬁliated Hospital of Soochow University1055 Sanxiang RoadSuzhouJiangsu 215004China Institute of Genomic Medicine Wenzhou Medical UniversityUniversity TownChashanWenzhouZhejiang 325035China

Primary biliary cholangitis(PBC) is an autoimmune disease involving dysregulation of a broad array of homeostatic and metabolic processes. Although considerable single-nucleotide polymorphisms have been unveiled, a large fraction of risk factors remains enigmatic. Candidate genes with rare mutations that tend to confer more deleterious effects need to be identified. To help pinpoint cellular and developmental mechanisms beyond common noncoding variants, we integrate whole exome sequencing with integrative network analysis to investigate genes harboring de novo mutations. Prominent convergence has been revealed on a network of disease-specific co-expression comprised of 55 genes associated with homeostasis and metabolism. The transcription factor gene MEF2 D and the DNA repair gene PARP2 are highlighted as hub genes and identified to be up-and down-regulated, respectively, in peripheral blood data set. Enrichment analysis demonstrates that altered expression of MEF2 D and PARP2 may trigger a series of molecular and cellular processes with pivotal roles in PBC pathophysiology. Our study identifies genes with de novo mutations in PBC and suggests that a subset of genes in homeostasis and metabolism tend to act in synergy through converging on co-expression network, providing novel insights into the etiology of PBC and expanding the pool of molecular candidates for discovering clinically actionable biomarkers.

关键词： Primary biliary cholangitis de novo mutations Whole exome sequencing Transcriptional networks Co-expression

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B7-H3在结直肠癌中的表达特征分析和临床意义

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细胞与分子免疫学杂志 2024年第5期40卷 435-442页

作者：邵宇阳石通国郭凌川陈卫昌苏州大学附属第一医院消化内科江苏苏州215006 苏州大学附属第一医院江苏省临床免疫研究所江苏苏州215006 苏州大学附属第一医院江苏省胃肠道肿瘤免疫重点实验室江苏苏州215006 苏州大学附属第一医院病理科江苏苏州215006

目的探讨B7同源物3(B7-H3)在结直肠癌(CRC)组织中的表达特征及临床意义,探究其与肿瘤糖酵解过程以及与肿瘤微环境中免疫细胞浸润的相关性。方法从肿瘤基因组图谱数据库(TCGA)下载CRC转录组数据和临床病理数据,分析B7-H3的表达情况和临... 详细信息

目的探讨B7同源物3(B7-H3)在结直肠癌(CRC)组织中的表达特征及临床意义,探究其与肿瘤糖酵解过程以及与肿瘤微环境中免疫细胞浸润的相关性。方法从肿瘤基因组图谱数据库(TCGA)下载CRC转录组数据和临床病理数据,分析B7-H3的表达情况和临床意义。基于TCGA数据分析CRC内糖酵解相关基因表达与B7-H3表达的相关性。使用通过估计RNA转录物相对子集的细胞类型鉴定(CIBERSORT)算法探究B7-H3表达与22种免疫细胞浸润的关系。收集51例CRC患者的手术标本及癌旁正常组织标本,应用免疫组织化学染色方法对数据库分析结果进行验证。结果B7-H3在CRC组织中的表达上调,且与肿瘤浸润深度、TNM分期晚期和不良预后密切相关。此外,B7-H3表达与CRC内糖酵解相关基因上调密切相关。免疫细胞浸润分析显示共有16种免疫细胞的浸润水平与B7-H3表达密切相关,进一步发现B7-H3表达与CD8+T细胞浸润在转录水平上呈负相关,但两者在蛋白水平上不相关。结论B7-H3在CRC组织中高表达,与CRC疾病进展和患者的不良预后密切相关。此外,B7-H3与糖酵解相关基因以及免疫细胞浸润之间的相关性,提示B7-H3在调控肿瘤糖酵解和肿瘤免疫中起到关键作用。

关键词：结直肠癌 B7同源物3(B7-H3) 免疫浸润生物信息学免疫组织化学

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过氧化物酶体增殖物活化受体γ(PPAR γ)与肝癌瘤内微循环的关系(英文)

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The Chinese-German Journal of Clinical Oncology 2008年第5期7卷 266-271页

作者： Xudong Wu weichang chen Suqing Zhang Department of Gastroenterology The First People Hospital of Yancheng Yancheng 224006 China Department of Gastroenterology The First Affiliated Hospital Soochow University Suzhou 215006 China Department of Surgery Tumor Hospital of Nantong Nantong 226361 China

观察 peroxisome 的表示的协会的目的有微容器密度(MVD ) 和在肝细胞癌(HCC ) 的血管形成模仿(VM ) 的激活 proliferator 的受体 γ(PPARγ) 并且探索他们的临床的意义。PPARγ 和 MVD 和 VM 的表情被 CD34 免疫测试的方法组织化学(IHC... 详细信息

观察 peroxisome 的表示的协会的目的有微容器密度(MVD ) 和在肝细胞癌(HCC ) 的血管形成模仿(VM ) 的激活 proliferator 的受体 γ(PPARγ) 并且探索他们的临床的意义。PPARγ 和 MVD 和 VM 的表情被 CD34 免疫测试的方法组织化学(IHC ) 染色并且在 HCC 纸巾和它的配对的非癌的纸巾的 34 种情况中的周期的 acid-Schiff (舞步) 反应。他们的生物行为被分析并且与 clinicopathological 特征联系了。结果 PPARγ 是过去表示的(24/34 ) 在 HCC 纸巾。它与肿瘤尺寸被联系(> 5 厘米， P = 0.027 ) ，破囊(P = 0.014 ) ，趋势到转移和复发(P = 0.001 ) 。MVD 更高(23/24 ) 在 HCC 纸巾比那在相应帕拉癌的纸巾(t = 18.925， P < 0.05 ) 。在 PPARγ 和高 MVD 的在表示上之间有重要积极关联(r = 0.519 ) 。Kaplan-Meier 分析显示 PPARγ 和 VM 和高 MVD 的那积极表情能被用于建立 HCC 病人的幸存率(P = 0.013， 0.036 和 0.022 分别地；木头等级测试) 。考克斯危险模型分析显示出那积极 PPARγ 表情，高 MVD 是为 HCC 的独立预示的因素。PPARγ 与发展相关的结论微在 HCC 循环。PPARγ 是为 HCC 评估的新奇预示的指示物。

关键词：血管生成病理分析肝脏新生物疾病预防

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Differential regulation of JAK1 expression by ETS1 associated with predisposition to primary biliary cholangitis

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Journal of Genetics and Genomics 2023年第10期50卷 807-812页

作者： Peng Jiang Chan Wang Mingming Zhang Ye Tian Weifeng Zhao Junyi Xin Yexi Huang Zhibin Zhao Wenjuan Sun Jie Long Ruqi Tang Fang Qiu Xingjuan Shi Yi Zhao Li Zhu Na Dai Lei Liu Xudong Wu Jinshan Nie Bo Jiang Youlin Shao Yueqiu Gao Jianjiang Yu Zhigang Hu Zhidong Zang Yuhua Gong Yaping Dai Lan Wang Ningling Ding Ping Xu Sufang chen Lu Wang Jing Xu Luyao Zhang Junyan Hong Ruonan Qian Hu Li Xuan Jiang Congwei chen Wenyan Tian Jian Wu Yuzhang Jiang Chongxu Han Kui Zhang Hong Qiu Li Li Hong Fan Liming chen Jianqiong Zhang Zhongsheng Sun Xiao Han Zhenhua Dai Erguang Li M.Eric Gershwin Zhexiong Lian Xiong Ma Michael F.Seldin weichang chen Meilin Wang Xiangdong Liu Key Laboratory of Developmental Genes and Human Diseases School of Life Science and TechnologySoutheast UniversityNanjingJiangsu 210096China Institute of Translational Medicine Yangzhou University Medical CollegeYangzhouJiangsu 225009China Department of Radiology&Oncology The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215004China The First Affiliated Hospital of Soochow University SuzhouJiangsu 215006China Department of Bioinformatics School of Biomedical Engineering and InformaticsNanjing Medical UniversityNanjingJiangsu 210029China Author links open overlay panelYexi Huang Guangdong Provincial People's Hospital Guangdong Academy of Medical SciencesGuangzhouGuangdong 510080China Department of Gastroenterology and Hepatology Shanghai Institute of Digestive DiseasesShanghai Jiao Tong University School of Medicine Affiliated Renji HospitalShanghai 200001China Department of Laboratory Medicine The Fourth Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210031China Department of Gastrointestinal Endoscopy Eastern Hepatobiliary Surgery HospitalShanghai 201800China The Fifth People's Hospital Soochow UniversitySuzhouJiangsu 215007China Department of Gastroenterology Jiangsu University Affiliated Kunshan HospitalKunshanJiangsu 215300China Department of Gastroenterology Yixing People's HospitalYixinJiangsu 214200China Department of Gastroenterology Yancheng First People's HospitalYanchengJiangsu 224005China Department of Gastroenterology Taicang First People's HospitalSoochow UniversityTaicangJiangsu 215400China Department of Hepatology Jingjiang Second People's HospitalJingjiangJiangsu 214500China Department of Hepatology The Third People's Hospital of ChangzhouChangzhouJiangsu 213001China Department of Liver Diseases Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 201203China Department of Laboratory Medicine Jiangyin People's HospitalSoutheast UniversityJiangyinJiangsu 214400China Department of Labora

Primary biliary cholangitis(PBC)is an autoimmune liver disease characterized by the destruction of intrahepatic small bile ducts and progressive cholestasis,eventually leading to liver cirrhosis and hepatic failure wi... 详细信息

关键词： cholangitis biliary

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Structural Variability and Rifting Process of the Segmented Cenozoic Pearl River Mouth Basin,Northern Continental Margin of the South China Sea

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Acta Geologica Sinica(English Edition) 2022年第6期96卷 2074-2092页

作者： MA Bingshan QI Jiafu WU Guanghui REN Jianye YANG Linlong SUN Tong chen Shi chen weichang GE Jiawang School of Geoscience and Technology Southwest Petroleum UniversityChengdu 610500China College of Geosciences China University of Petroleum(Beijing)Beijing 102249China College of Marine Science and Technology China University of GeosciencesWuhan 430074China Working Station for Postdoctoral Scientific Research Shengli OilfieldDongyingShandong 257001China Research Institute of Petroleum Exploration Dagang Oilfield CompanyTianjin 300450China College of Geography Jining Normal UniversityUlanqabInner Mongolia 012000China

The Pearl River Mouth Basin(PRMB)is an important area for studying the evolution of continental marginal basins in the northern South China Sea(SCS),but the structural variability and spatiotemporal rifting process remains poorly understood.This study investigates the differential structural features of the eastern,middle and western PRMB,as well as the extensional deformation laws in operation during the rifting stage,according to an integrated analysis of geometric characteristics and kinematic parameters,i.e.,horizontal displacement and stretching factors of basin and crust.The PRMB underwent at least three phases of intense extension,which varied in time and space.(1)During the middle Eocene,most sags in the PRMB were intensely stretched and high-angle planar to listric boundary faults controlled the wedge-shaped stratigraphic geometry.(2)During the late Eocene-to-early Oligocene,the stratigraphic geometry of the sags was slightly wedge-shaped and continuously controlled by boundary faults,however,the extensional strength decreased relatively in the Northern depression zone,but increased in the Southern depression zone.(3)During the late Oligocene,the extension was extremely weak in the northeast PRMB,but relatively strong in the southwest PRMB,leading to tabular stratigraphic geometry in the northeast PRMB,but localized slightly wedge-shaped stratigraphic geometry in the southwest.The southwest PRMB still underwent relatively strong extension during the early Miocene.The southwest PRMB that was induced by a small-scale localized mantle convection system constantly rifted during the late Oligocene,controlled by the weak lithosphere,westward(southwestward)diachronous opening and southward jump of the ocean ridge.The applied quantitative parameters and spatiotemporal rifting process may be used as a reference with which to study the segmented continental margin rifts.

关键词： basin structure extensional feature rifting process Pearl River Mouth Basin northern South China Sea

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Electrode structure enabling dendrite inhibition for high cycle stability quasi-solid-state lithium metal batteries

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Journal of Energy Chemistry 2023年第4期79卷 232-241页

作者： Kaiming Wang Ao Yu Zhiyi Zhou Fei Shen Manni Li Liang Zhang weichang Guo Yifei chen Le Shi Xiaogang Han State Key Laboratory of Electrical Insulation and Power Equipment School of Electrical EngineeringXi’an Jiaotong UniversityXi’an 710049ShaanxiChina School of Future Technology Xi’an Jiaotong UniversityXi’an 710049ShaanxiChina National Innovation Platform(Center)for Industry-Education Integration of Energy Storage Technology Xi’an 710049ShaanxiChina

Lithium(Li)metal batteries(LMBs)are widely regarded as the ultimate choice for the next generation of high-energy–density batteries.However,the uncontrollable growth of Li dendrites formed by inhomogeneous deposition seriously hinders its commercialization.Although many studies have achieved significant results in inhibiting the formation of Li dendrites,it is still impossible to eradicate them completely.Therefore,regulating the deposition behavior,such as the growth direction of unevenly deposited Li,is preferable to unilaterally suppressing them in some cases.Here we report a structured anode that can confine the deposited Li within holes and tune it to become vertical-up/horizontal-centripetal mixed growth mode by optimizing the electric field/Li^(+)concentration gradient.The Li^(+) adsorbed by the poly(amic acid)(PAA)insulating layer coated on the anode surface can form the Li^(+)concentration gradient pointing to the center of the hole.Combined with the special electric field formed by the hole structure,it is favorable for the Li^(+)to move into the vertically arrayed holes and simultaneously deposit on the bottom and walls.Furthermore,both in-situ and ex-situ observations confirm that the growth mode is changed and the Li deposition morphology is denser,which can greatly delay capacity fading and prolong cycle life in both liquid and quasi-solid-state LMBs.All the results show that the novel anode provides a new perspective for deep research into solid-state LMBs.

关键词： Lithium metal batteries Structured anode Deposition behavior Quasi-solid-state

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计及可再生能源不确定性的储能系统优化配置方法研究

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电气自动化 2024年第3期46卷 8-11,17页

作者：刘军福张怀鹏马耀东周伟昌魏鹏陈雨国网宁夏电力有限公司中卫供电公司宁夏中卫755000

为减少配电网的功率损耗,提升系统的可靠性和灵活性,提出了计及可再生能源不确定性的的储能系统多目标优化配置方法。首先,通过概率密度函数对光伏、风电等可再生能源的不确定性进行了分析,并基于可再生能源的不确定性构建储能系统优化... 详细信息

为减少配电网的功率损耗,提升系统的可靠性和灵活性,提出了计及可再生能源不确定性的的储能系统多目标优化配置方法。首先,通过概率密度函数对光伏、风电等可再生能源的不确定性进行了分析,并基于可再生能源的不确定性构建储能系统优化配置模型;其次,提出改进海鸥优化算法求解优化配置模型,通过引入Logistic映射模型、非线性移动系数和局部收敛挖掘算子以克服传统算法中早熟收敛和局部最优问题;最后,在IEEE 14节点系统中进行案例分析。案例分析结果验证了所提模型的可行性和所提算法的有效性,配电网运行的可靠性和灵活性得到了有效的提高。

关键词：配电网可再生能源储能系统改进海鸥优化算法优化配置

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