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Genes & Diseases 2024年第1期11卷 11-14页

作者： Xinghui Li Haiping Wang Yandi Wu Li Zou Shijie Dengg Xintu Fu Tongsheng Huang Conghui Shen Teng Wu weibin cai Guangdong Engineering&Technology Research Center for Disease-Model Animals Laboratory Animal CenterZhongshan School of MedicineSun Yat-sen UniversityGuangzhouGuangdong 510080China Department of Biochemistry Zhongshan School of MedicineSun Yat-sen UniversityGuangzhouGuangdong 510080China School of Pharmacy Guangdong Pharmaceutical UniversityGuangzhouGuangdong 510006China Guangdong Provincial Key Laboratory of Digestive Cancer Research The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhenGuangdong 518107China

There are no approvedtherapeuticdrugs for nonalcoholic steatohepatitis(NASH)due to the many bottlenecks,including the lack of preclinical animal models that can perfectly mimic human NASH features,such as systemic metabolic disorders,hepatic steatosis,intense liver inflammation and fibrosis,liver tumorigenesis,and cardiovascularcomplications.i,2"Pigment"epitheliumderived factor(PEDF)is a lipid metabolism regulator with high expression in the liver,and its reduced expression in the liver is closely related to the development of nonalcoholic fatty liver disease(NAFLD).

关键词： inflammation PEDF hepatic

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岭南头皮针治疗卒中后认知障碍理论探析

新中医 2024年第9期56卷 191-195页

作者：蔡科妍苏利梅蔡科达蔡伟彬郑晓彤王小寅秦敏广州中医药大学第五临床医学院广东广州510095 广东省第二中医院广东广州510095 南方医科大学南方医院白云分院广东广州510440

卒中后认知障碍(PSCI)是卒中后常见的并发症,严重影响患者的日常生活及预后效果。岭南头皮针是常见的岭南飞针疗法之一,临床上治疗PSCI具有一定的疗效及优势。笔者从中医对PSCI的认识出发,结合现代医学研究探讨岭南头皮针治疗PSCI的作... 详细信息

卒中后认知障碍(PSCI)是卒中后常见的并发症,严重影响患者的日常生活及预后效果。岭南头皮针是常见的岭南飞针疗法之一,临床上治疗PSCI具有一定的疗效及优势。笔者从中医对PSCI的认识出发,结合现代医学研究探讨岭南头皮针治疗PSCI的作用机制,以期为岭南头皮针治疗PSCI提供更多参考。

关键词：卒中后认知障碍岭南头皮针作用机制

Solvent Recovery from Soybean Oil/Hexane Miscella by PDMS Composite Membrane

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Chinese Journal of Chemical Engineering 2011年第4期19卷 575-580页

作者： cai weibin SUN Yanzhi PIAO Xianglan LI Jiding ZHU Shenlin State Key Laboratory of Chemical Engineering Department of Chemical Engineering Tsinghua University Beijing 100084 China

Traditional solvent recovery in the extraction step of edible oil processing is distillation,which consumes large amounts of *** the distillation is replaced by membrane process,the energy consumption can be reduced *** this work,two kinds of membrane,PDMS(polydimethylsiloxane) composite membrane and Zeolite filled PDMS membrane were prepared,in which asymmetric microporous PVDF(polyvinylidenefluoride) membrane prepared with phase inversion method was functioned as the microporous supporting layer in the flat-plate composite *** different function compositions of the PDMS/PVDF composite membranes were characterized by reflection Fourier transform infrared(FTIR) *** surface and section of PDMS/PVDF composite membranes were investigated by scanning electron microscope(SEM).The PDMS NF(nanofiltration) membranes were then applied in the recovery of hexane from soybean oil/hexane miscellas(1:3,mass ratio).The effects of pressure(0.5-1.5 MPa),cross-linking temperature and PDMS layer thickness on membrane performances were *** results indicated that both two kinds of NF membranes were promising for solvent recovery,and zeolite filled in PDMS NF membrane could enhance the separation performance.

关键词：硅橡胶复合膜溶剂回收正己烷大豆油傅里叶变换红外光谱 PDMS膜聚二甲基硅氧烷扫描电子显微镜

IL-25 stimulates M2 macrophage polarization and thereby promotes mitochondrial respiratory capacity and lipolysis in adipose tissues against obesity

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Cellular & Molecular Immunology 2018年第5期15卷 493-505页

作者： Juan Feng Lingyi Li Zhiying Ou Qiao Li Baoyong Gong Zhenxian Zhao Weiwei Qi Ti Zhou Jun Zhong weibin cai Xia Yang Aiping Zhao Guoquan Gao Zhonghan Yang Program of Molecular Medicine Affiliated Guangzhou Women and Children’s HospitalZhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China Institute of Pediatrics Affiliated Guangzhou Women and Children's Medical CenterSun Yat-sen UniversityGuangzhou 510623China Guangdong Provincial Key Laboratory of Laboratory Animals Guangdong Laboratory Animals Monitoring InstituteGuangzhou 510063China PancreatoBiliary Surgery First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Guangdong Engineering and Technology Research Center for Disease-Model Animals SUN Yat-sen UniversityGuangzhou 510006China Department of Radiation Oncology Department of MedicineUniversity of Maryland School of MedicineBaltimoreMD 21201USA

Obesity and associated metabolic diseases are characterized by a chronic low-grade inflammatory state with the infiltration of many inflammatory cells,especially *** molecules,including some cytokines,have a close relationship with ***(IL)-25 is a member of the IL-17 cytokine family that can regulate macrophages and alleviate some metabolic dysfunction;however,its role and mechanisms in lipid metabolism remain to be extensively *** serum and liver biopsy specimens,high-fat diet-induced obesity mice and DB/DB(Lepr−/−)animal models were used to examine IL-25 expression in obesity and nonalcoholic fatty liver diseases(NAFLD).To observe the role of IL-25 in lipid metabolism,model mice were administered with IL-25 or adoptively transferred with IL-25-educated macrophages in vivo,whereas bone marrow-derived macrophages,the macrophage cell line RAW264.7 and adipocytes differentiated from 3T3-L1 were used in ***-25 was decreased in NAFLD patients and obese *** addition,IL-25 reduced body weight gain and lipid accumulation,enhanced lipid uptake by macrophages and increased the expression of lipolysis andβ-oxidation enzymes via alternatively activating ***-25 also promoted lipolysis and suppressed lipogenesis in adipocytes co-cultured with the IL-25-educated ***,IL-25 improved the mitochondrial respiratory capacity and oxygen consumption rate of macrophages and produced more NAD+/NADH and *** conclusion,IL-25 can stimulate M2 macrophage polarization and thereby promote lipolysis and mitochondrial respiratory capacity,highlighting the potential for IL-25 to be used as a therapeutic agent against obesity and associated metabolic syndromes.

关键词： adipocyte immunometabolism IL-25 macrophage obesity

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证券市场混合交易模式制度研究

证券市场导报 2005年第7期 74-77页

作者：蔡伟彬深圳证券交易所广东深圳518010

做市商交易制度、竞价交易制度以及混合交易模式三者如何选择和取舍是国内证券市场一个长期争论的话题。本文尝试以德国证券交易所积极管理型上市基金指定保荐人制度为例,从积极管理型上市基金目前的发展现状为出发点,对混合交易模式进... 详细信息

做市商交易制度、竞价交易制度以及混合交易模式三者如何选择和取舍是国内证券市场一个长期争论的话题。本文尝试以德国证券交易所积极管理型上市基金指定保荐人制度为例,从积极管理型上市基金目前的发展现状为出发点,对混合交易模式进行分析。

关键词：交易制度混合模式做市商制度

高校实验动物中心动物质量控制研究与创新实践

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中国比较医学杂志 2022年第12期32卷 77-81页

作者：张志妮杨力衡严楚蔡卫斌中山大学实验动物中心广州510006 广州市白云区畜牧兽医站广州510550

目的实验动物质量直接关系着研究和评价数据的准确性和可重复性,亦是公共卫生安全的主要部分。方法针对高校动物中心来源复杂、人员流动性大、需求多样等特点,从管理体系建立和病原检测角度提升实验动物质量。结果建立并执行了实验动物... 详细信息

目的实验动物质量直接关系着研究和评价数据的准确性和可重复性,亦是公共卫生安全的主要部分。方法针对高校动物中心来源复杂、人员流动性大、需求多样等特点,从管理体系建立和病原检测角度提升实验动物质量。结果建立并执行了实验动物准入制度、哨兵动物监测制度、动物用品监测制度等系列管理体系,自2018年以来,检测了1481批次非活体动物样本,106批次病原阳性,检测了395例活体动物样本,38例病原阳性,检测了363份动物相关用品。结论禁止了数批烈性传染病病原阳性动物的进入、严密监视了条件致病菌阳性动物的来源单位、及时调整和更新了大小鼠监测病原谱,从而提升了实验动物质量。

关键词：实验动物质量控制病原高校

Studies on the anti-angiogenic activity of PEDF34 and its molecular mechanism

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Studies on the anti-angiogenic activity of PEDF34 and its mo...

Distinct cardiac energy metabolism and oxidative stress adaptations between obese and non-obese type 2 diabetes mellitus

中国生物化学与分子生物学会第十届会员代表大会暨全国学术...

作者： Qing Gong Xia Yang Zhonghan Yang weibin cai Guoquan Gao Department of Biochemistry Zhongshan Medical School of Sun Yat-Sen University

Objective The aim of this study is to observe the effect of PEDF34(a functional peptide of PEDF) on angiogenesis and tumor growth in xenografted prostate carcinoma athymic mouse model and to explore the effect and the potent mechanism of PEDF34 on endothelial cells. Materials and Methods Human PEDF34 cDNA was obtained by PCR and and the PEDF34-GST fusion protein was produced using pGEX-4T-l/ BL21(DE3) prokaryotic expression *** fusion protein was purified by passing through the GST-Binding column and identified by SDS-PAGE electrophoresis and Western ***

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Distinct cardiac energy metabolism and oxidative stress adap...

不同交联剂对PDMS／PVDF纳滤膜溶剂回收性能的影响

第十六届中国实验动物科学年会

作者： Xinghui Li Yandi Wu Jingjing Zhao Haiping Wang Jing Tan Ming Yang Yuanlong Li Shijie Deng Saifei Gao Hui Li Zhenyu Yang Fengmin Yang Jianxing Ma Jianding Cheng weibin cai Guangdong Engineering & Technology Research Center for Disease-Model Animals Laboratory Animal CenterZhongshan School of MedicineSun Yat-sen University Department of Biochemistry Zhongshan School of MedicineSun Yat-sen University NHC Key Laboratory on Assisted Circulation Department of Cardiologythe First Affiliated HospitalSun Yat-Sen University Department of Physiology Health Sciences CenterUniversity of Oklahoma Department of Forensic Pathology Zhongshan School of MedicineSun Yat-sen University

Background Little is known about the pathophysiological diversity of myocardial injury in type 2 diabetes mellitus(T2DM),but analyzing these differences is important for the accurate diagnosis and precise treatment of diabetic *** study aimed to elucidate the key cardiac pathophysiological differences in myocardial injury between obese and non-obese T2DM from mice to *** Obese and non-obese T2DM mouse models were successfully constructed and observed until systolic dysfunction *** in cardiac structure,function,energy metabolism and oxidative stress were assessed by biochemical and pathological tests,echocardiography,free fatty acids(FFAs) uptake fluorescence imaging,transmission electron microscopy,*** molecule changes were screened and verified by RNA sequencing,quantitative real-time polymerase chain reaction and western ***,28 human heart samples of healthy population and T2DM patients were collected to observe the cardiac remodeling,energy metabolism and oxidative stress adaptations as measured by pathological and immunohistochemistry *** Obese T2DM mice exhibited more severe cardiac structure remodeling and earlier systolic dysfunction than non-obese ***,obese T2DM mice exhibited severe and persistent myocardial lipotoxicity,mainly manifested by increased FFAs uptake,accumulation of lipid droplets and glycogen,accompanied by continuous activation of the peroxisome proliferator activated receptor alpha(PPARα) pathway and phosphorylated glycogen synthase kinase 3 beta(p-GSK-3β),and sustained inhibition of glucose transport protein 4(GLUT4) and adipose triglyceride lipase(ATGL),whereas non-obese mice showed no myocardial lipotoxicity characteristics at systolic dysfunction stage,accompanied by the restored PPARa pathway and GLUT4,sustained inhibition of p-GSK-3β and activation of ***,both obese and non-obese T2DM mice showed significant accumulation of reactive oxygen specie

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化工学报 2013年第2期64卷 581-589页

作者：蔡卫滨朴香兰李继定朱慎林清华大学化学工程系化学工程联合国家重点实验室北京100084

以聚二甲基硅氧烷(PDMS)为分离层材料,聚偏氟乙烯(PVDF)超滤膜为底膜,采用正硅酸乙酯(TEOS)、苯基三甲氧基硅烷(PTMOS)、辛基三甲氧基硅烷(OTMOS)、γ-氨基丙基三乙氧基硅烷(AP-TEOS)4种不同的交联剂对PDMS进行交联,制备了PDMS/PVDF纳... 详细信息

以聚二甲基硅氧烷(PDMS)为分离层材料,聚偏氟乙烯(PVDF)超滤膜为底膜,采用正硅酸乙酯(TEOS)、苯基三甲氧基硅烷(PTMOS)、辛基三甲氧基硅烷(OTMOS)、γ-氨基丙基三乙氧基硅烷(AP-TEOS)4种不同的交联剂对PDMS进行交联,制备了PDMS/PVDF纳滤膜。采用接触角、红外谱图、扫描电镜等对膜的物理和化学结构进行了分析和表征。以大豆油/己烷混合油为实验体系,考察了压力和料液浓度对纳滤膜分离性能的影响。结果表明,纳滤膜的通量随压力线性增长,截留率初始随压力上升较快,随后增幅减慢而趋于稳定。随料液浓度的增加,纳滤膜的通量和截留率都有较大幅度的下降。相比较而言,以TEOS为交联剂所制得的纳滤膜分离性能最佳。大豆油/己烷混合油体系同水溶液体系的渗透特性类似,其渗透压可用van’tHoff方程计算。

关键词：聚二甲基硅氧烷纳滤膜溶剂回收己烷大豆油

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三平祖师公药签用药特点研究

中华中医药杂志 2024年第3期39卷 1554-1557页

作者：蔡秋梅韩春雯张丽娜潘伟滨漳州卫生职业学院漳州363000

目的:运用现代数据挖掘方法统计整理三平祖师公药签75首方药以探讨药签用药特点,从中医医学理论上剖析药签的起效机制,为科学传承中医药民间文化拓展平台。方法:运用Excel软件数据处理系统,对药签处方药物的性能、功效元素频次进行统计... 详细信息

目的:运用现代数据挖掘方法统计整理三平祖师公药签75首方药以探讨药签用药特点,从中医医学理论上剖析药签的起效机制,为科学传承中医药民间文化拓展平台。方法:运用Excel软件数据处理系统,对药签处方药物的性能、功效元素频次进行统计分析,探讨其用药特点。结果:三平祖师公药签用药共49味,选药平和无毒,以甘草、茯苓、当归、牛膝、山药为常;四性以平、温、寒为主;五味以甘、苦、辛为要;归经以入脾、肺、肾经为重;药物功效以健脾祛湿为首。结论:三平祖师公药签用药精简,其立法参闽南气候湿热之实,组方量病患久疾中虚之情,重视甘平之药培补中焦以恢复元气,配伍合理,用药平和,与医理相符,值得科学传承。

关键词：三平祖师公药签四性五味归经毒性功效元素文化