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Genes & Diseases 2024年第1期11卷 11-14页

作者： Xinghui Li Haiping Wang Yandi Wu Li Zou Shijie Dengg Xintu Fu Tongsheng Huang Conghui Shen Teng Wu weibin cai Guangdong Engineering&Technology Research Center for Disease-Model Animals Laboratory Animal CenterZhongshan School of MedicineSun Yat-sen UniversityGuangzhouGuangdong 510080China Department of Biochemistry Zhongshan School of MedicineSun Yat-sen UniversityGuangzhouGuangdong 510080China School of Pharmacy Guangdong Pharmaceutical UniversityGuangzhouGuangdong 510006China Guangdong Provincial Key Laboratory of Digestive Cancer Research The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhenGuangdong 518107China

There are no approvedtherapeuticdrugs for nonalcoholic steatohepatitis(NASH)due to the many bottlenecks,including the lack of preclinical animal models that can perfectly mimic human NASH features,such as systemic metabolic disorders,hepatic steatosis,intense liver inflammation and fibrosis,liver tumorigenesis,and cardiovascularcomplications.i,2"Pigment"epitheliumderived factor(PEDF)is a lipid metabolism regulator with high expression in the liver,and its reduced expression in the liver is closely related to the development of nonalcoholic fatty liver disease(NAFLD).

关键词： inflammation PEDF hepatic

Solvent Recovery from Soybean Oil/Hexane Miscella by PDMS Composite Membrane

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Chinese Journal of Chemical Engineering 2011年第4期19卷 575-580页

作者： cai weibin SUN Yanzhi PIAO Xianglan LI Jiding ZHU Shenlin State Key Laboratory of Chemical Engineering Department of Chemical Engineering Tsinghua University Beijing 100084 China

Traditional solvent recovery in the extraction step of edible oil processing is distillation,which consumes large amounts of *** the distillation is replaced by membrane process,the energy consumption can be reduced *** this work,two kinds of membrane,PDMS(polydimethylsiloxane) composite membrane and Zeolite filled PDMS membrane were prepared,in which asymmetric microporous PVDF(polyvinylidenefluoride) membrane prepared with phase inversion method was functioned as the microporous supporting layer in the flat-plate composite *** different function compositions of the PDMS/PVDF composite membranes were characterized by reflection Fourier transform infrared(FTIR) *** surface and section of PDMS/PVDF composite membranes were investigated by scanning electron microscope(SEM).The PDMS NF(nanofiltration) membranes were then applied in the recovery of hexane from soybean oil/hexane miscellas(1:3,mass ratio).The effects of pressure(0.5-1.5 MPa),cross-linking temperature and PDMS layer thickness on membrane performances were *** results indicated that both two kinds of NF membranes were promising for solvent recovery,and zeolite filled in PDMS NF membrane could enhance the separation performance.

关键词： PDMS composite membrane miscella zeolite solvent recovery

IL-25 stimulates M2 macrophage polarization and thereby promotes mitochondrial respiratory capacity and lipolysis in adipose tissues against obesity

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Cellular & Molecular Immunology 2018年第5期15卷 493-505页

作者： Juan Feng Lingyi Li Zhiying Ou Qiao Li Baoyong Gong Zhenxian Zhao Weiwei Qi Ti Zhou Jun Zhong weibin cai Xia Yang Aiping Zhao Guoquan Gao Zhonghan Yang Program of Molecular Medicine Affiliated Guangzhou Women and Children’s HospitalZhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China Institute of Pediatrics Affiliated Guangzhou Women and Children's Medical CenterSun Yat-sen UniversityGuangzhou 510623China Guangdong Provincial Key Laboratory of Laboratory Animals Guangdong Laboratory Animals Monitoring InstituteGuangzhou 510063China PancreatoBiliary Surgery First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Guangdong Engineering and Technology Research Center for Disease-Model Animals SUN Yat-sen UniversityGuangzhou 510006China Department of Radiation Oncology Department of MedicineUniversity of Maryland School of MedicineBaltimoreMD 21201USA

Obesity and associated metabolic diseases are characterized by a chronic low-grade inflammatory state with the infiltration of many inflammatory cells,especially *** molecules,including some cytokines,have a close relationship with ***(IL)-25 is a member of the IL-17 cytokine family that can regulate macrophages and alleviate some metabolic dysfunction;however,its role and mechanisms in lipid metabolism remain to be extensively *** serum and liver biopsy specimens,high-fat diet-induced obesity mice and DB/DB(Lepr−/−)animal models were used to examine IL-25 expression in obesity and nonalcoholic fatty liver diseases(NAFLD).To observe the role of IL-25 in lipid metabolism,model mice were administered with IL-25 or adoptively transferred with IL-25-educated macrophages in vivo,whereas bone marrow-derived macrophages,the macrophage cell line RAW264.7 and adipocytes differentiated from 3T3-L1 were used in ***-25 was decreased in NAFLD patients and obese *** addition,IL-25 reduced body weight gain and lipid accumulation,enhanced lipid uptake by macrophages and increased the expression of lipolysis andβ-oxidation enzymes via alternatively activating ***-25 also promoted lipolysis and suppressed lipogenesis in adipocytes co-cultured with the IL-25-educated ***,IL-25 improved the mitochondrial respiratory capacity and oxygen consumption rate of macrophages and produced more NAD+/NADH and *** conclusion,IL-25 can stimulate M2 macrophage polarization and thereby promote lipolysis and mitochondrial respiratory capacity,highlighting the potential for IL-25 to be used as a therapeutic agent against obesity and associated metabolic syndromes.

关键词： adipocyte immunometabolism IL-25 macrophage obesity

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证券市场混合交易模式制度研究

证券市场导报 2005年第7期 74-77页

作者：蔡伟彬深圳证券交易所广东深圳518010

做市商交易制度、竞价交易制度以及混合交易模式三者如何选择和取舍是国内证券市场一个长期争论的话题。本文尝试以德国证券交易所积极管理型上市基金指定保荐人制度为例,从积极管理型上市基金目前的发展现状为出发点,对混合交易模式进... 详细信息

做市商交易制度、竞价交易制度以及混合交易模式三者如何选择和取舍是国内证券市场一个长期争论的话题。本文尝试以德国证券交易所积极管理型上市基金指定保荐人制度为例,从积极管理型上市基金目前的发展现状为出发点,对混合交易模式进行分析。

关键词：交易制度混合模式做市商制度

Studies on the anti-angiogenic activity of PEDF34 and its molecular mechanism

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不同交联剂对PDMS／PVDF纳滤膜溶剂回收性能的影响

中国生物化学与分子生物学会第十届会员代表大会暨全国学术会议

作者： Qing Gong Xia Yang Zhonghan Yang weibin cai Guoquan Gao Department of Biochemistry Zhongshan Medical School of Sun Yat-Sen University

Objective The aim of this study is to observe the effect of PEDF34(a functional peptide of PEDF) on angiogenesis and tumor growth in xenografted prostate carcinoma athymic mouse model and to explore the effect and the potent mechanism of PEDF34 on endothelial cells. Materials and Methods Human PEDF34 cDNA was obtained by PCR and and the PEDF34-GST fusion protein was produced using pGEX-4T-l/ BL21(DE3) prokaryotic expression *** fusion protein was purified by passing through the GST-Binding column and identified by SDS-PAGE electrophoresis and Western ***

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化工学报 2013年第2期64卷 581-589页

作者：蔡卫滨朴香兰李继定朱慎林清华大学化学工程系化学工程联合国家重点实验室北京100084

以聚二甲基硅氧烷(PDMS)为分离层材料,聚偏氟乙烯(PVDF)超滤膜为底膜,采用正硅酸乙酯(TEOS)、苯基三甲氧基硅烷(PTMOS)、辛基三甲氧基硅烷(OTMOS)、γ-氨基丙基三乙氧基硅烷(AP-TEOS)4种不同的交联剂对PDMS进行交联,制备了PDMS/PVDF纳... 详细信息

以聚二甲基硅氧烷(PDMS)为分离层材料,聚偏氟乙烯(PVDF)超滤膜为底膜,采用正硅酸乙酯(TEOS)、苯基三甲氧基硅烷(PTMOS)、辛基三甲氧基硅烷(OTMOS)、γ-氨基丙基三乙氧基硅烷(AP-TEOS)4种不同的交联剂对PDMS进行交联,制备了PDMS/PVDF纳滤膜。采用接触角、红外谱图、扫描电镜等对膜的物理和化学结构进行了分析和表征。以大豆油/己烷混合油为实验体系,考察了压力和料液浓度对纳滤膜分离性能的影响。结果表明,纳滤膜的通量随压力线性增长,截留率初始随压力上升较快,随后增幅减慢而趋于稳定。随料液浓度的增加,纳滤膜的通量和截留率都有较大幅度的下降。相比较而言,以TEOS为交联剂所制得的纳滤膜分离性能最佳。大豆油/己烷混合油体系同水溶液体系的渗透特性类似,其渗透压可用van’tHoff方程计算。

关键词：聚二甲基硅氧烷纳滤膜溶剂回收己烷大豆油

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对县级报账制涉农项目资金管理的调查与思考

财政科学 2019年第7期 136-143页

作者：蔡卫彬湖南省桃江县财政局

加强涉农项目资金管理,积极从源头上预防和杜绝违纪违规行为,严格落实责任追究制度。把握关键环节,对实行县级报账制涉农项目资金的安排、使用、管理采取有力措施认真组织自查自纠,并对其全过程及效果开展全方位的检查、调研和剖析,通... 详细信息

加强涉农项目资金管理,积极从源头上预防和杜绝违纪违规行为,严格落实责任追究制度。把握关键环节,对实行县级报账制涉农项目资金的安排、使用、管理采取有力措施认真组织自查自纠,并对其全过程及效果开展全方位的检查、调研和剖析,通过多种多样的形式对工作成效不足的地方加强督查,责任落实到位,形成环环相扣、畅通无阻的内控体系。对县级财政部门、主管部门和实施单位的责权范围要有明确的界定,使部门与部门之间任务明确、责任清晰、权限清楚,减少推诿扯皮的现象。做到对项目资金的拨付、使用和报账的步骤有统一的标准,对报销凭证的合理性、真实性和有效性的审核有严格的要求,对报账方式的制度、程序和定位的明确有具体的细则,在实际工作中不断提高其可操作性,提升管理水平,加大支付改革力度。按照“保基本、强服务、惠民生、促发展”的原则,不断提高财政支农发展质量、管养水平和服务水平,积极开展以"建好、管好、护好、运营好"为主题的"四好项目"建设活动,加快消除制约农村经济发展的瓶颈,加大美丽乡村建设,助推乡村健康发展,为广大农民群众致富奔小康提供基础保障。

关键词：县级报账涉农项目资金管理对策建议

Pigment epithelium-derived factor plus radiotherapy enhanced the inhibitory effect on the growth of nasopharygngeal carcinoma

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Pigment epithelium-derived factor plus radiotherapy enhanced...

MicroRNA-21, 204 and 125b Play Potential Roles in Tumorigenesis of Melanoma

中国生物化学与分子生物学会第十届会员代表大会暨全国学术会议

作者： Zumin Xu Yufang Zuo Yang Zhang Qingsong Wang weibin cai Xia Yang Zhonghan Yang Ming Chen Guoquan Gao Department of Biochemistry Zhongshan Medical School of Sun Yat-sen University State Key Laboratory of Oncology in South China Cancer Center of Sun Yat-sen University Department of Radiation Oncology Cancer Center of Sun Yat-sen University

Objective:The aim of this study is to explore the effect and mechanism of PEDF on the growth of nasopharyngeal carcinoma and to investigate the combined effect of PEDF and radiotherapy on nasopharyngeal carcinoma. Materials and Methods:The recombinant PEDF protein was generated by pET30a/ *** BL21(DE3) system and purified by passing through the Ni2+-His-Bind *** effect of PEDF on nasopharyngeal carcinoma growth was assessed by *** of PEDF at a total dose of 15mg/kg

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Advances in Bioscience and Biotechnology 2015年第12期6卷 677-692页

作者： Chengtan Li Xiayu Wang Ya’ni Chen Xiaohua Tan Wen Li Sheng Yan weibin cai Xianrong Xu Liangwen Xu Lei Yang Yutao Yan School of Medicine Hangzhou Normal University Hangzhou China IHRC Inc. Atlanta GA USA

Aim: The high mortality rate of melanoma is due to partially the lack of good diagnostic markers and treatment strategies. Over the past several years, several microRNA (miRNA) profiling studies have been performed on melanoma tissues, but with extremely inconsistency, the diagnostic value of miRNA candidates in melanoma remains under debate. Thus, this study aims to systematically evaluate the consistency of miRNAs tissue in multiple independent studies in melanoma. Method: Eligible studies were screened and selected from the PubMed, EMBASE, and Web of Science. A systematic analysis of published miRNA expression studies that compared the miRNA expression profiles between melanoma tissues and normal skin tissue was conducted. A vote-counting strategy was followed with the collection of information. Real time PCRs were employed to validate miRNA candidates with high consistency. Targets of consistent miRNAs were predicted by online programs (like miRTarBase, *** and TargetScanHuman 6.2). Enrichment analyses for gene ontology (GO) terms and Kyoto encyclopedia of genes and genomes (KEGG) pathways were carried out with Database for Annotation, Visualization, and Integrated Discovery (DAVID). Results: A total of 303 differentially expressed miRNAs were reported in the 10 miRNA-profiling studies during comparison of melanoma tissues with normal tissues;132 were up-regulated in melanoma, and 171 were down-regulated. However, in the group of consistently reported miRNAs (cutoff > 3 times), only moderate numbers of consistent and differentially expressed miRNAs were selected. miRNA-21 was found increased in 5 different studies, miRNA-146b, miRNA-17 and miRNA-18a were reported up-regulated in 4 profiling studies. Meanwhile, miRNA-204 and miRNA-125b were found down-regulated in 5 studies, miRNA-141, miRNA-149, miRNA-224, miRNA-200b, miRNA-200c were consistently decreased in just 4 out of 10 profiling studies in total. The directions of differential expression of these

关键词： Melanoma miRNA Systematic Analysis Programmed Cell Death Transcription

Character and pathway of proapoptotic PEDF functional peptides responsible for tumor suppression

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Character and pathway of proapoptotic PEDF functional peptid...