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Major depressive disorder:hypothesis,mechanism,prevention and treatment

Signal Transduction and Targeted Therapy 2024年第3期9卷 913-944页

作者： Lulu Cui Shu Li Siman Wang Xiafang Wu Yingyu Liu weiyang yu Yijun Wang Yong Tang Maosheng Xia Baoman Li Department of Forensic Analytical Toxicology School of Forensic MedicineChina Medical UniversityShenyangChina Liaoning Province Key Laboratory of Forensic Bioevidence Sciences ShenyangChina China Medical University Centre of Forensic Investigation ShenyangChina International Joint Research Centre on Purinergic Signalling/Key Laboratory of Acupuncture for Senile Disease(Chengdu University of TCM) Ministry of Education/School of Health and RehabilitationChengdu University of Traditional Chinese Medicine/Acupuncture and Chronobiology Key Laboratory of Sichuan ProvinceChengduChina Department of Orthopaedics The First HospitalChina Medical UniversityShenyangChina

Worldwide,the incidence of major depressive disorder(MDD)is increasing annually,resulting in greater economic and social ***,the pathological mechanisms of MDD and the mechanisms underlying the effects of pharmacological treatments for MDD are complex and unclear,and additional diagnostic and therapeutic strategies for MDD still are *** currently widely accepted theories of MDD pathogenesis include the neurotransmitter and receptor hypothesis,hypothalamicpituitary-adrenal(HPA)axis hypothesis,cytokine hypothesis,neuroplasticity hypothesis and systemic influence hypothesis,but these hypothesis cannot completely explain the pathological mechanism of *** it is still hard to adopt only one hypothesis to completely reveal the pathogenesis of MDD,thus in recent years,great progress has been made in elucidating the roles of multiple organ interactions in the pathogenesis MDD and identifying novel therapeutic approaches and multitarget modulatory strategies,further revealing the disease features of ***,some newly discovered potential pharmacological targets and newly studied antidepressants have attracted widespread attention,some reagents have even been approved for clinical treatment and some novel therapeutic methods such as phototherapy and acupuncture have been discovered to have effective improvement for the depressive *** this work,we comprehensively summarize the latest research on the pathogenesis and diagnosis of MDD,preventive approaches and therapeutic medicines,as well as the related clinical trials.

关键词： prevention acupuncture hypothesis

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Analysis and optimum design of rider-bicycle mechanisms:Design of bicycle parameters for a specified rider

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Science China(Technological Sciences) 2011年第11期54卷 3027-3034页

作者： LIU XinJun WANG Jing yu weiyang WU JinHua State Key Laboratory of Tribology and Institute of Manufacturing Engineering Department of Precision Instruments and Mechanology Tsinghua University Beijing 100084 China

Optimum design of rider-bicycle mechanisms is very important for customizing bicycles and plays a crucial role in the improvement of athletes' performances and in protection of the *** the birth of the first bicycle,people have been keeping optimizing bicycles with respect to physical conditions of *** modern design,the basic structure of a bicycle has been formulized,while many geographic parameters remain *** this paper,the bicycle and the human body are considered as a kinematic mechanism,called rider-bicycle *** optimum design is implemented from the perspective of ***-saving and comfortableness are considered at the same *** corresponding performance charts are drawn and the relationship between the performances and parameters of seat height,crank length and body parameters are *** using these charts,the optimal design method of bicycle's parameters for a specified person is then *** solutions to get suitable seat height and crank length for a person are obtained *** research is of significance for customizing bicycles and design of bicycle robot.

关键词： optimum design rider-bicycle mechanism performance index performance chart

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太阳能光热+市电耦合相变蓄能供暖系统测试分析

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天津科技 2024年第9期51卷 71-74,78页

作者：韦新东李妍朱林丑雪松于伟洋吉林建筑大学吉林长春130118 吉林建筑科技学院吉林长春130114

在环境污染和能源危机的双重背景下,太阳能是建筑供暖的首选能源。以太阳能光热+市电耦合相变蓄能(源侧及负荷侧)供暖系统为例,研究入口参数对相变蓄热装置蓄热过程的影响及有无相变蓄热地板对室温的影响。结果表明:提高入口温度和入口... 详细信息

在环境污染和能源危机的双重背景下,太阳能是建筑供暖的首选能源。以太阳能光热+市电耦合相变蓄能(源侧及负荷侧)供暖系统为例,研究入口参数对相变蓄热装置蓄热过程的影响及有无相变蓄热地板对室温的影响。结果表明:提高入口温度和入口流量有利于缩短相变蓄热所需的时间;有相变蓄热地板的房间温度波动更平稳,舒适度更高。

关键词：太阳能光热相变蓄能系统测试分析

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A periodic DFT study on adsorption of small molecules(CH4,CO,H2O,H2S,NH3)on the WO3(001) surface-supported Au

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Communications in Theoretical Physics 2020年第3期72卷 69-82页

作者： Long Lin Jingtao Huang weiyang yu Chaozheng He Hualong Tao Yonghao Xu Linghao Zhu Pengtao Wang Zhanying Zhang Cultivating Base for Key Laboratory of Environment-Friendly Inorganic Materials in Henan Province School of Materials Science and EngineeringHenan Polytechnic UniversityJiaozuo 454000China School of Mathematics and Informatics Henan Polytechnic UniversityJiaozuo 454000China School of Physics and Electronic Information Engineering Henan Polytechnic UniversityJiaozuo 454000China Institute of Environmental and Energy Catalysis School of Materials Science and Chemical EngineeringXi’an Technological UniversityXi’anShaanxi 710021China Liaoning Key Materials Laboratory for Railway School of Materials Science and EngineeringDalian Jiaotong UniversityDalian 116028Liaoning ProvinceChina

Gas molecules(such as CH4,CO,H2O,H2S,NH_3)adsorption on the pure and Au-doped WO3(001)surface have been studied by Density functional theory calculations with generalized gradient *** on the the calculation of adsorption energy,we found the most stable adsorption site for gas molecules by comparing the adsorption energies of different gas molecules on the WO3(001)*** have also compared the adsorption energy of five different gas molecules on the WO3(001)surface,our calculation results show that when the five kinds of gases are adsorbed on the pure WO3(001)surface,the order of the surface adsorption energy is CO>H2S>CH4>H2O>*** the results show that NH3 is the most easily adsorbed gas among the other four gases adsorbed on the surface of pure WO3(001)*** also calculated the five different gases on the Au-doped WO3(001)*** order of adsorption energy was found to be different from the previous calculation:CO>CH4>H2S>H2O>*** results provide a new route for the potential applications of Au-doped WO3 in gas molecules adsorption.

关键词： WO3 gas molecules adsorption density functional theory

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Controlling of coordination state of Ru_(x)N_(y) clusters for efficient oxygen reduction electrocatalysis

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Nano Research 2024年第3期17卷 1035-1041页

作者： weiyang Fu Yihuan yu Tongtong Liu Yinliang Cao Zhengping Zhang Feng Wang State Key Laboratory of Chemical Resource Engineering Beijing Key Laboratory of Electrochemical Process and Technology for MaterialsBeijing University of Chemical TechnologyBeijing 100029China Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical TechnologyBeijing 100029China Zhejiang Tianneng Hydrogen Energy Technology Co. Ltd.Huzhou 313100China

Ruthenium(Ru)is an attractive potential alternative to platinum as an electrocatalyst for the oxygen reduction reaction(ORR),in virtue of its high catalytic selectivity and relatively low *** this work,a series of well-dispersed nitrogen-coordinated Ru-clusters on carbon black(Ru_(x)N_(y)/C)were prepared by pyrolyzing different Ru-containing sandwich compounds as the Ru *** higher thermal stability of these complexed sandwich precursors(bis(1,2,3,4,5-pentamethylcyclopentadienyl)Ru(II)monomer,dichloro(p-cymene)Ru(II)dimer,and chloro(1,2,3,4,5-pentamethylcyclopentadienyl)Ru(II)tetramer)affords the control of coordinated state for the resulting Ru-clusters,in comparison of that derived from ruthenium *** the pyrolysis treatment,the Ru coordinated state in Ru_(x)N_(y)/C,with the Ru–N and Ru–Ru bonds,still showed the structural inheritance from the Ru(II)monomer,dimer,and tetramer,but using ruthenium chlorides as the Ru source resulted in the nanoscale Ru *** ORR testing exhibited that the Ru_(x)N_(y)/C sample derived from the Ru(II)tetramer(Ru_(x)N_(y)/C-T)presents the higher catalytic activity than the other obtained samples in either alkaline or acidic *** in the acidic electrolyte,Ru_(x)N_(y)/C-T shows the comparable ORR activity to that of Pt/C catalysts,and it shows the superior tolerance against methanol and *** X-ray absorption spectroscopy and density functional theory calculations demonstrate that these tetra-nuclear Ru-clusters could be the most active site due to their broadened d-orbital bands and lower energy d-band center than those of other subnano species and nanocrystals,and their favorable Yeager-type adsorption of O_(2)-molecules is also contributed to promoting O–O bond cleavage and accelerating the ORR process.

关键词： ruthenium clusters coordination environment sandwich compounds electrocatalysis oxygen reduction reaction

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Insight into the microbial community of denitrification process using different solid carbon sources: Not only bacteria

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Journal of Environmental Sciences 2024年第10期144卷 87-99页

作者： Congyu Li yu Ling Yanjie Zhang Haiyan Wang Huan Wang Guokai Yan weiyang Dong Yang Chang Liang Duan State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China College of Environmental Science and Engineering Tongji UniversityShanghai 200092China College of Water Sciences Beijing Normal UniversityBeijing 100875China Research Center of Environmental Pollution Control Technology Chinese Research Academy of Environmental ScienceBeijing 100012China State Environmental Protection Key Laboratory of Estuarine and Coastal Environment Chinese Research Academy of Environmental SciencesBeijing 100012China

There is a lack of understanding about the bacterial,fungal and archaeal communities’composition of solid-phase denitrification(SPD)*** investigated four SPD systems with different carbon sources by analyzing microbial gene sequences based on operational taxonomic unit(OTU)and amplicon sequence variant(ASV).The results showed that the corncob-polyvinyl alcohol sodium alginate-polycaprolactone(CPSP,0.86±0.04 mg NO_(3)^(−)-N/(g·day))and corncob(0.85±0.06 mg NO_(3)^(−)-N/(g·day))had better denitrification efficiency than polycaprolactone(PCL,0.29±0.11 mg NO_(3)^(−)-N/(g·day))and polyvinyl alcoholsodium alginate(PVA-SA,0.24±0.07 mg NO_(3)^(−)-N/(g·day)).The bacterial,fungal and archaeal microbial composition was significantly different among carbon source types such as Proteobacteria in PCL(OTU:83.72%,ASV:82.49%)and Rozellomycota in PVA-SA(OTU:71.99%,ASV:81.30%).ASV methods can read more microbial units than that of OTU and exhibit higher alpha diversity and classify some species that had not been identified by OTU such as Nanoarchaeota phylum,unclassified_f_Xanthobacteraceae genus,etc.,indicating ASV may be more conducive to understand SPD microbial *** co-occurring network showed some correlation between the bacteria fungi and archaea species,indicating different species may collaborate in SPD *** KEGG function prediction results were obtained in two bioinformatic methods generally and some fungi and archaea functions should not be ignored in SPD *** results may be beneficial for understanding microbial communities in SPD systems.

关键词： Solid-phase denitrification Solid carbon source Microbial community ASV analysis OTU analysis

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A new optimum design method of bicycle parameters for a specified rider

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Chinese Science Bulletin 2012年第17期57卷 2192-2192页

作者： XinJun Liu Jing Wang weiyang yu JinHua Wu

The optimum design of bicycle parameters has been explored by many scholars and institutes since bicycles were first invented. Professor XinJun Liu and his group at Tsinghua

关键词：自行车优化设计方法参数优化设计研究机构清华大学设计参数系统

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多样性正则的神经网络训练方法探索

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南京大学学报（自然科学版） 2017年第2期53卷 340-349页

作者：屈伟洋俞扬南京大学软件新技术国家重点实验室南京210046

传统神经网络训练方法通过计算输出Y和目标T之间误差,并将该误差反向传递,用以修改节点权重,并不断重复该过程直至达到预期结果.该方法在模型训练时存在收敛较慢、容易过度拟合的问题.多样性正则项(diversity regularization)最近显示... 详细信息

传统神经网络训练方法通过计算输出Y和目标T之间误差,并将该误差反向传递,用以修改节点权重,并不断重复该过程直至达到预期结果.该方法在模型训练时存在收敛较慢、容易过度拟合的问题.多样性正则项(diversity regularization)最近显示出有简化模型、提高泛化能力的作用,对带有多样性正则项的神经网络训练方法进行探索,在计算目标函数时加入权重多样性的考虑,从而使得网络的内部结构减少重复.与传统神经网络训练方法——反向传播算法(back-propagation algorithm,BP)和目标差传播方法(difference target propagation,DTP)的结合与对比实验表明,带多样性正则项的训练方法具有更快的收敛速度和较低的错误率.

关键词：多样性正则项前馈神经网络反向传播算法目标差传播算法

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中国工业废气排放的空间特征及其影响因素研究

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地理科学 2016年第2期36卷 196-203页

作者：韩楠于维洋燕山大学经济管理学院河北秦皇岛066004

基于2000-2012年中国31个省（市、自治区）面板数据,运用探索性空间数据分析方法对中国工业废气排放的空间分布特征进行研究,结果显示中国各省域（不含港澳台）工业废气排放存在显著的空间自相关和空间集聚效应;总体呈现东部、西部地区... 详细信息

基于2000-2012年中国31个省（市、自治区）面板数据,运用探索性空间数据分析方法对中国工业废气排放的空间分布特征进行研究,结果显示中国各省域（不含港澳台）工业废气排放存在显著的空间自相关和空间集聚效应;总体呈现东部、西部地区集聚的空间分布特征,其中东部多为高-高集聚区、西部则多为低-低集聚区,并且高值集聚现象的显著性逐渐增强,显著区域呈持续扩张趋势。在此基础上,以STIRPAT模型为基础构建空间计量模型,分析经济发展、人口规模、产业结构、技术水平和国家政策等因素对工业废气排放量的影响。研究结果表明,中国各省域工业废气排放存在空间依赖作用和正的空间溢出效应;经济发展、产业结构与工业废气排放之间呈现显著的正相关关系;技术进步和国家政策对工业废气排放具有抑制作用,而人口增长对工业废气排放的影响并不显著。

关键词：工业废气排放空间特征探索性空间数据分析空间计量影响因素

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Percutaneous internal fixation with PKP and simple PKP for thoracolumbar burst fractures of the aged patients:A prospective randomized controlled trial

Percutaneous internal fixation with PKP and simple PKP for t...

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2013年浙江省医学会骨质疏松与骨矿盐疾病分会学术年会暨国家级骨质疏松症和骨质疏松性骨折诊治进展专题研讨会

作者： Dengwei He Kejun Zhu Xiaoyong Sheng Ye Zhu weiyang yu Feijun Liu 丽水市中心医院温州医学院附属第五医院骨科

Background:The impact of percutaneous internal fixation as a supplement to percutaneous kyphoplasty(PKP) for the management of the thoracolumbar burst fractures of the aged patients is *** conducted a clinical controlled trial to define the effect of percutaneous internal fixation with PKP on thoracolumbar fractures and patientrelated functional outcomes. Method:This study included 43 patients with thoracolumbar burst fractures without nerve injuries who were elder than 65 years *** were randomly assigned to treatment with simple PKP(control group,n=22) and percutaneous short-segment pedicle screw internal fixation with PKP(treatment group,n=21).The patients were followed for at least two years postoperatively and were assessed with regard to clinical and radiological outcomes. Clinical outcomes were evaluated mainly with use of visual pain analog scale(VAS) and questionnaire score of Oswestry disability index(ODI).Radiological outcomes were assessed mainly on the basis of Cobb kyphosis angle and loss of kyphosis correction. Results:There was no significant difference between the two groups with regard to the preoperative indexes. The treatment group had better VAS values and had more postoperative improvements in ODI results as compared with the control group(P < 0.05).Postoperative kyphosis angle correction of the treatment group was superior to that of the control group,and postoperative correction loss was significant less compared with the control group(P < 0.05). In the control group,two patients postoperatively suffered refractures in the injured vertebra and one patient had refracture in the adjacent *** operation complications need managements were noted postoperatively in both groups. Conclusions:Compared with simple PKP operation,percutaneous internal fixation with PKP is one kind of more ideal surgical technique for the treatment of selected elderly thoracolumbar burst fractures.

关键词： the elderly patient thoracolumbar burst fracture percutaneous internal fixation simple PKP randomized controlled trial

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