检索结果-南通市图书馆

Current State of Clinical Studies on Diagnosis and Treatment of Sudden Deafness in China

在线全文

学校读者我要写书评

暂无评论

Journal of Otology 2006年第1期1卷 22-24页

作者： yu Yaping, YANG Shiming, GUO Wei, YANG weiyan, GU RuiDepartment of Otolaryngology, Head and Neck Surgery, Institute of Otolaryngology, Chinese PLAGeneral Hospital, Beijing 100853, China. Department of Otolaryngology Head and Neck Surgery Institute of Otolaryngology Chinese PLA General Hospital Beijing 100853 China.

Objective To evaluate the current status of clinical studies on diagnosis and treatment of sudden deafness (SD) in China by retrospective reviewing articles on SD published in Chinese journals in the past 5 years. Special attention is given to whether the diagnosis and treatment standards established in 1996 by the otolaryngology branch of Chinese Medical Association (the'1996 standard') were followed. Methods The terms of 'Sudden deafness' and 'treatment' were used as the keywords in searching articles published between 2000 and 2004 in the Chinese biomedicine literature database and Chinese journal network. Principles of evidence-based medicine were applied in reviewing the articles. Results Two hundreds and thirty- four articles were identified, including 176 between 2000 and 2002 and 58 between 2003 and 2004. Among the 176 articles published between 2000 and 2002, effects of medications were studies in 126 articles, of which only 26 (20.6%) followed the'1996 standards'. Eighty-nine (70.6%) were reported based on controlled clinical trials (CCT) and 36 (28.5%) met the criteria of randomized controlled trails (RCT). Of the 58 articles published between 2003 and 2004, drug effects were evaluated in 25 articles, which were all based on the '1996 standards'. However, there lacked placebo control, follow-up data or statistical analysis in these papers. Only 6 articles reported side-effects from pharmacological treatment. Conclusions While a significant number of articles on SD were published in the past 5 years, the '1996 standards' were followed only in a small number of them. The standards may not be appropriate in guiding research and need to be modified for improved guidance to SD management. Multi-center, RCTs should be a crucial part in studies on SD.

关键词： sudden deafness therapy evidence-based medicine randomized controlled trails

Mitochondrial DNA A1555G mutation screening using a testing kit method and its significance in preventing aminoglycoside-related hearing loss

在线全文

学校读者我要写书评

暂无评论

Journal of Otology 2006年第1期1卷 61-64页

作者： LIU Xin DAI Pu HUANG Deliang yuAN Huijun LI Weiming yu Fei ZHANG Xin KANG Dongyang CAO Juyang YANG weiyan HAN Dongyi JIN Zhengce GUAN Minxin Department of Otolaryngology Chinese PLA General HospitalBeijingChina Weihai Aomaier Gene Technological CO. LTD.WeihaiShandong 264200China. Division and Program in Human Genetics and Center for Hearing and Deafness Research Cincinnati Children’s Hospital Medical CenterCincinnatiOhioUSA

To report a new screening method for mitochondrial DNA 1555A→G mutation and the results of genotype analysis in 19 maternal inherited deafness pedigrees. Method Five hundred and forty-six non-syndromic neuro-sensory hearing loss patients were tested for 1555A→G mutation using a new compact testing kit, which allows clear distinction between wild type and 1555 A→G mutated mtDNAs. Results Nineteen subjects among the 546 patients (3.48%) were found to carry mtDNA A1555G mutation. The results were confirmed by sequencing in an ABI 3100 Avant sequencer. Conclusions Maternal inherited deafness families are a frequently seen in outpatient group. The detection of mtDNA 1555 A→G mutation with a low cost, ready to use detection kit is needed and suitable in China for large scale screening and preventive testing before usage of aminoglycoside antibiotics.

关键词： ototoxic deafness maternal pedigree gene mutation prevention

Coverage of 13-Valent Pneumococcal Conjugate Vaccine Among Children 0–15 Months of Age—9 Provinces,China,2019–2021

在线全文

学校读者我要写书评

暂无评论

China CDC weekly 2023年第17期5卷 379-384页

作者： Lijun Liu Zhaonan Zhang Xixi Zhang Changsha Xu Yifan Song Li Li Jiakai Ye Zhiguo Wang Hui Liang weiyan Zhang Ling Lin Ning Li Shujun Zhang Qianli Ma Wen Du Yongzhuo Jiao Lingsheng Cao Qi Qi Lei Cao Wenzhou yu Sichuan Center for Disease Control and Prevention Chengdu CitySichuan ProvinceChina National Immunization Program Chinese Center for Disease Control and PreventionBeijingChina Suqian Center for Disease Control and Prevention Suqian CityJiangsu ProvinceChina Jiangsu Center for Disease Control and Prevention Nanjing CityJiangsu ProvinceChina Zhejiang Center for Disease Control and Prevention Hangzhou CityZhejiang ProvinceChina Shandong Center for Disease Control and Prevention Jinan CityShandong ProvinceChina Anhui Center for Disease Control and Prevention Hefei CityAnhui ProvinceChina Hubei Center for Disease Control and Prevention Wuhan CityHubei ProvinceChina Hunan Center for Disease Control and Prevention Changsha CityHunan ProvinceChina Guizhou Center for Disease Control and Prevention Guiyang CityGuizhou ProvinceChina Gansu Center for Disease Control and Prevention Lanzhou CityGansu ProvinceChina

Summary What is already known on this topic?Limited data exist regarding the coverage of the 13-valent pneumococcal conjugate vaccine(PCV13)in China.A lack of official statistics,coupled with an insufficient body of published literature,hinders the accurate depiction of the current *** is added by this report?This study investigated the utilization of PCV13 and estimated its coverage in nine provinces across eastern,central,and western China between 2019 and *** an annual increase in PCV13 usage during this period,the overall coverage remained suboptimal.

关键词： spite coverage hinder

Restoration of reservoir diagenesis and hydrocarbon accumulation process by calcite in-situ U-Pb dating and fluid inclusion analysis: A case study on Cretaceous Qingshuihe Formation in Gaoquan Structure, southern Junggar Basin, NW China

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Petroleum Exploration and Development 2023年第6期50卷 1386-1397页

作者： GUI Lili ZHUO Qingong LU Xuesong YANG Wenxia CHEN weiyan WU Hai FAN Junjia HE Yinjun CAO Rizhou yu Xiaoqing Research Institute of Petroleum Exploration and Development PetroChinaBeijing 100083China CNPC Key Laboratory of Basin Structure and Hydrocarbon Accumulation Beijing 100083China CNOOC Experimental Center Engineering Technology BranchCNOOC Energy Development Co.Ltd.Tianjin 300452China Wuxi Institute of Petroleum Geology SINOPEC Petroleum Exploration and Production Research InstituteWuxi 214126China

The complexity of diagenesis and hydrocarbon accumulation in the deep reservoirs in southern Junggar Basin restricts hydrocarbon exploration in the lower reservoir assemblage. The lithofacies and diagenesis of reservoirs in the Cretaceous Qingshuihe Formation in the Gaoquan structure of the Sikeshu Sag, southern Junggar Basin were analyzed. On this basis, the thermal history was calibrated using calcite in-situ U-Pb dating and fluid inclusion analysis to depict the hydrocarbon accumulation process in the Gaoquan structure. The results show that the Qingshuihe reservoir experienced two phases of calcite cementation and three phases of hydrocarbon charging. The calcite cements are dated to be (122.1±6.4) Ma, (14.4±1.0) Ma - (14.2±0.3) Ma. The hydrocarbon charging events occurred at around 14.2-30.0 Ma (low-mature oil), 14.2 Ma (mature oil), and 2 Ma (high-mature gas). The latter two phases of hydrocarbon charging contributed dominantly to the formation of reservoir. Due to the S-N compressive thrust activity during the late Himalayan period since 2 Ma, the traps in the Gaoquan structure were reshaped, especially the effective traps which developed in the main reservoir-forming period were decreased significantly in scale, resulting in weak hydrocarbon shows in the middle-lower part of the structure. This indicates that the effective traps in key reservoir-forming period controlled hydrocarbon enrichment and distribution in the lower reservoir assemblage. Calcite U-Pb dating combined with fluid inclusion analysis can help effectively describe the complex diagenesis and hydrocarbon accumulation process in the central-west part of the basin.

关键词： fluid inclusion calcite in-situ U-Pb dating diagenetic sequence hydrocarbon accumulation timing Sikeshu Sag southern Junggar Basin Cretaceous Qingshuihe Formation

The characterization of a novel,sustained-release ivermectin solid dispersion

在线全文

学校读者我要写书评

暂无评论

The characterization of a novel,sustained-release ivermectin...

NTF4 possesses both anti-tumorigenic and pro-metastatic roles in breast cancer progression

中国畜牧兽医学会兽医寄生虫学分会第十三次学术研讨会

作者： Lu Mengmeng Xiong Dan Sun Weiwei yu Tong Hu Zixia Ding Jiafeng Niu weiyan Pan Baoliang College of Veterinary Medicine China Agriculture University

We prepared a novel,sustained-release ivermectin solid dispersion(IVM-SDs) with a hydrophobic matrix(hydrogenated castor oil,HCO).No IVM crystals were observed in the IVM-SDs under polarized light microscopy and scanning electron microscopy(SEM) indicating that IVM was completely dispersed in *** state of the IVM in IVM-SDs was investigated by differential scanning calorimetry(DSC) and X-ray powder diffraction(XRPD).IVM molecules were completely dispersed in the carrier as an amorphous state in the IVM-SDs when the drug:carrier ratio was lower than 1:*** addition,no chemical reaction between drug and carrier were seen in Fourier transform infrared spectroscopy(FTIR) and H nuclear magnetic resonance(NMR).The in vitro release study showed that the percent drug release and release rate of IVM from IVM-SDs was considerably lower than that of pure IVM and physical mixtures(PMs)indicating that the IVM-SDs exhibited a sustained release effect of *** was also found that the drug-to-carrier ratio was the critical factor for drug *** study demonstrates that the prepared IVM-SD was an excellent candidate for the preparation of a long-acting IVM injectable aqueous suspension.

关键词： ivermectin hydrogenated castor oil solid dispersion sustained-release amorphous

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

NTF4 possesses both anti-tumorigenic and pro-metastatic role...

热休克蛋白Hsp70在抗原呈递过程中的作用

2021年中国肿瘤标志物学术大会暨第十五届肿瘤标志物青年科学家论坛

作者： Ran Sun Jin He yu Cheng Chun Yan Jiuyi Xia Jun Tang weiyan Peng Zhu Qiu Tingxiu Xiang 重庆医科大学附属第一医院

Background: The molecular underpinnings behind malignant progression of breast cancer(Br Ca) from a localized lesion to an invasion and ultimately metastatic disease are incompletely understood. Here we report that neurotrophin 4(NTF4) plays a dual role in mammary tumorigenesis and *** and Methods: NTF4 functions were analyzed by various cell biology assays in *** tumor model and metastatic lung colonization model were used to explore NTF4 effects in vivo. WB, IHC, IF, qRT-PCR, Co-IP, Mass Spectrum analysis, and i TRAQ were further applied to determine the detailed ***: NTF4 was downregulated in primary breast tumors, but upregulated in normal breast tissues and metastasic lymph nodes. NTF4 inhibited cell proliferation and colony formation in vitro and xenograft tumorigenicity in vivo. Meanwhile, NTF4 promoted cell apoptosis and cell cycle arrest in ***, NTF4 promoted epithelial-mesenchymal transition(EMT), cell motility, and invasiveness in vitro and metastatic lung colonization in vivo. Clinical data showed that expression levels of NTF4 were associated with poor clinical outcomes, supporting the notion that metastasis,rather than primary cancer, is the major determinant of the mortality of Br Ca patients. Mechanistic investigations futher revesled that NTF4 elicits its pro-metastasis effects by targeting DNA-PKcs and ANXA1. Importantly, using DNA-PKcs inhibitor and AKT inhibitor, and knockdown ANXA1 rescued NTF4-mediated promotion of EMT, cell migration, and invasion, respectively. Interesting,NTF4 exert its anti-proliferation effects by increasing the phosphoserine level of ANXA1, which was important for ANXA1 to import into the nucleus. Then ANXA1 nuclear translocation induced expression of the pro-apoptotic Bid gene, and activated the caspase-3 apoptotic pathway, which was almost completely reversed by knockdown ***: Collectively, these findings uncover an unexpected dual role for NTF4 i

关键词： Breast cancer invasion and metastasis epithelial-mesenchymal transition NTF4

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

中国公共卫生 2006年第9期22卷 1084-1085页

作者：黄唯燕余权赵玫武汉大学生命科学学院2003级生物技术基地班武汉430072 中国医学科学院肿瘤医院肿瘤研究所

目的研究热休克蛋白Hsp70家族在抗原呈递中的作用,探讨其与肿瘤免疫反应的关系。方法利用反义RNA技术,将反义Hsp70、反义Hsc70、B7表达质粒导入肿瘤细胞B16中,24 h后检测细胞中热休克蛋白表达水平。利用混合淋巴细胞培养,检测T淋巴细胞... 详细信息

目的研究热休克蛋白Hsp70家族在抗原呈递中的作用,探讨其与肿瘤免疫反应的关系。方法利用反义RNA技术,将反义Hsp70、反义Hsc70、B7表达质粒导入肿瘤细胞B16中,24 h后检测细胞中热休克蛋白表达水平。利用混合淋巴细胞培养,检测T淋巴细胞增殖能力。结果在黑色素瘤细胞B16中转染pLXSN-antihsp70、pLXSN-antihsc70及2者共转染,转染反义质粒能够抑制B16细胞中Hsp70/Hsc70的表达,导致Hsp70表达下调,其刺激T淋巴细胞增殖能力均大幅下降。而将pLXSNmB7转染入B16细胞中,其刺激T细胞增殖的能力均有所上升。转染pLXSNmB7后,B16细胞中Hsp70/Hsc70的表达量有所提高。结论抑制各热休克蛋白Hsp70家族的表达能够导致T细胞增值数降低。在肿瘤细胞中导入B7分子能够提高Hsp70的表达水平,从而提高其抗原呈递的能力。

关键词：热休克蛋白70(Hsp70) 抗原呈递肿瘤免疫反应

剩余骨高度<4 mm上颌窦经牙槽嵴提升不植骨的可行性研究

在线全文

学校读者我要写书评

暂无评论

口腔医学研究 2021年第5期37卷 389-392页

作者：余海纳孟维艳吉林大学口腔医院口腔种植中心吉林长春130014

上颌后牙区由于拔牙后骨吸收导致牙槽嵴高度降低常需要上颌窦提升,传统观念认为骨高度4 mm以下的后牙区无法使用经牙槽嵴上颌窦提升。由于不使用骨材料上颌窦提升的成功以及经牙槽嵴上颌窦提升的优势,近年不断有学者挑战低剩余骨高度的... 详细信息

上颌后牙区由于拔牙后骨吸收导致牙槽嵴高度降低常需要上颌窦提升,传统观念认为骨高度4 mm以下的后牙区无法使用经牙槽嵴上颌窦提升。由于不使用骨材料上颌窦提升的成功以及经牙槽嵴上颌窦提升的优势,近年不断有学者挑战低剩余骨高度的不植骨经牙槽嵴提升并取得良好效果。本文旨在对剩余骨高度<4 mm不植骨进行上颌窦经牙槽嵴提升的现状进行系统综述。

关键词：上颌窦提升牙种植牙槽嵴高度植骨

在线全文

学校读者我要写书评

暂无评论

压水堆轴向氙振荡监测与控制技术研究

核动力工程 2024年第5期45卷 40-44页

作者：费敬然毕光文杨波杨伟焱韩宇汤春桃上海核工程研究设计院股份有限公司上海200233

三代非能动先进压水堆(CAP1000/CAP1400)核电厂的控制棒系统处于手动控制模式时,需要给运行人员提供实时、准确、易读的堆芯氙分布变化信息,以支持其合理决策,执行恰当的操作。本文基于CAP1000反应堆的中子物理模型,研究了氙振荡监测方... 详细信息

三代非能动先进压水堆(CAP1000/CAP1400)核电厂的控制棒系统处于手动控制模式时,需要给运行人员提供实时、准确、易读的堆芯氙分布变化信息,以支持其合理决策,执行恰当的操作。本文基于CAP1000反应堆的中子物理模型,研究了氙振荡监测方法,在三代非能动先进压水堆堆芯在线监测系统中开发了氙模式图功能,可以有效监测与控制轴向氙振荡的发展。该方案具有一定的适用性,可以推广应用至其他类型压水堆核电厂。

关键词：氙振荡轴向氙偏差氙模式图堆芯在线监测 CAP1000