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Complete Genome Sequences of the SARS-CoV: the BJ Group (Isolates BJ01-BJ04)

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Genomics, Proteomics & Bioinformatics 2003年第3期1卷 180-192页

作者： ShengliBi E‘deQin ZuyuanXu WeiLi JingWang YongWuHu YongLiu ShuminDuan JianfeiHu YujunHan JingXu YanLi YaoYi YongdongZhou weilin1 JieWen HongXu RuanLi ZizhangZhang HaiyanSun JinguiZhu ManYu BaochangFan QingfaWu weilin2 LinTang Bao’anYang GuoqingLi WenmingPeng WenjieLi TaoJiang YajunDeng BohuaLiu JianpingShi YongqiangDeng WeiWei HongLiu ZongzhongTong FengZhang YuZhang Cui‘eWang YuquanLi JiaYe YonghuaGan JiaJi XiaoyuLi XiangjunTian FushuangLu GangTan RuifuYang BinLiu SiqiLiu SonggangLi JunWang JianWang WuchunCao JunYu XiaopingDong HuanmingYang CenterofDiseaseControlandPrevention Beijing100050China InstituteofMicrobiologyandEpidemiology ChineseAcademyofMilitaryMedicalSciencesBeijing100071China JamesD.WatsonInstituteofGenomeSciences ZhijiangCampusZhejiangUniversityandHangzhouGenomicsInstituteHangzhou310008China BeijingGenomicsInstitute ChineseAcademyofSciencesBeijing101300China CollegeofLifeSciences PekingUniversityBeijing100871China WenzhouMedicalCollege Wenzhou325003China PekinaUnionMedicalColleqeHospital ChineseAcademyofMedicalSciencesBeijing100730China CollegeofMaterialsScienceandChemicalEngineering YuquanCampusZhejiangUniversityHangzhou310027China

Beijing has been one of the epicenters attacked most severely by the SARS-CoV (severe acute respiratory syndrome-associated coronavirus) since the first patient was diagnosed in one of the city's hospitals. We now report complete genome sequences of the BJ Group, including four isolates (Isolates BJ01, BJ02, BJ03, and BJ04) of the *** is remarkable that all members of the BJ Group share a common haplotype, consisting of seven loci that differentiate the group from other isolates published to date. Among 42 substitutions uniquely identified from the BJ group, 32 are non-synonymous changes at the amino acid level. Rooted phylogenetic trees, proposed on the basis of haplotypes and other sequence variations of SARS-CoV isolates from Canada, USA, Singapore, and China, gave rise to different paradigms but positioned the BJ Group, together with the newly discovered GD01 (GD-Ins29) in the same clade, followed by the H-U Group (from Hong Kong to USA) and the H-T Group (from Hong Kong to Toronto), leaving the SP Group (Singapore) more distant. This result appears to suggest a possible transmission path from Guangdong to Beijing/Hong Kong, then to other countries and regions.

关键词： SARS SARS-CoV haplotype substitution phylogeny

基于CASI/SASI高光谱影像的几何校正方法及误差分析

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河南科学 2018年第9期36卷 1336-1342页

作者：王柯戴晓爱王乾翟伟林成都理工大学国土资源部地学空间信息技术重点实验室成都610059 中国冶金地质总局地球物理勘察院河北保定071000

CASI/SASI高光谱遥感影像在380~2450 nm的波谱范围内,最多可构建388个连续光谱通道,具备很高的光谱分辨率.针对影像在采集过程中的严重畸变,采用Buddle(实验区)辅助POS数据的方法进行高精度几何校正.通过利用Buddle与POS数据进行联合计... 详细信息

CASI/SASI高光谱遥感影像在380~2450 nm的波谱范围内,最多可构建388个连续光谱通道,具备很高的光谱分辨率.针对影像在采集过程中的严重畸变,采用Buddle(实验区)辅助POS数据的方法进行高精度几何校正.通过利用Buddle与POS数据进行联合计算,获取最佳的位置偏移量和角度偏移量.并将偏移量参数用于修正后的共线方程方法中,结合DEM数据进行几何校正.该方法有效解决了偏心矢量和偏心角无法精确测量而带来系统误差的问题,绝对定位精度达到4.87 m,校正精度较高.

关键词： CASI/SASI 位置偏移量方向偏移量 Buddle POS数据

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喷射气举设计方法验证及优化建议

中外能源 2018年第3期23卷 44-49页

作者：罗威齐韦林王静孙冰恒涂亚明长江大学石油工程学院湖北武汉430100 中国石油吐哈油田公司工程技术研究院新疆鄯善839009

通过前期研究,在G/L型射流泵流动过程中遵循质量守恒、动量守恒、能量守恒和气体状态方程的基础上,导出了射流泵排出口压力的计算方法,并将其运用到节点分析方法中,形成了一套可行的喷射气举工艺设计方法,但是未能在现场试验中进行进一... 详细信息

通过前期研究,在G/L型射流泵流动过程中遵循质量守恒、动量守恒、能量守恒和气体状态方程的基础上,导出了射流泵排出口压力的计算方法,并将其运用到节点分析方法中,形成了一套可行的喷射气举工艺设计方法,但是未能在现场试验中进行进一步验证。鉴于此,展开了通过现场试验实测数据进行该设计方法验证的研究,通过海外某油田优选出具有普遍性的两口试验井的喷射气举生产资料,对建立的射流泵排出口压力计算方法进行了验证,结果表明：所建立的计算模型预测得到的喷射气举生产情况与油井实际生产情况较符合,计算误差较小,喷射气举效果一般。并以其中一口井为例,通过对喷射泵设计参数和工作参数进行敏感性分析和评价,给出了提高喷射气举效果的建议：适当减小喉管尺寸,适当减小泵的下入深度或增加注气量,确定最优喷嘴尺寸、注气量和注气压力组合。

关键词： G/L型射流泵排出口压力喷射气举敏感性分析

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HPLC法测定消炎汤合剂中绿原酸的含量

天津药学 2004年第5期16卷 13-14页

作者：张玉琪董伟林天津市中心妇产科医院天津300052 天津医科大学实验中心天津300070

目的 :采用 HPL C法测定绿原酸的含量 ,为消炎汤合剂的质量控制提供检测方法。方法 :采用 Kromasil C1 8色谱柱 (4.6 mm× 2 5 0 mm ,5μm) ,甲醇 - 0 .4 %磷酸水溶液 (15∶ 85 )为流动相 ,流速 1.0 ml/ min,检测波长 32 7nm。结果 :绿... 详细信息

目的 :采用 HPL C法测定绿原酸的含量 ,为消炎汤合剂的质量控制提供检测方法。方法 :采用 Kromasil C1 8色谱柱 (4.6 mm× 2 5 0 mm ,5μm) ,甲醇 - 0 .4 %磷酸水溶液 (15∶ 85 )为流动相 ,流速 1.0 ml/ min,检测波长 32 7nm。结果 :绿原酸在 0 .1～ 2 .0μg范围内线性关系良好 (r =0 .9999) ,平均回收率为 95 .1%± 1.2 8% ,日内及日间的 RSD均小于 2 %。结论 :本方法具有快速、简便、灵敏、准确、经济等特点 ,适用于消炎汤合剂的质量控制。

关键词：消炎汤合剂绿原酸高效液相色谱法含量测定

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基于死亡数据用DLNM构建气象健康指数

环境卫生学杂志 2018年第5期8卷 368-373,380页

作者：黄照刘涛许燕君李杏曾韦霖肖建鹏许晓君马文军广东药科大学公共卫生学院广东省疾病预防控制中心广东省公共卫生研究院广东省疾病预防控制中心慢性非传染性疾病预防控制所

目的探索建立气象健康指数,预警提示气温导致的健康风险。方法基于2011—2015年广州市居民死亡数据,用分布滞后非线性模型(DLNM)分析气温与居民非意外日死亡数的关系;对气温导致的健康风险进行分级,用不同风险等级对应的温度范围开展健... 详细信息

目的探索建立气象健康指数,预警提示气温导致的健康风险。方法基于2011—2015年广州市居民死亡数据,用分布滞后非线性模型(DLNM)分析气温与居民非意外日死亡数的关系;对气温导致的健康风险进行分级,用不同风险等级对应的温度范围开展健康风险预报。结果 2011—2015年广州市的日平均气温为21.7℃,日相对湿度为78.6%,日均居民死亡为132例。日平均温度与居民死亡之间暴露—反应曲线呈U形,是非线性关系,低温和高温都会引起死亡风险,高温对人群死亡的影响是急性效应,低温产生的效应会比较延迟,但持续时间长。舒适温度区间为19.4℃～25.4℃,其所对应的RR值为1.02～1.03。冷效应RR值低中高三个风险等级分别为1.03～1.17,1.17～1.31,1.32～1.46,其对应的温度区间依次为12.9℃～19.3℃,8.5℃～12.8℃,4.8℃～8.4℃;热效应RR值低中高三个风险等级分别为1.02～1.08,1.08～1.13,1.13～1.19,其对应的温度区间依次为25.5℃～27.8℃,27.9℃～29.5℃,29.6℃～31.1℃。结论由DLNM评估气象条件与居民日死亡人数的关系可反映气温引起的健康风险,将健康风险等间隔分级预警较合理,可对开展气象健康指数预报服务提供理论支持。

关键词：健康温度气象指数分布滞后非线性模型

妊娠期糖尿病对新生儿代谢相关指标及预后的影响

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重庆医学 2018年第13期47卷 1743-1745页

作者：邓毅阳华妹杨伟丽唐正荣雷凤王丽蒙真谢勇欧维琳桂林医学院第二附属医院新生儿科广西桂林541199 桂林医学院附属医院广西桂林541001

目的探讨妊娠期糖尿病(GDM)对新生儿代谢水平及预后的影响。方法选取265例单胎GDM患者为观察组,260例健康单胎妊娠产妇作为对照组。测定血清脂联素、胰岛素、C肽、糖化血红蛋白和新生儿血糖水平等指标,比较两组新生儿的预后情况。结果... 详细信息

目的探讨妊娠期糖尿病(GDM)对新生儿代谢水平及预后的影响。方法选取265例单胎GDM患者为观察组,260例健康单胎妊娠产妇作为对照组。测定血清脂联素、胰岛素、C肽、糖化血红蛋白和新生儿血糖水平等指标,比较两组新生儿的预后情况。结果观察组脐静脉脂联素水平及新生儿出生后2h血糖水平低于对照组,胰岛素、C肽及糖化血红蛋白水平均高于对照组,观察组剖宫产例数多于对照组,差异有统计学意义(P<0.05)。观察组低体质量儿、巨大儿、新生儿窒息、新生儿低血糖、新生儿高胆红素血症、新生儿肺炎、死胎、新生儿畸形发生率均明显高于对照组,差异具有统计学意义(P<0.05)。结论 GDM可引起新生儿代谢指标异常,影响胎儿生长发育,导致预后不良。

关键词：糖尿病妊娠脂联素胰岛素婴儿新生预后

Recent Advances in Fibrous Materials for Hydroelectricity Generation

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Nano-Micro Letters 2025年第2期17卷 109-133页

作者： Can Ge Duo Xu Xiao Feng Xing Yang Zheheng Song Yuhang Song Jingyu Chen Yingcun Liu Chong Gao Yong Du Zhe Sun weilin Xu Jian Fang College of Textile and Clothing Engineering Soochow UniversitySuzhou 215123People’s Republic of China National Engineering Laboratory for Modern Silk Soochow UniversitySuzhou 215123People’s Republic of China State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200People’s Republic of China Institute of Functional Nano&Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123People’s Republic of China Department of Electrical and Computer Engineering University of MassachusettsAmherstMA 01003USA Department of Materials Imperial College LondonSouth Kensington CampusLondon SW72AZUK College of Textile Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310018People’s Republic of China School of Materials Science and Engineering Shanghai Institute of Technology100 Haiquan RoadShanghai 201418People’s Republic of China

Depleting fossil energy sources and conventional polluting power generation pose a threat to sustainable *** generation from ubiquitous and spontaneous phase transitions between liquid and gaseous water has been considered a promising strategy for mitigating the energy *** materials with unique flexibility,processability,multifunctionality,and practicability have been widely applied for fibrous materials-based hydroelectricity generation(FHG).In this review,the power generation mechanisms,design principles,and electricity enhancement factors of FHG are first ***,the fabrication strategies and characteristics of varied constructions including 1D fiber,1D yarn,2D fabric,2D membrane,3D fibrous framework,and 3D fibrous gel are ***,the advanced functions of FHG during water harvesting,proton dissociation,ion separation,and charge accumulation processes are analyzed in ***,the potential applications including power supply,energy storage,electrical sensor,and information expression are also ***,some existing challenges are considered and prospects for future development are sincerely proposed.

关键词： Hydroelectricity Fibrous material Streaming potential Ion diffusion

Experimental Study on Geometry Characteristics of Turbulent Premixed Flames for Natural Gas/Air Mixtures

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Journal of Thermal Science 2025年第1期 268-282页

作者： ZHENG weilin WANG Qijiao XIAO Huahua CHEN Xiaoxiao XIE Fan ZENG Wen Liaoning Key Lab of Advanced Test Technology for Aerospace Propulsion System Shenyang Aerospace University State Key Laboratory of Fire Science University of science and Technology of China AVIC Shenyang Aircraft Design and Research Institute

In this study,focusing on the geometry characteristics of spherical expanding flame,the turbulent premixed flames of natural gas/air mixtures were investigated in a fan-stirred turbulent *** effects of initial temperature（T=300-400 K）,initial pressure（P=0.1-0.3 MPa）,turbulence intensity（u'=1.0-2.7 m/s）,oxygen volumetric percentage(φ（O2）=15%-21%) and carbon dioxide volumetric percentage(φ（CO2）=0-20%)were delved *** flame profile under the Cartesian coordinate system was derived from the schlieren images taken by the high-speed ***,from both macroscopic and microscopic perspectives,the influence of experimental conditions on the flame geometry characteristics was explored through flame front extraction,wavelet decomposition and network *** results demonstrate that for significant flame wrinkling,changes in species concentrations and turbulence intensity have more pronounced effects on the flame wrinkling *** wrinkling of the flame front maintains a certain degree of similarity,as evidenced by the locally concentrated distribution of the angles of the maximum fluctuation *** disturbance energy under large-scale（D6-D8） disturbances exhibits relatively high values with a similar trend,exerting a significant impact on the geometry characteristics of the flame *** peaks of correlation degree are scattered either with the decomposition scale or the development of flame radius,indicating no linear correlation between different detail ***,the probability distribution of node degrees in key wrinkled regions exhibits different trends with that of large-scale wrinkling and disturbance energy,especially with changes in initial *** occurs because the number of key wrinkles varies based on the perturbation's strength or the region's ***,an increase in the fluctuation frequency of the flame's local radius may not necessarily lead to an increase in the number of key folded regions.

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Fast-spreading SARS-CoV-2 variants:challenges to and new design strategies of COVID-19 vaccines

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Signal Transduction and Targeted Therapy 2021年第7期6卷 1953-1958页

作者： weilin Zhou Wei Wang State Key Laboratory of Biotherapy and Cancer Center West China HospitalSichuan Universityand Collaborative Innovation Center for BiotherapyChengduPR China

The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is still threatening global *** to the latest data,the number of diagnosed cases has exceeded 100 ***,experiences have been accumulated in preventing and treating COVID-19 through virological,immunoloqical,epidemiological,and clinical investigations of this disease/Besides,the continuous advancement of different vaccines brings the dawn to defeat the epidemic.

关键词： vaccines Comfort acute