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Cystine proportion regulates fate of polypeptide nanogel as nanocarrier for chemotherapeutics

Science China Chemistry 2021年第2期64卷 293-301页

作者： Xiangru Feng weiguo xu Xiaoru xu Gao Li Jianxun Ding xuesi Chen Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei230026China College of Acumox and Tuina Changchun University of Chinese MedicineChangchun130022China

The physicochemical characteristics of nanoparticles are closely related to their drug delivery performances in vitro and in vivo.A well-designed nanocarrier can prolong the drug half-life in the blood circulation,upregulate the drug accumulation at the target site,and enhance the treatment *** elucidate the impact of physicochemical properties on the fate of nanogel as a nanocarrier of chemotherapeutics,three methoxy poly(ethylene glycol)-poly(L-phenylalanine-co-L-cystine)(mPEG-P(LP-coLC))nanogels with different L-cystine proportions were developed,namely mPEG-P(LP10-co-LC5)(NG10-5),mPEG-P(LP10-coLC10)(NG10-10),and mPEG-P(LP10-co-LC15)(NG10-15).The three nanogels shared similar surface charge and reductionresponsive behavior,but they had distinct diameters and different drug release *** them,NG10-5,which has the smallest diameter,was preferentially internalized by tumor cells in vitro and showed rapid migration to the tumor site in *** doxorubicin(DOX)as a model chemotherapeutic agent,NG10-5/DOX had the most prolonged blood circulation period and highest tumor accumulation after intravenous ***10-5/DOX also had the most potent antitumor effect of all three drug-loaded ***,adjusting physicochemical characteristics by changing the amino acid composition might improve the therapeutic efficacies of nanogels and enhance their potential for clinical application.

关键词： polypeptide nanogel cystine proportion fate of nanocarrier controlled drug delivery cancer therapy

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Superiority of poly(L-lactic acid)microspheres as dermal fillers

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Chinese Chemical Letters 2021年第1期32卷 577-582页

作者： Quan Gao Lijie Duan Xiangru Feng weiguo xu School of Chemistry and Life Science Changchun University of TechnologyChangchun 130012China Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China

The demand for injectable dermal filler has unde rgone significant growth with the rapid development of the beauty ***(lactic acid)(PLA) as a benefit of excellent biocompatibility and long-term promotion of collagen regeneration has been favored as a commonly used ***,the effects of chirality and particle size of PLA on the efficacy of dermal filler have not been *** this study,we prepared three kinds of microspheres(MSs) consisting of poly(D-lactic acid)(PDLA MS),poly(L-lactic acid)(PLLA MS),or meso-PLA(PDLLA MS)at 5,10 and 20 μmto reveal the different biological functions as dermal *** intradermal injection into guinea pig,it was found that PLLA MS induced the slightest inflammation,and the level of pro-inflammatory cytokine IL-1β induced by PLLA MS is only 0.3 or 0.7-fold of that induced by PDLA or PDLLA MS,*** importantly,PLLA MS significantly stimulated the regeneration of collagen,which was 1.4 or 1.1 times higher than those stimulated by PDLA MS or PDLLA MS,*** size of PLA MSs did not affect the levels of inflammation and collagen *** results confirmed the superiority of PLLA as a dermal filler.

关键词： Chiral poly(L-lactic acid) Particle Collagen regeneration Inflammation inhibition Dermal filler

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The impacts of fabrication systems on 3D concrete printing building forms

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Frontiers of Architectural Research 2022年第4期11卷 653-669页

作者： Shuyi Huang weiguo xu Yuqian Li School of Architecture Tsinghua UniversityBeijingChina

Recently,3D concrete printing(3DCP)technology starts entering the market from factories and laboratories,contributing to the creation of new construction methods and architectural ***,since the technologies of most 3DCP institutions are independently developed,there is a lack of consensus in terms of construction methods and development approaches in the *** this paper,based on 423DCP architectural works completed in last five years,a quantitative analysis was made to evaluate the impacts of the fabrication system on 3DCP building *** paper introduced three criteria,including Workspace Index,Geometric Complexity Index,and Tectonic Prospect Index,analyzing and answering the discussions about"adopting in-situ printing or prefabrication","using gantry printers or robotic arms"from the perspective of architectural *** analyzing specific construction methods and design strategies in these projects,the research summarized three development trends,"mobile equipment,algorithmic structure,and intelligent construction",which will affect the future development of 3DCP building ***,the paper discussed the advantages,limitations,and potential of four different 3DCP fabrication systems,expecting to point out the directions to further optimize each system and realize more diverse 3DCP buildings.

关键词： 3D concrete printing Fabrication system Building form Robotic system 3D printing Gantry system 3D printing Prefabrication In-situ fabrication

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Heat transfer and friction factor of Therminol liquid phase heat transfer fluid in a ribbed tube

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Chinese Journal of Chemical Engineering 2017年第10期25卷 1343-1351页

作者： weiguo xu Guodong Liu Qinghong Zhang Shuai Wang Huilin Lu Heping Tan School of Energy Science and Engineering Harbin Institute of Technology Harbin 150001 China

Experiments and simulations on flow and heat transfer behavior of Therminol-55 liquid phase heat transfer fluid have been conducted in a ribbed tube with the outer diameter and inner diameter 25.0 and 20.0 mm,pitch and rib height of 4.5 and 1.0 *** results show that the heat transfer and thermal performance of Therminol-55 liquid phase heat transfer fluid in the ribbed tube are considerably improved compared to those of the smooth *** Nusselt number increase with the increase of Reynolds *** increase in heat transfer rate of the ribbed tube has a mean value of 2.24 ***,the pressure drop results reveal that the average friction factor of the ribbed tube is in a range of 2.4 and 2.8 times over the smooth *** simulations of three-dimensional flow behavior of Therminol-55 liquid phase heat transfer fluid are carried out using three different turbulence models in the ribbed *** numerical results show that the heat transfer of ribbed tube is improved because vortices are generated behind ribs,which produce some disruptions to fluid flow and enhance heat transfer compared with smooth *** numerical results prove that the ribbed tube can improve heat transfer and fluid flow performances of Therminol liquid phase heat transfer fluid.

关键词： Ribbed tube Heat transfer fluid Friction factor Experiments Numerical simulations

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Poly(L-glutamic acid)-cisplatin nanoformulations with detachable PEGylation for prolonged circulation half-life and enhanced cell internalization

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Bioactive Materials 2021年第9期6卷 2688-2697页

作者： Zhongyu Jiang Xiangru Feng Haoyang Zou weiguo xu Xiuli Zhuang Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of Sciences5625 Renmin StreetChangchun130022P.R.China School of Applied Chemistry and Engineering University of Science and Technology of China96 Jinzhai RoadHefei230026P.R.China

PEGylation has been widely applied to prolong the circulation times of nanomedicines via the steric shielding effect,which consequently improves the intratumoral ***,cell uptake of PEGylated nanoformulations is always blocked by the steric repulsion of PEG,which limits their therapeutic *** this end,we designed and prepared two kinds of poly(L-glutamic acid)-cisplatin(PLG-CDDP)nanoformulations with detachable PEG,which is responsive to specific tumor tissue microenvironments for prolonged circulation time and enhanced cell *** extracellular pH(pHe)-responsive cleavage 2-propionic-3-methylmaleic anhydride(CDM)-derived amide bond and matrix metalloproteinases-2/9(MMP-2/9)-sensitive degradable peptide PLGLAG were utilized to link PLG and PEG,yielding pHe-responsive PEG-pHe-PLG and MMP-sensitive *** corresponding smart nanoformulations PEG-pHe-PLG-Pt and PEG-MMP-PLG-Pt were then prepared by the complexation of polypeptides and cisplatin(CDDP).The circulation half-lives of PEG-pHe-PLG-Pt and PEG-MMP-PLG-Pt were about 4.6 and 4.2 times higher than that of the control PLG-Pt,*** reaching tumor tissue,PEG on the surface of nanomedicines was detached as triggered by pHe or MMP,which increased intratumoral CDDP retention,enhanced cell uptake,and improved antitumor efficacy toward a fatal high-grade serous ovarian cancer(HGSOC)mouse model,indicating the promising prospects for clinical application of detachable PEGylated nanoformulations.

关键词： Poly(L-glutamic acid) Detachable PEGylation Prolonged circulation time Enhanced cell uptake Platinum chemotherapy

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Targeted pH-responsive polyion complex micelle for controlled intracellular drug delivery

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Chinese Chemical Letters 2020年第5期31卷 1178-1182页

作者： Pan Zheng Yang Liu Jinjin Chen weiguo xu Gao Li Jianxun Ding Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of Sciences.Changchun 130022China University of Chinese Academy of Sciences Beijing 100049China Jilin Biomedical Polymers Engineering Laboratory Changchun 130022China

Cancer the rapy with nanoscale drug formulations has made significant progress in the past few ***,the selective accumulation and release of therapeutic agents in the lesion sites are still great *** this end,we developed a cRGD-decorated pH-responsive polyion complex(PIC)micelle for intracellular targeted delivery of doxorubicin(DOX)to upregulate tumor inhibition and reduce *** PIC micelle was self-assembled via the electrostatic interaction between the positively charged cRGD-modified poly(ethylene glycol)-block-poly(L-lysine)and the anionic acid-sensitive 2,3-dimethylmaleic anhydride-modified doxorubicin(DAD).The decoration of cRGD enhanced the cell internalization of PIC micelle through the specific recognition ofαvβ3 integrin on the membrane of tumor *** active DOX was released under intracellular acidic microenvironment after endocytosis following the decomposition of ***,the targeted PIC micelle exhibited enhanced inhibition efficacies toward hepatoma in vitro and in vivo compared with the insensitive *** smart multifunctional micelle provides a promising platform for target intracellular delivery of therapeutic agent in cancer therapy.

关键词： Polypeptide Targeting pH-responsiveness Intracellular drug delivery Cancer therapy

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Immunologically effective poly(D-lactic acid) nanoparticle enhances anticancer immune response

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Science China Chemistry 2023年第4期66卷 1150-1160页

作者： weiguo xu Yuanzhen Su Yang Ma Qi Wei Jiazhen Yang Xiuli Zhuang Jianxun Ding xuesi Chen School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Department of Thoracic Surgery China-Japan Union Hospital of Jilin UniversityChangchun 130033China

Chiral materials with the same atomic compositions exhibit different chemical,physical,and biological properties because of their distinct spatial ***,a chiral strategy was proposed to develop poly(lactic acid)(PLA)nanoparticle as an efficient nanoadjuvant to activate adaptive anticancer *** chiral nanovaccines were prepared by directly mixing amino-terminated PLA(PLLA-NH2 or PDLA-NH2)with the model protein antigen ovalbumin(OVA).After being injected into mice subcutaneously,both nanovaccines efficiently migrated to the lymph nodes to initiate the sequential anticancer immune *** with the PLLA nanovaccine(PLLA-OVA),the PDLA one(PDLA-OVA)contributed to more robust dendritic cell(DC)maturation,antigen presentation,and T lymphocyte *** addition to the activation of cellular immunity,PDLA-OVA also triggered a more vigorous activation of humoral immunity,which induced the production of more anti-OVA immunoglobulin G(IgG)than *** used as prophylactic or therapeutic nanovaccine toward murine melanoma models,PDLA-OVA triggered more potent adaptive anticancer immune responses that more effectively inhibited the cancer genesis and progression,indicating the significant potential of immunologically effective PDLA nanoadjuvant in cancer immunotherapy.

关键词： poly(D-lactic acid) chiral nanomaterial immune nanoadjuvant nanovaccine cancer immunotherapy

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Effects of the Interaction between Hydroxyapatite Nanoparticles and Hepatoma Cells

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Journal of Wuhan University of Technology(Materials Science) 2014年第3期29卷 635-642页

作者：尹美珍 xu weiguo CUI Bingcun 戴红莲 HAN Yingchao YIN Yixia LI Shipu School of Medicine Hubei Polytechnic University Tongji Hospital Tongji Medical College Huazhong University of Science and Technology State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Biomedical Materials and Engineering Center Wuhan University of Technology

To gain a better understanding of the anticancer effects of hydroxyapatite （HAP） nanoparticles in vivo and in vitro, the effects of the interaction of HAP nanoparticles with hepatoma cells were explored. HAP nanoparticles were prepared by homogeneous precipitation and characterized by laser particle analysis and transmission electron microscopy （TEM）. HAP nanoparticles were observed to be uniformly distributed, with rod-like shapes and diameters in the range of 42.1-87.1 nm. Overnight attached, suspended, and proliferating Bel-7402 cells were incubated with HAP nanoparticles. Inverted microscopy observation revealed that HAP nanoparticles with a cell membrane showed good adsorption. TEM demonstrated that HAP nanoparticles were present on the surface of cells, continuously taken up by cells through endocytosis, and transported in vesicles close to the nucleus. Fluorescence microscopy showed that the concentrations of intracellular Ca2＋ labeled with Fluo-3 calcium fluorescent probe were significantly enhanced. In addition, inverted microscopy observation revealed that suspended cells treated with HAP nanoparticles did not adhere to the culture bottle, resulting in cell death. After the overnight attached cells were treated with HAP nanoparticles for 96 h with increasing doses of HAP nanoparticles, inverted microscopy observation revealed that cell proliferation was slowed and ceU-ceU adhesion was weakened. Feulgen staining and image analysis indicated that the nuclear DNA content of the cells was markedly reduced, and argyrophilic nucleolar organizer region （AgNOR） staining and image analysis indicated that the number of AgNORs was significantly decreased. Therefore, hepatoma cells brought about the adsorption, uptake, transport and degradation of HAP nanoparticles. In addition, HAP nanoparticles affected hepatoma cells with regard to cell-cell adhesion, cell and extracellular matrix adhesion, and DNA and protein synthesis; thus inhibiting cell proliferation. This und

关键词： hydroxyapatite nanoparticles hepatoma cells interaction effects cell adhesion

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Functional biomaterials for comprehensive periodontitis therapy

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Acta Pharmaceutica Sinica B 2023年第6期13卷 2310-2333页

作者： Jiayi Luan Ruotao Li weiguo xu Huiying Sun Qiqi Li Di Wang Shujun Dong Jianxun Ding VIP Integrated Department Jilin Provincial Key Laboratory of Tooth Development and Bone RemodelingSchool and Hospital of StomatologyJilin UniversityChangchun 130021China Department of Hand and Foot Surgery the First Hospital of Jilin UniversityChangchun 130061China Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China

Periodontitis is an inflammatory disease caused by bacterial infection directly, and the dysregulation of host immune-inflammatory response finally destroys periodontal tissues. Current treatment strategies for periodontitis mainly involve mechanical scaling/root planing(SRP), surgical procedures,and systemic or localized delivery of antimicrobial agents. However, SRP or surgical treatment alone has unsatisfactory long-term effects and is easy to relapse. In addition, the existing drugs for local periodontal therapy do not stay in the periodontal pocket long enough and have difficulties in maintaining a steady, effective concentration to obtain a therapeutic effect, and continuous administration always causes drug resistance. Many recent studies have shown that adding bio-functional materials and drug delivery systems upregulates the therapeutic effectiveness of periodontitis. This review focuses on the role of biomaterials in periodontitis treatment and presents an overview of antibacterial therapy, host modulatory therapy, periodontal regeneration, and multifunctional regulation of periodontitis therapy. Biomaterials provide advanced approaches for periodontal therapy, and it is foreseeable that further understanding and applications of biomaterials will promote the development of periodontal therapy.

关键词： Biomaterial Antibacterial effect Host modulation Periodontal regeneration Periodontitis therapy Anti-oxidant Anti-inflammation Drug delivery

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Self-targeting visualizable hyaluronate nanogel for synchronized intracellular release of doxorubicin and cisplatin in combating multidrug-resistant breast cancer

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Nano Research 2021年第3期14卷 846-857页

作者： Wen Ma Qiling Chen weiguo xu Meng Yu Yuanyuan Yang Binhua Zou Yu Shrike Zhang Jianxun Ding Zhiqiang Yu Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou510515China Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolCambridgeMA02139USA

Multidrug-resistance(MDR)featuring complicated and poorly defined mechanisms is a major obstacle to the success of cancer chemotherapy in the *** nanoparticles comprising multiple cytostatics with different mechanisms of action are commonly developed to tackle the multifaceted nature of clinical ***,the different pharmacokinetics and release profiles of various drugs result in inconsistent drug internalization and suboptimal drug synergy at the tumor *** the present study,a type of self-targeting hyaluronate(HA)nanogels((CDDPH)^ANG/DOX)to reverse drug resistance through the synchronized pharmacokinetics,intratumoral distribution,and intracellular release of topoisomerase II inhibitor doxorubicin(DOX)and DNA-crosslinking agent cisplatin(CDDP)is *** prolonged circulation time and enhanced intratumoral accumulation in vivo,(CDDP)^HANG/DOX shows efficient drug delivery into the drug-resistant MCF-7/ADR breast cancer cells and enhanced antitumor ***,fluorescence imaging of DOX combined with the micro-computed tomography(micro-CT)imaging of CDDP facilitates the visualization of this combination tumor *** visualizable synchronized drug delivery,the self-targeting in situ crosslinked nanoplatform may hold good potential in future clinical therapy of advanced cancers.

关键词： hyaluronate nanogel self-targetability intracellular drug codelivery multimodal imaging reversal of multidrug resistance

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