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Transarterial chemoembolization combined with lenvatinib and sintilimab vs lenvatinib alone in intermediate-advanced hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 52-61页

作者： Fei-Da Wu Hai-Feng zhou wei Yang Di Zhu Bi-Fei Wu Hai-Bin Shi Sheng Liu wei-zhong zhou Department of Interventional Radiology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is the most common form of liver cancer that has limited treatment options and a poor *** chemoembolization(TACE)is the first-line treatment for intermediate-stage HCC but can induce tumour hypoxia,thereby promoting *** studies suggested that combining TACE with anti-angiogenic therapies and immunotherapy might im-prove ***,a tyrosine kinase inhibitor,has demonstrated superior outcomes compared to sorafenib,while immune checkpoint inhibitors such as sintilimab show potential when combined with ***,the efficacy and safety of TACE combined with lenvatinib and sintilimab(TACE+SL)compared to TACE with lenvatinib alone(TACE+L)in patients with intermediate-ad-vanced HCC has not yet been *** To evaluate the efficacy and safety of TACE+SL therapy in comparison to TACE+L therapy in patients with intermediate-advanced *** A retrospective analysis was performed on patients with intermediate-advanced HCC who received TACE plus lenvatinib with or without sintilimab between September 2019 and September *** characteristics were compared,and propensity score matching was *** survival(OS),progression-free survival(PFS),and objective response rate(ORR)were evaluated between the two groups,and adverse events were *** The study included 57 patients,with 30 in the TACE+SL group and 27 in the TACE+L *** TACE+SL group demonstrated significantly improved median PFS and OS compared to the TACE+L group(PFS:14.1 months vs 9.6 months,P=0.016;OS:22.4 months vs 14.1 months,P=0.039),along with a higher ORR(70.0%vs 55.6%).After propensity score matching,30 patients were included,with the TACE+SL group again showing longer median PFS and a trend toward improved OS(PFS:14.6 months vs 9.2 months,P=0.012;OS:23.9 months vs 16.3 months,P=0.063),and a higher ORR(73.3%vs 53.3%).No severe adverse events were *** TACE+SL demonstrat

关键词： Hepatocellular carcinoma Transarterial chemoembolization Sintilimab Lenvatinib Immunotherapy Programmed cell death 1 Prognosis

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A numerical local orthogonal transform method forstratified waveguides

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Journal of Zhejiang University-Science C(Computers and Electronics) 2010年第12期11卷 998-1008页

作者： Peng LI wei-zhou zhong Guo-sheng LI Zhi-hua CHEN School of Economies and Finance Xi'an Jiaotong University Xi'an 710061 China Department of Mathematics North China University of Water Conservancy and Electric Power Zhengzhou 450045 China Department of Mathematics Zhongyuan University of Technology Zhengzhou 450007 China Science Department Zhijiang College of Zhejiang University of Technology Hangzhou 310027 China

Flattening of the interfaces is necessary in computing wave propagation along strati?ed waveguides in large range step sizes while using marching methods. When the supposition that there exists one horizontal straight line in two adjacent interfaces does not hold, the previously suggested local orthogonal transform method with an analytical formulation is not feasible. This paper presents a numerical coordinate transform and an equation transform to perform the transforms numerically for waveguides without satisfying the supposition. The boundary value problem is then reduced to an initial value problem by one-way reformulation based on the Dirichlet-to-Neumann (DtN) map. This method is applicable in solving long-range wave propagation problems in slowly varying waveguides with a multilayered medium structure.

关键词： Helmholtz equation Local orthogonal transform Dirichlet-to-Neumann (DtN) reformulation Marching method Internal interface

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Electronic Structure and Catalysis on (001) Polar Surface of Cubic Zirconia

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Chemical Research in Chinese Universities 2010年第3期26卷 460-464页

作者： SHEN Pei-jun DING wei-zhong zhou Yu-ding HUANG Shao-qing Department of Materials Science and Engineering Shanghai University Shanghai 200072 P. R. China

The electronic structure of （001） polar surface of cubic zirconia was studied by GGA（WC） approximation. We found the cubic lattice near （001） surface showed an intensive tendency to transfer to tetragonal lattice. The metallic state appeared on both the terminations. For O-termination, some O2p states were vacated and hole carriers concentrated on surface oxygen-ions. For Zr-termination, some Zr4d states became partial occupied for the loss of O2p states. We observed the hole states were mainly localized at the corresponding ions on surface for both the terminations, while the charge states on Zr-termination were dispersed on surface.

关键词： Polar surface Electronic structure Hole/charge distribution Cataylsis Article

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Placement of ^(125)I seed strands and stents for a type Ⅳ Klatskin tumor

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World Journal of Gastroenterology 2015年第1期21卷 373-376页

作者： Wen Zhang Zheng-Qiang Yang Hai-Bin Shi Shen Liu wei-zhong zhou Lin-Bo Zhao Department of Interventional Radiology First Affiliate Hospital of Nanjing Medical University

Herein,we report a new technique that consists of placing two 125 I seed strands and two stents in the right and left intrahepatic bile ducts for the treatment of hilar cholangiocarcinoma.A 75-year-old man presented with jaundice and was diagnosed with Bismuth type Ⅳ Klatskin *** computed tomography(CT) showed intrahepatic and extrahepatic bile ductdilatation and a soft tissue mass in the hepatic *** curative surgical resection was not possible,we placed 125 I seed strands and stents in the right and left intrahepatic bile *** months later,abdominal CT showed less intrahepatic and extrahepatic bile duct dilatation than before the *** technique was feasible and could be considered for the treatment of patients with Bismuth type Ⅳ tumors.

关键词： Cholangiocarcinoma Klatskin tumor 125I seed strand

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Transarterial embolization for massive gastrointestinal hemorrhage following abdominal surgery

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World Journal of Gastroenterology 2013年第40期19卷 6869-6875页

作者： Chun-Gao zhou Hai-Bin Shi Sheng Liu Zheng-Qiang Yang Lin-Bo Zhao Jin-Guo Xia wei-zhong zhou Lin-Sun Li Department of Interventional Radiology the First Affiliated Hospital of Nanjing Medical University

AIM:To evaluate the clinical results of angiography and embolization for massive gastrointestinal hemorrhage after abdominal ***:This retrospective study included 26 patients with postoperative hemorrhage after abdominal surgery. All patients underwent emergency transarterial angiography,and 21 patients underwent emergency embolization. We retrospectively analyzed the angiographic features and the clinical outcomes of transcatheter arterial ***:Angiography showed that a discrete bleeding focus was detected in 21(81%) of 26 *** angiographic findings included extravasations of contrast medium(n = 9),pseudoaneurysms(n =9),and fusiform aneurysms(n = 3). Transarterial embolization was technically successful in 21(95%) of 22patients. Clinical success was achieved in 18(82%) of 22 patients. No postembolization complications were observed. Three patients died of ***:The positive rate of angiographic findings in 26 patients with postoperative gastrointestinal hemorrhage was 81%. Transcatheter arterial embolization seems to be an effective and safe method in the management of postoperative gastrointestinal hemorrhage.

关键词： Transcatheter arterial embolization Postoperative hemorrhage Complications Surgery

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