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Effect of advanced paternal age on reproductive outcomes in IVF cycles of non-male-factor infertility: a retrospective cohort study

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Asian Journal of Andrology 2023年第2期25卷 245-251页

作者： xin-Mei Lu Yu-Bing Liu Dou-Dou Zhang Xiang Cao Tian-Cheng Zhang Miao Liu Hui-Juan Shi Xi dong Su-Ying Liu Reproductive Medicine Center Zhongshan HospitalFudan UniversityNo.180 Fenglin RoadShanghai 200032China NHC Key Lab of Reproduction Regulation Shanghai Institute for Biomedical and Pharmaceutical TechnologiesPharmacy SchoolFudan UniversityNo.2140 Xietu RoadShanghai 200032China Center for Reproductive Medicine Tenth People’s Hospital of Tongji University301 Middle Yanchang RoadShanghai 200072China

Advanced paternal age has been overlooked,and its effect on fertility remains *** studies have focused mainly on intracytoplasmic sperm injection(ICSI)cycles in men with ***,few studies have reported on men with semen parameters within reference ***,we conducted a retrospective cohort study analyzing the reproductive outcomes of couples with non-male-factor infertility undergoing in vitro fertilization(IVF)*** total,381 cycles included were subgrouped according to paternal age(0.05).The pregnancy rate was not significantly different in the 35–39-year-old group(42.0%;P>0.05),but was significantly lower in the≥40-year-old group(26.1%;P0.05),but showed a declining *** miscarriage rate significantly increased in the 35–39-year-old group(44.8%)compared with that in theweight was *** results indicated that paternal age over 40 years is a key risk factor that influences the assisted reproductive technology success rate even with good semen parameters,although it has no impact on embryo development.

关键词： embryo development implantation in vitro fertilization paternal age pregnancy sperm

Protection mechanism of deacetylase inhibitor on spleen of rats with severe hemorrhagic shock

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Asian Pacific Journal of Tropical Medicine 2016年第6期9卷 553-558页

作者： Gao-Rong Deng Qiang Ling Bing-Hua Wu Yu-Ying dong Xiang Gao Tai-Qiang Li xin Miu Zong-Fang Li The Second Affiliated Hospital of Xi'an Jiaotong University Department of Orthopedics Nanchang University Fourth Affiliated Hospital

Objective: To explore the protection and molecular mechanism of histone deacetylase inhibitors(HDACIs) on the spleen of rats with hemorrhagic shock. Methods: A total of 60 SPF male SD rats were selected for the modeling of severe hemorrhagic shock using the method of arterial and venous cannulation with the time-divided bleeding. The measurement of mean arterial blood pressure and blood lactic acid was used to verify the modeling. The modeled rats were randomly divided into shock group, shock+suberoylanilide hydroxamic acid(SAHA) group, shock+autogenous transfusion group, and shock+SAHA+autogenous transfusion group. Three hours after the treatment, the spleen of rats was collected and TUNEL method was employed to detect the apoptosis of spleen cells in each group. Afterwards, real-time PCR and western blot were employed to detect the expression of BCL-2, BAX, and caspass3 in the spleen of rats in each group. Results: A total of 55 rats had successful modeling of severe hemorrhagic shock, with success rate of 92%. Cell apoptosis in the severe hemorrhagic model group was the most serious. After the intervention of HDACIs and the autogenous transfusion, the tissue injury was a bit recovered. Cell apoptosis was least in the shock+SAHA+autogenous transfusion group(P<0.05). After the intervention of HDACIs and the autogenous transfusion, the relative expression of BCL-2 was significantly increased(P<0.05), with highest relative expression of BCL-2 in shock+SAHA+autogenous transfusion group(P<0.05). After the intervention of HDACIs and the autogenous transfusion, the relative expression of BAX was significantly decreased(P<0.05), with lowest relative expression of BAX in the intervention group of single HDACIs. The change in the expression of caspass3 was similar to BAX, namely the relative expression of caspass3 was significantly decreased after the intervention of HDACIs and the autogenous transfusion(P<0.05). Conclusions: HDACIs and autogenous transfusion can all protec

关键词： Hemorrhagic shock HDACIs Apoptosis Histone acetylation

Surveying the electrocatalytic CO_(2)-to-CO activity of heterogenized metallomacrocycles via accurate clipping at the molecular level

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Nano Research 2022年第12期15卷 10070-10077页

作者： Meng-Ke Hu Ning Wang dong-dong Ma Qi-Long Zhu State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences(CAS)Fuzhou350002China College of Chemistry Fuzhou UniversityFuzhou350002China Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou350108China

Heterogenized phthalocyanine-based molecular catalysts are the ideal electrocatalytic platforms for CO_(2)reduction reaction(CO_(2)RR)because of their well-defined structures and potential *** addition to the pursuit of catalytic performances at industrial potentials,it is equally important to explore experimental rules and design considerations behind activity and ***,we successfully developed a series of nickel phthalocyanines(NiPcs)with different alkyl chains immobilized on multi-walled carbon nanotubes(CNT)to unveil the structure-performance relationship for electrocatalytic CO_(2)RR in neutral ***,a volcano-type trend was found between the activity for CO_(2)-to-CO conversion and alkyl chain lengths of NiPcs on *** results further indicate that their electrocatalytic CO_(2)RR activities are highly related to the molecular dispersion and the heterointerfacial charge transfer capability adjusted by the alkyl ***,the optimized electrocatalyst via accurate clipping at the molecular level exhibits an ultrahigh activity with Faradaic efficiency of CO up to 99.52%.

关键词： nickel phthalocyanines carbon nanotubes CO_(2)reduction reaction alkyl chains structure-performance relationship

Dripping retardation with corrugated ceiling

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Applied Mathematics and Mechanics(English Edition) 2018年第8期39卷 1165-1172页

作者： dong LUO Jianjun TAO CAPT-HEDPS SKLTCS Collaborative Innovation Center of IFSADepartment of Mechanics and Engineering Science College of EngineeringPeking University

The instabilities of a pendent viscous thin film underneath two corrugated ceilings are studied numerically and theoretically in comparison with the case of a flat wall. With the same initial interface perturbations, it is shown numerically that both the supercritical instability and the subcritical instability can be retarded by the in-phase corrugated ceilings. The lubrication approximation is used to explain the retardation effect of the corrugated ceiling on the supercritical instability of the pendant film, where the linear growth rate is revealed to be power three of the initial film thickness.

关键词： pendent film surface tension Rayleigh-Taylor instability(RTI) corrugated wall

2019 Chinese expert consensus statement on aspirin application in primary prevention of cardiovascular disease

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Chinese Medical Journal 2020年第10期133卷 1221-1223页

作者： Xiao-Ying Li Zhong-wei Shi dong Zhao Da-wei Yin Chinese People's Liberation Army General Hospital Beijing 100853 the writing group of 2019 Chinese expert consensus statement on aspirin application in primary prevention of cardiovascular disease

Aspirin has been widely used in primary prevention of atherosclerotic cardiovascular disease(ASCVD)J141 Aspirin for primary prevention of ASCVD does not significantly reduce all-cause mortality or cardiovascular mortality,and the main benefit of aspirin for primary prevention of ASCVD is a significant reduction in non-fatal ischemic events including myocardial infarction,transient ischemic attack,ischemic stroke,and major cardiovascular events(cardiovascular death,non-fatal myocardial infarction,and non-fatal stroke),whereas the main risk is a significant increase in non-fatal major bleeding events including gastrointestinal bleeding and intracranial hemorrhage.1 Obviously,it makes sense to prescribe aspirin for primary prevention only if the benefits clearly outweigh the *** Europe and the United States,the benefit-risk ratio of aspirin for primary prevention has gradually decreased compared to the past due to the wide application of other primary prevention measures such as blood pressure reduction,smoking cessation,and the use of *** recent large-scale clinical trials have shown that aspirin has no net clinical benefit when used in low-risk populations.19'1^Therefore,aspirin must be used with caution in the primary prevention of ASCVD.

关键词： prevention aspirin cardiovascular

Berberine inhibits hepatic gluconeogenesis via the LKB1-AMPK-TORC2 signaling pathway in streptozotocin-induced diabetic rats

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World Journal of Gastroenterology 2015年第25期21卷 7777-7785页

作者： Shu-Jun Jiang Hui dong Jing-Bin Li Li-Jun Xu xin Zou Kai-Fu Wang Fu-Er Lu Ping Yi Institute of Integrated Traditional Chinese and Western Medicine Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Department of Integrated Traditional Chinese and Western Medicine Tongji Hospital Tongji Medical College Huazhong University of Science and Technology

AIM: To investigate the molecular mechanisms of berberine inhibition of hepatic gluconeogenesis in a diabetic rat ***: The 40 rats were randomly divided into five groups. One group was selected as the normal group. In the remaining groups(n = 8 each), the rats were fed on a high-fat diet for 1 mo and received intravenous injection of streptozotocin for induction of the diabetic models. Berberine(156 mg/kg per day)(berberine group) or metformin(184 mg/kg per day)(metformin group) was intragastrically administered to the diabetic rats and 5-aminoimidazole-4-carboxamide1-β-D-ribofuranoside(AICAR)(0.5 mg/kg per day)(AICAR group) was subcutaneously injected to the diabetic rats for 12 wk. The remaining eight diabetic rats served as the model group. Fasting plasma glucose and insulin levels as well as lipid profile were *** expressions of proteins were examined by western blotting. The nuclear translocation of CREB-regulated transcription co-activator(TORC)2 was observed by immunohistochemical staining. RESULTS: Berberine improved impaired glucose tolerance and decreased plasma hyperlipidemia. Moreover, berberine decreased fasting plasma insulin and homeostasis model assessment of insulin resistance(HOMA-IR). Berberine upregulated protein expression of liver kinase(LK)B1, AMP-activated protein kinase(AMPK) and phosphorylated AMPK(p-AMPK). The level of phophorylated TORC2(p-TORC2) protein in the cytoplasm was higher in the berberine group than in the model group, and no significant difference in total TORC2 protein level was observed. Immunohistochemical staining revealed that more TORC2 was localized in the cytoplasm of the berberine group than in the model group. Moreover, berberine treatment downregulated protein expression of the key gluconeogenic enzymes(phosphoenolpyruvate carboxykinase and glucose-6-phosphatase) in the liver tissues. CONCLUSION: Our findings revealed that berberine inhibited hepatic gluconeogenesis via the regulation of the LKB1-AMP

关键词： Berberine Diabetes AMPK LKB1 Hepaticgluconeogenesis TORC2

Low lighting image enhancement using local maximum color value prior

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Frontiers of Computer Science 2016年第1期10卷 147-156页

作者： Xuan dong Jiangtao WEN Department of Computer Science and Technology Tsinghua University Beijing 100084 China

We study the problem of low lighting image en- hancement. Previous enhancement methods for images un- der low lighting conditions usually fail to consider the factor of image degradation during image formation. As a result, the lost contrast could not be recovered after enhancement. This paper will adaptively recover the contrast and adjust the exposure for low lighting images. Our first contribution is the modeling of image degradation in low lighting con- ditions. Then, the local maximum color value prior is pro- posed, i.e., in most regions of well exposed images, the lo- cal maximum color value of a pixel will be very high. By combining the image degradation model and local maximum color value prior, we propose to recover the un-degraded im- ages under low lighting conditions. Last, an adaptive expo- sure adjustment module is proposed to obtain the final result. We show that our approach enables better enhancement com- paring with popular image editing tools and academic algo- rithms.

关键词： low lighting enhancement image degradationmodel

Adaptive Electric Load Forecaster

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Tsinghua Science and Technology 2015年第2期20卷 164-174页

作者： Mingchui dong Chinwang Lou the Department of Electrical and Computer Engineering University of Macao

In this paper, a methodology, Self-Developing and Self-Adaptive Fuzzy Neural Networks using Type-2 Fuzzy Bayesian Ying-Yang Learning （SDSA-FNN-T2FBYYL） algorithm and multi-objective optimization is proposed. The features of this methodology are as follows：（1） A Bayesian Ying-Yang Learning （BYYL） algorithm is used to construct a compact but high-performance system automatically. （2） A novel multi-objective T2FBYYL is presented that integrates the T2 fuzzy theory with BYYL to automatically construct its best structure and better tackle various data uncertainty problems simultaneously. （3） The weighted sum multi-objective optimization technique with combinations of different weightings is implemented to achieve the best trade-off among multiple objectives in the T2FBYYL. The proposed methods are applied to electric load forecast using a real operational dataset collected from Macao electric utility. The test results reveal that the proposed method is superior to other existing relevant techniques.

关键词： load forecaster Bayesian Ying-Yang learning algorithm type-2 fuzzy theory

Influences of different diluents on ignition delay of syngas at gas turbine conditions：A numerical study

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Chinese Journal of Chemical Engineering 2017年第1期25卷 79-88页

作者： dong He weiping Yan MOE's Key Lab of Condition Monitoring and Control for Power Plant Equipment North China Electric Power University Baoding 071003 China

Ignition delay of syngas is an important factor that affects stable operation of combustor and adding diluents to syngas can reduce NO_x *** paper used H_2O,CO_2 and N_2 as diluents and calculated ignition delay of syngas in temperature range of 900-1400 K and at pressures of 10 and 30 atm *** high temperature range,comparing with N_2 dilution,adding H_2O and CO_2 can significantly inhibit autoignition of syngas because they have higher collision efficiencies in reaction H + O_2(+ M) = HO_2(+ M).As for low temperature conditions,adding H_2O can increase reactivity of syngas,especially under high pressure,because of its high collision efficiency in reaction H_2O_2(+ M) = 2OH(+ M).Comparing with different dilution rates shows that for syngas and operating conditions in this paper,adding N_2 mainly influences temperature rising process of syngas combustion,thus inhibiting reactivity of *** addition,this paper calculated ignition delay of syngas at different equivalence ratios(φ= 0.5,1.0).Higher equivalence ratio(φ≤1) means that less air(especially N_2) needs to be heated,thus promoting ignition of syngas,

关键词： Ignition delay Reaction mechanism Combustion Kinetic modeling Syngas