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Vascular Damages in Rats Immunized by α_1-Adrenoceptor Peptides

Cellular & Molecular Immunology 2008年第5期5卷 349-356页

作者： Zihua Zhou Yuhua Liao Liudong Li Fen wei Bin wang Yumiao wei Min wang xiang Cheng Institute of Cardiology Union Hospital Tongji Medical College of Huazhong University of Science and Technology Wuhan 430022 China

Autoantibodies against the α1-adrenoceptor which had agonist activity as norepinephrine might play roles in the progression of hypertension, but whether the autoantibodies could induce vascular remodeling as norepinephrine is not clear. In this paper, the models with antibodies against the α1-adrenoceptor were made by immunizing Wistar rats with the synthesized the second extracellular loop of α1-adrenoceptor peptides. The homo-age male Wistar rats received BSA in the same immunizing manner and male spontaneous hypertensive rats （SHR） were used as control. All the rats were raised for one year. The blood pressure and morphological changes of arteries were measured. In the end, despite the systolic blood pressure of immunized rats had no difference with normal control, the media thickness of aortas and ratio of media to lumen in the third-order arteries of mesenteric vasculature were increased in immunized rats. The observation with electron microscope showed that the mitochondria of vascular smooth muscle cells （VSMCs） had notable hyperplasia, and the interstitial collagen fibril was increased too. The effects of purified antibodies against α1-adrenoceptor on the proliferation of cultured VSMCs, and the expressions of c-jun, c-fos and α1-adrenoceptor were detected. The results showed that the antibodies could promote the proliferation of cultured VSMCs, and enhance the expression of c-jun both in vitro and in vivo. So we concluded that antibodies against the α1-adrenoceptor could contribute to vascular damages in rats by stimulating the growth of VSMCs which might be caused by the increased c-jun expression, and might play particular roles in the pathological changes of hypertension.

关键词： α1-adrenoceptor autoantibody vascular remodeling

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Surface microtopography and micromechanics of various rank coals

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International Journal of Minerals,Metallurgy and Materials 2019年第11期26卷 1351-1363页

作者： xiang-hui Tian Da-zhao Song Xue-qiu He Hui-fang Liu wei-xiang wang Zhen-lei Li Key Laboratory of Ministry of Education for Efficient Mining and Safety of Metal Mine University of Science and Technology BeijingBeijing 100083China School of Civil and Resources Engineering University of Science and Technology BeijingBeijing 100083China School of Civil Mining and Environmental EngineeringUniversity of WollongongWollongong NSW 2522Australia

For a long time,coalbed gas has brought about various problems to the safety of coal mine *** addition,the mining of gas and coalbed methane(CBM)has attracted much *** occurrence and migration of CBM are believed to be closely related to the micro-surface properties of *** further explore the characteristics of CBM occurrence and migration,in this study,the micro-surface topography,adhesion,and elastic modulus of five metamorphic coals were measured by atomic force microscopy(AFM).The results show that the microtopography of coal fluctuates around 40 nm,reaching a maximum of 66.5 nm and the roughness of the surface decreases with the increase of *** elastic modulus of coal micro-surface varies from 95.40 to 9626.41 MPa,while the adhesion varies from 15.08 to 436.22 nN,and they both exhibit a trend of"M"shape with the increase of ***,a high correlation exists between adhesion and microtopography *** most cases,the adhesion is larger in the concavity area and smaller in the convexity *** research results may provide a new method for revealing the occurrence and migration of CBM and ensure efficient and safe CBM exploitation.

关键词： coal atomic force microscopy microtopography adhesion elastic modulus

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A review on chemical oxygen supply technology within confined spaces: Challenges, strategies, and opportunities toward chemical oxygen generators(COGs)

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International Journal of Minerals,Metallurgy and Materials 2019年第8期26卷 925-937页

作者： Jian-guo Liu Long-zhe Jin Na Gao Sheng-nan Ou Shu wang wei-xiang wang School of Civil and Resource Engineering University of Science and Technology BeijingBeijing 100083China Key Laboratory of High-Efficient Mining and Safety of Metal Mines of the Ministry of Education University of Science and Technology BeijingBeijing 100083China Mine Emergency Technology Research Center University of Science and Technology BeijingBeijing 100083China

Chemical oxygen generators(COGs)have been used worldwide in confined spaces as an emergency oxygen supply technology,mainly because they are independent and have a long shelf ***,a number of challenges related to COGs remain unsolved,and a literature review of the current state of the technology is ***,the present article summarizes the basic information and applications of COGs,including their oxygen production mechanism,components,forming technology,and ignition *** current challenges encountered in applying COGs are discussed,along with the strategies adopted thus far to solve these problems,as found in the published *** literature survey reveals that,although much effort has been devoted to controlling the oxygen production rate and the heat output of COGs,the mechanism of producing toxic gases remains unclear and a reliable and safe ignition system has not been fully ***,future opportunities in the development of COGs are briefly listed.

关键词： chemical oxygen generators oxygen supply technology thermal decomposition catalytic metal fuel combustion

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Subcutaneous angiolipoma in the scrotum: A case report

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World Journal of Clinical Cases 2021年第26期9卷 7954-7958页

作者： Shu-Lin Li Jia-wei Zhang Yu-Qi Wu Ke-Shi Lu Pei Zhu xiang-wei wang Department of Urology Shenzhen University General HospitalShenzhen 518055Guangdong ProvinceChina Clinical Medical Academy Center Shenzhen UniversityShenzhen 518055Guangdong ProvinceChina

BACKGROUND Angiolipoma has been reported in many cases,and it often occurs in the skin of the trunk and ***,angiolipoma in the scrotum is a rare disease with unknown *** condition is difficult to diagnosis with other lumps in the *** SUMMARY A 32-year-old man presented to the urinary department with a history of an enlarged left scrotum with increasing discomfort for about 5 *** examination revealed that there were a palpable mass measuring about 7.0 cm×6.5 cm in the left scrotum,with smooth surfaces but without tenderness or adhesion to the *** showed that there was a hyperechoic mass under the skin of the top scrotum,about 72 mm×64 mm×21 mm in size,with clear borders,uneven internal echo,and abundant blood flow *** human chorionic gonadotropin and alpha-fetoprotein were in normal *** mass resection at the bottom of the left scrotum was performed under local anesthesia with 1%*** pathological examination resulted in a diagnosis of subcutaneous angiolipoma of the *** evidence of recurrence was found at 6 mo after surgery and there were no complaints of *** Angiolipoma is an extremely rare type of benign tumor extremely rarely found in the scrotum,but needs to be considered when evaluating scrotal masses especially when the mass is *** to the characteristics of angiolipoma,surgical resection is the best treatment strategy and it is not prone to recurrence after resection.

关键词： Angiolipoma in the scrotum Ultrasound Pathological diagnosis Operation Case report

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Reviews and Prospects of Clean Steel Production Practices in Ansteel

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Journal of Iron and Steel Research International 2011年第S2期18卷 9-15页

作者： TANG Fu-ping,LI De-gang,LIAO xiang-wei,wang Xiao-feng,WAN Xue-feng,JIA Ji-xiang,ZHANG Ji-gang(Anshan Iron and steel group company,Anshan 114000,Liaoning,China) Anshan Iron & steel Grp Co Anshan 114000 Liaoning Peoples R China

It summarizes the recognition of clean steel through the reviews the historical development and production practices of clean steel of Ansteel in this *** technological characteristic,equipment,controlling capability and new exploratory of clean steel production of Ansteel are *** has also made a new appraisal to the production line of different clean steel from the angle of high efficiency,stabilization and *** prospects of new production technology of clean steel are introduced at the end of the paper.

关键词： clean steel energy-saving and emission reduction low-cost new technology

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Deep learning identification of novel autophagic protein-protein interactions and experimental validation of Beclin 2-Ubiquilin 1 axis in triple-negative breast cancer

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Oncology Research 2025年第1期33卷 67-81页

作者： xiang LI WENKE JIN LIFENG WU HUAN wang XIN XIE wei HUANG BO LIU State Key Laboratory of Southwestern Chinese Medicine Resources School of Pharmacy and College of Medical TechnologyChengdu University of Traditional Chinese MedicineChengdu611137China Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu610041China

Background:Triple-negative breast cancer(TNBC),characterized by its lack of traditional hormone receptors and HER2,presents a significant challenge in oncology due to its poor response to conventional *** is an important process for maintaining cellular homeostasis,and there are currently autophagy biomarkers that play an effective role in the clinical treatment of *** contrast to targeting protein activity,intervention with proteinprotein interaction(PPI)can avoid unrelated crosstalk and regulate the autophagy process with minimal interference ***:Here,we employed Naive Bayes,Decision Tree,and k-Nearest Neighbors to elucidate the complex PPI network associated with autophagy in TNBC,aiming to uncover novel therapeutic ***,the candidate proteins interacting with Beclin 2 were initially screened in MDA-MB-231 cells using Beclin 2 as bait protein by immunoprecipitation-mass spectrometry assay,and the interaction relationship was verified by molecular docking and CO-IP experiments after *** formation,cellular immunofluorescence,cell scratch and 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)tests were used to predict the clinical therapeutic effects of manipulating candidate ***:By developing three PPI classification models and analyzing over 13,000 datasets,we identified 3733 previously unknown autophagy-related *** network analysis revealed the central role of Beclin 2 in autophagy regulation,uncovering its interactions with 39 newly identified ***,the CO-IP studies identified the substantial interaction between Beclin 2 and Ubiquilin 1,which was anticipated by our model and discovered in immunoprecipitation-mass spectrometry assay ***,in vitro investigations showed that overexpressing Beclin 2 increased Ubiquilin 1,promoted autophagy-dependent cell death,and inhibited proliferation and metastasis in MDA-MB-231 ***:This study not

关键词： Triple-negative breast cancer(TNBC) Autophagy Protein-protein interactions(PPI) Artificial intelligence(AI) Beclin 2 Ubiquilin 1

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Vascularity of hepatic VX2 tumors of rabbits: Assessment with conventional power Doppler US and contrast enhanced harmonic power Doppler US

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World Journal of Gastroenterology 2003年第2期9卷 258-261页

作者： Wen-Hua Du wei-Xiao Yang xiang wang Xiu-Qin Xiong Yi Zhou Tao Li Department of US, Daping Hospital & Research Institute of Surgery, the Third Military Medical University, Chongqing 400042, China Dept. of US Daping Hospital & Research Institute of Surgery the Third Military Medical University Chongqing 400042 China. duwenhua001@***

AIM: To investigate the characteristics of the vascularity ofhepatic ***: Six New Zealand rabbits, weighing averagely2.7±0.4 kg, were selected and operated to establish hepaticVX2 tumor carrier model. Hepatic VX2 tumors were thenimaged with conventional B mode US, second harmonicimaging (SHI), color Doppler flow imaging (CDFI), powerDoppler imaging (PDI) and harmonic PDI by a transducerS8 connected to HP-5 500 ultrasound system. A kind of selfmade echo contrast agent was intravenously injected at adose of 0.01 mL/kg through ear vein, and then the venouspassage was cleaned with sterilized ***: Totally, 6 hypoechoic lesions and 3 hyperechoiclesions were found in the six carrier rabbits with a mean sizeabout 2.1±0.4 cm under conventional B mode ultrasound, theywere oval or round in shape with a dear outline or a hypoechoichalo at the margin of the lesions. Contrast agent could notchange the echogenicity of the lesions under conventional Bmode and SHI, however, it could greatly increase the flowsensitivity of the lesions under PDI and harmonic PDI. Nutrientartery of these metastatic lesions might also be well depictedunder contrast enhanced PDI and harmonic ***: Our result suggested that contrast enhancedPDI, especially harmonic PDI, was a promised method inthe detection of vascularity of hepatic tumor nodules.

关键词：肝癌动物模型微血管密度多普勒超声肿瘤转移

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Assessment of hepatic VX2 tumors of rabbits with second harmonic imaging under high and low acoustic pressures

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World Journal of Gastroenterology 2003年第8期9卷 1679-1682页

作者： Wen-Hua Du wei-Xiao Yang xiang wang Xiu-Qin Xiong Yi Zhou Tao Li, Department of Ultrasonography, Daping Hospital and Research Institute of Surgery, the Third Military Medical University, Chongqing 400042, China Department of Ultrasonography Daping Hospital and Research Institute of Surgery the Third Military Medical University Chongqing 400042 China. duwenhua001@***

AIM: To investigate the possible clinical application value of second harmonic imaging under low acoustic ***: Six New Zealand rabbits, averaging 2.7±0.4kg, were selected and operated upon to construct hepatic VX2 tumor carrier model. Hepatic VX2 tumors were imaged with B mode Ultrasonography (US), and second harmonic imaging (SHI) under high mechanic index (1.6) and low mechanic index (0.1). Echo agent was intravenously injected through ear vein at a dose of 0.01 mL/kg under B mode US and high MI SHI, and 0.05 mL/kg under low MI SHI, and then the venous channel was cleaned with sterilized *** the images were recorded by magnetic optics (MO),and they were analyzed further by at least two independent experienced ***: Totally 6 hypoechoic and 3 hyperechoic lesions were found in the six carrier rabbits with a mean size about 2.1±0.4 under B mode ultrasound, they were oval or round in shape with a clear outline or a hypoechoic halo at the margin of the lesions. Contrast agent could not change the echogenicity of the lesions under B mode US and SHI under high acoustic pressure. However, it could greatly increase the real time visualization sensitivity of the lesions with SHI under low acoustic ***: Our results suggest that contrast enhanced SHI with low MI and a bubble non-destructive method would be much more helpful than conventional SHI in our future clinical applications.

关键词：肝肿瘤超声检查次谐波成像低声压

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基于聚乙二醇接枝丙烯酸树酯光固化电解质的制备及性能研究

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高分子学报 2021年第1期52卷 94-101,I0005页

作者：郑鹏轩王向伟王栋于志伟哈尔滨工程大学材料科学与化学工程学院伪装隐身技术与工程研究院哈尔滨150001 山东科技大学材料科学与工程学院青岛266590

聚氧化乙烯(PEO)(聚乙二醇(PEG))和丙烯酸树脂在聚合物基电解质中具有很好的应用,本文通过紫外光引发单/双官能度的聚乙二醇接枝丙烯酸树脂单体聚合构建了离子电导率高、易于封装,可避免电解质泄漏的准固态聚合物电解质.通过调控聚乙二... 详细信息

聚氧化乙烯(PEO)(聚乙二醇(PEG))和丙烯酸树脂在聚合物基电解质中具有很好的应用,本文通过紫外光引发单/双官能度的聚乙二醇接枝丙烯酸树脂单体聚合构建了离子电导率高、易于封装,可避免电解质泄漏的准固态聚合物电解质.通过调控聚乙二醇二甲基丙烯酸酯(PEGDA)和甲氧基聚乙二醇单甲基丙烯酸酯(PEGMA)2种单体的比例以及锂盐溶液的含量,成功制备出具有高离电导率的准固态聚合物电解质.采用傅里叶变换红外光谱仪(FTIR),电化学工作站对PEGMA/PEGDA基聚合物电解质进行表征,研究各组分比例对电解质的电化学性能影响.当PEGMA/PEGDA单体比例为75/25,锂盐溶液的占比为75%时,形成的薄膜状态电解质表现出1.96×10^−3 S·cm^−1的高离子电导率,较原始配比提高了14倍.将制备的电解质应用于电致变色器件,在580个变色循环后,器件依然可以实现稳定快速的颜色切换,2种颜色变换时间均在3 s以内,本文中研究的聚醚接枝丙烯酸树酯基电解质材料在电致变色器件中有较好的应用前景.

关键词：聚醚接枝丙烯酸树脂光固化准固态聚合物电解质电致变色

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YG8硬质合金与45钢非晶钎焊行为

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材料热处理学报 2017年第3期38卷 128-132页

作者：王微王春香王刚安徽机电职业技术学院机械工程系安徽芜湖241000 安徽工程大学机械与汽车工程学院安徽芜湖241000

为改善YG8硬质合金与45钢的焊接性能,采用Cu_(39.37)Ti_(32.19)Zr_(19.38)Ni_(9.06)(at%)非晶态钎料对YG8硬质合金和45钢进行钎焊。通过XRD、SEM、万能试验机对钎料的微观结构以及钎焊接头形貌、析出相和力学性能进行分析。结果表明:在... 详细信息

为改善YG8硬质合金与45钢的焊接性能,采用Cu_(39.37)Ti_(32.19)Zr_(19.38)Ni_(9.06)(at%)非晶态钎料对YG8硬质合金和45钢进行钎焊。通过XRD、SEM、万能试验机对钎料的微观结构以及钎焊接头形貌、析出相和力学性能进行分析。结果表明:在一定钎焊温度下,随钎焊时间的增加,接头强度逐渐减小,有明显的裂纹,且裂纹在YG8硬质合金一侧反应层中萌生并扩展。在钎焊温度900℃,钎焊时间10 min时获得的抗拉强度最高,约为250 MPa。焊接头强度与YG8硬质合金一侧形成的反应层厚度有关。通过计算得到了反应层厚度形成的激活能Q和反应层生长速度A_0。

关键词：钎焊非晶钎料结合强度反应层厚度

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