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Microrna-1224-5p Is a Potential Prognostic and Therapeutic Biomarker in Glioblastoma:Integrating Bioinformatics and Clinical Analyses

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Current Medical Science 2022年第3期42卷 584-596页

作者： Xing wei Qing-mei ZHANG Chang LIU Song WU wei-xia nong Ying-ying GE Li-na LIN Feng LI xiao-xun XIE Bin LUO Department of Histology and Embryology School of Pre-clinical MedicineGuangxi Medical UniversityNanning 530021China Department of Neurology the First Affiliated HospitalGuangxi Medical UniversityNanning 530021China Central Laboratory of Pre-Clinical Medicine(Key Laboratory of Guangxi Colleges and Universities) Guangxi Medical UniversityNanning 530021China Department of Neurosurgery the First Affiliated HospitalGuangxi Medical UniversityNanning 530021China Key Laboratory of Early Prevention and Treatment of Regional High Frequency Tumor(Guangxi Medical University) Ministry of EducationNanning 530021China

Objective Glioblastoma(GBM)is the most common,invasive,and malignant primary brain tumor with a poor prognosis and high recurrence ***’s known that some microRNAs(miRNAs)which are associated with tumorigenesis and progression can be considered as prognostic and therapeutic targets in tumors including *** study aims to highlight the potential role of the core miRNAs in GBM and their potential use as a prognostic and therapeutic *** Differentially expressed miRNAs(DEmiRNAs)were identified in GBM by integrating miRNA-sequencing results and a GBM microarray dataset from the Gene Expression Omnibus(GEO)database through bioinformatics *** dysregulated miRNAs were identified by survival analysis through Chinese Glioma Genome Atlas(CGGA).Target genes of the dysregulated miRNAs were predicted on MiRWalk and miRTarBase ***2.0 database,Gene ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathways analysis were used to analyze the function of the dysregulated ***,protein-protein interaction(PPI)network analysis was used to identify the top 20 hub targets of the up-regulated and down-regulated miRNAs,***,core miRNAs in GBM were identified by constructing dysregulated miRNA-differentially expressed hub gene *** of the core miRNAs expression was detected in 41 GBM tissues compared to 8 normal brain ***,the potential biomarkers were identified by clinical correlation analysis and survival *** Totally,68 intersecting DEmiRNAs were identified,40 of which were upregulated and the other 28 miRNAs were *** upregulated and 4 downregulated miRNAs showed prognostic *** differentially expressed hub genes were regulated by the miR-28-5p and miR-1224-5p,which were respectively upregulated and downregulated in *** correlation between miR-1224-5p level and recurrence was statistically significant(P=0.011).Survival analysis showed that high

关键词： glioblastoma microRNAs microRNA-1224-5p bioinformatics

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High Expression of Fibronectin 1 Predicts a Poor Prognosis in Glioblastoma

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Current Medical Science 2022年第5期42卷 1055-1065页

作者： Song WU Chang LIU Xing wei wei-xia nong Li-na LIN Feng LI xiao-xun XIE Xing-sheng LIAO Bin LUO Qing-mei ZHANG Shao-wen xiaO Department of Neurosurgery the First Affiliated HospitalGuangxi Medical UniversityNanning530021China Department of Histology and Embryology School of Pre-clinical MedicineGuangxi Medical UniversityNanning530021China Central Laboratory of Pre-Clinical Medicine(Key Laboratory of Guangxi Colleges and Universities) Guangxi Medical UniversityNanning530021China Key Laboratory of Early Prevention and Treatment of Regional High Frequency Tumor(Guangxi Medical University) Ministry of EducationNanning530021China Department of Neurology the First Affiliated HospitalGuangxi Medical UniversityNanning530021China

Objective Glioblastoma multiforme(GBM),the most malignant intracranial neoplasm,is associated with a high mortality and recurrence rate due to the aggressive nature and heterogeneity of the *** of the molecular markers involved in the tumorigenesis of GBM are essential in prognosis,diagnosis,and *** to the limitations of therapeutic effects,this study aims to explore novel biomarkers with prognostic value and to provide new insights into therapeutic *** The expression profile of mRNAs in GBM was detected by RNA-sequencing,and differentially expressed genes were identified by integrating the data from RNA-seq results and the GEPIA2 *** the total 40 hub genes,FN1,P4HB,and PPIB showed prognostic significance based on both GEPIA2 and CGGA *** validation of FN1,P4HB,and PPIB expression by qPCR and correlation analysis with clinicopathological features were performed in 41 GBM tissues from our *** Kaplan-Meier analysis revealed that FN1 and P4HB expressions levels were related to the overall survival(OS)of GBM patients(P<0.05).Multivariate analysis showed that FN1 overexpression(HR=9.199,P=0.002)was an independent and unfavorable prognostic factor for GBM *** median survival time was 8.5 months and 21 months for high and low expressions of FN1,*** It was suggested that FN1 could be an ideal target for prognosis and a potential therapeutic target in GBM.

关键词： glioblastoma FN1 overall survival prognosis

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FMR1NB Involved in Glioma Tumorigenesis Is a Promising Target for Prognosis and Therapy

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Current Medical Science 2022年第4期42卷 803-816页

作者： Shui-qing BI Ya PENG Zong-dang wei Sheng-zhong YAO Bin LUO Ying-ying GE xiao-xun XIE wei-xia nong Chang LIU Shao-wen xiaO Qing-mei ZHANG Department of Neurosurgery the First Affiliated Hospital of Guangxi Medical UniversityNanning 530021China Department of Histology and Embryology School of Pre-Clinical MedicineGuangxi Medical UniversityNanning 530021China Central Laboratory School of Pre-Clinical MedicineGuangxi Medical UniversityNanning 530021China

Objective:Cancer/testis antigen FMR1NB is aberrantly expressed in various types of cancer,but not in normal tissues except for *** study aimed to investigate the expression and functional role of FMR1NB in ***:The expression of FMR1NB mRNA and protein was determined using RT-PCR and immunohistochemistry,respectively,in glioma specimens from 83 patients at *** effects of siRNA-mediated FMR1NB silencing on malignant biological behaviors were evaluated in glioma cell lines Al 72 and ***:FMR1NB mRNA and protein expression was detected in 58.8%(77/131)and 46.34%(57/123)of glioma tissues,***1NB protein was positively correlated with World Health Organization grade and found to be an independent prognostic marker for poor *** of FMR1NB induced apoptosis and suppressed proliferation,adhesion,migration,and invasion by modulating the expression of cyclin A,CDK2,caspase-3,E-cadherin,and N-cadherin in A172 and U251 ***:Our findings suggest that FMR1NB contributes to the tumorigenesis of glioma cells and may represent a potential prognostic biomarker and an attractive therapeutic target in glioma.

关键词： cancer/testis antigen FMR1NB glioma

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Cancer-testis Antigen OY-TES-1 Expression and Immunogenicity in Hepatocellular Carcinoma

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Current Medical Science 2020年第4期40卷 719-728页

作者： Bin LUO xiang YUN Jing LI Rong FAN Wen-wen GUO Chang LIU Yong-da LIN Ying-ying GE xia ZENG Shui-qing BI wei-xia nong Qing-mei ZHANG xiao-xun XIE School of Basic Medical Sciences Guangxi Medical UniversityNanning 530021China Department of Surgery the First Affiliated HospitalGuangxi Medical UniversityNanning 530021China Clinical Laboratory Chinese Medicine HospitalQuanzhou 362000China School of Basic Medical Sciences Guangxi University of Chinese MedicineNanning 530021China Department of Pathology the People's Hospital of Guangxi Zhuang Autonomous RegionNanning 530021China Guangxi Key Laboratory of Early Prevention and Treatmentfor Regional High Frequency Tumor Guangxi Medical UniversityNanning 530021China Key Laboratory Research on Preclinical Medicine Guangxi Medical UniversityNanning 530021China

Summary:Cancer testis(CT)antigens have received particular attention in cancer ***-TES-1 is a member of CT *** study was to evaluate OY-TES-1 expression and immunogenicity in hepatocelluar carcinoma(HCC).OY-TES-1 mRNA expression was detected in 56 HCC tissues and 5 normal liver tissues by reverse transcriptase PCR(RT-PCR).Of the 56 cases of HCC tissues tested,37 cases had tumor and matched adjacent non-cancer tissues and were subjected to both RT-PCR and quantitative real-time ***-TES-1 protein was subsequently observed on a panel of tissue *** from patients were tested for OY-TES-1 antibody by *** identify OY-TES-1 capable of inducing cellular immune response,OY-TES-1 protein was used to sensitize dentritic cells and the cytotoxicity effect was measured in *** results showed that OY-TES-1 mRNA was highly expressed in 41 of the 56(73.21%)HCC tissues,whereas none in 5 normal liver ***-TES-1 mRNA was frequently expressed not only in HCC tissues(72.97%,27/37),but also in paired adjacent non-cancer tissues(64.86%,24/37).But the mean expression level of OY-TES-1 mRNA in HCC tissues was significantly higher than that in adjacent non-cancer tissues(0.76854 vs.0.09834,P=0.021).Immunohistochemistry showed that OY-TES-1 protein expression was detected in 6 of the 49 cases of HCC tissues,and absent in 9 cases of normal liver and 6 cases of cirrhosis *** was detected in 10 of the 45 HCC patients,but not detected in 17 cirrhosis patients and 76 healthy *** specific cytotoxic T cells elicited by OY-TES-1 could kill HLA-A2^+HCC cell line which expressed *** target lysis was mainly HLA class I-dependent and could be blocked by antibodies against monomorphic HLA class I but not HLA class II *** summary,OY-TES-1 expression is upregulated in HCC tissues and can be recognized by humoral and cellular responses,which suggests that OY-TES-1 is an attractive target for tumor immunotherapy in

关键词： cancer testis antigen hepatocelluar cancer tumor immunotherapy

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Relationship between parenting stress and behavioral and emotional problems in preschool children: A mediation effect analysis

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World Journal of Psychiatry 2025年第1期15卷 128-136页

作者： Zhi-wei Fu Yue-Jing Li Ran Yu Rui-Qing Guo Li-xia Gao Sheng-xia Zhao Department of Children's Health Shijiazhuang Maternity and Child Healthcare HospitalShijiazhuang 050000Hebei ProvinceChina

BACKGROUND Emotional reactions,such as anxiety,irritability,and aggressive behavior,have attracted clinical attention as behavioral and emotional problems in preschool-age *** To investigate the current status of family rearing,parental stress,and behavioral and emotional problems of preschool children and to analyze the mediating effect of the current status of family rearing on parental stress and behavioral/emo-tional *** We use convenience sampling to select 258 preschool children in the physical examination center of our hospital from October 2021 to September *** children and their parents were evaluated using a questionnaire ***'s correlation was used to analyze the correlation between child behavioral and emotional problems and parental stress and family rearing,and the structural equation model was constructed to test the mediating *** The score for behavioral/emotional problems of 258 preschool children was(27.54±3.63),the score for parental stress was(87.64±11.34),and the score for parental family rearing was(31.54±5.24).There was a positive correlation between the behavioral and emotional problems of the children and the“hostile/mandatory”parenting style;meanwhile,showed a negative correlation with the“support/participation”parenting style(all P<0.05).The intermediary effect value between the family upbringing of parents in parental stress and children's behavior problems was 29.89%.CONCLUSION Parental family upbringing has a mediating effect between parental stress and behavioral and emotional problems of *** paying attention to the behavioral and emotional problems of preschool-age children,clinical medical staff should provide correct and reasonable parenting advice to their parents to promote the mental health of preschool-age children.

关键词： Preschool children Parenting stress Children's behavioral and emotional problems Family rearing Mediating effect

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Exfoliation and dispersion of graphene in ethanol-water mixtures

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Frontiers of Materials Science 2012年第2期6卷 176-182页

作者： wei-wei LIU Bao-Yu xia xiao-xia WANG Jian-nong WANG Shanghai Key Laboratory for Laser Processing and Materials Modification School of Materials Science and EngineeringShanghai Jiao Tong University800 Dong Chuan RoadShanghai 200240China School of Materials Science and Engineering Tongji University1239 Siping RoadShanghai 200092China Key Laboratory of Safety Science of Pressurized System(Ministry of Education) ScHool of Mechanical and Power EngineeringEast China University of Science and Technology130 Meilong RoadShanghai 200237China

Graphene has attracted much attention as a new nano-carbon for its unique structure and properties. However, production and dispersion of unfunctionalized graphene are still big challenges. Herein, we demonstrate a simple method for preparation and dispersion of such graphene with low cost and non toxicum. This approach is achieved by exfoliating graphite in an ethanol/water mixture and forming stable dispersion of mono- and few-layer graphenes. The ratio of ethanol/water in the mixture is found to be crucial to both the exfoliation and dispersion processes. Exfoliation in pure water or pure ethanol produces no graphene. This method avoids the conventional use of harsh oxidants and surfactants; therefore, the graphitic structure is well maintained without destruction. Benefiting from the use of ethanol and water, it can be easy to prepare transparent and conductive graphene films by vacuum filtering or spray method, and does not need special post-treatment to remove the impurity, which could be beneficial for potential applications in electronic, optic and energy areas.

关键词： graphene liquid-phase exfoliation transparent conductive film solubilityparameter

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Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑Life Lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： wei-Min Qin Zhongliang Li Wen‑xia Su Jia‑Min Hu Hanqin Zou Zhixuan Wu Zhiqin Ruan Yue‑Peng Cai Kang Li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of Li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high Li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous Li deposition and highly reversible Li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous Li+flux Lithium metal battery

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Stroma-epithelium crosstalk in prostate cancer

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Asian Journal of Andrology 2009年第1期11卷 28-35页

作者： Yi-nong Niu Shu-Jie xia Department of Urology Beijing Chaoyang Hospital Capital Medical University Beijing 100020 China Department of Urology Shanghai First People＇s Hospital Shanghai Jiao Tong University Shanghai 200080 China

The critical role played by stroma-epithelium crosstalk in carcinogenesis and progression of prostate cancer has been increasingly recognized. These interactions are mediated by a variety of paracrine factors secreted by cancer cells and/or stromal cells. In human prostate cancer, reactive stroma is characterized by an increase in myofibroblasts and a corresponding amplification of extracellular matrix production and angiogenesis. Permanent genetic mutations have been reported in stromal cells as well as in tumour cells. Transforming growth factor-J3, vascular endothelial growth factor, platelet-derived growth factor and fibroblast growth factor signalling pathways are involved in the process of angiogenesis, whereas hepatocyte growth factor, insulin-like growth factor-l, epidermal growth factor, CXC12 and Interleukin-6 play active roles in the progression, androgen-independent conversion and distal metastasis of prostate cancer. Some soluble factors have reciprocal interactions with androgens and the androgen receptor （AR）, and can even activate AR in the absence of the androgen ligand. In this article, we review the complex interactions between cancer cells and the surrounding microenvironment, and discuss the potential therapeutic targets in the stromal compartment of prostate cancer.

关键词： angiogenesis metastasis paracrine growth factors prostate prostatic neoplasm stroma

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Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu xiangbing Wu wei Wu Ying Wang Yan Sun Lingxiao Deng Melissa Walker Chen Chen Heqiao Dai Qi Han Ying Ding Yongzhi xia George Smith Rui Li Nai-Kui Liu xiao-Ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

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基于个体化机器学习的原发性免疫性血小板减少症危重出血预测模型:一项全国前瞻性队列研究

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Science Bulletin 2023年第18期68卷 2106-2114,M0004页

作者： Zhuo-Yu An Ye-Jun Wu Yu Hou Heng Mei wei-xia nong Wen-Qian Li Hu Zhou Ru Feng Jian-Ping Shen Jun Peng Hai Zhou Yi Liu Yong-Ping Song Lin-Hua Yang Mei-Yun Fang Jian-Yong Li Yun-Feng Cheng Peng Liu Ya-Jing Xu Zhao Wang Yi Luo Zhen Cai Hui Liu Jing-Wen Wang Juan Li Xi Zhang Zi-Min Sun xiao-Yu Zhu Xin Wang Rong Fu Liang Huang Shao-Yuan Wang Tong-Hua Yang Li-Ping Su Liang-Ming Ma Xie-Qun Chen Dai-Hong Liu Hong-xia Yao Jia Feng Hong-Yu Zhang Ming Jiang Ze-Ping Zhou Wen-Sheng Wang Xu-Liang Shen Yangjin Baima Yue-Ying Li Qian-Fei Wang Qiu-Sha Huang Hai-xia Fu xiao-Lu Zhu Yun He Qian Jiang Hao Jiang Jin Lu xiang-Yu Zhao Ying-Jun Chang Tao Wu Yao-Zhu Pan Lin Qiu Da Gao A-Rong Jin wei Li Su-Jun Gao Lei Zhang Ming Hou xiao-Jun Huang xiao-Hui Zhang on behalf of the National Cooperative ITP Working Group Peking University People’s Hospital Peking University Institute of HematologyBeijing 100044China Collaborative Innovation Center of Hematology Peking UniversityBeijing 100044China Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing 100044China National Clinical Research Center for Hematologic Disease Beijing 100044China Department of Hematology Qilu HospitalCheeloo College of MedicineShandong UniversityJinan 250014China Institute of Hematology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430074China Department of Hematology First Affiliated HospitalSchool of MedicineShihezi UniversityShihezi 832002China Department of Hematology Qinghai Provincial People’s HospitalXining 810007China Henan Cancer Hospital Affiliated Cancer Hospital of Zhengzhou UniversityHenan Institute of HematologyZhengzhou 450008China Department of Hematology Beijing HospitalBeijing 100044China Department of Hematology Zhejiang Provincial Hospital of Traditional Chinese MedicineHangzhou 310006China Department of Hematology Senior Department of Hematologythe Fifth Medical Center of PLA General HospitalBeijing 100044China Department of Hematology the Second Hospital of Shanxi Medical UniversityTaiyuan 030001China Department of Hematology Affiliated Zhongshan Hospital of Dalian UniversityDalian 116001China Department of Hematology The First Affiliated Hospital with Nanjing Medical University(Jiangsu Province Hospital)Nanjing 210029China Department of Hematology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Hematology Xiangya HospitalCentral South UniversityChangsha 410008China Department of Hematology Beijing Friendship HospitalCapital Medical UniversityBeijing 100044China Institute of Hematology the First Affiliated HospitalZhejiang UniversityHangzhou 310058China Department of Hematology Beijing Tongren HospitalBeijing 100005China Department of Hematology The First Affiliated HospitalSun Yat-sen UniversityGuang

原发性免疫性血小板减少症(ITP)中少见但至关重要的危重出血事件,给患者的预后、生活质量和治疗决策带来严重影响。尽管有一些研究探讨了ITP中与危重出血相关的风险因素,但目前尚缺乏大样本数据、大规模多中心研究结果以及针对ITP患者... 详细信息

原发性免疫性血小板减少症(ITP)中少见但至关重要的危重出血事件,给患者的预后、生活质量和治疗决策带来严重影响。尽管有一些研究探讨了ITP中与危重出血相关的风险因素,但目前尚缺乏大样本数据、大规模多中心研究结果以及针对ITP患者致命出血事件的预测模型。本研究首次采用国际血栓与止血学会新提出的ITP致命出血标准,利用大样本数据开发了首个基于机器学习的在线应用,用于预测ITP患者的致命出血.研究中,我们使用中国各地大型多中心数据进行开发,并对全国39家医疗中心进行为期一年的外部测试,得到了较好的训练、验证和测试数据集预测能力该基于新算法的便捷网络工具能够快速识别ITP患者的出血风险,辅助临床决策,有望未来降低不良事件的发生。

关键词： Critical bleeding Severe bleeding Immune thrombocytopenia Machine learning Prediction model

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