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Preoperative prediction of lymphovascular and perineural invasion in gastric cancer using spectral computed tomography imaging and machine learning

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World Journal of Gastroenterology 2024年第6期30卷 542-555页

作者： Hui-Ting Ge Jian-Wu Chen Li-Li Wang Tian-Xiu Zou Bin Zheng Yuan-Fen Liu Yun-Jing Xue wei-wen lin Department of Radiology Fujian Medical University Union HospitalFuzhou 350001Fujian ProvinceChina Fujian Key Laboratory of Intelligent Imaging and Precision Radiotherapy for Tumors Fujian Medical UniversityFuzhou 350001Fujian ProvinceChina Digestive Hematological and Breast MalignanciesClinical Research Center for Radiology and Radiotherapy of Fujian ProvinceFuzhou 350001Fujian ProvinceChina Department of Radiation Oncology Fujian Medical University Union HospitalFuzhou 350001Fujian ProvinceChina Department of Diagnostic Radiology Fujian Medical University Union HospitalFuzhou 350001Fujian ProvinceChina School of Electrical and Computer Engineering University of OklahomaOklahomaOK 73019United States

BACKGROUND Lymphovascular invasion(LVI)and perineural invasion(PNI)are important prognostic factors for gastric cancer(GC)that indicate an increased risk of metastasis and poor *** preoperative prediction of LVI/PNI status could help clinicians identify high-risk patients and guide treatment ***,prior models using conventional computed tomography(CT)images to predict LVI or PNI separately have had limited *** CT provides quantitative enhancement parameters that may better capture tumor *** hypothesized that a predictive model combining clinical and spectral CT parameters would accurately preoperatively predict LVI/PNI status in GC *** To develop and test a machine learning model that fuses spectral CT parameters and clinical indicators to predict LVI/PNI status *** This study used a retrospective dataset involving 257 GC patients(training cohort,n=172;validation cohort,n=85).First,several clinical indicators,including serum tumor markers,CT-TN stages and CT-detected extramural vein invasion(CT-EMVI),were extracted,as were quantitative spectral CT parameters from the delineated tumor ***,a two-step feature selection approach using correlation-based methods and information gain ranking inside a 10-fold cross-validation loop was utilized to select informative clinical and spectral CT parameters.A logistic regression(LR)-based nomogram model was subsequently constructed to predict LVI/PNI status,and its performance was evaluated using the area under the receiver operating characteristic curve(AUC).RESULTS In both the training and validation cohorts,CT T3-4 stage,CT-N positive status,and CT-EMVI positive status are more prevalent in the LVI/PNI-positive group and these differences are statistically significant(P<0.05).LR analysis of the training group showed preoperative CT-T stage,CT-EMVI,single-energy CT values of 70 keV of venous phase(VP-70 keV),and the ratio of standardized iodine co

关键词： Spectral computed tomography Gastric cancer Lymphovascular invasion Perineural invasion

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A Numerical Calculation Algorithm of the Inclination Function Based on the Representation of SO(3) Group

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Acta Mathematicae Applicatae Sinica 2024年第1期40卷 137-148页

作者： Yu-xiao wei wen-lin Tang Department of Geophysics School of Geology Engineering and GeomaticsChang’An UniversityXi’an710064China Key Laboratory of Electronics and Information Technology for Space Systems National Space Science CenterChinese Academy of SciencesBeijing100190China

In the determination of the Earth gravity field in satellite geodesy, the inclination functions represent the projection of data observed along the orbital plane of a satellite orbit into the sphere in the terrestial reference frame. The inclination functions in this work is studied from a group theoretical perspective. The inclination functions are proved to generate a representation of the SO(3) group. An orthogonal relation of the inclination functions is derived and some recurrence relations for the inclination functions are given, based on which an algorithm to calculate the inclination functions is proposed.

关键词： SO(3)group inclination function satellite geodesy representation of SO(3)

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Experimental,Numerical,and Analytical Studies on the Bending of Mechanically lined Pipe

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China Ocean Engineering 2024年第2期38卷 221-232页

作者： wei wen-bin YUAN lin ZHOU Jia-sheng LIU Zheng State Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin UniversityTianjin 300072China School of Civil Engineering Tianjin UniversityTianjin 300072China School of Mechanical Engineering Tianjin UniversityTianjin 300072China

Mechanically lined pipe(MLP)is often used for offshore oil and gas transport because of its low cost and corrosion *** installation and operation,the pipe may undergo severe bending deformation,which causes the liner to separate from the outer pipe and buckles,affecting the stability of the whole *** this paper,the buckling response of MLP subjected to bending is investigated to clarify its bending characteristics by employing both experiments,numerical simulation,as theoretical *** types of MLPs were manufactured with GB 45 carbon steel(SLP)and Al 6061(ALP)used as the outer pipe material,*** hydraulic expansion and bending experiments of small-scale MLPs are *** addition to the ovalized shape of the cross-section for the SLP specimens,the copper liner was found to wrinkle on the compressive *** contrast,the liner of ALP remains intact without developing any wrinkling and collapse *** addition,a dedicated numerical framework and theoretical models were also *** was found both the manufacturing and bending responses of the MLP can be well reproduced,and the predicted maximum moment and critical curvatures are in good agreement with the experimental results.

关键词： lined pipe bending nonlinear ring theory buckling plasticity

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A rare case of hepatic vein-portal vein fistula with hepatolithiasis presenting as cholangiocarcinoma

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 538-540页

作者： wei Li wen lin Le Xiao General Surgery Center The General Hospital of Western Theater CommandChengdu 610083China

To the Editor: We sincerely applaud the work by Tang et al., in which they described caudate lobe-sparing subtotal hepatectomy as treatment for intrahepatic arterioportal fistulas [ 1 ]. Compared to intrahepatic arterioportal fistulas, portal vein-hepatic vein fistulas are rarely reported. Patients typically lack clinical symptoms such as hyperammonemia, cholestatic jaundice, and hypoglycemia, unless the shunt becomes relatively large [ 2, 3 ]. Herein, we describe partial hepatectomy as a treatment for cases of left portal vein-middle hepatic vein fistulas.

关键词： hepatic clinical

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Rational design and energy catalytic application of high-loading single-atom catalysts

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Rare Metals 2024年第10期43卷 4844-4866页

作者： Zi-wei Deng Yue Liu Jie lin wen-Xing Chen Energy and Catalysis Center School of Materials Science and EngineeringBeijing Institute of Technology Ningbo Institute of Materials Technology and Engineering Chinese Academy of Science

It is well known that single-atom catalysts(SACs)have become a hot topic in the field of catalysis due to their advantages such as 100% metal atom utilization efficiency,high catalytic activity and selectivity compared with conventional catalysts and nanocatalysts. However, the isolated metal atoms on SACs have thermodynamic instability and tend to agglomerate, which limit their catalytic ***, it is of great significance to synthesize stable and high-loading single-atom catalysts(HLSACs). In this paper,we review the research progress of HLSACs from two aspects:design and application. Firstly, we comprehensively introduce the synthesis strategies of HLSACs, namely, top-down and bottom-up methods. Secondly, we overview the application status of HLSACs in three fields: electrocatalysis, thermal catalysis and photocatalysis. Finally, we summarize the development prospects and challenges of HLSACs.

关键词： Design Electrocatalysis High-loading single-atom catalysts Photocatalysis Thermal catalysis

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Nearly optimal stochastic approximation for online principal subspace estimation

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Science China Mathematics 2023年第5期66卷 1087-1122页

作者： Xin Liang Zhen-Chen Guo Li Wang Ren-Cang Li wen-wei lin Yau Mathematical Sciences Center Tsinghua UniversityBeijing 100084China Yanqi Lake Beijing Institute of Mathematical Sciences and Applications Beijing 101408China Department of Mathematics Nanjing UniversityNanjing 210093China Department of Mathematics University of Texas at ArlingtonArlingtonTX 76019USA Department of Mathematics Hong Kong Baptist UniversityHong KongChina Nanjing Center for Applied Mathematics Nanjing 211135China Department of Applied Mathematics Yang Ming Chiao Tung UniversityHsinchu 300China

Principal component analysis(PCA) has been widely used in analyzing high-dimensional data. It converts a set of observed data points of possibly correlated variables into a set of linearly uncorrelated variables via an orthogonal transformation. To handle streaming data and reduce the complexities of PCA,(subspace)online PCA iterations were proposed to iteratively update the orthogonal transformation by taking one observed data point at a time. Existing works on the convergence of(subspace) online PCA iterations mostly focus on the case where the samples are almost surely uniformly bounded. In this paper, we analyze the convergence of a subspace online PCA iteration under more practical assumptions and obtain a nearly optimal finite-sample error bound. Our convergence rate almost matches the minimax information lower bound. We prove that the convergence is nearly global in the sense that the subspace online PCA iteration is convergent with high probability for random initial guesses. This work also leads to a simpler proof of the recent work on analyzing online PCA for the first principal component only.

关键词： principal component analysis principal component subspace stochastic approximation high-dimensional data online algorithm nite-sample analysis

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Isolation and identification of Sclerotinia stem rot causal pathogen in Arabidopsis thaliana

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第10期9卷 818-822页

作者： Ai-rong WANG wen-wei lin Xiao-ting CHEN Guo-dong LU Jie ZHOU Zong-hua WANG Computer and Information College Fujian Agriculture and Forestry University Fuzhou 350002 China Ministry of Education Key Laboratory of Biopesticide and Chemical Biology Fujian Agriculture and Forestry University Fuzhou 350002 China

A new stem rot disease is found to occur naturally on Arabidopsis plants in greenhouses of Fuzhou, China. In order to identify its pathogen, we conducted a series of fungal isolation and purification, plant reinoculation, and ascus and ascospore induction from the sclerotia. The isolate caused typical water-soaked lesions after reinoculation and produced sclerotia both on Arabidopsis plants and culture medium plates, and the sclerotia could be induced to produce discal apothecia and 8 binucleate ascospores per ascus. These disease symptom and fungal morphology data revealed that the fungus Sclerotinia sclerotiorum (Lib.) de Bary was the pathogen for Arabidopsis stem rot. To confirm this, we further amplified its large subunit ribosomal DNA (LSU rDNA) by polymerase chain reaction (PCR), and compared the sequence with the known LSU rDNA sequences in GenBank. The results show that the sequence shares the highest identities with the LSU rDNAs of different S. sclerotiorum strains. Taking all these data together, we concluded that the fungus that caused the Arabidopsis stem rot is S. sclerotiorum (Lib.) de Bary. This is the first report that Arabidopsis is naturally infected by S. sclerotiorum.

关键词： Sclerotinia sclerotiorum Arabidopsis thaliana Large subunit ribosomal DNA (LSU rDNA) Systematic classification

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Intermittent Behaviors in Coupled Piecewise Expanding Map Lattices

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Analysis in Theory and Applications 2021年第4期37卷 481-519页

作者： Tiexiang Li wen-wei lin Yiqian Wang Shing-Tung Yau Department of Mathematics Southeast UniveristyNanjingJiangsu 211189China Nanjing Center for Applied Mathematics NanjingJiangsu 211135China Department of Mathematics National Chiao Tung UniversityHsinchu300Taiwan Department of Mathematics Nanjing UniversityNanjingJiangsu 210093China Department of Mathematics Harvard UniversityBostonUSA

In this paper,we propose a new method to study intermittent behaviors of coupled piecewise-expanding map *** show that the successive transition between ordered and disordered phases occurs for almost every orbit when the coupling is *** is,lim inf n→∞∑1≤i,j≤m|x_(i)(n)−x_(j)(n)|=0,lim sup n→∞∑1≤i,j≤m|x_(i)(n)−x_(j)(n)|≥c_(0)>0,where xi(n)correspond to the coordinates of m nodes at the iterative step ***,when the uncoupled system is generated by the tent map and the lattice consists of two nodes,we prove a phase transition occurs between synchronization and intermittent *** is,limn→∞|x_(1)(n)−x_(2)(n)|=0 for c−1/21/4,where 0≤c≤1 is the coupling.

关键词： Synchronization pseudo synchronization phase transition Coupled map Lattices piecewise expanding map

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Visual test paper based on Au/δ-MnO_(2) hollow nanosphere oxidase-like activity regulation using hexavalent chromium as a smart switch

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Rare Metals 2024年第2期43卷 711-722页

作者： wen-Chang Zhuang Hai-Yue Zhang Zhen-Yang Chen wen-Jing Cheng wei-Dan Na Zhao Li lin Tian School of Materials and Chemical Engineering Xuzhou University of TechnologyXuzhou221018China School of Chemistry and Environmental Science Yili Normal UniversityYining835000China

Paper-based sensing platform is a point of need analytical toolkit for safety ***,the sensitivity,specificity,and simplicity are still ***,we report a novel strategy(Au/δ-MnO_(2) hollow nanosphere and 3,3′,5,5′-tetramethylbenzidine(TMB)induced test strips for signal-on detection)that can be utilized for hexavalent chromium(Cr^(6+))***,Cr^(6+)(CrO_(4)^(2−)) as a smart switch can remarkably enhance the oxidase-like activity of Au/δ-MnO_(2) hollow *** presence of Cr^(6+) can regulate the surface electronic redistribution of Au/δ-MnO_(2) and adjust the geometric configuration,which leads to the improvement in oxidase-like activity of Au/δ-MnO_(2).As a proof-of-concept application,a visual paper-based sensing platform of Cr^(6+) along with quantitative analysis by the test strips was successfully *** paper-based sensing platform exhibits a linear range with excellent selectivity for other interfering substances and lower limit of detection of 0.09μmol·L^(−1),providing a promising toolkit at-home Cr^(6+) measurement and environmental monitoring.

关键词： Point of need Colorimetric biosensing platform Au/δ-MnO_(2) hollow nanosphere Test strip Cr^(6+)

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The Existence of a Meridional Curve in Closed Incompressible Surfaces in Fully Alternating link Complements

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Chinese Annals of Mathematics,Series B 2024年第1期45卷 73-80页

作者： wei lin School of Mathematical Sciences Dalian University of TechnologyDalian 116024LiaoningChina

Menasco showed that a closed incompressible surface in the complement of a non-split prime alternating link in S^(3) contains a circle isotopic in the link complement to a meridian of the *** on this result,he was able to argue the hyperbolicity of non-split prime alternating links in *** et *** that if F■S×I\L is an essential torus,then F contains a circle which is isotopic in S×I\L to a meridian of *** author generalizes his result as follows:Let S be a closed orientable surface,L be a fully alternating link in S×I\If F ■ S×I\L is a closed essential surface,then F contains a circle which is isotopic in S×I\L to a meridian of L.

关键词： Fully alternating Incompressible surfaces Meridionally incompressible

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