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The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-Yan Sun Lingyun Nie Jing Zhang Xue fang Hongmei Luo Chuanhai Fu Zhiyi wei Ai-Hui tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

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Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury

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Neural Regeneration Research 2025年第10期20卷 2955-2968页

作者： wei Zhang Yubao Lu Ruoqi Shen Yingjie Wu Chenrui Liu Xingxing fang Liangming Zhang Bin Liu Limin Rong Department of Spine Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina National Medical Products Administration(NMPA)Key Laboratory for Quality Research and Evaluation of Cell Products GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Quality Control of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Engineering and Technology Research of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina

Microglia,the resident monocyte of the central nervous system,play a crucial role in the response to spinal cord ***,the precise mechanism remains *** investigate the molecular mechanisms by which microglia regulate the neuroinflammatory response to spinal cord injury,we performed single-cell RNA sequencing dataset analysis,focusing on changes in microglial *** found that the MG1 subpopulation emerged in the acute/subacute phase of spinal cord injury and expressed genes related to cell pyroptosis,sphingomyelin metabolism,and neuroinflammation at high ***,we established a mouse model of contusive injury and performed intrathecal injection of siRNA and molecular inhibitors to validate the role of ceramide synthase 5 in the neuroinflammatory responses and pyroptosis after spinal cord ***,we established a PC12-BV2 cell co-culture system and found that ceramide synthase 5 and pyroptosis-associated proteins were highly expressed to induce the apoptosis of neuron *** ceramide synthase 5 expression in a mouse model of spinal cord injury effectively reduced ***,ceramide synthase 5-induced pyroptosis was dependent on activation of the NLRP3 signaling *** ceramide synthase 5 expression in microglia in vivo reduced neuronal apoptosis and promoted recovery of neurological ***2g7 formed a“bridge”between sphingolipid metabolism and ceramide synthase 5-mediated cell death by inhibiting the NLRP3 signaling ***,these findings suggest that inhibiting ceramide synthase 5 expression in microglia after spinal cord injury effectively suppressed microglial pyroptosis mediated by NLRP3,thereby exerting neuroprotective effects.

关键词： ceramide synthase 5 gasdermin D microglia neuroinflammation NLRP3 nuclear factor kappa B Pla2g7 pyroptosis sphingomyelin metabolism spinal cord injury

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双针-板结构脉冲气泡放电等离子体固氮研究

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原子与分子物理学报 2025年第6期42卷 122-128页

作者：赵少伟张丽方志南京工业大学电气工程与控制科学学院南京211816

大气压低温等离子体可以利用空气直接进行氧化固氮,具有反应条件温和、参数灵活可控、避免温室气体排放等优点.本文利用双针-板电极在水中形成气泡放电等离子体,以空气为放电气体进行了固氮研究,分析了产物浓度和固氮能耗的影响因素.研... 详细信息

大气压低温等离子体可以利用空气直接进行氧化固氮,具有反应条件温和、参数灵活可控、避免温室气体排放等优点.本文利用双针-板电极在水中形成气泡放电等离子体,以空气为放电气体进行了固氮研究,分析了产物浓度和固氮能耗的影响因素.研究结果表明,等离子体中含有丰富的氮原子、氧原子、氢原子、激发态氮分子等活性物种,可高效合成硝态含氮产物.研究发现,脉冲参数、电极间隙、工作气体组分对气泡放电等离子体的固氮性能有重要影响.装置最高NO~-_x合成速率为19.2μmol/min,最小能耗约为11 MJ/mol.此外还发现,电极间隙为6 mm时,固氮性能最优;空气中增加适量氧气(氧气/氮气比例为0.4)可以增强产物合成,降低能耗.

关键词：低温等离子体纳秒脉冲放电气液放电固氮

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Dynamic behavior of stormwater quality parameters in South Texas

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Frontiers of Environmental Science & Engineering 2012年第6期6卷 825-830页

作者： Xubin PAN Jingyi ZHANG wei-ta.fang Kim D.JONES Institute of Plant Quarantine Chinese Academy of Inspection and QuarantineBeijing 100029China Department of Environmental Engineering Texas A&M University-KingsvilleKingsvilleTX 78363USA Graduate Institute of Environmental Education Taiwan Normal UniversityTaipei 116China

To control water impairment in urban storm- water, it is important to evaluate changing patterns of water quality parameters in stormwater runoff. Thus, the authors performed a series of experiments to investigate the dynamics of common water parameters during storm events in semi-arid areas, with multiple samples collected and analyzed in field stormwater applications. At this field monitoring site within McAuliffe Park, McAllen, Texas, in the United States, a storm event increased the concentra- tions of Escherichia coli （E. coli）, but this event represented a decreasing trend over the entire event period. Besides, peak intensity of different pollutants in the stormwater runoff occurred at different times other than at any peak flows, representing a complexity of the temporal and spatial measurements. Multi-sample per- event approaches recommended based on the complexity of the hydrograph and different peak intensity times of pollutants. In addition, high bacteria and total suspended solids （TSS） concentrations in the initial stage of the storm event should be considered when designing Best Manage- ment Practices （BMPs） and Low Impact Developments （LIDs）. New strategies and solutions for addressing ecohydrological challenges should be proposed to avoid collateral damages to their both common wealth in ecosystems and human well-beings.

关键词： event mean concentration first flush multi-sample per event ecohydrology

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Pullout characteristics and conceptual model of gabion reinforcement

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岩石力学与工程学报 2017年第7期36卷 1670-1679页

作者： fang wei School offranc and Transportation Engineering Changsha University of Science and TechnologyChangshaHunan 410004China Co-innovation Centerfor Advanced Construction and Maintenance Technology of Modern Transportation Infrastructural Facility Changsha University of Science and TechnologyChangshaHunan 410004China

The reinforced gabion wall on the west line of Xiangtan to Hengyang highway in Hunan province was studied with the large scale pullout model tests and numerical simulations to obtain the interface friction characteristics between the double twisted hexagonal gabion mesh(2.2 mm and 2.7 mm respectively) and red sandstone. The experimental results showed that the pullout displacement-shear stress curve could be roughly divided into 3 sections:the rapid growth,the steady progression and the yielding sections. The thinner gabion mesh led to the higher peak shear stress,larger cohesion and friction angle under the same normal stress. The pullout displacement-shear stress curve from the numerical simulation had two sections,namely,the rapid growth of shear stress and the yielding of gabion mesh. Under the same conditions,the 2.2 mm meshes resulted in the larger drawing coefficient and pseudo-friction coefficient and thus presented the better interface friction properties. The conceptual model suggested that the proportion of pullout force shared by the horizontal bars and longitudinal bars relied on the magnitude,the length,the coefficient of earth pressure and the friction factor,etc. The pullout bearing resistance on the transversal bars(T_1) comprises the largest proportion of the total resistance(about 62%–72%),on the other hand,the proportions of the annular pullout friction on the longitudinal bars(T_2) and the interface friction acting on the surfaces of all nodes(T_3) both grow against T_1 when the normal stress increases.

关键词： numerical simulation gabion mesh pullout test interface friction characteristics conceptual model

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Single-metal-atom site with high-spin state embedded in defective BN nanosheet promotes electrocatalytic nitrogen reduction

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Nano Research 2021年第11期14卷 4211-4219页

作者： Cong fang wei An College of Chemistry and Chemical Engineering Shanghai University of Engineering ScienceShanghai201620China

Single-atom catalysts (SACs) especially supported on two-dimensional nitrogen-doped carbon substrate have been widely reported to be able to effectively promote electrocatalytic N_(2) reduction reaction (eNRR). The precise design of single-metal-atom active site (SMAS) calls for fundamental understanding of its working mechanism for enhanced eNRR performance. Herein, by means of density functional theory calculations, we theoretically investigate the eNRR performance of nine prototypical SMAS, namely, MN_(2)B_(2) (M: transition metals of IIIB, IVB and VB groups) which comprises of asymmetric ligands of N_(2)B_(2) embedded in defective BN nanosheet. Our results reveal the significant role of spin state of SMAS in tuning the potential-determining steps of eNRR, in which MN_(2)B_(2) site with higher spin magnetic moment (μ) is beneficial to reducing limiting potentials (U_(L)) of eNRR. Specially, CrN_(2)B_(2) (μ = 4μB), VN_(2)B_(2) (μ = 3μB) and MoN_(2)B_(2) (μ = 2μB) demonstrate high activity and selectivity to eNRR. The asymmetric ligands of N_(2)B_(2) are deemed to be superior over mono-symmetric ligands. More importantly, our results demonstrate that breaking (or deviating) of the scaling relations between key N-containing intermediates (*N_(2)H/*N_(2) and *NH2/*N_(2)) on MN_(2)B_(2) can be realized by enhancing spin state of SMAS which renders the active site a balanced N-affinity critical for efficient eNRR. This observation is validated by the calculated Sabatier volcano-shape relation between eNRR limiting potentials and N_(2) adsorption energy. Our study develops the guidance for catalyst design to boost eNRR performance by tuning the spin state of an active site.

关键词： electrocatalysis N_(2)reduction BN nanosheet spin state single-atom catalyst jdensity functional theory(DFT)

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A low-frequency and broadband wave-insulating vibration isolator based on plate-shaped metastructures

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Applied Mathematics and Mechanics(English Edition) 2024年第7期45卷 1171-1188页

作者： wei wei Feng GUAN Xin fang College of Intelligent Science National University of Defense TechnologyChangsha410073China Naval Research Academy Beijing100161China

A metamaterial vibration isolator,termed as wave-insulating isolator,is proposed,which preserves enough load-bearing capability and offers ultra-low and broad bandgaps for greatly enhanced wave *** consists of plate-shaped metacells,whose symmetric and antisymmetric local resonant modes offer several low and broad mode bandgaps although the complete bandgap remains high and *** bandgap mechanisms,vibration isolation properties,effects of key parameters,and robustness to complex conditions are *** experimentally demonstrated,the wave-insulating isolator can improve the vibration insulation in the ranges of[50 Hz,180 Hz]and[260 Hz,400 Hz]by 15 dB and 25 dB,respectively,in contrast to the conventional isolator with the same first resonant frequency.

关键词： metamaterial and metastructure vibration isolation bandgap wave insulation plate

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A generalized dilatancy angle equation of granular soil

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Journal of Mountain Science 2022年第5期19卷 1456-1463页

作者： YU fang-wei Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu 610041China Center for Excellence in Tibetan Plateau Earth Sciences Chinese Academy of SciencesBeijing 100101China China-Pakistan Joint Research Center on Earth Sciences CAS-HECIslamabad 45320Pakistan University of Chinese Academy of Sciences Beijing 100049China Department of Civil Engineering The University of TokyoTokyo 113-8656Japan

This paper presents a generalized dilatancy angle equation of granular soil to cover not only the drained tests but also the undrained tests by introducing a generalized structure of soil:soil skeleton formed by soil particles and the fluid in soil voids,under the assumptions of the incompressibility of soil particles and the compressibility of the fluid in soil *** the drained tests,the generalized dilatancy angle equation of granular soil would be degenerated to its current dilatancy angle ***,for the undrained tests,the generalized dilatancy angle equation of granular soil was derived with aλparameter that was related to the stress-strain state of soil and the nature of the fluid in soil ***λparameter was determined by the initial dilatancy angles of granular soil at the onset of shearing on the same initial state of the soil in the drained and undrained *** addition,the generalized dilatancy angle equation of granular soil was verified for application in calculation of the dilatancy angles of sands in the drained and undrained tests.

关键词： Elastoplastic theory Dilatancy Granular soil Sands Soil Skeleton Triaxial tests

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Dynamic response analysis of blocks-combined dam under impact load

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Journal of Mountain Science 2020年第11期17卷 2827-2839页

作者： GAO fang-fang TIAN wei School of Civil Engineering Chang’an UniversityXi'an 710061China

In order to reduce the damage of ordinary gravity dam impacted by boulders in debris flow,a blocks-combined dam based practical project is *** dynamic response of the proposed dam under impact load is investigated by using ABAQUS finite element *** the impact velocity and impact height,the anti-impact performance of blocks-combined dam is discussed in terms of deformation,displacement,impact force,acceleration,and energy,and is compared with that of ordinary *** show that the displacement,impact force and acceleration of dam increase with the increase of impact velocity and *** impact energy of blocks-combined dam is mainly absorbed and consumed by the friction between the component interfaces,which is related to the location of impact *** with the ordinary gravity dam,the blocks-combined dam has better impact resistance to boulders in debris flow.

关键词： Impact load Blocks-combined dam Unbonded post tensioned steel strand Debris flow Dynamic response Numerical simulation

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Multi-agent consensus with time-varying delays and switching topologies

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Journal of Systems Engineering and Electronics 2014年第3期25卷 489-495页

作者： Jia wei Huajing fang School of Automation Huazhong University of Science and Technology College of Engineering Huazhong Agricultural University

The consensus problems of multi-agents with time-varying delays and switching topologies are studied. First, assume that an agent receives state information from its neighbors with fixed communication delays and processes its own state information with time-varying self-delay respectively. The state time-delay feedback is introduced into the existing consensus protocol to begenerate an improved protocol. Then a sufficient condition is derived which can make the system with time-varying self-delays achieve the consensus. On this basis, a specific form of consensus equilibrium influenced by the initial states of agents, time-delays and state feedback intensity is figured out. In addition, the multi-agent consensus is considered with time-varying topologies. Finally, simulations are presented to il ustrate the validity of theoretical results.

关键词： consensus multi-agent system time-varying delay switching topology convergence analysis.

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