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Prognostic nomograms for predicting overall survival and causespecific survival of signet ring cell carcinoma in colorectal cancer patients

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World Journal of Clinical Cases 2021年第11期9卷 2503-2518页

作者： Fu-Rong Kou Yang-Zi Zhang wei-ran xu Department of Day Oncology Unit Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Peking University Cancer Hospital and InstituteBeijing 100142China Department of Radiation Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Peking University Cancer Hospital and InstituteBeijing 100142China Department of Oncology Peking University International HospitalBeijing 102206China

BACKGROUND Signet ring cell carcinoma(SRCC)is an uncommon subtype in colorectal cancer(CRC),with a short survival ***,it is imperative to establish a useful prognostic *** a simple visual predictive tool,nomograms combining a quantification of all proven prognostic factors have been widely used for predicting the outcomes of patients with different cancers in recent *** now,there has been no nomogram to predict the outcome of CRC patients with *** To build effective nomograms for predicting overall survival(OS)and causespecific survival(CSS)of CRC patients with *** Data were extracted from the Surveillance,Epidemiology,and End Results database between 2004 and *** Cox regression analyses were used to identify independent variables for both OS and CSS to construct the *** of the nomograms was assessed by concordance index,calibration curves,and receiver operating characteristic(ROC)*** curves were also utilized to compare benefits between the nomograms and the tumor-node-metastasis(TNM)staging *** were classified as high-risk,moderate-risk,and low-risk groups using the novel ***-Meier curves were plotted to compare survival *** In total,1230 patients were *** concordance index of the nomograms for OS and CSS were 0.737(95%confidence interval:0.728-0.747)and 0.758(95%confidence interval:0.738-0.778),*** calibration curves and ROC curves demonstrated good predictive *** 1-,3-,and 5-year area under the curve values of the nomogram for predicting OS were 0.796,0.825 and 0.819,in comparison to 0.743,0.798,and 0.803 for the TNM staging *** addition,the 1-,3-,and 5-year area under the curve values of the nomogram for predicting CSS were 0.805,0.847 and 0.863,in comparison to 0.740,0.794,and 0.800 for the TNM staging *** on the novel nomograms,stratified analysis showed that the 5-year probability of survival in t

关键词： Colorectal carcinoma Signet ring cell carcinoma Nomogram Overall survival Cause-specific survival Prognosis

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Effect of Inoculation with Arbuscular Mycorrhizal Fungus on Nitrogen and Phosphorus Utilization in Upland Rice-Mungbean Intercropping System

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Agricultural Sciences in China 2010年第4期9卷 528-535页

作者： XIAO Tong-jian YANG Qing-song ran wei xu Guo-hua SHEN Qi-rong Department of Plant Nutrition College of Resoures and Environmental Sciences Nanjing Agricultural University Nanjing 210095 P.R.China

The effect of arbuscular mycorrhiza fungi （AMF） on plant growth and nutrition utilization in upland rice and mungbean intercropping system was studied. A pot experiment was conducted in the greenhouse and AMF colonization rates of rice and mungbean roots, plant nutrient contents, the ability of nitrogen fixation, and nutrient contents changed in the soil were analyzed. The results were obtained as follows： the rates of AMF colonization of rice and mungbean roots were reached to 14.47 and 92.2% in intercopping system, and increased by 4.11 and 11.95% compared with that of in monocropping; the nirtrogen contents of mungbean and rice were increased by 83.72 and 64.83% in shoots, and 53.76 and 41.29% in roots, respectively, while the contents of iron in shoot and root of mungbean were increased by 223.08 and 60.19%, respectively. In the intercropping system with inoculation of AMF, the biomass of mungbean increased by 288.8%. However, the biomass of rice was not significantly changed among all treatments with or without inoculation of AMF recorded. The number and dry weight of nodules were significantly increased either when mungbean was intercropped with rice or inoculated with AMF. When compared with that of monocropping without AMF inoculation, the contents of nitrogen, phosphorus and iron in nodules of intercropping mungbean with inoculation increased by 80.14, 69.54 and 39.62%, respectively. Additionally, intercropping with AMF inoculation significantly increased soil nitrogen content, but reduced soil phosphorus content. We concluded that upland rice-mungbean intercropping system and inoculation with AMF improved the nutrient uptake, the ability of nitrogen fixation and the growth of mungbean.

关键词： mungbean rice arbuscular mycorrhizal fungi (AMF) intercropping nitrogen phosphorus iron root nodule

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Applications of in-situ solid-state nuclear magnetic resonance in methanol to olefins reaction

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Science China Chemistry 2025年第1期68卷 134-151页

作者： Jing Niu Shutao xu Yingxu wei Zhongmin Liu National Engineering Research Center of Lower-Carbon Catalysis Technology Dalian Institute of Chemical PhysicsChinese Academy of Sciences State Key Laboratory of Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences University of Chinese Academy of Sciences

The methanol-to-olefins（MTO） reaction offers an alternative pathway for the production of low-carbon olefins from non-oil feedstocks. Fundamental research has been impeded by a lack of comprehensive understanding of its underlying mechanism,despite the significant progress made in industry. In-situ solid-state nuclear magnetic resonance（ss NMR） spectroscopy has emerged as a pivotal tool, offering crucial insights into key species under real-time operando conditions. Furthermore, the host–guest interaction between zeolites or surface species residing on zeolites and the reactant/active intermediates is revealed by the combination of in-situ13C MAS NMR and 2D correlation spectroscopy. Moreover, recent technological advancements in hyperpolarization（HP） methods, including HP129Xe NMR and dynamic nuclear polarization（DNP）, have significantly improved the sensitivity of ss NMR, enabling detailed structural and kinetic analysis as well as the detection of trace species. In this feature article, we summarized recent advancements in（in-situ） ss NMR spectroscopy applied to MTO reaction processes,encompassing mechanistic investigations at various stages and the intricate host–guest interactions. These theoretical insights into the dynamic evolution of MTO reactions lay a solid foundation for the optimization of catalytic processes and the development of efficient catalysts, thereby advancing the techniques towards more sustainable and economical production route for olefins.

关键词： MTO zeolites in-situ ssNMR reactive intermediates reaction mechanism

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Muon flux measurement at China Jinping Underground Laboratory

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Chinese Physics C 2021年第2期45卷 509-517页

作者： Zi-yi Guo Lars Bathe-Peters Shao-min Chen Mourad Chouaki wei Dou Lei Guo Ghulam Hussain Jin-jing Li Qian Liu Guang Luo Wen-tai Luo Ming Qi Wen-hui Shao Jian Tang Lin-yan Wan Zhe Wang Ben-da xu Tong xu wei-ran xu Yu-zi Yang Minfang Yeh Lin Zhao Department of Engineering Physics Tsinghua UniversityBeijing 100084China Center for High Energy Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Particle&Radiation Imaging(Tsinghua University) Ministry of EducationChina Institut für Physik Technische Universität BerlinBerlin 10623Germany École Polytechnique Fédérale de Lausanne Lausanne 1015Switzerland School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China School of Physics Sun Yat-Sen UniversityGuangzhou 510275China School of Physics Nanjing UniversityNanjing 210093China Brookhaven National Laboratory UptonNew York 11973USA

China Jinping Underground Laboratory(CJPL)is ideal for studying solar,geo-,and supernova neutrinos.A precise measurement of the cosmic-ray background is essential in proceeding with R&D research for these MeV-scale neutrino *** a 1-ton prototype detector for the Jinping Neutrino Experiment(JNE),we detected 264 high-energy muon events from a 645.2-day dataset from the first phase of CJPL(CJPL-I),reconstructed their directions,and measured the cosmic-ray muon flux to be (3.53±0.22_stat.±0.07_sys.)×-10^(-10)cm^(-2).The observed angular distributions indicate the leakage of cosmic-ray muon background and agree with simulation data accounting for Jinping mountain's terrain.A survey of muon fluxes at different laboratory locations,considering both those situated under mountains and those down mine shafts,indicates that the flux at the former is generally a factor of (4±2) larger than at the latter,with the same vertical *** study provides a convenient back-of-the-envelope estimation for the muon flux of an underground experiment.

关键词： CJPL cosmic-ray muon flux angular distribution neutrino detector liquid scintillator

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Photoinduced radical sulfur dioxide insertion with asymmetric cyclization of alkenes: accessing β-chiral sulfones bearing S-stereocentric cyclic sulfinamides

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Science China Chemistry 2025年第1期68卷 257-263页

作者： Jiapian Huang Chenxin Wang xu Wang Xiaoyu Zhou wei Xiao Jie Wu School of Pharmaceutical and Chemical Engineering & Institute for Advanced Studies Taizhou University State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences School of Chemistry and Chemical Engineering Henan Normal University

The generation of various β-chiral sulfones bearing chiral cyclic sulfinamides through photoredox-catalyzed sulfur dioxide insertion with asymmetric radical cyclization is described. This method features a broad substrate scope and excellent stereospecificity. Computational studies reveal that the dispersion interaction between sulfinyl group and CH2SO2Ph group plays a crucial role in the stereoselectivity control.

关键词： β-chiral sulfones chiral cyclic sulfinamides sulfur dioxide insertion asymmetric radical cyclization stereoselectivity

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Software-defined process-near-memory architecture using 3D hybrid bonding integration

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Science China(Information Sciences) 2025年第1期68卷 366-378页

作者： Anlin xu Chenchen DENG Jianfeng ZHU Yao WANG Shaojun wei Leibo LIU School of Integrated Circuits Tsinghua University Beijing Institution of Tracking and Communication Technology Beijing National Research Center for Information Science and Technology Tsinghua University

With the unprecedented explosive growing amount of global data, the development of computing chips, which encounter bottlenecks such as power wall and memory wall, cannot satisfy the demanding requirement. This work proposes a software-defined process-near-memory(SDPNM) computing architecture implemented using 3D hybrid bonding *** software-defined chip architecture, featuring spatial computations and dynamic reconfiguration, innovates in a top-down manner to achieve high energy efficiency while maintaining flexibility after fabrication. The process-near-memory integration further advances the SDNPM chip in a bottom-up way to reduce the energy consumption of data movement while improving the bandwidth. Utilizing a relatively mature fabrication and bonding process can result in feasible solutions for both data-intensive and compute-intensive applications including digital signal processing and artificial intelligence. The logic die is fabricated in the SMIC 40 nm process and the DRAM die is fabricated in the PSMC 25 nm process. The hybrid bonding is implemented by XMC. The experimental results show that the energy efficiency of the proposed SDPNM chip is 33.1× better than the state-of-the-art FPGA ranging from 8.2× to 104.1×.

关键词： software-defined chips process near memory energy efficiency dynamic reconfiguration domain specific

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基于温度的隔膜超弹性本构模型

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上海交通大学学报 2017年第9期51卷 1025-1030页

作者：王立冬魏冉徐鹏赵科新彭雄奇上海交通大学材料科学与工程学院上海200030 上海飞机制造有限公司航空制造技术研究所上海201324

为获得复合材料热隔膜预成型中隔膜的基本力学性能参数,在不同温度下进行了隔膜材料的单向拉伸实验;基于连续介质力学超弹性理论和虚功原理,建立了描述隔膜材料在90℃以下的不同温度及大变形条件下的本构模型,并通过Abaqus软件的材料子... 详细信息

为获得复合材料热隔膜预成型中隔膜的基本力学性能参数,在不同温度下进行了隔膜材料的单向拉伸实验;基于连续介质力学超弹性理论和虚功原理,建立了描述隔膜材料在90℃以下的不同温度及大变形条件下的本构模型,并通过Abaqus软件的材料子程序UHYPER来实现;通过拟合实验数据获得材料模型参数并分析了模型的稳定性;采用有限元法分别对隔膜单向拉伸性能和隔膜覆盖进行模拟.结果表明:仿真结果与实验结果较吻合,从而验证了所提出的隔膜本构模型的准确性.

关键词：热隔膜成型隔膜超弹性本构模型温度复合材料

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Role of iron ore in enhancing gasification of iron coke:Structural evolution,influence mechanism and kinetic analysis

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 58-69页

作者： Jie Wang wei Wang xuheng Chen Junfang Bao Qiuyue Hao Heng Zheng Runsheng xu School of Chemistry and Materials Science Hubei Engineering UniversityXiaogan 432000China Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081China Institue of Ironmaking Technology Baosteel Central Research InstituteShanghai 201999China State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

The utilization of iron coke provides a green pathway for low-carbon *** uncover the influence mechanism of iron ore on the behavior and kinetics of iron coke gasification,the effect of iron ore on the microstructure of iron coke was ***,a comparative study of the gasification reactions between iron coke and coke was conducted through non-isothermal thermogravimetric *** findings indicate that compared to coke,iron coke exhibits an augmentation in micropores and specific surface area,and the micropores further extend and *** provides more adsorption sites for CO_(2) molecules during the gasification process,resulting in a reduction in the initial gasification temperature of iron *** the heating rate in non-isothermal gasification can enhance the reactivity of iron *** metallic iron reduced from iron ore is embedded in the carbon matrix,reducing the orderliness of the carbon structure,which is primarily responsible for the heightened reactivity of the carbon *** kinetic study indicates that the random pore model can effectively represent the gasification process of iron coke due to its rich pore ***,as the proportion of iron ore increases,the activation energy for the carbon gasification gradually decreases,from 246.2 kJ/mol for coke to 192.5 kJ/mol for iron coke 15wt%.

关键词： low-carbon ironmaking iron coke gasification structural evolution kinetic model

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Analysis of Micromechanical Properties at the Interface of Pre-wet SBS Modified Asphalt Mixture Based on Molecular Simulation Technology

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 103-113页

作者： CHEN Wuxing CHEN Shuang YU Yan ZHANG Jiangyi xu Haiyang GUO wei School of Mines China University of Mining and TechnologyXuzhou 221000China College of Construction Engineering Jilin Uni-versityChangchun 130026China

The pre-wetting of aggregate surface is a means to improve the interface performance of SBS modified asphalt and *** effect of pre-wetting technology on the interaction between SBS modified asphalt and aggregate was analyzed by molecular dynamics *** diffusion coefficient and concentration distribution of SBS modified asphalt on aggregate surface are *** simulation results show that the diffusion coefficient of the aggregate surface of SBS modified asphalt is increased by 47.6%and 70.5%respectively after 110#asphalt and 130#asphalt are *** concentration distribution of SBS modified asphalt on the aggregate surface after pre-wetting is more *** to the results of interface energy calculation,the interface energy of SBS modified bitumen and aggregate can be increased by about 5%after *** to the results of molecular dynamics simulation,the pre-wetting technology can effectively improve the interface workability of SBS modified bitumen and aggregate,so as to improve the interface performance.

关键词： pre-wet oil-stone interface interface interaction interface mechanics molecular dynamics simulation

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SensFL:Privacy-Preserving Vertical Federated Learning with Sensitive Regularization

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 385-404页

作者： Chongzhen Zhang Zhichen Liu Xiangrui xu Fuqiang Hu Jiao Dai Baigen Cai wei Wang School of Automation and Intelligence Beijing Jiaotong UniversityBeijing100044China Shuohuang Railway Development Co. Ltd.National Energy GroupCangzhou062350China Beijing Key Laboratory of Security and Privacy in Intelligent Transportation School of Computer Science and TechnologyBeijing Jiaotong UniversityBeijing100044China

In the realm of Intelligent Railway Transportation Systems,effective multi-party collaboration is crucial due to concerns over privacy and data *** Federated Learning(VFL)has emerged as a promising approach to facilitate such collaboration,allowing diverse entities to collectively enhance machine learning models without the need to share sensitive training ***,existing works have highlighted VFL’s susceptibility to privacy inference attacks,where an honest but curious server could potentially reconstruct a client’s raw data from embeddings uploaded by the *** vulnerability poses a significant threat to VFL-based intelligent railway transportation *** this paper,we introduce SensFL,a novel privacy-enhancing method to against privacy inference attacks in ***,SensFL integrates regularization of the sensitivity of embeddings to the original data into the model training process,effectively limiting the information contained in shared *** reducing the sensitivity of embeddings to the original data,SensFL can effectively resist reverse privacy attacks and prevent the reconstruction of the original data from the *** experiments were conducted on four distinct datasets and three different models to demonstrate the efficacy of *** results show that SensFL can effectively mitigate privacy inference attacks while maintaining the accuracy of the primary learning *** results underscore SensFL’s potential to advance privacy protection technologies within VFL-based intelligent railway systems,addressing critical security concerns in collaborative learning environments.

关键词： Vertical federated learning privacy defenses

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