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Prognostic nomograms for predicting overall survival and causespecific survival of signet ring cell carcinoma in colorectal cancer patients

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World Journal of Clinical Cases 2021年第11期9卷 2503-2518页

作者： Fu-Rong Kou Yang-Zi Zhang wei-ran xu Department of Day Oncology Unit Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Peking University Cancer Hospital and InstituteBeijing 100142China Department of Radiation Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Peking University Cancer Hospital and InstituteBeijing 100142China Department of Oncology Peking University International HospitalBeijing 102206China

BACKGROUND Signet ring cell carcinoma(SRCC)is an uncommon subtype in colorectal cancer(CRC),with a short survival ***,it is imperative to establish a useful prognostic *** a simple visual predictive tool,nomograms combining a quantification of all proven prognostic factors have been widely used for predicting the outcomes of patients with different cancers in recent *** now,there has been no nomogram to predict the outcome of CRC patients with *** To build effective nomograms for predicting overall survival(OS)and causespecific survival(CSS)of CRC patients with *** Data were extracted from the Surveillance,Epidemiology,and End Results database between 2004 and *** Cox regression analyses were used to identify independent variables for both OS and CSS to construct the *** of the nomograms was assessed by concordance index,calibration curves,and receiver operating characteristic(ROC)*** curves were also utilized to compare benefits between the nomograms and the tumor-node-metastasis(TNM)staging *** were classified as high-risk,moderate-risk,and low-risk groups using the novel ***-Meier curves were plotted to compare survival *** In total,1230 patients were *** concordance index of the nomograms for OS and CSS were 0.737(95%confidence interval:0.728-0.747)and 0.758(95%confidence interval:0.738-0.778),*** calibration curves and ROC curves demonstrated good predictive *** 1-,3-,and 5-year area under the curve values of the nomogram for predicting OS were 0.796,0.825 and 0.819,in comparison to 0.743,0.798,and 0.803 for the TNM staging *** addition,the 1-,3-,and 5-year area under the curve values of the nomogram for predicting CSS were 0.805,0.847 and 0.863,in comparison to 0.740,0.794,and 0.800 for the TNM staging *** on the novel nomograms,stratified analysis showed that the 5-year probability of survival in t

关键词： Colorectal carcinoma Signet ring cell carcinoma Nomogram Overall survival Cause-specific survival Prognosis

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Effect of Inoculation with Arbuscular Mycorrhizal Fungus on Nitrogen and Phosphorus Utilization in Upland Rice-Mungbean Intercropping System

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Agricultural Sciences in China 2010年第4期9卷 528-535页

作者： XIAO Tong-jian YANG Qing-song ran wei xu Guo-hua SHEN Qi-rong Department of Plant Nutrition College of Resoures and Environmental Sciences Nanjing Agricultural University Nanjing 210095 P.R.China

The effect of arbuscular mycorrhiza fungi （AMF） on plant growth and nutrition utilization in upland rice and mungbean intercropping system was studied. A pot experiment was conducted in the greenhouse and AMF colonization rates of rice and mungbean roots, plant nutrient contents, the ability of nitrogen fixation, and nutrient contents changed in the soil were analyzed. The results were obtained as follows： the rates of AMF colonization of rice and mungbean roots were reached to 14.47 and 92.2% in intercopping system, and increased by 4.11 and 11.95% compared with that of in monocropping; the nirtrogen contents of mungbean and rice were increased by 83.72 and 64.83% in shoots, and 53.76 and 41.29% in roots, respectively, while the contents of iron in shoot and root of mungbean were increased by 223.08 and 60.19%, respectively. In the intercropping system with inoculation of AMF, the biomass of mungbean increased by 288.8%. However, the biomass of rice was not significantly changed among all treatments with or without inoculation of AMF recorded. The number and dry weight of nodules were significantly increased either when mungbean was intercropped with rice or inoculated with AMF. When compared with that of monocropping without AMF inoculation, the contents of nitrogen, phosphorus and iron in nodules of intercropping mungbean with inoculation increased by 80.14, 69.54 and 39.62%, respectively. Additionally, intercropping with AMF inoculation significantly increased soil nitrogen content, but reduced soil phosphorus content. We concluded that upland rice-mungbean intercropping system and inoculation with AMF improved the nutrient uptake, the ability of nitrogen fixation and the growth of mungbean.

关键词： mungbean rice arbuscular mycorrhizal fungi (AMF) intercropping nitrogen phosphorus iron root nodule

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Muon flux measurement at China Jinping Underground Laboratory

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Chinese Physics C 2021年第2期45卷 509-517页

作者： Zi-yi Guo Lars Bathe-Peters Shao-min Chen Mourad Chouaki wei Dou Lei Guo Ghulam Hussain Jin-jing Li Qian Liu Guang Luo Wen-tai Luo Ming Qi Wen-hui Shao Jian Tang Lin-yan Wan Zhe Wang Ben-da xu Tong xu wei-ran xu Yu-zi Yang Minfang Yeh Lin Zhao Department of Engineering Physics Tsinghua UniversityBeijing 100084China Center for High Energy Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Particle&Radiation Imaging(Tsinghua University) Ministry of EducationChina Institut für Physik Technische Universität BerlinBerlin 10623Germany École Polytechnique Fédérale de Lausanne Lausanne 1015Switzerland School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China School of Physics Sun Yat-Sen UniversityGuangzhou 510275China School of Physics Nanjing UniversityNanjing 210093China Brookhaven National Laboratory UptonNew York 11973USA

China Jinping Underground Laboratory(CJPL)is ideal for studying solar,geo-,and supernova neutrinos.A precise measurement of the cosmic-ray background is essential in proceeding with R&D research for these MeV-scale neutrino *** a 1-ton prototype detector for the Jinping Neutrino Experiment(JNE),we detected 264 high-energy muon events from a 645.2-day dataset from the first phase of CJPL(CJPL-I),reconstructed their directions,and measured the cosmic-ray muon flux to be (3.53±0.22_stat.±0.07_sys.)×-10^(-10)cm^(-2).The observed angular distributions indicate the leakage of cosmic-ray muon background and agree with simulation data accounting for Jinping mountain's terrain.A survey of muon fluxes at different laboratory locations,considering both those situated under mountains and those down mine shafts,indicates that the flux at the former is generally a factor of (4±2) larger than at the latter,with the same vertical *** study provides a convenient back-of-the-envelope estimation for the muon flux of an underground experiment.

关键词： CJPL cosmic-ray muon flux angular distribution neutrino detector liquid scintillator

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基于温度的隔膜超弹性本构模型

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上海交通大学学报 2017年第9期51卷 1025-1030页

作者：王立冬魏冉徐鹏赵科新彭雄奇上海交通大学材料科学与工程学院上海200030 上海飞机制造有限公司航空制造技术研究所上海201324

为获得复合材料热隔膜预成型中隔膜的基本力学性能参数,在不同温度下进行了隔膜材料的单向拉伸实验;基于连续介质力学超弹性理论和虚功原理,建立了描述隔膜材料在90℃以下的不同温度及大变形条件下的本构模型,并通过Abaqus软件的材料子... 详细信息

为获得复合材料热隔膜预成型中隔膜的基本力学性能参数,在不同温度下进行了隔膜材料的单向拉伸实验;基于连续介质力学超弹性理论和虚功原理,建立了描述隔膜材料在90℃以下的不同温度及大变形条件下的本构模型,并通过Abaqus软件的材料子程序UHYPER来实现;通过拟合实验数据获得材料模型参数并分析了模型的稳定性;采用有限元法分别对隔膜单向拉伸性能和隔膜覆盖进行模拟.结果表明:仿真结果与实验结果较吻合,从而验证了所提出的隔膜本构模型的准确性.

关键词：热隔膜成型隔膜超弹性本构模型温度复合材料

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Role of iron ore in enhancing gasification of iron coke:Structural evolution,influence mechanism and kinetic analysis

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 58-69页

作者： Jie Wang wei Wang xuheng Chen Junfang Bao Qiuyue Hao Heng Zheng Runsheng xu School of Chemistry and Materials Science Hubei Engineering UniversityXiaogan 432000China Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081China Institue of Ironmaking Technology Baosteel Central Research InstituteShanghai 201999China State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

The utilization of iron coke provides a green pathway for low-carbon *** uncover the influence mechanism of iron ore on the behavior and kinetics of iron coke gasification,the effect of iron ore on the microstructure of iron coke was ***,a comparative study of the gasification reactions between iron coke and coke was conducted through non-isothermal thermogravimetric *** findings indicate that compared to coke,iron coke exhibits an augmentation in micropores and specific surface area,and the micropores further extend and *** provides more adsorption sites for CO_(2) molecules during the gasification process,resulting in a reduction in the initial gasification temperature of iron *** the heating rate in non-isothermal gasification can enhance the reactivity of iron *** metallic iron reduced from iron ore is embedded in the carbon matrix,reducing the orderliness of the carbon structure,which is primarily responsible for the heightened reactivity of the carbon *** kinetic study indicates that the random pore model can effectively represent the gasification process of iron coke due to its rich pore ***,as the proportion of iron ore increases,the activation energy for the carbon gasification gradually decreases,from 246.2 kJ/mol for coke to 192.5 kJ/mol for iron coke 15wt%.

关键词： low-carbon ironmaking iron coke gasification structural evolution kinetic model

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Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-Lin Li Xin-ran Song Qian-Qian Wan Yu-Ming Wang Han-Zhou Li wei-Quan xu Jia-Bao Liao wei-Bo Wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

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夏王散结胶囊提取工艺研究

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山东中医杂志 2017年第3期36卷 237-240页

作者：魏冉徐莉林桂涛山东中医药大学药学院山东济南250355 齐鲁医院山东济南250012

目的:确定夏王散结胶囊的提取工艺,保证其安全性和有效性。方法:根据处方中各药味有效成分的性质,分别采用煎煮法提取和乙醇回流法提取。以有效成分提取量、乙醇可溶物的量和正丁醇可溶物的量为指标,用正交试验法考察、优选最佳提取工... 详细信息

目的:确定夏王散结胶囊的提取工艺,保证其安全性和有效性。方法:根据处方中各药味有效成分的性质,分别采用煎煮法提取和乙醇回流法提取。以有效成分提取量、乙醇可溶物的量和正丁醇可溶物的量为指标,用正交试验法考察、优选最佳提取工艺条件。结果:夏枯草、王不留行、浙贝母、山慈菇、柴胡用70%乙醇回流提取两次,分别加10倍量和8倍量溶剂,每次提取3 h;莪术、白术、香附提取挥发油后的药渣与牡蛎、昆布加水浸泡1 h,煎煮两次,分别加8倍量和6倍量水,每次2 h。结论:确定的提取工艺较好地提取了有效成分,可保证制剂的有效性和安全性。

关键词：夏王散结胶囊乳腺增生症提取工艺正交试验

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Enhancement of motor functional recovery in thoracic spinal cord injury: voluntary wheel running versus forced treadmill exercise

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Neural Regeneration Research 2025年第3期20卷 836-844页

作者： Do-Hun Lee Dan Cao Younghye Moon Chen Chen Nai-Kui Liu Xiao-Ming xu wei Wu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteIndiana University School of MedicineIndianapolisINUSA Department of Neurological Surgery Indiana University School of MedicineIndianapolisINUSA Department of Neuroscience Baylor College of MedicineHoustonTXUSA

Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery and morphological changes following thoracic contusive spinal cord injury. After a 7-day recovery period after spinal cord injury, mice were assigned to either a trained group(10 weeks of voluntary running wheel or forced treadmill exercise) or an untrained group. Bi-weekly assessments revealed that the exercise-trained group, particularly the voluntary wheel exercise subgroup, displayed significantly improved locomotor recovery, more plasticity of dopaminergic and serotonin modulation compared with the untrained group. Additionally, exercise interventions led to gait pattern restoration and enhanced transcranial magnetic motor-evoked potentials. Despite consistent injury areas across groups, exercise training promoted terminal innervation of descending axons. In summary, voluntary wheel exercise shows promise for enhancing outcomes after thoracic contusive spinal cord injury, emphasizing the role of exercise modality in promoting recovery and morphological changes in spinal cord injuries. Our findings will influence future strategies for rehabilitation exercises, restoring functional movement after spinal cord injury.

关键词： behavioral assessment motor function neural plasticity running wheel exercise spinal cord injury treadmill exercise voluntary exercise

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Development of a nomogram for overall survival in patients with esophageal carcinoma:A prospective cohort study in China

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 158-168页

作者： Shi-Shi Yu Xi Zheng Xiao-Sheng Li Qian-Jie xu wei Zhang Zhong-Li Liao Hai-Ke Lei Department of Gastroenterology Chongqing University Cancer HospitalChongqing 400030China Chongqing Cancer Multi-omics Big Data Application Engineering Research Center Chongqing University Cancer HospitalChongqing 400030China Department of Health Statistics School of Public HealthChongqing Medical UniversityChongqing 400016China

BACKGROUND Esophageal carcinoma(EC)presents a significant public health issue in China,with its prognosis impacted by myriad *** creation of a reliable prog-nostic model for the overall survival(OS)of EC patients promises to greatly advance the customization of treatment *** To create a more systematic and practical model that incorporates clinically significant indicators to support decision-making in clinical *** This study utilized data from a prospective longitudinal cohort of 3127 EC patients treated at Chongqing University Cancer Hospital between January 1,2018,and December 12,*** the least absolute shrinkage and selection operator regression alongside multivariate Cox regression analyses helped pinpoint pertinent variables for constructing the *** efficacy was assessed by concordance index(C-index),area under the receiver operating characteristic curve(AUC),calibration curves,and decision curve analysis(DCA).RESULTS Nine variables were determined to be significant predictors of OS in EC patients:Body mass index(BMI),Karnofsky performance status,TNM stage,surgery,radiotherapy,chemotherapy,immunotherapy,platelet-to-lymphocyte ratio,and albumin-to-globulin ratio(ALB/GLB).The model demonstrated a C-index of 0.715(95%CI:0.701-0.729)in the training cohort and 0.711(95%CI:0.689-0.732)in the validation *** the training cohort,AUCs for 1-year,3-year,and 5-year OS predictions were 0.773,0.787,and 0.750,respectively;in the validation cohort,they were 0.772,0.768,and 0.723,respectively,illustrating the model's *** curves and DCA verified the model's predictive accuracy and net *** A novel prognostic model for determining the OS of EC patients was successfully developed and validated to help clinicians in devising individualized treatment schemes for EC patients.

关键词： Esophageal carcinoma High-risk factors Prognosis Overall survival Prediction model

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Pretreatment red blood cell distribution width as a predictive marker for postoperative complications after laparoscopic pancreatoduodenectomy

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 143-157页

作者： Xian-rang Cao Yin-Long xu Jia-wei Chai Kai Zheng Jun-Jie Kong Jun Liu Shun-Zhen Zheng Department of Liver Transplantation and Hepatobiliary Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Department of Breast and Thyroid Surgery Shandong Provincial Maternal and Child Health Care HospitalJinan 250014Shandong ProvinceChina

BACKGROUND Red blood cell distribution width(RDW)is associated with the development and progression of various *** To explore the association between pretreatment RDW and short-term outcomes after laparoscopic pancreatoduodenectomy(LPD).METHODS A total of 804 consecutive patients who underwent LPD at our hospital between March 2017 and November 2021 were retrospectively *** between pretreatment RDW and clinicopathological characteristics and short-term outcomes were *** Patients with higher pretreatment RDW were older,had higher Eastern Cooperative Oncology Group scores and were associated with poorer short-term outcomes than those with normal *** pretreatment RDW was an independent risk factor for postoperative complications(POCs)(hazard ratio=2.973,95%confidence interval:2.032-4.350,P<0.001)and severe POCs of grade IIIa or higher(hazard ratio=3.138,95%confidence interval:2.042-4.824,P<0.001)based on the Clavien-Dino classification *** analysis showed that high pretreatment RDW was an independent risk factor for Clavien-Dino classi-fication grade IIIb or higher POCs,a comprehensive complication index score≥26.2,severe postoperative pancreatic fistula,severe bile leakage and severe *** pretreatment RDW was positively associated with the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio and was negatively associated with albumin and the prognostic nutritional *** Pretreatment RDW was a special parameter for patients who underwent *** was associated with malnutrition,severe inflammatory status and poorer short-term *** could be a surrogate marker for nutritional and inflammatory status in identifying patients who were at high risk of developing POCs after LPD.

关键词： Biomarker Laparoscopic pancreatoduodenectomy Postoperative complication Red blood cell distribution width Short-term outcomes

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