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Comparative DNA methylation reveals epigenetic adaptation to high altitude in snub-nosed monkeys

Zoological Research 2024年第5期45卷 1013-1026页

作者： Ling Wang wei-qiang liu Juan Du Meng Li Rui-Feng Wu Ming Li Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunmingYunnan 650223China

DNA methylation plays a crucial role in environmental ***,using whole-genome bisulfite sequencing,we generated comprehensive genome-wide DNA methylation profiles for the high-altitude Yunnan snub-nosed monkey(Rhinopithecus bieti)and the closely related golden snub-nosed monkey(***).Our findings indicated a slight increase in overall DNA methylation levels in golden snub-nosed monkeys compared to Yunnan snub-nosed monkeys,suggesting a higher prevalence of hypermethylated genomic regions in the *** genomic methylation analysis demonstrated that genes associated with differentially methylated regions were involved in membrane fusion,vesicular formation and trafficking,hemoglobin function,cell cycle regulation,and neuronal *** results suggest that the high-altitude-related epigenetic modifications are extensive,involving a complete adaptation process from the inhibition of single Ca^(2+)channel proteins to multiple proteins collaboratively enhancing vesicular function or inhibiting cell differentiation and *** assays demonstrated that overexpression or down-regulation of candidate genes,such as SNX10,TIMELESS,and CACYBP,influenced cell viability under stress ***,this research suggests that comparing DNA methylation across closely related species can identify novel candidate genomic regions and genes associated with local adaptations,thereby deepening our understanding of the mechanisms underlying environmental adaptations.

关键词： Snub-nosed monkeys Whole-genome bisulfite sequencing DNA methylation High-altitude adaptation

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Preparation and magnetic hardening of low Ti content(Sm,Zr)(Fe,Co,Ti)_(12)magnets by rapid solidification non-equilibrium method

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Chinese Physics B 2024年第9期33卷 576-580页

作者： Xing-Feng Zhang Li-Bin liu Yu-Qing Li Dong-Tao Zhang wei-qiang liu Ming Yue College of Materials Science and Engineering Key Laboratory of Advanced Functional MaterialsMinistry of Education of ChinaBeijing University of TechnologyBeijing 100124China

The Sm–Zr–Fe–Co–Ti quinary-alloys with ThMn12 structure has attracted wide attention for ultra-high intrinsic magnetic properties,showing potentiality to be developed into rare-earth permanent *** Ti element in alloys is crucial for phase stability and magnetic properties,and lower Ti content can increase intrinsic magnetic properties but reduce phase *** this study,the 1:12 single-phase melt-spun ribbons with low Ti content was successfully prepared using a rapid solidification non-equilibrium method for the Sm1.1Zr_(0.2)Fe_(9.2)Co_(2.3)Ti_(0.5) ***,this non-equilibrium ribbon did not achieve good magnetic hardening due to the uneven microstructure and ***,annealing was carried out to eliminate micro-strain and homogenize microstructure,therefore,remanence and coercivity were significantly improved even the precipitation of a small amount of a-Fe phase which were not conducive to *** remanence of 86.1 emu/g and coercivity of 151 kA/m was achieved when annealing at 850℃ for 45 *** hot pressing,under the action of high temperature and pressure,a small portion of ThMn12 phases in the magnet decompose into Sm-rich phases and a-Fe,while remanence of 4.02 kGs(1 Gs=10^(-4) T),and coercivity of 1.12 kOe(1 Oe=79.5775 A·m^(-1))were still *** findings can provide reference for exploring practical permanent magnets made of 1:12 type quinary-alloys.

关键词： magnetic materials (Sm,Zr)(Fe,Co,Ti)_(12) magnets nanocrystalline magnet microstructure

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Comparative DNA methylation reveals epigenetic adaptation to high altitude in snub-nosed monkeys

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动物学研究 2024年第5期 1013页

作者： Ling Wang wei-qiang liu Juan Du Meng Li Rui-Feng Wu Ming Li Key Laboratory of Animal Ecology and Conservation Biology Institute of Zoology Chinese Academy of Sciences University of Chinese Academy of Sciences Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences

DNA methylation plays a crucial role in environmental adaptations. Here, using whole-genome bisulfite sequencing, we generated comprehensive genome-wide DNA methylation profiles for the high-altitude Yunnan snub-nosed monkey（Rhinopithecus bieti） and the closely related golden snub-nosed monkey（R. roxellana）. Our findings indicated a slight increase in overall DNA methylation levels in golden snub-nosed monkeys compared to Yunnan snub-nosed monkeys, suggesting a higher prevalence of hypermethylated genomic regions in the former. Comparative genomic methylation analysis demonstrated that genes associated with differentially methylated regions were involved in membrane fusion,vesicular formation and trafficking, hemoglobin function,cell cycle regulation, and neuronal differentiation. These results suggest that the high-altitude-related epigenetic modifications are extensive, involving a complete adaptation process from the inhibition of single Ca2+channel proteins to multiple proteins collaboratively enhancing vesicular function or inhibiting cell differentiation and proliferation. Functional assays demonstrated that overexpression or down-regulation of candidate genes,such as SNX10, TIMELESS, and CACYBP, influenced cell viability under stress conditions. Overall, this research suggests that comparing DNA methylation across closely related species can identify novel candidate genomic regions and genes associated with local adaptations,thereby deepening our understanding of the mechanisms underlying environmental adaptations.

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Effect of oxygen enrichment on sintering behavior of high proportion vanadium-titanium magnesite concentrates

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Journal of Iron and Steel Research International 2023年第11期30卷 2122-2132页

作者： Shi-hong Peng Hao liu Ze-zheng Sun Chang-wei Li Yue-lin Qin wei-qiang liu Guang Wang School of Metallurgy and Materials Engineering Chongqing University of Science and TechnologyChongqing401331China Value-Added Process and Clean Extraction of Complex Metal Mineral Resources Chongqing Municipal Key Laboratory of Institutions of Higher EducationChongqing401331China Chongqing Chuanyi Automation Co. Ltd.Chongqing401120China Process and Systems Engineering Åbo Akademi UniversityÅbo20500Finland Department of Materials Science and Engineering McMaster UniversityOntarioL8S 4L7Canada

To achieve high-efficiency utilization of complex and unmanageable iron-containing minerals,the effects of oxygen enrichment on productivity,yield,flame front speed,exhaust gas peak temperature,and desulphurization reaction of the vanadium-titanium magnetite sintering process as well as sinter tumble index and mineralogy were clarified,with oxygen enrichment concentrations ranging from 21 to 29 vol.%.Results indicated that with increasing the oxygen enrichment concentration from 21 to 27 vol.%,the flame front speed increased from 30.3 to 40.0 mm min^(-1),the yield enhanced from 72%to 77%,and the productivity augmented from 1.83 to 2.67t m^(-2)h^(-1);in the meantime,the tumble index was improved from 73.7%to 77.9%,and the exhaust gas peak temperature rose from 376.4 to 484.8℃.The main reason for the improvement in sintering properties was the increased combustibility of fuels and the generation of proper liquid phase that improved the permeability of the packed *** improved sinter strength is mainly due to the increase in the phase fraction of silico-ferrites of calcium and *** addition,oxygen enrichment sintering could significantly increase the desulphurization level of vanadium-titanium magnetite sinter and the rate of desulphurization reaction during sintering process.

关键词： Sinter Oxygen enrichment Vanadium-titanium magnetite Sintering behavior

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Microstructure and magnetic properties of SmCo_(5) sintered magnets

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Rare Metals 2020年第11期39卷 1295-1299页

作者： Dong-Tao Zhang Rong-Chun Zhu Ming Yue wei-qiang liu College of Materials Science and Engineering Key Laboratory of Advanced Functional MaterialsMinistry of Education of ChinaBeijing University of TechnologyBeijing 100124China

SmCo_(5)sintered magnets with good thermal stability are mainly used in high-temperature *** this study,two types of SmCo_(5) powders with different nominal z values were mixed and synthesized into SmCo_(5) magnets by the traditional powder metallurgy *** magnetic properties of the SmCo_(5) sintered magnet are maximum energy product of(BH)_(max)=172.29 kJ·m^(-3),remanence of B_(r)=7.47×10^(5)A·m^(-1)and coercivity of H_(ci)=2.42 *** results show that there are three coexisting phases in the magnet,which are SmCo_(5)phase,Sm_(2)Co_(7)phase and Sm_(2)O_(3)*** microstructural observation indicates that the average grain size in the magnet is about 8μm,and the high coercivity of this magnet is attributed to these fine grains.X-ray diffraction(XRD)and electron backscatter diffraction(EBSD)results indicate that the magnet has a well-aligned(00l)orientation texture.

关键词： SmCo_(5) Sintered magnets Magnetic properties

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Numerical simulation of single roller melt spinning for NdFeB alloy based on finite element method

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Rare Metals 2020年第10期39卷 1145-1150页

作者： Xu-Chao Wang Ming Yue Dong-Tao Zhang wei-qiang liu Ming-Gang Zhu College of Materials Science and Engineering Beijing University of TechnologyBeijing 100124.China Central Iron and Steel Research Institute Beijing 100081China

The numerical simulation model of single roller melt spinning for rapid quenching process of NdFeB alloy was built,and the vacuum chamber,cooling roller and sample were taken into account as a *** existing mature technology was in order to verify the correctness of *** rapid quenching ribbons with different roll speeds were used as the simulation *** results of the numerical simulation and experiments show that the validity of the model has been testified and the reasons of the formation of complete quenching ribbons and by-product have been *** experimental thickness of the ribbons is proportional to the theoretical *** the same spray condition,with the roll speed increasing,the thickness decreases *** the speed range of25-30 m·s^(-1),the simulated calculation date is close to the experimental date,which can be considered as an ideal technological parameter.

关键词： NdFeB Melt spinning Finite element method Numerical simulation

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Low-cost Sm0.7Y0.3Co5 sintered magnet produced by traditional powder metallurgical techniques

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Rare Metals 2020年第4期39卷 421-428页

作者： Dong-Tao Zhang Nai-Xing Cai Rong-Chun Zhu wei-qiang liu Ming Yue College of Materials Science and Engineering Key Laboratory of Advanced Functional MaterialsMinistry of Education of ChinaBeijing University of TechnologyBeijing 100124China

RCo5(R=rare earth)sintered magnets have good temperature stability,so it is still widely used in high temperature *** this paper,by the method of adding liquid phase SmCo1.7 to the main phase,Sm0.7Y0.3Co5 magnet was prepared by traditional powder metallurgical *** results show the presence of a main phase RCo5,a minor phase R2 Co7,and a R-rich phase in the *** the results of the XRD(X-ray diffraction)in random and oriented directions,the magnet has a well-aligned(00l)orientated texture,which is consistent with the result of the electron backscattered diffraction(EBSD).The Sm0.7Y0.3Co5 sintered magnet has good magnetic properties as remanence(Br)is 0.96 T,the coercivity(Hcj)is 1201.96 kA·m-1,and maximum magnetic energy product((BH)max)is 175.16 kJ m-3.

关键词： Sm0.7Y0.3Co5 Sintered magnets Low-cost Magnetic properties RCo5

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Origin of low coercivity of high La-Ce-containing Nd-Fe-B sintered magnets

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Rare Metals 2021年第1期40卷 180-184页

作者： Zhi Li Yu-Qing Li wei-qiang liu Dan Wu Hao Chen wei-Xing Xia Ming Yue College of Materials Science and Engineering Key Laboratory of Advanced Functional MaterialsMinistry of Education of ChinaBeijing University of TechnologyBeijing 100124China Key Laboratory of Magnetic Materials and Devices Ningbo Institute of Material Technology and EngineeringChinese Academy of SciencesNingbo 315201China

The origin of low coercivity of high La-Cecontaining Nd-Fe-B sintered magnets was analyzed based on characterization of the microstructure,magnetic domain structure,and magnetization reversal *** can be found that the coercivity of magnet decreases sharply and the ratio value of coercivity(H_(cj))to anisotropic field(H_(A))is below the theoretical value when the amount of La-Ce substitution for Nd is more than 40 wt%.The grain boundaries with poor magnetic isolation in the high La-Cecontaining Nd-Fe-B sintered magnets play an important role in reducing the coercivity of the *** addition,a larger proportion of the reversible portions can be found for the magnet with a large content of La-Ce,which will lead to the low performance of the magnet.

关键词： La-Ce-containing Nd-Fe-B sintered magnets Magnetic properties Magnetic domain Magnetization reversal

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High-temperature magnetic properties of anisotropic Mn Bi/Nd Fe B hybrid bonded magnets

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Rare Metals 2016年第6期35卷 471-474页

作者： Dong-Tao Zhang Peng-Fan Wang Ming Yue wei-qiang liu Jiu-Xing Zhang Jennifer Anand Sundararajan You qiang College of Materials Science and Engineering Beijing University of Technology Physics Department University of Idaho

Anisotropic MnBi/NdFeB （MnBi contents of 0 wt%, 20 wt%, 40 wt%, 60 wt%, 80 wt%, and 100 wt%） hybrid bonded magnets were prepared by molding compression using MnBi powders and commercial hydro-genation disproportionation desorption and recombination （HDDR） NdFeB powders. Magnetic measurements at room temperature show that with MnBi content increasing, the magnetic properties of the MnBi/NdFeB hybrid bonded magnets all decrease gradually, while the density of the hybrid magnets improves almost linearly. In a temperature range of 293-398 K, the coercivity temperature coefficient of the hybrid magnets improves gradually from -0.59 %.K^-1 for the pure NdFeB bonded magnet to -0.32 %.K^-1 for the hybrid bonded magnet with 80 wt% MnBi, and the pure MnBi bonded magnet exhibits a positive coercivity temperature coefficient of 0.61%-K^-1.

关键词： Hybrid bonded magnet NdFeB MnBi Coercivity temperature coefficient

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Multiple modes of perpendicular magnetization switching scheme in single spin-orbit torque device

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Chinese Physics B 2022年第10期31卷 283-287页

作者： Tong-Xi liu Zhao-Hao Wang Min Wang Chao Wang Bi Wu wei-qiang liu wei-Sheng Zhao Fert Beijing Institute MIIT Key Laboratory of SpintronicsSchool of Integrated Circuit Science and Engineering2 Beihang UniversityBeijing 100191China College of Integrated Circuits Nanjing University of Aeronautics and AstronauticsNanjing 211106China

Spin-orbit torque(SOT)has been considered as one of the promising technologies for the next-generation magnetic random access memory(MRAM).So far,SOT has been widely utilized for inducing various modes of magnetization ***,it is a challenge that so many multiple modes of magnetization switching are integrated *** we propose a method of implementing both unipolar switching and bipolar switching of the perpendicular magnetization within a single SOT *** mode of switching can be easily changed by tuning the amplitude of the applied *** show that the field-like torque plays an important role in switching *** field-like torque induces the precession of the magnetization in the case of unipolar switching,however,the field-like torque helps to generate an effective zcomponent torque in the case of bipolar *** addition,the influence of key parameters on the mode of switching is discussed,including the field-like torque strength,the bias field,and the current *** proposal can be used to design novel reconfigurable logic circuits in the near future.

关键词： spin-orbit torque(SOT) field-like torque magnetization switching perpendicular magnetization

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