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Molecular Characteristics of Cephalosporin-Resistant Neisseria gonorrhoeae Strains in China:A Retrospective Study

International Journal of Dermatology and Venereology 2024年第2期7卷 78-83页

作者： Jin Zhang Xiao-Yu zhu Jing-wei Liu Yue-ping Yin Shao-Chun Chen Reference Laboratory for STD Control Hospital for Skin Diseases(Institute of Dermatology)Chinese Academy of Medical Sciences&Peking Union Medical CollegeNanjingJiangsu 210042China National Center for STD Control Chinese Center for Disease Control and PreventionNanjingJiangsu 210042China

Objective:An increasing level of antimicrobial resistance to extended-spectrum cephalosporins has been reported,so we conducted this study to investigate the molecular characteristics of cephalosporin resistant Neisseria gonorrhoeae(NG)strains isolated from China Gonococcal Antimicrobial Resistance Surveillance Programme(China-GRSP).Methods:In total,2,038 NG isolates were collected from the China-GRSP between 2015 and *** multiantigen sequence typing(NG-MAST),multilocus sequence typing(MLST),and NG sequence typing for antimicrobial resistance(NG-STAR)were used to determine characteristics and resistant determinants of cephalosporin-resistant *** results are described as ***:Seventy-four(3.6%)cephalosporin-resistant isolates were ***_(ST7363)was the most prevalent MLST among cefixime-resistant(CFX-R)isolates,whereas MLST_(ST7365)(n=8)in was the most prevalent sequence type among ceftriaxone-resistant(CRO-R)***-R strains were mainly associated with penA-X(n=27,44.3%),penA-XIII(n=6,9.8%),penA-XVIII(n=5,8.2%),and CRO-R strains were mainly related to penA-XVIII(n=10,25.6%),penA-43(n=9,23.1%),penA-XIII(n=7,17.9%).Conclusion:The main conclusion of this study is that the predominant cephalosporin-resistant clones in China include locally emerged and imported *** CFX-R and CRO-R strains are primarily related to penA mutations,and their predominant genotypes are *** the increase in international travel,tracking high-risk-resistant clones and identifying outbreaks and their associations with epidemiological characteristics are critical to improve public health.

关键词： gonorrhea resistance cephalosporin cefixime ceftriaxone

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Gas–solid reactor optimization based on EMMS-DPM simulation and machine learning

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Particuology 2024年第6期89卷 131-143页

作者： Haolei Zhang Aiqi zhu Ji Xu wei Ge State Key Laboratory of Mesoscience and Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China State Key Laboratory of Multiphase Complex Systems Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China Innovation Academy for Green Manufacture Chinese Academy of SciencesBeijing 100190China

Design,scaling-up,and optimization of industrial reactors mainly depend on step-by-step experiments and engineering experience,which is usually time-consuming,high cost,and high *** numerical simulation can reproduce high resolution details of hydrodynamics,thermal transfer,and reaction process in reactors,it is still challenging for industrial reactors due to huge computational *** this study,by combining the numerical simulation and artificial intelligence(AI)technology of machine learning(ML),a method is proposed to efficiently predict and optimize the performance of industrial reactors.A gas–solid fluidization reactor for the methanol to olefins process is taken as an example.1500 cases under different conditions are simulated by the coarse-grain discrete particle method based on the Energy-Minimization Multi-Scale model,and thus,the reactor performance data set is *** develop an efficient reactor performance prediction model influenced by multiple factors,the ML method is established including the ensemble learning strategy and automatic hyperparameter optimization technique,which has better performance than the methods based on the artificial neural ***,the operating conditions for highest yield of ethylene and propylene or lowest pressure drop are searched with the particle swarm optimization algorithm due to its strength to solve non-linear optimization *** show that decreasing the methanol inflow rate and increasing the catalyst inventory can maximize the yield,while decreasing methanol the inflow rate and reducing the catalyst inventory can minimize the pressure *** two objectives are thus conflicting,and the practical operations need to be compromised under different circumstance.

关键词： Discrete particle method Artificial intelligence Machine learning Particle swarm optimization Industrial reactor optimization

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Reconfigurable mechanism-based metamaterials for ternary-coded elastic wave polarizers and programmable refraction control

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Applied Mathematics and Mechanics(English Edition) 2024年第7期45卷 1225-1242页

作者： Zhou HU Zhibo wei Yan CHEN Rui zhu School of Aerospace Engineering Beijing Institute of TechnologyBeijing100081China School of Mechanical Engineering Tianjin UniversityTianjin300350China Key Laboratory of Mechanism Theory and Equipment Design of Ministry of Education Tianjin UniversityTianjin300350China

Elastic metamaterials with unusual elastic properties offer unprecedented ways to modulate the polarization and propagation of elastic ***,most of them rely on the resonant structural components,and thus are frequency-dependent and ***,we present a reconfigurable 2D mechanism-based metamaterial which possesses transformable and frequency-independent elastic *** on the proposed mechanism-based metamaterial,interesting functionalities,such as ternarycoded elastic wave polarizer and programmable refraction,are ***,unique ternary-coded polarizers,with 1-trit polarization filtering and 2-trit polarization separating of longitudinal and transverse waves,are first ***,the strong anisotropy of the proposed metamaterial is harnessed to realize positive-negative bi-refraction,only-positive refraction,and only-negative ***,the wave functions with detailed microstructures are numerically verified.

关键词： elastic metamaterial elastic wave reconfigurable design zero mode ternary code programmable refraction

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Micro-flow structure at regime transition from bubbling to turbulent fluidization in a fluidized bed

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Particuology 2024年第6期89卷 117-130页

作者： Chaoyu Yan Yue Yuan Xiaoyang wei Jesse zhu State Key Laboratory of Heavy Oil Processing Beijing Key Laboratory of Process Fluid Filtration and SeparationCollege of Mechanical and Transportation EngineeringChina University of PetroleumBeijing 102249China China Beacons Institute The University of NottinghamNingbo315100China Department of Chemical and Biochemical Engineering University of Western OntarioLondonOntarioN6A 5B9Canada

Gas-solid fluidized beds have found extensive utilization in frontline manufacturing,in particular as low-velocity *** fluidization status,the bubbling or turbulent flow regime and the transition in between,determine the system performance in practical *** the convoluted hydrodynamics are quantitively evaluated through numerous data-processing methodologies,none of them alone can reflect all the critical information to identify the transition from the bubbling to the turbulent ***,this study was to exploit a coupling data processing methodology,in the combination of standard deviation,power spectrum density,probability density function,wavelet transform,and wavelet multiresolution method,to jointly explain the micro-flow structure at the regime transition from bubbling to turbulent *** transient differential pressure fluctuation was measured for the evaluation in a fluidized bed(0.267 m i.d.×2.5 m height)with FCC catalysts(d_(p)=65μm,ρ_(p)=1780kg/m^(3))at different superficial gas velocities(0.02–1.4 m/s).The results show that the onset of turbulent fluidization starts earlier in the top section of the bed than in the bottom *** wavelet decomposition displays that the fluctuation of differential pressure mainly concentrates on the sub-signals with an intermediate frequency *** sub-signals could be synthesized into three types of scales(micro-scale,meso-scale,and macro-scale),representing the multi-scale hydrodynamics in the fluidized *** micro-scale signal has the characteristic information of bubbling fluidization,and the characteristic information of turbulent fluidization is mainly represented by the meso-scale *** work provides a systematic comprehension of fluidization status assessment and serves as an impetus for more coupling analysis in this sector.

关键词： Flow regime transition Bubbling fluidization Turbulent fluidization Micro-flow structure Differential pressure fluctuation

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Sparse-view neutron CT 3D image reconstruction algorithm based on split Bregman method

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NUCLEAR SCIENCE AND TECHNIQUES 2024年第9期35卷 1-15页

作者： zhu, Teng-Fei Liu, Yang Luo, Zhi Ouyang, Xiao-ping North China Elect Power Univ Sch Nucl Sci & Engn Beijing 102206 Peoples R China East China Univ Technol State Key Lab Nucl Resources & Environm Nanchang 330013 Peoples R China State Key Lab Intense Pulsed Radiat Simulat & Effe Xian 710024 Peoples R China

As a complement to X-ray computed tomography (CT), neutron tomography has been extensively used in nuclear engineering, materials science, cultural heritage, and industrial applications. Reconstruction of the attenuation matrix for neutron tomography with a traditional analytical algorithm requires hundreds of projection views in the range of 0 degrees to 180 degrees and typically takes several hours to complete. Such a low time-resolved resolution degrades the quality of neutron imaging. Decreasing the number of projection acquisitions is an important approach to improve the time resolution of images; however, this requires efficient reconstruction algorithms. Therefore, sparse-view reconstruction algorithms in neutron tomography need to be investigated. In this study, we investigated the three-dimensional reconstruction algorithm for sparse-view neutron CT scans. To enhance the reconstructed image quality of neutron CT, we propose an algorithm that uses OS-SART to reconstruct images and a split Bregman to solve for the total variation (SBTV). A comparative analysis of the performances of each reconstruction algorithm was performed using simulated and actual experimental data. According to the analyzed results, OS-SART-SBTV is superior to the other algorithms in terms of denoising, suppressing artifacts, and preserving detailed structural information of images.

关键词： Neutron CT OS-SART Sparse-view 3D reconstruction Split Bregman Total variation ALGEBRAIC RECONSTRUCTION 2-PHASE FLOW BEAM ART

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Does Green Food Certification promote agri-food export quality?Evidence from China

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Journal of Integrative Agriculture 2024年第3期23卷 1061-1074页

作者： ping wei Hongman Liu Chaokai Xu Shibin Wen College of Economics and Management China Agricultural UniversityBeijing 100083China School of Public Affairs Zhejiang UniversityHangzhou 310058China

The construction of a food certification system plays a vital role in upgrading export quality, which previous studies have largely overlooked. We match China's industry-level data of Green Food Certification with its HS6-digit export data of agri-food products to quantify the impact of Green Food Certification on export quality. We identify the significant and positive effect of Green Food Certification on export quality. The 2SLS estimation based on instrumental variables and a range of robustness checks confirm the validity and robustness of the benchmark conclusions. Further analysis discloses that Green Food Certification improves export quality by raising agricultural production efficiency and brand premiums. Heterogeneity analysis shows that the effect of Green Food Certification varies across regions, notably improving the quality of agri-food products exported to developed regions and regions with high levels of import supervision. Furthermore, among various product types, Green Food Certification significantly improves the export quality of primary products and products vulnerable to non-tariff measures. The above findings could guide the future development of agri-food quality certification systems, potentially leading to a transformation and promotion of the agri-food trade.

关键词： Green Food Certification agri-food products green transformation export quality food labeling

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A Second-Order Image Denoising Model for Contrast Preservation

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Communications on Applied Mathematics and Computation 2024年第2期6卷 1406-1427页

作者： wei Zhi Department of Mathematics University of AlabamaBox 870350TuscaloosaAL35487USA

In this work,we propose a second-order model for image denoising by employing a novel potential function recently developed in zhu(J Sci Comput 88:46,2021)for the design of a regularization *** to this new second-order derivative based regularizer,the model is able to alleviate the staircase effect and preserve image *** augmented Lagrangian method(ALM)is utilized to minimize the associated functional and convergence analysis is established for the proposed *** experiments are presented to demonstrate the features of the proposed model.

关键词： Image denoising Variational model Image contrast Augmented Lagrangian method(ALM)

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The Metallicity Dimension of the Super Earth-cold Jupiter Correlation

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Research in Astronomy and Astrophysics 2024年第4期24卷 141-146页

作者：祝伟 Department of Astronomy Tsinghua UniversityBeijing 100084China

The correlation between close-in super Earths and distant cold Jupiters in planetary systems has important implications for their formation and *** to some earlier findings,a recent study conducted by Bonomo et *** that the occurrence of cold Jupiter companions is not excessive in super-Earth *** we show that this discrepancy can be seen as a Simpson’s paradox and is resolved once the metallicity dependence of the super-Earth-cold Jupiter relation is taken into account.A common feature is noticed that almost all the cold Jupiter detections with inner super-Earth companions are found around metal-rich *** on the Sun-like hosts with super-solar metallicities,we show that the frequency of cold Jupiters conditioned on the presence of inner super Earths is 39_(-11)^(+12)%,whereas the frequency of cold Jupiters in the same metallicity range is no more than 20%.Therefore,the occurrences of close-in super Earths and distant cold Jupiters appear correlated around metal-rich *** relation between the two types of planets remains unclear for stars with metal-poor hosts due to the limited sample size and the much lower occurrence rate of cold Jupiters,but a correlation between the two cannot be ruled out.

关键词： Planetary Systems stars:abundances methods:statistical

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Multi-level intelligence empowering lithium-ion batteries

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Journal of Energy Chemistry 2024年第10期97卷 535-552页

作者： Guangxu Zhang Jiangong zhu Haifeng Dai Xuezhe wei School of Materials Science and Engineering Tongji University School of Automotive Studies Tongji University

With the significant and widespread application of lithium-ion batteries,there is a growing demand for improved performances of lithium-ion *** intricate degradation throughout the whole lifecycle profoundly impacts the safety,durability,and reliability of lithium-ion *** ensure the long-term,safe,and efficient operation of lithium-ion batteries in various fields,there is a pressing need for enhanced battery intelligence that can withstand extreme *** work reviews the current status of intelligent battery technology from three perspectives:intelligent response,intelligent sensing,and intelligent *** intelligent response of battery materials forms the foundation for battery stability,the intelligent sensing of multi-dimensional signals is essential for battery management,and the intelligent management ensures the long-term stable operation of lithium-ion *** critical challenges encountered in the development of intelligent battery technology from each perspective are thoroughly analyzed,and potential solutions are proposed,aiming to facilitate the rapid development of intelligent battery technologies.

关键词： Battery intelligence Intelligent management Intelligent response Intelligent sensing

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The discovery of new scaffold of plant activators：From salicylic acid to benzotriazole

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Chinese Chemical Letters 2017年第4期28卷 919-926页

作者： Kang Chang Jian-Qin Chen Yan-Xia Shi Mei-Jian Sun Peng-Fei Li Zhen-Jiang Zhao wei-ping zhu Hong-Lin Li Yu-Fang Xu Bao-Ju Li Xu-Hong Qian State Key Laboratory of Bioreactor Engineering Shanghai Key Laboratory of Chemical Biology School of Pharmacy East China University of Science and Technology Shanghai 200237 China State Key Laboratory of Bioreactor Engineering Shanghai Key Laboratory of New Drug Design School of Pharmacy East China University of Science and Technology Shanghai 200237 China Institute of Vegetables and Flowers Chinese Academy of AgricuRural Science Beijing 100081 China

Started from salicylic acid（SA） and related commercialized plant activators,based on molecular threedimensional shape and pharmacophore similarity comparison（SHAFTS）,a new lead compound benzotriazole was predicted and a series of benzotriazole derivatives were designed and *** bioassay showed that benzotriazole had high activity against a broad spectrum of diseases including fungi and oomycetes in vivo,but no activity in *** the introduction of proper groups at the1＇-position and 5＇-position was beneficial to the ***,they had the potential to be exploited as novel plant activators.

关键词： Plant activator Systemic acquired resistance Salicylic acid Benzotriazole Virtual screening

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