检索结果-南通市图书馆

Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

引用

Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu Xiangbing Wu wei Wu Ying Wang Yan Sun Lingxiao Deng Melissa Walker Chen Chen Heqiao Dai Qi Han Ying Ding Yongzhi Xia George Smith Rui Li Nai-Kui Liu Xiao-ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Thermally driven carbon nanotube@polycaprolactone coaxial artificial muscle fibers working in subzero environments

引用

International Journal of Smart and Nano Materials 2023年第2期14卷 216-229页

作者： Lizhong dong Xulin wei ming Ren Jiangtao Di Advanced Materials Division Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhouChina Division of Nanomaterials and Jiangxi Key Lab of Carbonene Materials Jiangxi Institute of NanotechnologyNanchangChina Zhejiang Lab HangzhouChina

Artificial muscle fibers driven electrothermally with excellent properties of response,stroke,and work capacity are expected to serve in some intelligent structures and ***,muscle fibers that operate in subzero environments are highly needed in industrial production and aerospace applications but remain ***,we reported a coaxial artificial muscle fiber by electrospinning a sheath of polycaprolactone(PCL)nanofibers on the surface of a carbon nanotube(CNT)fiber core,achieving the actuation in response to thermal at subzero *** CNT@PCL coaxial muscle fiber under 0.3 MPa achieved a maximum contractile stroke of~18%as the temperature changed from−130℃ to 45℃.The actuation mechanism at subzero temperatures of this muscle fiber was analyzed in combination with the temperature-deformation schematic curve of different ***,a temperature sensor based on this muscle fiber was developed,due to the excellent linear relationship between the contraction and temperature.A 3D-printed prosthetic arm was designed to further exhibit the application demonstrations of this muscle fiber in subzero *** work provides new insights into artificial muscle fibers for serving in extreme environments with ultralow temperatures.

关键词： Artificial muscles thermally driven subzero environment carbon nanotubes polycaprolactone

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

心型脂肪酸结合蛋白、高敏肌钙蛋白T、氨基末端B型钠尿肽原对慢性心力衰竭的诊断价值

引用

中国卫生检验杂志 2016年第20期26卷 2962-2964页

作者：丁琳陆卫良凌丽燕田才林史卫明汪明东平湖市第二人民医院检验科浙江平湖314201 平湖市第二人民医院心内科浙江平湖314201 上海市东方医院检验科上海200120

目的探讨心型脂肪酸结合蛋白(H-FABP)、高敏肌钙蛋白T(hs-cTnT)、氨基末端B型钠尿肽原(NT-proBNP)检测对慢性心力衰竭(CHF)的诊断价值。方法选择慢性心力衰竭患者101例为心衰组(CHF组),将CHF组分为Ⅰ、Ⅱ、Ⅲ、Ⅳ级4个亚组,同时选取健... 详细信息

目的探讨心型脂肪酸结合蛋白(H-FABP)、高敏肌钙蛋白T(hs-cTnT)、氨基末端B型钠尿肽原(NT-proBNP)检测对慢性心力衰竭(CHF)的诊断价值。方法选择慢性心力衰竭患者101例为心衰组(CHF组),将CHF组分为Ⅰ、Ⅱ、Ⅲ、Ⅳ级4个亚组,同时选取健康体检者25例为对照组。检测血清H-FABP、hs-cTnT及NT-proBNP浓度。结果 CHF组的H-FABP、hs-cTnT和NT-proBNP水平较对照组均显著升高,差异具有统计学意义(P<0.05);心衰组各亚组间H-FABP、hs-cTnT和NT-proBNP差异均有统计学意义(P<0.05),且随心功能分级增加逐渐增高;心衰亚组Ⅰ级组较对照组H-FABP、hs-cTnT水平升高,差异具有统计学意义(P<0.05);血清NT-proBNP水平变化与hs-cTnT、H-FABP呈正相关,r值分别为0.354 4和0.517 6,P值<0.05。非重症心力衰竭患者血清中多项标志物联合检测的灵敏度显著高于单项检测的灵敏度。结论联合检测H-FABP、hs-cTnT和NT-proBNP有助于慢性心力衰竭早期诊断,值得在临床工作中推广应用。

关键词：心型脂肪酸结合蛋白高敏肌钙蛋白T 氨基末端B型钠尿肽原慢性心力衰竭

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of inhibitors on macroscopical oxidation kinetics of calcium sulfite

引用

Journal of Environmental Sciences 2005年第3期17卷 483-487页

作者： ZHAOYi WANGLi-dong WANGXiao-ming LIQiang-wei XUPei-yao SchoolofEnvironmentalScienceandEngineering NorthChinaElectricPowerUniversityBaoding071003China StatePowerEnvironmentalProtectionResearchInstitute Nanjing210031China

In the presence of inhibitors, the macroscopical oxidation kinetics of calcium sulfite, the main byproduct in wet limestone scrubbing, was studied for the first time by adding different inhibitors and varying pH, concentration of calcium sulfite, oxygen partial pressure, concentration of inhibitors and temperature. The mathematical model about the general oxidation reaction was established, which was controlled by three steps involving dissolution of calcium sulfite, mass transfer of oxygen and chemical reaction in the solution. It was concluded that the general reaction was controlled by mass transfer of oxygen under uncatalyzed conditions, while it was controlled by dissolution of calcium sulfite after adding three kinds of inhibitors. Thus, the theory was provided for investigating the mechanism and oxidation kinetics of sulfite. The beneficial references were also supplied for design of oxidation technics in the wet limestone scrubbing.

关键词： calcium sulfite macroscopical oxidation kinetics inhibitor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Numerical simulation of single roller melt spinning for NdFeB alloy based on finite element method

引用

Rare Metals 2020年第10期39卷 1145-1150页

作者： Xu-Chao Wang ming Yue dong-Tao Zhang wei-Qiang Liu ming-Gang Zhu College of Materials Science and Engineering Beijing University of TechnologyBeijing 100124.China Central Iron and Steel Research Institute Beijing 100081China

The numerical simulation model of single roller melt spinning for rapid quenching process of NdFeB alloy was built,and the vacuum chamber,cooling roller and sample were taken into account as a *** existing mature technology was in order to verify the correctness of *** rapid quenching ribbons with different roll speeds were used as the simulation *** results of the numerical simulation and experiments show that the validity of the model has been testified and the reasons of the formation of complete quenching ribbons and by-product have been *** experimental thickness of the ribbons is proportional to the theoretical *** the same spray condition,with the roll speed increasing,the thickness decreases *** the speed range of25-30 m·s^(-1),the simulated calculation date is close to the experimental date,which can be considered as an ideal technological parameter.

关键词： NdFeB Melt spinning Finite element method Numerical simulation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Event-Triggered Robust Parallel Optimal Consensus Control for Multiagent Systems

引用

IEEE/CAA Journal of Automatica Sinica 2025年第1期 40-53页

作者： Qinglai wei Shanshan Jiao Qi dong Fei-Yue Wang IEEE the Institute of Systems Engineering Macau University of Science and Technology the State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of Automation Chinese Academy of Sciences the School of Artificial Intelligence University of Chinese Academy of Sciences China Academy of Electronics and Information Technology the State Key Laboratory of Multimodal Artificial Intelligence Systems the School of Artificial Intelligence University of Chinese Academy of Sciences

This paper highlights the utilization of parallel control and adaptive dynamic programming(ADP) for event-triggered robust parallel optimal consensus control(ETRPOC) of uncertain nonlinear continuous-time multiagent systems(MASs).First, the parallel control system, which consists of a virtual control variable and a specific auxiliary variable obtained from the coupled Hamiltonian, allows general systems to be transformed into affine systems. Of interest is the fact that the parallel control technique's introduction provides an unprecedented perspective on eliminating the negative effects of disturbance. Then, an eventtriggered mechanism is adopted to save communication resources while ensuring the system's stability. The coupled HamiltonJacobi(HJ) equation's solution is approximated using a critic neural network(NN), whose weights are updated in response to events. Furthermore, theoretical analysis reveals that the weight estimation error is uniformly ultimately bounded(UUB). Finally,numerical simulations demonstrate the effectiveness of the developed ETRPOC method.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

DAO媒介:驱动未来社会算法化与自组织的元媒介

引用

新疆师范大学学报（哲学社会科学版） 2025年第1期46卷 132-141页

作者：喻国明苏健威北京师范大学新闻传播学院北京师范大学传播创新与未来媒体实验平台北京100875

DAO媒介是以区块链算法等技术为基础,支持数字社群协同自治的媒介,具有区块链、智能合约与投票等功能特性和要素确权、技术信任、规则构架以及场景聚合等价值禀赋。对于数字生态显露的各种问题,“算法化”是重构数字生态、降解社会系统... 详细信息

DAO媒介是以区块链算法等技术为基础,支持数字社群协同自治的媒介,具有区块链、智能合约与投票等功能特性和要素确权、技术信任、规则构架以及场景聚合等价值禀赋。对于数字生态显露的各种问题,“算法化”是重构数字生态、降解社会系统复杂性的关键机制,DAO媒介是支撑“自组织式”算法化的元媒介。DAO媒介与数字文明时代喷发的微粒个体、微资源、微价值、微需求、微场景等相匹配,能够深度匹配人的个性与自我,形成有效的趣缘连接,进而极大地释放数字文明的生产力。DAO媒介将深刻影响社会系统的构造,将微粒个体与相关社会要素“包裹”为闭环子系统,支持其准开放的系统边界、有效的异质性整合、可持续的规则重构、子系统与父级系统的持续分化和快速进化,等等。在数字文明时代,DAO媒介将使“重新部落化”的“地球村”变为现实,其驱动构筑的DAO社会将更加多元、更加富有创造力,不断拓展人类群体实践的自由度,使人类在高度异质性聚合基础上更加和谐有序地整合协同。

关键词： DAO 数字媒介算法自组织社会系统

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Thermal conductivity prediction of MgAl2O4:a non-equilibrium molecular dynamics calculation

引用

Journal of Iron and Steel Research International 2020年第5期27卷 500-505页

作者： Cheng-ming Ni Hua-wei Fan Xu-dong Wang Man Yao School of Materials Science and Engineering Dalian University of TechnologyDalian 116000LiaoningChina

Magnesium aluminate spinel(MgAl2O4)is widely used in steel metallurgy *** conductivity at high temperature signifcantly infuences the cooling process of blast furnace and the heat preservation of steel *** efect of external(temperature)and internal(antisite defect and grain boundary)factors on the thermal conductivity of MgAl2O4 was studied with non-equilibrium molecular *** main factors afecting the thermal conductivity of MgAl2O4 were *** the temperature range of 100-2000 K,the results showed that the thermal conductivity of MgAl2O4 changed from 11.54 to 4.95 W/(m K)with the increase in temperature and was relatively stable at the temperature above 1000 *** thermal conductivity of MgAl2O4 declined frst and then rose with the increase in the antisite defects,and the minimum value was 6.95 W/(m K)at the inversion parameter i=*** addition,grain boundaries reduced the thermal conductivity of MgAl2O4 by 20%-30%at temperature below 1000 K comparing with the non-grain boundary *** grain boundary rotation angle at temperature above 1000 K had less efect on the thermal conductivity than that below 1000 *** simulation scheme for thermal conductivity of MgAl2O4 can also be applied to the study of other nonmetallic ceramics.

关键词： Non-equilibrium molecular dynamics Thermal conductivity Magnesium aluminate spinel Antisite defect Grain boundary

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Interpretation of gas-film cooling against aero-thermal heating for high-speed vehicles

引用

Applied Mathematics and Mechanics(English Edition) 2016年第12期37卷 1615-1630页

作者： ming dong Department of Mechanics Tianjin UniversityTianjin 300072China Tianjin Key Laboratory of Modern Engineering Mechanics Tianjin 300072China

The possible application of the film-cooling technique against aero-thermal heating for surfaces of high-speed flying vehicles is discussed. The technique has been widely used in the heat protection of gas turbine blades. It is shown in this paper that, by applying this technique to high-speed flying vehicles, the working principle is fundamentally different. Numerical simulations for two model problems axe performed to support the argument. Besides the heat protection, the appreciable drag reduction is found to be another favorable effect. For the second model problem, i.e., the gas cooling for an optical window on a sphere cone, the hydrodynamic instability of the film is studied by the linear stability analysis to observe possible occurrence of laminar-turbulent transition.

关键词： film cooling aero-thermal heating numerical simulation laminar-turbulenttransition linear stability analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Distinguishing Computer-Generated Images from Natural Images Using Channel and Pixel Correlation

引用

Journal of Computer Science & Technology 2020年第3期35卷 592-602页

作者： Rui-Song Zhang wei-Ze Quan Lu-Bin Fan Li-ming Hu dong-ming Yan National Laboratory of Pattern Recognition Institute of AutomationChinese Academy of SciencesBeijing 100190China School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China Alibaba Group Hangzhou 310023China State Key Laboratory of Hydro-Science and Engineering Tsinghua UniversityBeijing 100084China

With the recent tremendous advances of computer graphics rendering and image editing technologies,computergenerated fake images,which in general do not reflect what happens in the reality,can now easily deceive the inspection of human visual *** this work,we propose a convolutional neural network(CNN)-based model to distinguish computergenerated(CG)images from natural images(NIs)with channel and pixel *** key component of the proposed CNN architecture is a self-coding module that takes the color images as input to extract the correlation between color channels *** previous approaches that directly apply CNN to solve this problem,we consider the generality of the network(or subnetwork),i.e.,the newly introduced hybrid correlation module can be directly combined with existing CNN models for enhancing the discrimination capacity of original *** results demonstrate that the proposed network outperforms state-of-the-art methods in terms of classification *** also show that the newly introduced hybrid correlation module can improve the classification accuracy of different CNN architectures.

关键词： natural image computer-generated image channel and pixel correlation convolutional neural network

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：