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Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu Xiangbing Wu wei Wu Ying Wang Yan sun Lingxiao Deng Melissa Walker Chen Chen Heqiao Dai Qi Han Ying Ding Yongzhi Xia George Smith Rui Li Nai-Kui Liu Xiao-ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

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Enhancement of motor functional recovery in thoracic spinal cord injury: voluntary wheel running versus forced treadmill exercise

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Neural Regeneration Research 2025年第3期20卷 836-844页

作者： Do-Hun Lee Dan Cao Younghye Moon Chen Chen Nai-Kui Liu Xiao-ming Xu wei Wu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteIndiana University School of MedicineIndianapolisINUSA Department of Neurological Surgery Indiana University School of MedicineIndianapolisINUSA Department of Neuroscience Baylor College of MedicineHoustonTXUSA

Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery and morphological changes following thoracic contusive spinal cord injury. After a 7-day recovery period after spinal cord injury, mice were assigned to either a trained group(10 weeks of voluntary running wheel or forced treadmill exercise) or an untrained group. Bi-weekly assessments revealed that the exercise-trained group, particularly the voluntary wheel exercise subgroup, displayed significantly improved locomotor recovery, more plasticity of dopaminergic and serotonin modulation compared with the untrained group. Additionally, exercise interventions led to gait pattern restoration and enhanced transcranial magnetic motor-evoked potentials. Despite consistent injury areas across groups, exercise training promoted terminal innervation of descending axons. In summary, voluntary wheel exercise shows promise for enhancing outcomes after thoracic contusive spinal cord injury, emphasizing the role of exercise modality in promoting recovery and morphological changes in spinal cord injuries. Our findings will influence future strategies for rehabilitation exercises, restoring functional movement after spinal cord injury.

关键词： behavioral assessment motor function neural plasticity running wheel exercise spinal cord injury treadmill exercise voluntary exercise

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Depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 335-345页

作者： Feng Zhang Chenyang Zhang Linlin Wu wei sun Hongliang Zhang Jianhua Chen Yong Pei Songjiang Li Engineering Research Center of Ministry of Education for Carbon Emission Reduction in Metal Resource Exploitation and Utilization Hunan International Joint Research Center for Efficient and Clean Utilization of Critical Metal Mineral ResourcesSchool of Minerals Processing and BioengineeringCentral South UniversityChangsha 410083China State Key Laboratory of Mineral Processing Beijing General Research Institute of Mining&MetallurgyBeijing 100160China Hunan Provincial Key Laboratory of Micro&Nano Materials Interfaces Science College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China School of Resources Environment and MaterialsGuangxi UniversityNanning 530004China Department of Chemistry Xiangtan UniversityXiangtan 411105China China Railway Resource Group Co.Ltd Beijing 102300China

The depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite still lacked in-depth ***,the depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite was further systematically investigated with experiments and density functional theory(DFT)*** X-ray photoelectric spectroscopy(XPS)results,DFT calculation results,and frontier molecular orbital analysis indicated that sulfite ions were difficult to be adsorbed on sphalerite surface,suggesting that sulfite ions achieved depression effects on sphalerite through other non-adsorption ***,the oxygen content in the surface of sphalerite treated with sulfite ions in creased,which enhanced the hydrophilicity of the sphalerite and further increased the difference in hydrophilicity between sphalerite and ***,sulfite ions were chelated with lead ions to form PbSO_(3)in *** hydrophilic PbSO_(3)was more easily adsorbed on sphalerite than *** interaction between sulfite ions and lead ions could effectively inhibit the activation of *** addition the UV spectrum showed that after adding sulfite ions,the peak of perxanthate in the sphalerite treated xanthate solution was significantly stronger than that in the galena with xanthate solution,indicating that xanthate interacted more readily with sulfite ions and oxygen mo lecules within the sphalerite system,leading to the formation of ***,sulfite ions hardly depressed the flotation of ga lena and could promote the flotation of galena to some *** study deepened the understanding of the depression mechanism o sulfite ions on sphalerite and Pb^(2+)activated sphalerite.

关键词： sphalerite galena sulfite ion density functional theory depression mechanism

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高校体育课不同教材内容的生理负荷强度分析

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体育学刊 2006年第4期13卷 63-65页

作者：邓伟明孙学川军事体育进修学院体能训练研究中心广东广州510500

评价各种体育课不同教材内容的生理负荷强度,评价高校体育课课质量。采用抽样调查的方法,结合现代数理统计学和运动生理学,对全国部分高校458名“标志学生”的体育课进行生理负荷强度的监测,建立不同教材内容的体育课的生理负荷分布模型... 详细信息

评价各种体育课不同教材内容的生理负荷强度,评价高校体育课课质量。采用抽样调查的方法,结合现代数理统计学和运动生理学,对全国部分高校458名“标志学生”的体育课进行生理负荷强度的监测,建立不同教材内容的体育课的生理负荷分布模型,结合当前高校体育课改革成果,从人体运动生理规律的角度,分析体育课的生理负荷强度。

关键词：体育课生理负荷强度高校体育

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The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

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Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-Yan sun Lingyun Nie Jing Zhang Xue Fang Hongmei Luo Chuanhai Fu Zhiyi wei Ai-Hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

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Iterative learning based fault diagnosis for discrete linear uncertain systems

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Journal of Systems Engineering and Electronics 2014年第3期25卷 496-501页

作者： wei Cao ming sun College of Computer and Control Engineering Qiqihar University

In order to detect and estimate faults in discrete lin-ear time-varying uncertain systems, the discrete iterative learning strategy is applied in fault diagnosis, and a novel fault detection and estimation algorithm is proposed. And the threshold limited technology is adopted in the proposed algorithm. Within the chosen optimal time region, residual signals are used in the proposed algorithm to correct the introduced virtual faults with iterative learning rules, making the virtual faults close to these occurred in practical systems. And the same method is repeated in the rest optimal time regions, thereby reaching the aim of fault diagnosis. The proposed algorithm not only completes fault detection and estimation for discrete linear time-varying uncertain systems, but also improves the reliability of fault detection and decreases the false alarm rate. The final simulation results verify the validity of the proposed algorithm.

关键词： discrete linear uncertain system threshold limited technology iterative learning fault estimation.

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Unknown Input Observer Design of Switched Systems Based on Iterative Learning

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Journal of Systems Science & Complexity 2019年第3期32卷 875-887页

作者： CAO wei sun ming College of Computer and Control Engineering Qiqihar University

For a class of discrete switched systems with unknown input, an unknown input observer design method is proposed under the premise of changes along time axis but no changes along iteration axis. This method applies the iterative learning control thought to the design of unknown input observer, construets the unknown input observer by introducing virtual input signal, and uses the error signal generated from the actual system output and the observer output to correct repetitively the virtual input, which gradually approxima tes the actual unknown input as the it erations increase. Moreover, the convergence of the observer is strictly proved based on contraction mapping theory, as well as the convergence condition is given. The theoretical analysis indicates that designed unknown input observer can accurately estimate the state and unknown input of the system simultaneously. Simulation example further verifies the effectiveness of the proposed algorithm.

关键词： Iterative learning control switched system unknown input observer virtual input

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350MW超临界供热机组热网加热器疏水系统分析

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吉林电力 2011年第6期39卷 29-31页

作者：王为明刘悦孙健秋吉林省电力勘测设计院长春130022

针对350 MW超临界机组热网加热器疏水去向进行论述,分析了直接去除氧器的弊端,提出了对热网加热器疏水系统的优化方案,即通过增设换热器,降低热网疏水温度,使热损失降低到84.6 GJ/h,同时避免了疏水进入凝汽器引起的背压升高。

关键词：超临界供热机组热网加热器换热器疏水系统

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Clinical application of pedicled myocutaneons flap for reconstruction of oral and maxillofacial defect after ablative surgery of neoplasm

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中国口腔颌面外科杂志 2008年第B5期6卷 190-190页

作者： Hai Bin Wang Xin ming Li Xin Guang Han wei He ming Lei sun Jun Fang Zhao wei Hong Xie Department of Oral & Maxillofacial Surgery First AffiliatedHospital Zhengzhou University Zhengzhou 450052 China

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阿立哌唑与奥氮平对精神分裂症患者血糖、血脂影响的Meta分析

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中国现代医学杂志 2016年第7期26卷 78-83页

作者：邹卿孙伟铭袁也丰童恋茹姜超南昌大学第一附属医院心身科江西南昌330006 南昌大学第一附属医院康复科江西南昌330006

目的利用Meta分析的方法评估阿立哌唑与奥氮平对精神分裂症患者血糖、血脂的差异。方法计算机检索中国知网、万方数据库、维普数据库、中国生物医学文献数据库、Pub Med、Elsevier、Cochrane Library等并手工检索杂志、书籍等相关资料,... 详细信息

目的利用Meta分析的方法评估阿立哌唑与奥氮平对精神分裂症患者血糖、血脂的差异。方法计算机检索中国知网、万方数据库、维普数据库、中国生物医学文献数据库、Pub Med、Elsevier、Cochrane Library等并手工检索杂志、书籍等相关资料,检索时间为2011年1月1日-2015年7月31日,对有关阿立哌唑与奥氮平治疗精神分裂症患者的随机对照研究资料进行全面收集,在质量评价的基础上,利用Rev Man 5.2软件进行Meta分析。结果共纳入9篇随机对照研究(915例患者)进行Meta分析,结果显示,干预结束后服用奥氮平的精神分裂症患者空腹血糖要高于阿立哌唑组[MD=-0.37,95%CI(-0.53,-0.21)],差异有统计学意义(P=0.000);干预结束后奥氮平组的血三酰甘油水平要高于阿立哌唑组[MD=-0.22,95%CI(-0.29,-0.15)],差异有统计学意义(P=0.000);干预结束后服用奥氮平组的血胆固醇水平要高于阿立哌唑组[MD=-0.42,95%CI(-0.54,-0.29)],差异有统计学意义(P=0.000)。结论奥氮平较阿立哌唑更易引起精神分裂症患者血糖、血脂紊乱。

关键词：阿立哌唑奥氮平随机对照试验精神分裂症 Meta分析

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