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DAO媒介:驱动未来社会算法化与自组织的元媒介

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新疆师范大学学报（哲学社会科学版） 2025年第1期46卷 132-141页

作者：喻国明苏健威北京师范大学新闻传播学院北京师范大学传播创新与未来媒体实验平台北京100875

DAO媒介是以区块链算法等技术为基础,支持数字社群协同自治的媒介,具有区块链、智能合约与投票等功能特性和要素确权、技术信任、规则构架以及场景聚合等价值禀赋。对于数字生态显露的各种问题,“算法化”是重构数字生态、降解社会系统... 详细信息

DAO媒介是以区块链算法等技术为基础,支持数字社群协同自治的媒介,具有区块链、智能合约与投票等功能特性和要素确权、技术信任、规则构架以及场景聚合等价值禀赋。对于数字生态显露的各种问题,“算法化”是重构数字生态、降解社会系统复杂性的关键机制,DAO媒介是支撑“自组织式”算法化的元媒介。DAO媒介与数字文明时代喷发的微粒个体、微资源、微价值、微需求、微场景等相匹配,能够深度匹配人的个性与自我,形成有效的趣缘连接,进而极大地释放数字文明的生产力。DAO媒介将深刻影响社会系统的构造,将微粒个体与相关社会要素“包裹”为闭环子系统,支持其准开放的系统边界、有效的异质性整合、可持续的规则重构、子系统与父级系统的持续分化和快速进化,等等。在数字文明时代,DAO媒介将使“重新部落化”的“地球村”变为现实,其驱动构筑的DAO社会将更加多元、更加富有创造力,不断拓展人类群体实践的自由度,使人类在高度异质性聚合基础上更加和谐有序地整合协同。

关键词： DAO 数字媒介算法自组织社会系统

Pancreatic β cell regeneration induced by clinical and preclinical agents

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World Journal of Stem Cells 2021年第1期13卷 64-77页

作者： kang-Li Wang ming Tao Tian-Jiao wei Rui wei Department of Endocrinology and Metabolism Peking University Third HospitalBeijing 100191China Department of General Surgery Peking University Third HospitalBeijing 100191China

Diabetes,one of the most common chronic diseases in the modern world,has pancreaticβcell deficiency as a major part of its pathophysiological *** regeneration is a potential therapeutic strategy for the recovery ofβcell ***,endocrine islets have limited regenerative capacity,especially in adult *** all hypoglycemic drugs can protectβcells by inhibitingβcell apoptosis and dedifferentiation via correction of hyperglycemia and amelioration of the consequent inflammation and oxidative *** agents,including glucagon-like peptide-1 andγ-aminobutyric acid,have been shown to promoteβcell proliferation,which is considered the main source of the regeneratedβcells in adult rodents,but with less clarity in *** progenitor cells might exist and be activated under particular *** andγ-aminobutyric acid can induceα-to-βcell conversion,although some disputes *** endocrine progenitors can transdeterminate into insulin-producing cells in the gut after FoxO1 deletion,and pharmacological research into FoxO1 inhibition is *** cells,including pancreatic acinar cells,can transdifferentiate intoβcells,and clinical and preclinical strategies are currently *** this review,we summarize the clinical and preclinical agents used in different approaches forβcell regeneration and make some suggestions regarding future perspectives for clinical application.

关键词： βcell regeneration βcell dedifferentiation Cell proliferation Pancreatic progenitors α-to-βcell transdifferentiation Enteroendocrine progenitor cells

Climate or Carbon Mitigation Engineering Management

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Engineering 2022年第10期17卷 17-21页

作者： Yi-ming wei Jia-Ning kang weiming Chen Center for Energy and Environmental Policy Research&School of Management and Economics Beijing Institute of Technology&Beijing Key Laboratory of Energy Economics and Environmental ManagementBeijing 100081China

*** Carbon mitigation engineering,also known as climate engineering internationally,is an umbrella term of engineering measures targeted at combating climate change and achieving carbon *** or mitigation engineering can be commonly divided into three categories based on technological principles[1]:(1)carbon dioxide removal(CDR),which has the potential to achieve negative emissions by removing atmospheric carbon dioxide[2].

关键词： dioxide removing carbon

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MRI灌注成像对老年痴呆诊断价值的研究

现代医用影像学 2016年第6期25卷 1046-1049页

作者：徐林彭薇明康李隽潘晓东周德程禹复旦大学附属中山医院徐汇医院放射科上海市200030

目的:探讨磁共振灌注成像(MRP)在诊断老年痴呆症中的应用价值。材料与方法:根据临床诊断标准入组30例老年痴呆症患者(痴呆组),其中18例患阿尔茨海默病,12例患血管性痴呆;另选20名健康志愿者为对照组。采用磁共振扫描仪对头颅进行灌注成... 详细信息

目的:探讨磁共振灌注成像(MRP)在诊断老年痴呆症中的应用价值。材料与方法:根据临床诊断标准入组30例老年痴呆症患者(痴呆组),其中18例患阿尔茨海默病,12例患血管性痴呆;另选20名健康志愿者为对照组。采用磁共振扫描仪对头颅进行灌注成像,灌注参数包括脑血容量(CBV)、脑血流量(CBF)、平均通过时间(MTT)和达峰时间(TTP)。选择双侧额叶、颞叶和双侧海马、基底节区域进行测量,并进行统计学分析。结果:痴呆组双侧额叶、颞叶皮质、海马和基底核的CBV、CBF测得值低于对照组,其MTT和TTP测得值大于对照组(P值均<0.05)。结论:MRP诊断老年痴呆症具有一定意义,可作为一种有效的临床诊断方法。

关键词：阿尔茨海默病痴呆灌注成像磁共振成像

circT P63-N suppresses the proliferation and metastasis of nasopharyngeal carcinoma via engaging with HSP90AB1 to modulate the YAP1/Hippo signaling pathway

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Science China Life Sciences 2025年

作者： Dan Wang Sicheng Zuo Junshang Ge Hongke Qu Jie Wu Na Yi Lei Shi Yumin Wang Yongzhen Mo Chunmei Fan Yi He Pan Chen ming Zhou Bo Xiang wei Xiong Wenjia Guo Zhaoyang Zeng Can Guo NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine Central South University Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education Cancer Research Institute and School of Basic Medicine Sciences Central South University Furong Laboratory Cancer Research Institute Affiliated Cancer Hospital of Xinjiang Medical University Xinjiang Key Laboratory of Translational Biomedical Engineering

Circular RNAs(circRNAs) play pivotal roles in the development and progression of various diseases, including malignant tumors. However,the biological functions and the underlying mechanisms of many circRNAs remain elusive. In this study, we identified a novel circRNA,circTP63-N, generated through the splicing of exons 2–4 of the TP63 gene in nasopharyngeal carcinoma(NPC). circTP63-N was found to be downregulated in clinical samples of NPC. Both in vitro and in vivo experiments unequivocally demonstrated that circTP63-N inhibits the proliferation and metastasis of NPC cells. Further investigations revealed that circTP63-N interacted with the HSP90AB1 protein, leading to the recruitment of LATS/YAP1 proteins. This, in turn, induced phosphorylation and ubiquitination-dependent degradation of YAP1, resulting in reduced nuclear translocation of YAP1 and inhibition of the transcriptional activation of downstream oncogenic genes, including INHBA, MMP3, and CCNE2. Our findings highlight the identification of circTP63-N, a novel circRNA encoded by an important tumor-relevant gene TP63 and elucidate its molecular mechanism as a tumor suppressor in NPC. These insights offer novel potential molecular markers and therapeutic targets for the clinical diagnosis and treatment of NPC.

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MPI-RCDD: A Framework for MPI Runtime Communication Deadlock Detection

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Journal of Computer Science & Technology 2020年第2期35卷 395-411页

作者： Hong-Mei wei Jian Gao Peng Qing kang Yu Yan-Fei Fang ming-Lu Li Department of Computer Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Jiangnan Institute of Computing Technology Wuxi 214083China

The message passing interface (MPI) has become a de facto standard for programming models of highperformance computing, but its rich and flexible interface semantics makes the program easy to generate communication deadlock, which seriously affects the usability of the system. However, the existing detection tools for MPI communication deadlock are not scalable enough to adapt to the continuous expansion of system scale. In this context, we propose a framework for MPI runtime communication deadlock detection, namely MPI-RCDD, which contains three kinds of main mechanisms. Firstly, MPI-RCDD has a message logging protocol that is associated with deadlock detection to ensure that the communication messages required for deadlock analysis are not lost. Secondly, it uses the asynchronous processing thread provided by the MPI to implement the transfer of dependencies between processes, so that multiple processes can participate in deadlock detection simultaneously, thus alleviating the performance bottleneck problem of centralized analysis. In addition, it uses an AND⊕OR model based algorithm named AODA to perform deadlock analysis work. The AODA algorithm combines the advantages of both timeout-based and dependency-based deadlock analysis approaches, and allows the processes in the timeout state to search for a deadlock circle or knot in the process of dependency transfer. Further, the AODA algorithm cannot lead to false positives and can represent the source of the deadlock accurately. The experimental results on typical MPI communication deadlock benchmarks such as Umpire Test Suit demonstrate the capability of MPIRCDD. Additionally, the experiments on the NPB benchmarks obtain the satisfying performance cost, which show that the MPI-RCDD has strong scalability.

关键词： high-performance computing message passing interface(MPI) communication deadlock deadlock detection AND⊕OR model

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不同来流条件下急弯段环流结构演化过程研究

化痰祛瘀方治疗痰瘀互结型高脂血症的临床研究

工程力学 2025年第1期42卷 259-272页

作者：胡呈维余明辉渠庚长江科学院河流研究所武汉430010 长江科学院水利部长江中下游河湖治理与防洪重点实验室武汉430010 武汉大学水资源与水电工程科学国家重点实验室武汉430072

弯道环流是弯道水流运动的典型特征之一，一直以来都是众多学者关注的重点。弯道环流主要分为两类：第一类由水流经过弯道时受到的径向压差力差而引起，流速较大;第二类主要由紊流各向异性引起，尽管流速很小，但其与弯道岸坡冲刷过程... 详细信息

弯道环流是弯道水流运动的典型特征之一，一直以来都是众多学者关注的重点。弯道环流主要分为两类：第一类由水流经过弯道时受到的径向压差力差而引起，流速较大;第二类主要由紊流各向异性引起，尽管流速很小，但其与弯道岸坡冲刷过程密切相关。然而当前成果较少关注第二类弯道环流发展演化过程。因此，该文采用弯道水槽试验与数值模拟方法得到的高精度三维流速数据，研究弯道环流结构的变化规律及其动力特性，特别是第二类弯道环流的发展变化。研究结果表明：对于高雷诺数的急弯水流，由于紊动各向异性特征明显，弯道水流常会出现多个环流;对于纵向流速，当水流流经弯顶断面后，纵向流速沿垂向的分布已经明显偏离对数流速分布;当水流经过弯顶断面后，纵向流速沿着垂线存在着显著的均匀化趋势;当弗劳德数较大时，大尺寸涡体在不断分解中，使得原来的各向异性影响越来越小，凹岸附近的小尺寸环流趋近于各向同性状态，造成凹岸小环流逐渐微弱并最后消失;急弯段中环流与纵向水流互馈作用十分显著，弯道环流将对断面内的动量进行重分配，携带某些高速流体到断面内的其他区域，因此，在出现弯道环流的区域其纵向流速也一般比较小。

关键词：弯曲型河流急弯河段弯道环流水槽试验数值模拟

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滨州医学院学报 2017年第1期40卷 46-48页

作者：李敏敏孙建魏铭张文青康文路玉良滨州医学院附属医院中医科滨州医学院附属医院医务处

目的观察和评价化痰祛瘀方对痰瘀互结型高脂血症的临床疗效,探讨从痰瘀互结及肝、脾、肾三脏功能失调为主要病机的角度论治高脂血症。方法收集痰瘀互结型的高脂血症患者60例,采用随机平行对照方法分为试验组和对照组,每组各30例,试验组... 详细信息

目的观察和评价化痰祛瘀方对痰瘀互结型高脂血症的临床疗效,探讨从痰瘀互结及肝、脾、肾三脏功能失调为主要病机的角度论治高脂血症。方法收集痰瘀互结型的高脂血症患者60例,采用随机平行对照方法分为试验组和对照组,每组各30例,试验组患者服用化痰祛瘀方,对照组服用瑞舒伐他汀钙片(可定),总疗程为60d。然后分析比较各组患者服药前后血脂、中医病情、中医证候等指标的变化。结果化痰祛瘀方对痰瘀互结型高脂血症(TC、TG LDL-C)方面具有明显降脂作用,其中在降低密度脂蛋白(LDL-C)方面与瑞舒伐他汀钙片(可定)相当,降胆固醇(TC)方面稍逊于瑞舒伐他汀钙片(可定);降甘油三脂(TG)和改善痰瘀互结证中医总体症状方面明显优于瑞舒伐他汀钙片(可定);化痰祛瘀方对痰瘀互结型高脂血症患者的血脂有很好的治疗作用,且在降TG及改善中医证候方面优于对照组。结论化痰祛瘀方对痰瘀互结型高脂血症治疗在症状改善、血脂及蛋白水平调节、伴随疾病治疗方面优于对照组,说明化痰祛瘀方对痰瘀互结型高脂血症有显著疗效。

关键词：化痰祛瘀方高脂血症临床研究

乡村振兴背景下大学生返乡创业政策评估与优化策略

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黑龙江高教研究 2025年第2期43卷 155-160页

作者：杨伟明栗麟李鑫深圳信息职业技术学院广东深圳518115 河南农业大学河南郑州450000 重庆工商大学重庆400067

大学生返乡创业是推进乡村振兴战略、缓解大学生就业压力的重要途径。基于大学生返乡创业政策文本,通过构建政策工具、发展阶段、利益相关主体的三维框架进行政策评估。研究发现,大学生返乡创业已经吸引了政府的持续关注和高度重视,环... 详细信息

大学生返乡创业是推进乡村振兴战略、缓解大学生就业压力的重要途径。基于大学生返乡创业政策文本,通过构建政策工具、发展阶段、利益相关主体的三维框架进行政策评估。研究发现,大学生返乡创业已经吸引了政府的持续关注和高度重视,环境型和供给型政策工具使用过度,而需求型政策工具使用不足;政策措施主要关注初创阶段和成长阶段,较少涉及成熟阶段;政策注意力主要集中在返乡创业者、返乡创业企业等核心利益主体上,较少关注金融机构、高校等次要利益主体。基于此,建议深度优化政策工具整体结构,增加需求型政策供给;强化政策措施与返乡创业生命周期匹配度,加大成熟期政策支持力度;协调兼顾各个参与主体的利益,推动金融机构、高校等利益相关主体为大学生返乡创业提供支持。

关键词：乡村振兴大学生返乡创业政策文本分析