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Detection of Stage I nasopharyngeal carcinoma by serologicscreening and clinical examination

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Chinese Journal of Cancer 2011年第2期30卷 120-123页

作者： ming-Fang Ji Yuan-Long Yu wei-ming cheng Yong-Sheng Zong Park Sze-Park Ng Daniel Tsin-Tien Chua Mun-Hon Ng Cancer Research Institute of Zhongshan City Zhongshan Guangdong 528403 P R China Department of Pathology Sun Yat-sen Medical College Sun Yat-sen University Guangzhou Guangdong 510080 P. R. China Department of Microbiology Faculty of Medicine The University of Hong Kong Hong Kong SAR P. R. China Department of Clinical Oncology Faculty of Medicine The University of Hong Kong Hong Kong SAR P. R. China

In a prospective study, 42 048 adults residing in Zhongshan City, Guangdong, China, were followed for 16 years, and 171 of them developed nasopharyngeal carcinoma (NPC). Although Epstein-Barr virus (EBV) antibody levels of the cohort fluctuated, the antibody levels of 93% of the patients with NPC were raised and maintained at high levels for up to 10 years prior to diagnosis. This suggests that the serologic window affords an opportunity to monitor tumor progression during the preclinical stage of NPC development, facilitating early NPC detection. We reviewed the clinical records of the 171 patients with NPC in the prospective study to assess the efficacy of early NPC detection by serologic screening and clinical examination. Of the 171 patients, 51 had Stage I tumor (44 were among the 73 patients detected by clinical examination and 7 were among the 98 patients presented to outpatient department). Initial serologic screening predicted 58 (95.1%) of the 61 patients detected within 2 years. The risk of the screened population (58/3093) raised 13 times relative to cohort (61/42 048) during this period. Clinical examination detected all the 58 predicted cases, and 35 (60.3%) of which were diagnosed with Stage I tumor. The serologic prediction rate fell to 33.6% (37/110) 2 to 16 years after screening. The proportion of cases detected by clinical examination fell to 40.5% (15/37). The proportion of Stage I tumors among the cases detected by clinical examination during both periods remained at about 60%. We concluded that early detection of NPC can be accomplished by repeated serologic screening to maintain high prediction rates and by promptly examining screened subjects to detect tumors before the symptoms develop.

关键词：血清学检测临床检查鼻咽癌筛查一阶全国人民代表大会抗体水平 EB病毒

A New Alkaloid from Sinomenium acutum

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Chinese Chemical Letters 2005年第11期 65-67页

作者： wei ming cheng, Feng QIU, Li Jun WU, Xin Sheng YAO Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang 110016

Sinomenium acutum is widely used in East and South Asia for the treatment of many diseases, especially rheumatoid arthritis (RA). The chemical research on Sinomenium acutum led to the isolation of a new alkaloid compound (1). On the basis of chemical evidences and spectral analysis, 1 was identified as N-(1, 7-dimethoxylphenanthren-2-yl)acetamide.

关键词： Sinomenium acutum alkaloid N-(1 7-dimethoxylphenanthren-2-yl)acetamide

Landscape distribution characteristics of northern foothill belts of Tianshan Mountains

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Journal of Geographical Sciences 2002年第1期12卷 23-28页

作者： cheng wei-ming, ZHOU cheng-hu, TANG Qi-cheng, YAO Yong-huiZHANG Bai-ping (State Key Laboratory of Resources and Environment Information System, Institute ofGeographic Sciences and Natural Resources Research, CAS, Beijing 100101, China) State Key Laboratory of Resources and Environment Information System Institute of Geographic Sciences and Natural Resources Research CAS Beijing China

The foothill belts of Tianshan Mountains are about 280 km long and 60 km wide, and the study area extends from Kuitun city to Fukang city. They are transitional belts between mountains and plains, appearing in three rows of folds with different morphologies and their age becoming younger from south to north. Based on GIS and RS methods, and materials of the previous researchers, this paper deals with the genetics of the foothill belts and their landscape features resulting from folding by neotectonic movements, and also describes their length, width and slope by remote sensing image interpretation. The characteristics of the foothill belts are found to be very important for the surrounding environment by preventing groundwater from flowing into plains, changing groundwater, increasing flow of surface runoff, in addition to their roles in protecting the surrounding environment. The purpose of this paper is to provide an in-depth understanding of the foothill belts and influence on its surrounding environment.

关键词： foothill belts foothill landscape geomorphic landscape geomorphic remote sensing Tianshan Mountains

STUDIES ON THE CHEMICAL CONSTITUENTS OF TAXUS CUSPIDATA

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Chinese Chemical Letters 1993年第10期4卷 887-890页

作者： Xiao Jie Tong wei Shuo Fang Jin Yun Zhou Cun Heng He wei ming Chen Qi cheng Fang Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050

From the methylene chloride extract of the leaves and stems of Taxus cuspidata Sieb et Zucc twelve taxane diterpenoids have been *** structures of two novel taxane diterpenes,named 10-deacetyltaxinine B(1)and taxacust... 详细信息

关键词： HNMR

Taxayuntin I from Thous Yunnanensis

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Chinese Chemical Letters 1999年第1期10卷 43-44页

作者： Jin Yun ZHOU Pei Ling ZHANG wei ming CHEN and Qi cheng FANG(Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking UnionMedical College, Beijing 100050)

Taxayuntin I, a new 11I (15→1)abeotaxane. was isolated from the leaves and stems ofTaxes yunnanensis. Its structure was elucidated on the basis of spectroscopic data.

关键词： TaxusyUnnanensis taxoids abeotaxane taxayuntin I

Three-dimensional fracture of UO2 ceramic pellets by phase field modeling

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 169-180页

作者： wei Xiong Xuan Ye Hongzhang cheng Xiaoming Liu Institute of Nuclear and New Energy Technology Collaborative Innovation Center of Advanced Nuclear Energy Technology Key Laboratory of Advanced Reactor Engineering and Safety of Ministry of Education Tsinghua University State Key Laboratory of Nonlinear Mechanics Institute of Mechanics Chinese Academy of Sciences School of Engineering Science University of Chinese Academy of Sciences

Fracture is the primary failure type for the UO2ceramic pellets,which are operated under irradiation and thermal processes,and physically confined by the *** this work,by combining closely coupled physical processes of heat conduction,heat transfer,and mechanical deformation with the cohesive phase field framework,we proposed a high-precision modeling of quasistatic cracking of three-dimensional （3D） UO2ceramic fuel pellets under high temperature and *** simulation results agree well with the experimental results,indicating that the proposed method has the potential to capture 3D crack modes in the interested time ***,we studied the relation of the 3D fracture patterns of fuel pellets with the peak power *** was found that the power level plays a critical role in determining the competition between radial and circumferential cracks,as well as transverse penetrating cracks.

关键词： phase field method nuclear fuel pellet coupled thermo-mechanical model thermal fracture

Induction of defence gene expression by oligogalacturonic acid requires in- creases in both cytosolic calcium and hydrogen peroxide in Arabidopsis thaliana

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Cell Research 2004年第3期14卷 234-240页

作者： Steven J NEILL Centre for Research in Plant Science University of the West of England Bristol Coldharbour Lane Bristol BS16 1QY UK

Responses to oligogalacturonic acid （OGA） were determined in transgenic Arabidopsis thaliana seedlings expressing the calcium reporter protein aequorin. OGA stimulated a rapid, substantial and transient increase in the concentration of cytosolic calcium （[Ca2+]cyt） that peaked after ca. 15 s. This increase was dose-dependent, saturating at ca. 50 μg Gal equiv/ml of OGA. OGA also stimulated a rapid generation of H2O2. A small, rapid increase in H2O2 content was followed by a much larger oxidative burst, with H2O2 content peaking after ca. 60 min and declining thereafter. Induction of the oxidative burst by OGA was also dose-dependent, with a maximum response again being achieved at ca. 50 μg Gal equiv/mL. Inhibitors of calcium fluxes inhibited both increases in [Ca2+]cyt and [H2O2], whereas inhibitors of NADPH oxidase blocked only the oxidative burst. OGA increased strongly the expression of the defence-related genes CHS, GST, PAL and PR-1. This induction was suppressed by inhibitors of calcium flux or

关键词： Arabidopsis thaliana cytosolic calcium defence gene expression hydrogen peroxide OGA.

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技术创新驱动与晚清出版业转型研究

编辑之友 2017年第10期 92-97页

作者：施威曹成铭冯锦荣南京信息工程大学科技史研究院江苏南京210044 香港大学中文学院香港薄扶林道999077

技术创新是出版业转型最活跃的因素和内生动力。晚清出版技术创新驱动机制是一个由利益驱动、技术溢出、协同演化机制构成的系统,在革新工作流程、改变产业形态、重塑经营模式三个层次上规约着晚清出版业转型升级的方式和路径。随着西... 详细信息

技术创新是出版业转型最活跃的因素和内生动力。晚清出版技术创新驱动机制是一个由利益驱动、技术溢出、协同演化机制构成的系统,在革新工作流程、改变产业形态、重塑经营模式三个层次上规约着晚清出版业转型升级的方式和路径。随着西方近代印刷、造纸、编辑、发行等技术、理念和规范的引进与广泛应用,晚清出版业的物质基础、组织形式、运营模式、产业性质都发生了根本变革。

关键词：出版技术创新驱动出版业近代化转型

A mild, configurable, flexible CoNi-LDH（v）/Zn battery based on H-vacancy-induced reversible Zn2+ intercalation

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Journal of Energy Chemistry 2025年第1期100卷 498-508页

作者： Xinyue cheng Dingsheng Wu Hao Gao Qingqing Wang Pengfei Lv Sam S.Yoon Qufu wei Key Laboratory of Eco-textiles Ministry of Education Jiangnan University School of Mechanical Engineering Korea University

Flexible Zn-based batteries have attracted increasing research interest as essential components of wearable energy storage ***,the advancement of flexible aqueous Zn-based batteries based on Co-Ni layered double hydroxide （CoNi-LDH） as the cathode material is hampered by their poor cycling stability and the corrosiveness of alkaline ***,CoNi-LDH nanosheets enriched with H vacancies (CoNi-LDH（v）) were constructed on a flexible carbon cloth （CC） substrate via electrochemical deposition and *** Zn-based battery comprising CoNi-LDH（v）@CC as the cathode exhibited highly reversible conversion reactions and stable operation in 3 M ZnSO4electrolyte （pH=4）.The battery delivered an excellent specific capacity (225 mA h g-1,0.26 mA h cm-2),acceptable cycling stability（53.9%,900 cycles）,and high discharging *** abundant H vacancies served as active sites for the reversible intercalation of Zn2+and the extravasation of NO3-generated channels and space for Zn2+transport and storage,together enabling an excellent Zn2+storage ***,a sandwich-structured solid-state CoNi-LDH（v）@CC//Zn@CC battery was fabricated and was found to exhibit a noteworthy electrochemical performance and mechanical *** a proof of concept,the unencapsulated battery powered a digital watch under various deformation conditions and operated stably for 80 ***,the flexible battery displayed outstanding customizability,maintaining an open-circuit voltage of 1.42 V even after being cut *** proposed engineering strategy contributes to the realization of textiles with truly wearable energy-storage devices.

关键词： CoNi/Zn battery H vacancies Mild aqueous electrolyte Tailorable battery Wearable energy storage device