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Chinese Journal of Chemistry 2021年第1期39卷 69-74页

作者： Yecai Lai wei-min dai Laboratory of Advanced Catalysis and Synthesis Department of Chemistry and Hong Kong Branch of the Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou)The Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong SARChina Baiyunshan Pharmaceutical General Factory Guang-zhou Baiyunshan Pharmaceutical Holdings Co.Ltd.Guangzhou 510515China

A pentamodule assembly approach has been established for total synthesis of the naturally occurring(-)-palmyrolide A and(+)-5,7-epi-palmyrolide *** using the racemic tert-butyl carbinol-containing alkyl iodide,the two diastereoisomeric macrolides could be obtained from the same sequence of reactions,demonstrating the flexibility of the multimodule assembly strategy for diverted total synthesis.

关键词： Alkene B-Alky Suzuki-Miyaura cross-coupling Modular total synthesis Cross coupling Ring-closing metathesis

A Concise Total Synthesis of Amphidinin B

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Chinese Journal of Chemistry 2013年第1期31卷 105-110页

作者： Dongdong Wu Jinlong Wu wei-min dai Laboratory of Asymmetric Catalysis and Synthesis Department of Chemistry Zhejiang University Hangzhou Zhejiang 310027 China Laboratory of Advaneed Catalysis and Synthesis Department of Chemistry The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong SAR China

A concise total synthesis of amphidinin B, a cytotoxic linear dicarboxylic acid associated with amphidinolide T marine macrolides, has been accomplished from the 19-membered cycloalkene intermediates designed for diverted total synthesis of amphidinolide T1 and T3-T5. The lH and 13C NMR spectra of the synthesized amphidinin B in C6D6 and CDC13 were compared with those for the natural and synthetic forms reported in the literature, showing solvent-dependence of the ^1H and ^13C NMR signals of amphidinin B in C6D6 and CDC13.

关键词： amphidinin B cycloalkene dihydroxylation oxidative cleavage total synthesis

State of the art of lightweight aggregates used in lightweight refractories for working lining of high-temperature furnaces

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Journal of Iron and Steel Research International 2024年第6期31卷 1320-1343页

作者： wei Zhang Wen-yong dai Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016LiaoningChina Research and Development Department AGC Plibrico(Dalian)Industries Inc.Dalian 116600LiaoningChina

Lightweight refractories for the working lining of high-temperature furnaces play an important role in the smelting of advanced steels and *** prepare lightweight refractories for the working lining of high-temperature furnaces,the synthesis of lightweight aggregates is the ***,the research on the synthesis of lightweight aggregates with high service temperature,low thermal conductivity,high strength,and good slag resistance has received widespread *** available literature on the synthesis of lightweight aggregates was summarized,including corundum,mullite,mullite-corundum,spinel,corundum-spinel,cordierite,cordierite-mullite,calcium hexaluminate,corundum-calcium hexaluminate,bauxite,magnesia,magnesia-based,and forsterite-based ***,the future development trend of lightweight aggregates was proposed.

关键词： Lightweight aggregate Lightweight refractory Working lining Apparent porosity Closed porosity Thermal conductivity Pore-forming approach

Navigating the complex terrain of hepatitis B virus reactivation in the era of Bruton tyrosine kinase inhibitors

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World Journal of Gastroenterology 2024年第21期30卷 2748-2750页

作者： wei-Nung Liu ming-Shen dai Felicia Lin Gen-min Lin Department of Medicine Tri-Service General HospitalTaipei 114Taiwan Division of Hematology/Oncology Department of Internal MedicineNational Defense Medical CenterTaipei 114Taiwan Community Care Minnesota OncologyMinneapolisMN 55404United States Department of Medicine Hualien Armed Forces General HospitalHualien City 970Taiwan

In this editorial,we offer a summary of the risk associated with hepatitis B reactivation(HBVr)in the setting of both solid and hematologic malignancies treated with Bruton tyrosine kinase(BTK)inhibitors,with insights derived from current ***,we emphasize the critical need for a framework regarding robust risk evaluation in patients undergoing such *** framework is essential for identifying those at increased risk of HBVr,enabling healthcare providers to implement proactive measures to prevent reactivation and ensure the safe administration of BTK inhibitor therapy.

关键词： Hepatitis B virus reactivation Bruton tyrosine kinase inhibitors Hematologic malignancies Solid tumors Prophylaxis guidelines

Study on Multimodule Total Synthesis of Amphidinolactone B

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Study on Multimodule Total Synthesis of Amphidinolactone B

中国化学会第九届全国有机化学学术会议

作者： wei-min dai Department of Chemistry The Hong Kong University of Science and Technology

＜正＞The 26-membered macrolide amphidinolactone B（1）was isolated from dinoflagellate Amphidinium *** it exhibits cytotoxicity against L1210 murine leukemia and human epidermoid carcinoma KB cell lines with IC50values of 3.3 and 5.3μg/m L,respectively.1However,the absolute configuration at C6 in amphidinolactone B（1）has not been *** envisioned a

关键词：

Total Synthesis of Amphidinolactone B via Multimodule Assembly Strategy

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Total Synthesis of Amphidinolactone B via Multimodule Assemb...

中国化学会第十一届全国天然有机化学学术会议

作者： wei-min dai Department of Chemistry The Hong Kong University of Science and Technology

In connection with our efforts on total synthesis and structural determination of the 26-membered macrolide,amphidinolactone B(1),isolated from the marine dinoflagellateAmphidinium sp.,

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Diverted total synthesis for decoding structure of iriomoteolide-1a

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Diverted total synthesis for decoding structure of iriomoteo...

中国化学会第十届全国天然有机化学学术会议

作者： wei-min dai Department of Chemistry The Hong Kong University of Science and Technology

＜正＞In connection with our continuing effort in decoding the structure of iriomoteolide-1a1 via a four-module coupling diverted total synthesis,we have successfully synthesized a dozen of diastereomers on the basis of the designed structure 2 possessing a（2E）-configuration（Chart 1a）.2By fixing the absolute configuration at C9 and C13,other 7 stereogenic centers at C4,C5,C14,C18,

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Asymmetric Hydroalkoxylation of Dienyl Alcohols for Synthesis of the 2,2,3,5-Tetrasubstituted Tetrahydrofuran Subunit of Amphidinolactone B

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Asymmetric Hydroalkoxylation of Dienyl Alcohols for Synthesi...

手性中国2014学术研讨会

作者： wei-min dai Department of Chemistry The Hong Kong University of Science and Technology

＜正＞Amphidinolactone B（1）,1 isolated from dinoflagellate Amphidinium *** a novel 26-membered macrolide with potent cytotoxicity against L1210 murine leukemia and human epidermoid carcinoma KB cell *** characteristic structural feature of 1 is the 2,2,3,5-tetrasubstituted tetrahydrofiiran subunit which distinguishes 1 from the related 26-membered macrolides,amphidinolide B,D,G,and H congeners.2We envisioned a four-module synthesis of the two C6 diastereomers of 1 from the fragments 2-5 for

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Metagenomics reveals the microbial community and functional metabolism variation in the partial nitritation-anammox process:From collapse to recovery

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Journal of Environmental Sciences 2024年第1期135卷 210-221页

作者： Hong Wang Hui Gong Xiaohu dai min Yang State Key Laboratory of Pollution Control and Resource Reuse College of Environmental Science and EngineeringTongji UniversityShanghai 200092China BIOMATH Department of Data Analysis and Mathematical ModellingGhent UniversityGhent 9000Belgium

Mainstream partial nitritation-anammox(PNA)process easily suffers from performance instability and even reactor collapse in ***,it is of great significance to unveil the characteristic of performance recovery,understand the intrinsic mechanism and then propose operational *** this study,we combined long-term reactor operation,batch tests,and metagenomics to reveal the succession of microbial community and functional metabolism variation from system collapse to *** aeration control(0.10-0.25mg O_(2)/L)was critical for performance *** was also found that Candidatus Brocadia became the dominant flora and its abundance increased from 3.5%to 11.0%.Significant enhancements in carbon metabolism and phospholipid biosynthesis were observed during system recovery,and the genes abundance related to signal transduction was dramatically *** up-regulation of sdh and suc genes showed the processes of succinate dehydrogenation and succinyl-CoA synthesis might stimulate the production of amino acids and the synthesis of proteins,thereby possibly improving the activity and abundance of AnAOB,which was conducive to the performance ***,the increase in abundance of hzs and hdh genes suggested the enhancement of the anammox *** in the abundance of key genes involved in nitrogen metabolism indicated that nitrogen removal pathway was more diverse after system *** achievement of performance recovery was driven by anammox,nitrification and denitrification coupled with dissimilatory nitrate reduction to *** results provide deeper insights into the recovery mechanism of PNA system and also provide a potential regulation strategy for the stable operation of the mainstream PNA process.

关键词： Partial nitritation-anammox Metagenomics Microbial community Functional metabolism Recovery

Is the Cape Stone Forest in Shantou City formed by wave erosion? A comparison of the pedestal rocks on the coasts and the mountains of Queshi in eastern Guangdong, China

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Journal of Mountain Science 2024年第5期21卷 1447-1463页

作者： CHEN min WANG wei School of Geography South China Normal UniversityGuangzhou 510631China

Cape Stone Forest is a group of granite rock pillars(pedestal rocks) towering over Shilin Lake, on the southern shore of Shantou Bay in eastern Guangdong, China. The rock pillars were previously identified as sea stacks because they have marine notch-like concave sidewalls at their base, and more importantly, the lake is immediately adjacent to the bay, which is exposed to the open sea. However, rock pillars similar in shape and size can also be found at the top of Queshi Mountain, which is only about 300 meters northwest of the lake and about 85 meters above sea level. Therefore, the marine origin of Cape Stone Forest is seriously questioned. In this study, 3D imagery and drone technology were used to collect data in the investigations without direct manual measurements in the water or on the mountain. It shows that the concave sidewalls of the rock pillars in the lake and on the mountains occur at different heights and are exposed to different directions, while a natural sea stack on Mayu Island at the mouth of Shantou Bay has a horizontal notch parallel to the sea level, although the granite rock of the sea stack is the same as that of the lake and the mountains. The eastern side of the island, where the sea stack is located, is exposed to the open sea but blocks large waves for the rock pillars in the lake. Therefore, the origin of Cape Stone Forest cannot be explained by wave-based mechanisms. The only satisfactory explanation that takes into account all the field evidence is that the narrow rock pillars of the lake and mountain were formed by chemical weathering that penetrated closely the spaced joints of the granite rock, and the notch-like concave sidewalls were formed by more effective chemical weathering at the base of the pillars.

关键词： Pedestal rock Granite Closely spaced joints Wave erosion Chemical weathering