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Optical coherence tomography angiography metrics in different stages of diabetic macular edema

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Eye and Vision 2024年第3期10卷 13-20页

作者： Ruyi Han Ruowen Gong wei Liu Gezhi Xu Eye Institute and Departm.nt of Ophthalmology Eye and ENT Hospital of Fudan University83 Fenyang RoadShanghai200031People’s Republic of China Key Laboratory of Visual Impairm.nt and Restoration Fudan UniversityShanghaiPeople’s Republic of China Key Laboratory of myopia(Fudan University) Chinese Academy of Medical SciencesNational Health CommissionShanghaiPeople’s Republic of China

Background To investigate the optical coherence tomography angiography(OCTA)characteristics of diabetic macular edema(DmE)at different *** This study was a cross-sectional *** diagnosed with DmE were *** was classified into early,advanced,and severe *** vessel density(VD)in the superficial vascular plexus(SVP),deep vascular plexus(DVP)and foveal avascular zone(FAZ)parameters,including FAZ area,FAZ perimeter,acircularity index and foveal VD in a 300-μm-wide region around the FAZ(FD-300),were calculated by the AngioVue software.A multivariate generalized estimating equation was used to evaluate the associations between visual acuity and OCTA *** ninety-two eyes from 74 patients with DmE were included in this *** to early(P=0.006)and advanced DmE(P=0.003),the acircularity index was higher in severe *** whole and parafoveal VD in the DVP decreased in eyes with severe DmE compared to early DmE(P=0.018,P=0.005,respectively)and advanced DmE(P=0.035,P=0.012,respectively).In the multivariate generalized estimating equation,DmE severity,FAZ area and foveal thickness were positively associated with worse visual acuity(P=0.001,P=0.007 and P=0.001,respectively).Conclusion Compared to early and advanced DmE,severe DmE showed increased irregularity in the FAZ and more extensive vessel damage in the *** severity level of DmE,larger FAZ area,and increased foveal thickness could be risk factors for poor visual *** registration The protocol was published in the Chinese Clinical Trial Registry(ChiCTR2000033082).

关键词： Optical coherence tomography angiography Diabetic macular edema Vessel density Acircularity index

Processing of a low-costγ-γ'niPtAl coating with improved oxidation resistance

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Rare metals 2024年第6期43卷 2832-2841页

作者： yan Jiang Liang-Liang wei Jian He Hong-Bo Guo School of materials Science and Engineering Beihang UniversityBeijing 100191China Key Laboratory of High-Temperature Structural materials and Protective Coatings Ministry of Industry and Information TechnologyBeihang UniversityBeijing 100191China

A novelγ-γ'(ni solid solution—ni_(3)Al)niPtAl coating was produced on advanced single-crystal(SC)superalloy n5 by electroplating of a thin Pt coating with~3μm in thickness followed by heat treatm.nt at 1000℃in *** comparison,a traditionalγ-γ'niPtAl coating was also produced by electroplating of a thick Pt coating with~6μm in thickness followed by heat treatm.nt at 1100℃in *** novel coating has a mass gain of~0.5 mg·cm^(-2)after 100 h 1-h cyclic oxidation at 1150℃,showing better oxidation resistance than the traditional *** oxide scale mostly consisting ofα-Al_(2)O_(3)grew on the novel coating because the elem.nt Cr from the SC alloy substrate contributes to the formation ofα-Al_(2)O_(3).Pt content in the novel coating has significant effect on the oxidation *** optimized Pt content in the coating is about 16 at%,which is helpful to reduce the diffusion of harmful elem.nts from the substrate into the coating but also to reduce the cost of the coating.

关键词： γ-γ'niPtAl coating Platinum Oxidation Al_(2)O_(3) Superalloy

Characterization of Fe-containing particles in Chengdu,southwest China,using single-particle aerosol mass spectrometry

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Journal of Environm.ntal Sciences 2024年第2期136卷 110-120页

作者： Renjiang He Junke Zhang Luyao Chen wei Zhang y.ngwei Xi School of Public Health Southwest Medical UniversityLuzhou 646000China Faculty of Geosciences and Environm.ntal Engineering Southwest Jiaotong UniversityChengdu 611756China Sichuan Environm.ntal m.nitoring Center Chengdu 610074China

Single-particle aerosol mass spectrometry was used to study the characteristics of Fecontaining particles during winter in Chengdu,southwest *** mass concentrations of Pm_(2.5)and Pm_(10)during the study period were 64±38 and 89±49μg/m~3,respectively,and nO_(2)and particulate matter were high compared with most other regions of *** Fecontaining particles were divided into seven categories with different mass spectra,sources and aging *** highest contribution was from Fe mixed with carbonaceous components(Fe-C,23.1%)*** was more mixed with sulfate than nitrate and therefore the contribution of Fe mixed with sulfate(Fe-S,20.7%)particles was higher than that of Fe mixed with nitrate(Fe-n,12.5%)*** contributions from Fe-containing particles related to primary combustion were high in the small particle size range,whereas aged Fecontaining particles and dust-related particles were mostly found in the coarse particle size *** air masses mainly originated from the west and east of Chengdu,and the corresponding Pm_(2.5)concentrations were 79±36 and 55±36μg/m~3,*** west and east air masses showed stronger contributions of Fe-containing particles related to biomass burning(Fe-B)and fossil fuel combustion(Fe-C and Fe-S)particles,*** southwest area contributed the most Fe-containing *** assessm.nts of the effects of Fe-containing particles during heavy pollution period should pay more attention to Fe-C and Fe-S ***-reduction of Fe-containing particles should consider both local emissions and short-distance transmission from the surrounding areas.

关键词： Fe-containing particles Particle composition Potential source areas Evolution Chengdu

A comparative investigation on wear behaviors of physical and chemical vapor deposited bronze coatings for hydraulic piston pump

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Chinese Journal of Aeronautics 2024年第3期37卷 391-403页

作者： wei HAO Andrews LARBI Hongkang DOng Dongyun WAng Shenghu LI Zhejiang Provincial Key Laboratory of Urban Rail Transit Intelligent Operation and maintenance Technology and Equipm.nt Zhejiang Normal UniversityJinhua 321004China College of Engineering Zhejiang Normal UniversityJinhua 321004China Hangzhou Lilong Hydraulic Co. LtdHangzhou 311200China

The cylinder block/valve plate interface is one of the most critical frictional interfaces of the swashplate-type axial piston ***,the poor lubrication interface caused rapid wear and high friction loss in an elastohydrodynamic lubrication system,decreasing the pump *** resistant bronze coatings were fabricated on 38CrmoAl substrate by Physical Vapor Deposition(PVD)and Chemical Vapor Deposition(CVD),***-on-disc wear tests were performed to comparatively investigate the wear behaviors of the coatings and bulk ductile iron *** can be found that the PVD-bronze coating exhibited better wear resistance than the other two *** enhanced wear resistance was attributed to the unique composite microstructure and desired mechanical strength,which could resist to mechanical shear and spallation,decreasing friction *** appropriate hardness of(1.33±0.07)GPa could be beneficial for enhancing its wear *** PVD-bronze coating possessed a much lower and stable coefficient of friction(about 0.1)and wear rate(about 6000μm3.n-1.m-1)under the loading forces of about 100 n after 20 *** wear mechanism was the abrasive wear.

关键词： Aircraft hydraulic pump Bronze Coatings Wear resistance mechanisms

Effect of heat treatm.nt on microstructural evolution,mechanical properties and tribological properties of H13 steel prepared using selective laser melting

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Journal of Iron and Steel Research International 2024年第5期31卷 1246-1259页

作者： Li-xiong Han yan Wang Shi-feng Liu Zhao-hui Zhang wei Liu Xin y.ng Dang-shen ma Jian Zhou y.ng-kang wei College of metallurgical Engineering Xi’an University of Architecture and TechnologyXi’an710055ShaanxiChina Zhejiang University City College Hangzhou310015ZhejiangChina China Iron and Steel Research Institute Group Co. Ltd.Beijing100081China

H13 tool steel was successfully prepared by selective laser melting(SLm)*** effects of heat treatm.nt on the microstructure,mechanical properties,and tribological properties of SLmed H13 steel were *** heat treatm.nt process involved a solution treatm.nt and a double aging treatm.nt of the deposited H13 tool steel prepared by *** aim is to optimize the microstructure and mechanical properties of SLmed H13 *** to the rapid heating and cooling effects of SLm,carbide precipitation in the deposited H13 steel was not uniform and residual stresses were *** purpose of the solution treatm.nt is to dissolve the solution at a high temperature to elim.nate the residual stresses and defects introduced by the SLm-form.ng *** solution treatm.nt and first aging treatm.nt produced the precipitation of small carbides at the grain boundaries and inside the crystals,which increased the hardness of SLmed H13 *** hardness increased from 538±4.0 HV of the as-deposited sample to 548±5.8 HV of samples after the first aging ***,the ultimate tensile strength and the elongation at break decreased from 1882 mPa and 11.5%in the as-deposited sample to 1697 mPa and 7.9%in those after the first aging treatm.nt,***,the friction coefficient and wear rate in the as-deposited sample decreased from 0.5160 and 2.36×10^(–6)mm^(−3)n^(−1)m^(−1)to 0.4244 and 1.04×10^(–6)mm^(−3)n^(−1)m^(−1),***,the distribution of carbides inside the crystals was not *** second aging treatm.nt adjusted the morphology of carbide precipitation and made it more uniform,but the precipitation of carbides grew and settled at the bottom of the grain *** hardness decreased to 533±6.7 HV compared with that with the first aging treatm.nt,but the ultimate tensile strength and plasticity reached a balance(1807 mPa,14.05%).Accordingly,the friction coefficient and wear rate also showed a stable and decreasin

关键词： Selective laser melting H13 steel Solution aging Double aging Friction and wear Retained austenite

Formation and properties of a Zr-based amorphous coating by laser cladding

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Rare metals 2024年第4期43卷 1809-1814页

作者： ning Zhang y.ng Liu wei y.ng Shu-Jie Pang Key Laboratory of Aerospace materials and Perform.nce(m.nistry of Education) School of Materials Science and EngineeringBeihang UniversityBeijing100191China

(Zr_(0.53)Al_(0.1)ni_(0.05)Cu_(0.3)Ti_(0.02))_(99)y_1(at%)coating with amorphous layer of about 180μm thick was prepared on a steel substrate by using laser cladding *** coating is compact and shows good metallurgical bonding with *** microstructure,microhardness and corrosion behavior along the depth from the coating surface to the substrate were *** is found that a gradient structure consisted of amorphous surface layer,amorphous-crystalline transitional layer and substrate is formed after the laser *** microhardness and corrosion behavior exhibit variation with the microstructural evolution at different depths from the coating *** microhardness and corrosion resistance in 3.5 wt%naCl solution of the amorphous surface layer are comparable to those of the as-cast Zr-based BmG with the same composition,and higher than those of the steel substrate.

关键词： Laser cladding Amorphous coating microstructure Hardness Corrosion resistance

RnA modifications in cellular metabolism:implications for metabolism-targeted therapy and imm.notherapy

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1565-1594页

作者： wei-wei Liu Si-Qing Zheng Tian Li yun-Fei Fei Chen Wang Shuang Zhang Fei Wang Guan-m.n Jiang Hao Wang Departm.nt of Laboratory medicine The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiChina School of Clinical medicine Shandong UniversityJinanChina Core Unit of national Clinical Research Center for Laboratory medicine HefeiChina neurosurgical Departm.nt The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiChina Departm.nt of Clinical Laboratory The Fifth Affiliated HospitalSun Yat-sen UniversityZhuhaiChina

Cellular metabolism is an intricate network satisfy.ng bioenergetic and biosynthesis requirem.nts of *** studies have been constantly making inroads in our understanding of pathophysiology,and inspiring developm.nt of *** a crucial component of epigenetics at post-transcription level,RnA modification significantly determ.nes RnA fates,further affecting various biological processes and cellular *** be noted,imm.nometabolism defines the metabolic alterations occur on imm.ne cells in different stages and imm.nological *** this review,we characterize the distribution features,modify.ng mechanisms and biological functions of 8 RnA modifications,including n6-methyladenosine(m6A),n6,2'-O-dimethyladenosine(m6Am),n1-methyladenosine(m1A),5-methylcytosine(m5C),n4-acetylcytosine(ac4C),n7-methylguanosine(m7G),Pseudouridine(V),adenosine-to-inosine(A-to-l)editing,which are relatively the most studied *** regulatory roles of these RnA modification on metabolism in diverse health and disease contexts are comprehensively described,categorized as glucose,lipid,am.no acid,and mitochondrial *** we highlight the regulation of RnA modifications on imm.nometabolism,further influencing imm.ne *** all,we provide a thorough discussion about clinical implications of RnA modification in metabolism-targeted therapy and imm.notherapy,progression of RnA modification-targeted agents,and its potential in RnAtargeted ***,we give legitimate perspectives for future researches in this field from methodological requirem.nts,mechanistic insights,to therapeutic applications.

关键词： metabolism targeted alterations

Slip rate and interseismic coupling along the moxi-Shimian segm.nt of the Xianshuihe fault, Eastern Qinghai-Xizang Plateau

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Geodesy and Geodynamics 2024年第4期15卷 338-351页

作者： Xinyu Zhao Gang Liu Zhaosheng nie wei Xiong wei Chen mu Lin Dijin Wang Qi Li Jiansheng yu Dongzhen Wang Pengfei yu Institute of Seismology China Earthquake AdministrationWuhan 430071China Key Laboratory of Earthquake Geodesy.China Earthquake Adm.nistration Wuhan 430071China State Key Laboratory of Geodesy and Earth's Dynamics Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430077China

On September 5,2022,the Luding m6.8 earthquake occurred in the moxi-Shimian segm.nt of the Xianshuihe fault,coinciding with the historical ruptured zone of the 1786 moxi *** seis-mogenic environm.nt provides a foundation for comprehending the mechanism of the earthquake and its future *** the moxi-Shimian segm.nt,we establish a series of near-field Global navigation Satellite Systems(GnsS)stations to enhance the spatial resolution of observational data for the inversion of the interseismic kinematic *** this study,with an elastic screw dislocation model con-strained by GnsS observations,the slip rate of the moxi-Shimian segm.nt is estimated to be 10.9±1.0 mm/yr,while the locking depth is 15.7±6.2 ***,we utilize a block-dislocation model to invert the interseismic fault coupling along the Kangding-moxi-Shimian *** result indicates a gradual deepening of the locking depth along the section from Kangding to *** coseismic rupture of the 2022 event occurred within the high coupling regions in the Kangding-moxi-Shimian segm.nt,which indicates that the rupture kinematics in this event might be controlled by the interseismic *** seismic mom.nt accumulated within the ruptured zone of the Luding earthquake since 1786 ranges in[1.42-3.40]×10^(19) n-m,which is significantly greater than the seismic mom.nt released during the 2022 *** a result,we infer that the Luding earthquake released only a portion of the accumulated energy within the original rupture zone since 1786,indicating that the 2022 event has not caused a complete rupture in the moxi-Shimian ***,there remains a substantial seismic hazard in this area.

关键词： moxi-Shimian segm.nt of Xianshuihe fault Luding earthquake Global positioning system Interseismic kinematic parameters

Sensitive and Specific y-Shaped Ratio Biosensor for Detecting Serum mi R-18a:Potential Early Scanning Tool for non-Small Cell Lung Cancer

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Journal of Analysis and Testing 2024年第2期8卷 237-244页

作者： Fei yu yue Wang Caiyuan yu wei Zhang Xuefeng Bai State Key Laboratory of Quality Research in Chinese medicines Macao Institute for Applied Research in Medicine and HealthMacao University of Science and TechnologyTaipaMacao999078China Baotou Cancer Hospital Baotou014040Inner MongoliaChina

miR-18a has been identified as a significantly expressed microRnA(miRnA)in non-small cell lung cancer(nSCLC)and plays a vital role in cancer cell transformation,metastasis,and ***,a pair of binary probes from.numerous probe pairs based on single nucleotide polymorphism analyses of miR-18a and miR-18b was first designed and screened to develop a y-shaped ratio biosensor for accurate detection of serum miR-18a in *** special structure of the binary probes combined with the hairpin showed strong specificity for miR-18a,which was confirmed by polyacrylamide gel electrophoresis assay and square wave voltammetry ***,it is beneficial to immobilize single-stranded DnA(ssDnA)probes due to the large specific surface area of nanoporous gold,thereby improving the sensitivity of the *** y-shaped ratio biosensor exhibited a wide detection range and can quantify the concentration of miR-18a in the range of 10 fmol/L–100 pmol/L,with a limit of detection of 0.211 fmol/L(S/n=3).moreover,it exhibits excellent detection capabilities in serum samples since the biosensor showed a high selectivity toward the coexistence of miR-18a and ***,the prepared y-shaped ratio biosensor is a highly sensitive and specific miR-18a detection tool,capable of identify.ng microscopic amounts of miR-18a in serum samples,providing great potential for early screening of nSCLC.

关键词： nanoporous gold y-shaped biosensor miR-18a nSCLC