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FGF21-mediated autophagy:Remodeling the homeostasis in response to stress in liver diseases

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Genes & Diseases 2024年第3期11卷 264-274页

作者： wei Shen Modan Yang Hao Chen Chiy He huigang Li Xinyu Yang Jianyong Zhuo Zuyuan lin Zhihang hu Di Lu Xiao Xu Zhejiang University School of Medicine HangzhouZhejiang 310058China Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Department of Hepatobiliary and Pancreatic SurgeryAffiliated Hangzhou First People's HospitalZhejiang University School of MedicineHangzhouZhejiang 310006China The Institute for Organ Repair and Regenerative Medicine of Hangzhou HangzhouZhejiang 310006China Institute of Organ Transplantation Zhejiang UniversityHangzhouZhejiang 310003China National Center for Healthcare Quality Management in Liver Transplant HangzhouZhejiang 310003China

Liver diseases are worldwide problems closely associated with various stresses,such as endoplasmic reticulum *** exact interplay between stress and liver diseases remains *** plays an essential role in maintaining homeostasis,and recent studies indicate tight crosstalk between stress and autophagy in liver *** the bal-ance between damage and autophagy is broken,autophagy can no longer resist injury or main-tain *** recent years,FGF21(fibroblast growth factor 21)-induced autophagy has attracted much ***21 is regarded as a stress hormone and can be up-regulated by an abundance of signaling pathways in response to ***,increased FGF21 activates autophagy by a complicated signaling network in which mTOR plays a pivotal *** review summarizes the mechanism of FGF21-mediated autophagy and its derived application in the defense of stress in liver diseases and offers a glimpse into its promising prospect in future clinical practice.

关键词： Autophagy Fibroblast growth factor 21 Liver diseases mTOR Stress

Exploring the correlation between temperature and crime:A case-crossover study of eight cities in America

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Journal of Safety Science and Resilience 2024年第1期5卷 13-36页

作者： Jinming hu Xiaofeng hu Xin’ge Han Yan lin huanggang Wu Bing Shen School of Information Technology and Cyber Security People’s Public Security University of ChinaBeijing 100038China Center for Capital Social Safety People’s Public Security University of ChinaBeijing 100038China China Association for Public Safety Beijing 100084China School of Emergency Management and Safety Engineering China University of Mining and TechnologyBeijing 100083China School of International Police Studies People’s Public Security University of ChinaBeijing 100038China

Recent years have seen increasing academic interest in exploring the correlation between temperature and ***,it is uncertain whether similar long-term trends or seasonality(rather than causal effect)of temper-ature and crime is the major reason for the observed correlation between *** explore whether there is still a correlation between temperature and crime when long-term trends and seasonal cycles are filtered out,we use the Kalman filter to decompose the time series of temperature and crimes,and then the fast Fourier transform is used to calculate the exact circle of their seasonality *** on that,the box-plot method and linear regression are used to explore the correlation between temperature residuals and crime *** results show that more than half of the crime types have similar seasonal cycles(approximately 1 year)to that of ***,the daily residual analyses show that temperature residuals have a positive correlation with assault and robbery residuals in all cities,whose average slopes are more than *** other four types of crimes vary greatly from case to *** temperature residuals show a weak correlation with the residuals of some crime types.

关键词： Time series decomposition Crime Temperature Kalman filter Fast fourier transform

A chromosome-level genome assembly for Chinese plum‘Wushancuili'reveals the molecular basis of its fruit color and susceptibility to rain-cracking

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Horticultural Plant Journal 2024年第3期10卷 672-688页

作者： Kun Zhou Jingwen Wang lin Pan Fang Xiang Yi Zhou wei Xiong Ming Zeng Donald Grierson Wenbin Kong lingyu hu Wanpeng Xi College of Horticulture and Landscape Architecture Southwest UniversityChongqing 400715China Key Laboratory of Agricultural Biosafety and Green Production of Upper Yangtze River(Ministry of Education) Southwest UniversityChongqing 400715China Department of Pomology Chongqing Agricultural Technology Extension StationChongqing 401420China Plant and Crop Sciences Division School of BiosciencesUniversity of NottinghamSutton Bonington CampusLoughborough LE125RDUK Wuxi Economical Crop Technology Extension Station Chongqing 405800China

Chinese plum(Prunus salicina lindl.)originates from China and makes a large contribution to the global production of *** ***‘Wushancuili'has a green coloration and high fruit quality and is economically important in eliminating poverty and protecting ecology in the Yangtze River Three Gorges ***,rain-induced cracking(rain-cracking,literally skin cracking caused by rain)is a limitation to‘Wushancuili'fruit production and causes severe *** study reported a high-quality‘Wushancuili'genome assembly consisting of a 302.17-Mb sequence with eight pseudo-chromosomes and a contig N50 of 23.59 Mb through the combination of Illumina sequencing,Pacific Biosciences HiFiⅢsequencing,and high-throughput chromosome conformation capture technology.A total of 25109 protein-coding genes are predicted and 54.17%of the genome is composed of repetitive sequences.‘Wushancuili'underwent a remarkable orthoselection during *** identification revealed that loss-of-function in four core MYB10 genes results in the anthocyanin deficiency and absence of red color,revealing the green coloration due to the residual high chlorophyll in fruit ***,the occurrence of cracking is assumed to be closely associated with cell wall modification and frequently rain-induced pathogen enrichment through transcriptomic *** loss of MYB10 genes might render fruit more susceptible to pathogen-mediated cracking by weakening the epidermal strength and reactive oxygen species(ROS)*** findings provided fundamental knowledge regarding fruit coloration and rain-cracking and will facilitate genetic improvement and cultivation management in Chinese plums.

关键词： Chinese plum Fruit coloration Fruit epidermis Genome MYB10 Rain-cracking

Fault Analysis on AES:A Property-Based Verification Perspective

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Tsinghua Science and Technology 2024年第2期29卷 576-588页

作者： Xiaojie Dai Xingxin Wang Xue Qu Baolei Mao wei hu School of Cybersecurity Northwestern Polytechnical UniversityXi’an 710072China School of Cyber Science and Engineering Zhengzhou UniversityZhengzhou 450001China

Fault analysis is a frequently used side-channel attack for ***,existing fault attack methods usually involve complex fault fusion analysis or computation-intensive statistical analysis of massive fault *** this work,we take a property-based formal verification approach to fault *** derive fine-grained formal models for automatic fault propagation and fusion,which establish a mathematical foundation for precise measurement and formal reasoning of fault *** extract the correlations in fault effects in order to create properties for fault *** further propose a method for key recovery,by formally checking when the extracted properties can be satisfied with partial keys as the search *** results using both unprotected and masked advanced encryption standard(AES)implementations show that our method has a key search complexity of 216,which only requires two correct and faulty ciphertext pairs to determine the secret key,and does not assume knowledge about fault location or pattern.

关键词： side-channel attack fault analysis fault propagation model property extraction fault verification

Effect of Guanxin Danshen Dripping Pills on Coronary Heart Disease Comorbid with Depression or Anxiety: The ADECODE-Real World Study

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Chinese Journal of Integrative Medicine 2024年第5期30卷 443-448页

作者： WU Shi-hao SHI wei-qi LI Yu-hang LIU Ru-hui hu Da-yi ZHENG Li-qiang MA Wen-lin Department of Geriatric Medicine Tongji HospitalSchool of MedicineTongji UniversityShanghai 200065China Department of Cardiology Tongji HospitalSchool of MedicineTongji UniversityShanghai 200065China Department of Cardiology Peking University People's HospitalBeijing 100044China School of Public Health Shanghai Jiao Tong UniversityShanghai 200030China

Objective: To evaluate the efficacy of Guanxin Danshen Dripping Pill(GXDSDP) in treating anxiety and depression in patients with coronary heart disease(CHD). Methods: A total of 1,428 patients diagnosed with CHD screened for anxiety, depression, and quality of life(QOL) at baseline received 0.4 g of GXDSDP treatment 3 times per day and returned for monthly reassessment. Patients were recruited after stable treatment for CHD and received assessment of General Anxiety Disorder-7(GAD-7), Patient Health Questionnaire-9(PHQ-9), and Seattle Angina Questionnaire(SAQ) for evaluating anxiety, depression, and *** were followed up 3 times, once every 4 weeks, during outpatient visits for 12 weeks. Results: At the third follow-up(F3), the anxiety symptom of 63.79%(673/1,055) of the patients improved to sub-clinical level, and the GAD-7 score improved significantly(8.11 vs. 3.87, Plinical level, with a significant improvement in PHQ-9 score(8.69 vs. 4.41, Pline(all P<0.01) as assessed by SAQ: physical limitation(31.17 vs. 34.14), anginal stability(2.74 vs. 4.14), anginal frequency(8.16vs. 9.10), treatment satisfaction(13.43 vs. 16.29), and disease perception(8.69 vs. 11.02). Conclusions: A fixed dosage of GXDSDP may be a potential treatment option for CHD patients comorbid with anxiety or depression.(Registration No. ChiCTR2100051523)

关键词： Guanxin Danshen Dripping Pill coronary heart disease depression anxiety quality of life Chinese medicine

Supporting IrO_(x)nanosheets on hollow TiO_(2)for highly efficient acidic water splitting

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Nano Research 2024年第8期17卷 6903-6909页

作者： Ge Yu Ruilong Li Yanmin hu Xingen lin Ze lin Dongyang Wu Gongming Wang Xun Hong Center of Advanced Nanocatalysis(CAN) Department of Applied ChemistryUniversity of Science and Technology of ChinaHefei 230026China

The efficiency of proton exchange membrane water electrolysis(PEM-WE)for hydrogen production is heavily dependent on the noble metal iridium-based ***,the scarcity of iridium limits the large-scale application of *** address this issue,it is promising to select an appropriate support because it not only enhances the utilization efficiency of noble metals but also improves mass transport under high ***,we supported amorphous IrO_(x)nanosheets onto the hollow TiO_(2)sphere(denoted as IrO_(x)),which demonstrated excellent performance in acidic electrolytic water ***,the annealed IrO_(x)catalyst at 150℃in air exhibited a mass activity of 1347.5 A·gIr^(−1),which is much higher than that of commercial IrO_(2)of 12.33 A·gIr^(−1)at the overpotential of 300 mV for oxygen evolution reaction(OER).Meanwhile,the annealed IrO_(x)exhibited good stability for 600 h operating at 10 mA·cm^(−2).Moreover,when using IrO_(x)and annealed IrO_(x)catalysts for water splitting,a cell voltage as low as 1.485 V can be achieved at 10 mA·cm^(−2).The cell can continuously operate for 200 h with negligible degradation of performance.

关键词： oxygen evolution reaction hydrogen evolution reaction amorphous IrO_(x) hollow TiO_(2) proton exchange membrane water electrolysis

Design of Low-Power Turbo Encoder and Decoder for NB-IoT

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Chinese Journal of Electronics 2024年第2期33卷 403-414页

作者： Chong ZHANG Yuhang lin Deming WANG Jianguo hu School of Microelectronics Science and Technology Sun Yat-sen University School of Physics and Telecommunication Engineering South China Normal University School of Electronics and Information Engineering South China Normal University Development Research Institute of Guangzhou Smart City Shenzhen Research Institute of Sun Yat-sen University

Turbo code is an error correction coding scheme close to the Shannon limit, usually used in wireless data transmission. Based on the parallel Turbo code algorithm, a parallel Turbo code circuit design scheme is *** the encoder, the recursive systematic convolutional encoder is multiplexed. The decoder is divided into branch metric, recursive, maximum likelihood ratio, and external information calculation modules. The decoding algorithm is based on Max-Log-MAP, controlling the component decoder in parallel. And the state metric calculation in the decoding circuit is combined to reduce the overall power consumption effectively, enabling the encoder and decoder to be used in narrowband Internet of things(NB-IoT). Finally, the hardware scheme of the main functional modules of Turbo code encoding and decoding is designed and implemented. The results show that the dynamic power consumption is less than 50 m W. The overall on-chip power consumption is reduced by 40% at the frequency of 125 MHz compared with previous jobs.

关键词： Measurement Wireless communication Power demand Systematics Turbo codes System-on-chip Power dissipation

Brain-inspired multimodal approach for effluent quality prediction using wastewater surface images and water quality data

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Frontiers of Environmental Science & Engineering 2024年第3期18卷 69-82页

作者： Junchen Li Sijie lin Liang Zhang Yuheng Liu Yongzhen Peng Qing hu School of Environment Harbin Institute of TechnologyHarbin 150090China School of Environmental Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Engineering Innovation Center of SUSTech(Beijing) Southern University of Science and TechnologyBeijing 100083China Faculty of Environment and Life Beijing University of TechnologyBeijing 100124China Engineering Research Center of Intelligence Perception and Autonomous Control Ministry of EducationBeijing 100124China

Efficiently predicting effluent quality through data-driven analysis presents a significant advancement for consistent wastewater treatment *** this study,we aimed to develop an integrated method for predicting effluent COD and NH3 *** employed a 200 L pilot-scale sequencing batch reactor(SBR)to gather multimodal data from urban sewage over 40 *** we collected data on critical parameters like COD,DO,pH,NH_(3),EC,ORP,SS,and water temperature,alongside wastewater surface images,resulting in a data set of approximately 40246 *** we proposed a brain-inspired image and temporal fusion model integrated with a CNN-LSTM network(BITF-CL)using this *** innovative model synergized sewage imagery with water quality data,enhancing prediction *** a result,the BITF-CL model reduced prediction error by over 23%compared to traditional methods and still performed comparably to conventional techniques even without using DO and SS sensor ***,this research presents a cost-effective and precise prediction system for sewage treatment,demonstrating the potential of brain-inspired models.

关键词： Wastewater treatment system Water quality prediction Data driven analysis Brain-inspired model Multimodal data Attention mechanism

Stability-Considered Lane Keeping Control of Commercial Vehicles Based on Improved APF Algorithm

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Chinese Journal of Mechanical Engineering 2024年第1期37卷 114-129页

作者： Bin Tang Zhengyi Yang Haobin Jiang Ziyan lin Zhanxiang Xu Zitian hu Automotive Engineering Research Institute Jiangsu UniversityZhenjiang 212013China

Regarding the lane keeping system,path tracking accuracy and lateral stability at high speeds need to be taken into account especially for commercial vehicles due to the characteristics of larger mass,longer wheelbase and higher mass *** improve the performance mentioned above comprehensively,the control strategy based on improved artificial potential field(APF)algorithm is *** the paper,time to lane crossing(TLC)is introduced into the potential field function to enhance the accuracy of path tracking,meanwhile the vehicle dynamics parameters including yaw rate and lateral acceleration are chosen as the repulsive force field *** lane keeping controller based on improved APF algorithm is designed and the stability of the control system is proved based on Lyapunov *** addition,adaptive inertial weight particle swarm optimization algorithm(AIWPSO)is applied to optimize the gain of each potential field *** co-simulation results indicate that the comprehensive evaluation index respecting lane tracking accuracy and lateral stability is reduced ***,the proposed control strategy is verified by the HiL *** provides a beneficial reference for dynamics control of commercial vehicles and enriches the theoretical development and practical application of artificial potential field method in the field of intelligent driving.

关键词： Lane keeping control Commercial vehicles Lateral stability Artificial potential field AIWPSO