检索结果-南通市图书馆

China Foundry 2024年第5期21卷 577-587页

作者： wei-li peng Jian-hua Zhao Cheng Gu Ya-jun Wang College of Materials Science and Engineering Chongqing UniversityChongqing 400045China National Engineering Research Center for Magnesium Alloys Chongqing UniversityChongqing 400044China National Key Laboratory of Advanced Casting Technologies Chongqing UniversityChongqing 400044China

The properties of the magnetic mold in magnetic mold casting directly determine the quality of the final cast *** this study,the magnetic mold properties in magnetic mold casting,were studied utilizing a coupled electromagnetic-structural method through numerical *** study investigated key factors including equivalent stress,the distribution of tensile and compressive stresses,and the area ratio of tensile *** compared molds made entirely of magnetic materials with those made partially of magnetic *** results indicate that as current increases from 4 A to 8 A,both the initial magnetic mold and the material-replaced magnetic mold initially show an increasing trend in equivalent stress,tensile-compressive stress,and the area ratio of tensile stress,peaking at 6 A before *** material replacement,the area ratio of tensile stress at 6 A decreases to 19.84%,representing a reduction of 29.72%.Magnetic molds comprising a combination of magnetic and non-magnetic materials exhibit sufficient strength and a reduced area ratio of tensile stress compared to those made entirely from magnetic *** study provides valuable insights for optimizing magnetic mold casting processes and offers practical guidance for advancing the application of magnetic molds.

关键词： magnetic mold casting coupled electromagnetic-structural method numerical simulation stress analysis

Fiber-Optic Surface Plasmon Resonance Sensor With Multi-Alternating Metal Layers for Biological Measurement

在线全文

学校读者我要写书评

暂无评论

Photonic Sensors 2013年第3期3卷 202-207页

作者： Yanjie WANG Shengwei MENG Yuzhang liANG lixia li wei peng College of Physics and Optoelectrical Engineering Dalian University of Technology Dalian 116023 China

Optical fiber based SPR sensors have attracted more and more attention due to their unique advantages over the prism-based SPR sensors. A novel fiber-optic SPR sensor with multi-alternating metal layers for biochemical analysis is presented in this paper. Based on the fundamental SPR theory of the fiber optic sensing technology, we theoretically investigated the effects of the existence of alternating layers deposited on sensing region SPR wavelength changes. The emphasis was placed on the numerical simulation of the fiber-optic SPR sensor＇s sensitivity which could be affected by its technical parameters such as the metal thickness, number of alternating layers. Results showed that, compared to the normal SPR sensor with the single metal layer, the proposed sensor had a wider detecting range of the refractive index and higher sensitivity, which can find applications in biological analysis.

关键词： Surface plasmon resonance fiber optics biological detection alternating metal layers

Molecular mechanism of panaxydol on promoting axonal growth in PC12 cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2018年第11期13卷 1927-1936页

作者： wei-peng li Ke Ma Xiao-Yan Jiang Rui Yang Pei-Hua Lu Bao-Ming Nie Yang Lu Department of Nuclear Medicine the First Affiliated Hospital of Bengbu Medical College Department of Pharmacy Shanghai Jiao Tong University School of Medicine Key Laboratory of Arrhythmias of Ministry of Education of China Tongji University School of Medicine

Nerve growth factor（NGF） promotes axonal growth in PC12 cells primarily by regulating the RTK-RAS-MEK-ERK pathway. Panaxydol, a polyacetylene isolated from Panax notoginseng, can mimic the effects of NGF. Panaxydol promotes neurite outgrowth in PC12 cells, but its molecular mechanism remains unclear. Indeed, although alkynol compounds such as panaxydol can increase intracellular cyclic adenosine 3′,5′-monophosphate（cAMP） levels and the ERK inhibitor U0126 inhibits alkynol-induced axonal growth, how pathways downstream of cAMP activate ERK have not been investigated. This study observed the molecular mechanism of panaxydol-, NGF-and forskolin-induced PC12 cell axon growth using specific signaling pathway inhibitors. The results demonstrated that although the RTK inhibitor SU5416 obviously inhibited the growth-promoting effect of NGF, it could not inhibit the promoting effect of panaxydol on axonal growth of PC12 cells. The adenylate cyclase inhibitor SQ22536 and cAMP-dependent protein kinase inhibitor RpcAMPS could suppress the promoting effect of forskolin and panaxydol on axonal growth. The ERK inhibitor U0126 inhibited axonal growth induced by all three factors. However, the PKA inhibitor H89 inhibited the promoting effect of forskolin on axonal growth but could not suppress the promoting effect of panaxydol. A western blot assay was used to determine the effects of stimulating factors and inhibitors on ERK phosphorylation levels. The results revealed that NGF activates the ERK pathway through tyrosine receptors to induce axonal growth of PC12 cells. In contrast, panaxydol and forskolin increased cellular cAMP levels and were inhibited by adenylyl cyclase inhibitors. The protein kinase A inhibitor H89 completely inhibited forskolin-induced axonal outgrowth and ERK phosphorylation, but could not inhibit panaxydol-induced axonal growth and ERK phosphorylation. These results indicated that panaxydol promoted axonal growth of PC12 cells through different pathways down

关键词： nerve regeneration panax notoginseng polyacetylene panaxydol nerve growth factor PC12 cells neurite outgrowth cAMP PKA Epacl ERK CREB neural regeneration

Clinical application value of long non-coding RNAs signatures of genomic instability in predicting prognosis of hepatocellular carcinoma

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Surgery 2024年第8期16卷 2386-2392页

作者： Xiao-Wen Xing Xiao Huang wei-peng li Ming-Ke Wang Ji-Shun Yang Department of Disease Control and Prevention Naval Medical CenterNaval Medical UniversityShanghai 200052China Medical Care Center Naval Medical UniversityShanghai 200052China

Hepatocellular carcinoma(HCC)presents challenges due to its high recurrence and metastasis rates and poor *** current clinical diagnostic and prognostic indicators exist,their accuracy remains imperfect due to their biol-ogical ***,there is a quest to identify improved biomarkers for HCC diagnosis and *** combining long non-coding RNA(lncRNA)expression and somatic mutations,Duan et al identified five representative lncRNAs from 88 lncRNAs related to genomic instability(GI),forming a GI-derived lncRNA signature(LncSig).This signature outperforms previously re-ported LncSig and TP53 mutations in predicting HCC *** this editorial,we comprehensively evaluate the clinical application value of such prognostic evaluation model based on sequencing technology in terms of cost,time,and ***,we provide an overview of various prognostic models for HCC,aiding in a comprehensive understanding of research progress in pro-gnostic evaluation methods.

关键词： Hepatocellular carcinoma Prognosis Prognostic model Biomarkers Genomic instability long non-coding RNA Clinical application value

Telomerase reverse transcriptase promoter-driven expression of iodine pump genes for targeted radioiodine therapy of malignant glioma cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Cancer 2011年第8期30卷 574-580页

作者： Jian Tan wei li peng Wang Department of Nuclear Medicine General Hospital ofTianjin Medical University Tianjin 300052 P. R. China.

Radioiodine i s a routine therapy for differentiated thyroid ***-thyroid cancers can intake radioiodine after transfection of the human sodium iodide symporter (hNIS) *** human telomerase reverse transcriptase (hTERT) promoter,an excellent tumor-specific promoter,has potential value for targeted gene therapy of *** used the hTERT promoter to drive the expression of the hNIS and human thyroid peroxidase (hTPO) gene as a primary step for testing the effects of radioiodine therapy on malignant *** U87 and U251 cells were co-transfected with two adenoviral vectors,in which the hNIS gene had been coupled to the hTERT promoter and the hTPO gene had been coupled to the CMV promoter,***,we performed Western blot,125I intake and efflux assays,and clonogenic assay with cancer *** also did 99mTc tumor imaging of nude mice *** co-transfection with Ad-hTERT-hNIS and Ad-CMV-hTPO,glioma cells showed the 125I intake almost 1.5 times higher than cells transfected with Ad-hTERT-hNIS *** blots revealed bands of approximately 70 kDa and 110 kDa,consistent with the hNIS and hTPO *** clonogenic assay,approximately 90% of cotransfected cells were killed,compared to 50% of control cells after incubated with 37 MBq of *** results demonstrated that radioiodine therapy was effective in treating malignant glioma cell lines following induction of tumor-specific iodide intake by the hTERT promoter-directed hNIS expression in *** hNIS and hTPO genes can result in increased intake and longer retention of *** mice harboring xenografts transfected with Ad-hTERT-NIS can take 99mTc scans.

关键词：人端粒酶逆转录酶特异性启动子胶质瘤细胞放射性碘基因转染基因治疗恶性驱动

COVID-19 and the digestive system:A comprehensive review

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2021年第16期9卷 3796-3813页

作者： Ming-Ke Wang Hai-Yan Yue Jin Cai Yu-Jia Zhai Jian-Hui peng Ju-Fen Hui Deng-Yong Hou wei-peng li Ji-Shun Yang Department of Disease Control and Prevention Naval Medical Center of PLANaval Medical UniversityShanghai 200052China Department of Digestive Diseases Naval Medical Center of PLANaval Medical UniversityShanghai 200052China Department of Geriatrics Naval Medical Center of PLANaval Medical UniversityShanghai 200052China Department of Infectious Diseases Naval Medical Center of PLANaval Medical UniversityShanghai 200052China Department of Outpatient Services Naval Medical Center of PLANaval Medical UniversityShanghai 200052China Department of Quality Management Guangdong Second Provincial General Hospital(Pazhou Campus)Guangzhou 510317Guangdong ProvinceChina Medical Care Center Naval Medical Center of PLANaval Medical UniversityShanghai 200052China

The coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)is spreading at an alarming rate,and it has created an unprecedented health emergency threatening tens of millions of people *** studies have indicated that SARS-CoV-2 ribonucleic acid could be detected in the feces of patients even after smearnegative respiratory ***,demonstration of confirmed fecal-oral transmission has been *** studies have shown an incidence rate of gastrointestinal(GI)symptoms ranging from 2%to 79.1%in patients with *** may precede or accompany respiratory *** most common GI symptoms included nausea,diarrhea,and abdominal *** addition,some patients also had liver injury,pancreatic damage,and even acute mesenteric ischemia/*** the incidence rates reported in different centers were quite different,the digestive system was the clinical component of the COVID-19 *** have shown that angiotensinconverting enzyme 2,the receptor of SARS-CoV-2,was not only expressed in the lungs,but also in the upper esophagus,small intestine,liver,and *** possible mechanism of GI symptoms in COVID-19 patients may include direct viral invasion into target cells,dysregulation of angiotensin-converting enzyme 2,immune-mediated tissue injury,and gut dysbiosis caused by ***,numerous experiences,guidelines,recommendations,and position statements were published or released by different organizations and societies worldwide to optimize the management practice of outpatients,inpatients,and endoscopy in the era of *** this review,based on our previous work and relevant literature,we mainly discuss potential fecal-oral transmission,GI manifestations,abdominal imaging findings,relevant pathophysiological mechanisms,and infection control and prevention measures in the time of COVID-19.

关键词： COVID-19 SARS-CoV-2 Gastrointestinal manifestations Abdominal imaging Mechanisms Prevention

COVID-19 and liver dysfunction:What nutritionists need to know

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2022年第15期28卷 1526-1535页

作者： Ming-Ke Wang Xue-Lu Yu li-Yun Zhou Hong-Mei Si Ju-Fen Hui Deng-Yong Hou wei-peng li Ji-Shun Yang Department of Disease Control and Prevention Naval Medical Center of PLANaval Medical UniversityShanghai 200052China Medical Care Center Naval Medical Center of PLANaval Medical UniversityShanghai 200052China

The coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus-2 has brought serious challenges for the medical *** with COVID-19 usually have respiratory ***,liver dysfunction is not an uncommon ***,the degree of liver dysfunction is associated with the severity and prognosis of ***,diagnosis,and treatment of malnutrition should be routinely recommended in the management of patients with COVID-19,especially in those with liver ***,a large number of studies have reported that nutrition therapy measures,including natural dietary supplements,vitamins,minerals and trace elements,and probiotics,might have potential hepatoprotective effects against COVID-19-related liver dysfunction via their antioxidant,antiviral,anti-inflammatory,and positive immunomodulatory *** review mainly focuses on the possible relationship between COVID-19 and liver dysfunction,nutritional and metabolic characteristics,nutritional status assessment,and nutrition therapy to provide a reference for the nutritionists while making evidence-based nutritional decisions during the COVID-19 pandemic.

关键词： COVID-19 SARS-CoV-2 liver dysfunction Nutritional status assessment Nutrition therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于Hexapod的精密跟瞄平台研究

宇航学报 2010年第3期31卷 681-686页

作者：李伟鹏黄海北京航空航天大学宇航学院北京100191

针对精密光学设备的空间应用,设计了基于并联机构的空间高稳定精密跟瞄系统。利用所设计的宏/微双重驱动复合作动器和精密铰接元件,研制了精密跟瞄Hexapod平台原理样机,考虑到精密跟瞄系统的特点,开发了包括宏动控制系统、微动控制系统... 详细信息

针对精密光学设备的空间应用,设计了基于并联机构的空间高稳定精密跟瞄系统。利用所设计的宏/微双重驱动复合作动器和精密铰接元件,研制了精密跟瞄Hexapod平台原理样机,考虑到精密跟瞄系统的特点,开发了包括宏动控制系统、微动控制系统和检测系统在内的实验测试系统,并利用实验初步测试了Hexapod平台原理样机关键性能。由实验结果可知,平台原理样机的转动范围超过10°,最高开环转动速度大于5deg/s,经压电微动部分补偿后的平台静态定位误差小于5μrad,通过主动控制使扰动振幅衰减至噪声水平,可用于驱动有效载荷以较高的速度在较大范围内搜索目标并具有较好的静态定位精度和稳定性。

关键词： Hexapod 跟瞄平台宏微双重驱动精密定位振动控制

1 - 3 Three-body Force Effect on Nucleon Momentum Distributions in Asymmetric Nuclear Matter within Framework of Extended BHF Approach

在线全文

学校读者我要写书评

暂无评论

IMP & HIRFL Annual Report 2012年第1期 5-6页

作者： Zuo wei Yin peng li Jianyang Wang Pei

Transplanted neuronal precursors migrate and differentiate in the devel-oping mouse brain

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cell Research 2002年第Z1期 223-228页

作者： wei MIN peng , li li YU, CHUN YING BAO, FAN liAO, XUE SHENG li, MING XUE ZUO* Biomedical Research Institute, Beijing Normal University, Beijing 100875, China

The subventricular zone (SVZ), lining the lateral ventricle in forebrain, retains a population of neuronal precursors with the ability of proliferation in adult mammals. To test the potential of neuronal precursors in adult mice, we transplanted adult SVZ cells labeled with fluorescent dye PKH26 into the lateral ventricle of the mouse brain in different development stages. The preliminary results indicated that the grafted cells were able to survive and migrate into multiple regions of the recipient brain, including SVZ, the third ventricle, thalamus, superior colliculus, inferior colliculus, cerebellum and olfactory bulb etc; and the amount of survival cells in different brain regions was correlated with the development stage of the recipient brain. Immunohistochemical studies showed that most of the grafted cells migrating into the specific target could express neuronal or astrocytic marker. Our results revealed that the neuronal precursors in adult SVZ still retained immortality and ability of prolife

关键词： subventricular zone (SVZ) neuronal precursor cell transplantation migration differentiation mouse.