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World Journal of Gastroenterology 2005年第34期11卷 5377-5380页

作者： Ping Fang Lei Dong wei-jin zhang jin-Yan Luo Department of Internal Medicine Second Hospital of Xi'an Jiaotong University Xi'an 710004 Shaanxi Province China Division of Cardiovascular Physiology and Pharmacology Medical School of Xi'an Jiaotong University Xi'an 710061 Shaanxi Province China

AIM： To investigate the effects of entero-hepatic bile add circulation on the inter-digestive migrating myoelectrical complex （MMC） in rats. METHODS： Thirty-two rats were divided into four groups. Three pairs of bipolar silver electrodes were chronically implanted in the antrum, duodenum and jejunum. Three groups of Uhem were ligatecl around the upper part of common bile duct （CBD）. The experiments were performed in consdous and fasting state. The gastrointestinal myoelectrical activity was recorded. Ursodeoxycholic acid （UDCA） and saline were then perfused into stomachs of two groups with CBD obstruction and the effects of them on the MMC were observed. RESULTS： A typical pattern of MMC was observed in normal fasting rats. MMC of antral and duodenal origin disappeared temporarily in earlier stage of CBD obstruction. While MMC of jejunum origin appeared. increased MMC cycle duration was seen after 4 d in rats with CBD obstruction. The MMC after CBD obstruction was characterized by an increased duration of phase Ⅱ-like activity and decreased duration of phase Ⅰ ＆ Ⅲ activity. Perfusion into stomachs with UDCA resulted in a shorter MMC cycle duration and a longer duration of phase III of duodenal origin compared to the normal group. CONCLUSION： Entero-hepatic bile add drculation initiates inter-digestive MMC of duodenal origin.

关键词： Migrating myoelectrical complex Entero-hepatic Bile acid circulation Ursodeoxycholic acid Common bile duct obstruction

A Novel Oscillating Chemical Reaction Using Ninhydrin as Single Organic Substrate

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Chinese Chemical Letters 2006年第1期17卷 77-80页

作者： Fu wei YANG jin zhang GAO Wu YANG Kan Jun SUN Institute of Chemistry Northwest Normal University Lanzhou 730070

A novel oscillating chemical reaction using ninhydrin as a single organic substrate was represented in this paper. It distinguished from the classically catalyzed BZ oscillating chemical reaction due to there was no active methene （CH2=） and/or enol structure in the ninhydrin molecule, which served as single organic substrate. This suggested that the substrates used in catalyzed BZ reaction were not always the organic compounds containing active methene （CH2=） and/or enol structure and bromination process in this kind of catalyzed chemical oscillating reaction was not also necessary.

关键词： Single organic substrate active methene enol structure oscillating chemical reaction.

Total polysaccharides of the Sijunzi decoction attenuate tumor necrosis factor-α-induced damage to the barrier function of a Caco-2 cell monolayer via the nuclear factor-κB-myosin light chain kinase-myosin light chain pathway

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World Journal of Gastroenterology 2018年第26期24卷 2867-2877页

作者： Yue Lu Leng Li jin-wei zhang Xiao-qin Zhong Jian-An wei Ling Han The Second Clinical College (Guangdong Provincial Hospital of Chinese Medicine) Guangzhou University of Chinese Medicine

AIM To explore the protective effects and underlying mechanisms of total polysaccharides of the Sijunzi decoction(TPSJ) on the epithelial barriers in vitro. METHODS Caco-2 cell monolayers were treated with or without TPSJ in the presence or absence of TNF-α, and paracellular permeability and transepithelial electrical resistance(TEER) were measured to evaluate the epithelial barrier function. Immunofluorescence and western blotting were respecti-vely used to evaluate the distribution and expression of the tight junction proteins claudin 1, claudin 2, zo3, and occludin in Caco-2 cells. western blotting was also used to evaluate the cellular expression of myosin light chain(MLC), phosphorylated MLC(pM LC), MLC kinase(MLCK), and nuclear factor(NF)-κB p65. RESULTS TPSJ promoted the proliferation of Caco-2 cells and inhibited TNF-α-induced secretion of pro-inflammatory cyto-kines. Furthermore, TPSJ significantly ameliorated both the reduction of TEER and the increased paracellular permeability observed in tumor necrosis factor(TNF)-α-damaged Caco-2 monolayers. Furthermore, TPSJ remarkably attenuated TNF-α-induced morphological changes, downregulated the expression of claudin 1, claudin 2, zo3, and occludin, and markedly suppressed TNF-α-mediated upregulation of p-MLC and MLCK expression. Finally, TPSJ inhibited the activation and expression of NF-κB p65. CONCLUSION Our results demonstrate that TPSJ alleviates the TNF-α-induced impairment of the intestinal epithelial cell barrier function by suppressing NF-κB p65-mediated phosphorylation of MLCK and MLC.

关键词： Inflammatory bowel disease tight junction total polysaccharides of the Sijunzi decoction Nuclear factor-κB pathway

Determination of Some Heavy-metal-ions Using a Sulfur Ion Modified BZ Oscillating System

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Chinese Chemical Letters 2006年第9期17卷 1221-1224页

作者： Hua CHEN Wu YANG Hong Xia DAI Xiao Xia wei Jie QU jin zhang GAO College of Chemistry ＆ Chemical Engineering Northwest Normal University Lanzhou 730070

A highly sensitive method is developed for the determination of trace amounts of some heavy metal ions in aqueous solution based on the classical Belousov-Zhabotinskii （BZ） oscillating chemical system. Introducing of S^2- ion makes the new oscillating system Ce（SO4）2 - KBrO3 - CH2（COOH）2 - Na2S - H2SO4 have to a high sensitivity for some heavy metal ions such as Ag^＋, Pb^2＋, Hg^2＋, Cd^2＋, Cu^2＋and Bi^3＋ with detection limits down to 10^-12 mol·L^- 1

关键词： BZ oscillating system kinetic determination heavy-metal-ion sulfur ion.

Preventive and inhibitive effects of Yiwei Xiaoyu granules on the development and progression of spasmolytic polypeptideexpressing metaplasia lesions

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World Journal of Gastrointestinal Oncology 2021年第11期13卷 1741-1754页

作者： Wan-Qun Chen Feng-Liang Tian jin-wei zhang Xiao-Jun Yang Yan-Ping Li Department of Gastroenterology Chongqing Hospital of Traditional Chinese MedicineChongqing 400000China Department of Dermatology and Cosmetology Chongqing Hospital of Traditional Chinese MedicineChongqing 400000China

BACKGROUND Spasmolytic polypeptide-expressing metaplasia(SPEM)is a potential preneoplastic *** To elucidate the microRNA(miR)-7-mediated preventive and inhibitive effects of Yiwei Xiaoyu granules(YWXY)in SPEM *** Gastric mucosa biopsies were collected from chronic atrophic gastritis patients and healthy people with signed informed *** was administered to the mice with induced SPEM by tamoxifen,and the gastric mucosa was harvested on the tenth day of the *** immunohistochemistry and immunofluorescence were performed to validate the SPEM,lesions and the potential mechanism was *** transcripts were detected with reverse transcriptionquantitative polymerase chain *** The expression of miR-7 was downregulated in the SPEM lesions,and expression of trefoil factor 2(TFF2)and clusterin was high in the human gastric *** vivo experiments showed that YWXY could inhibit the cell proliferation in the tamoxifen-induced SPEM lesions by regulating ***,YWXY could restore the expression of miR-7 by regulating TFF2 by detection with immunofluorescence but not with reverse transcription-quantitative polymerase chain reaction,indicating its potential mechanism of targeting miR-7 by mediating *** expression of vascular endothelial growth factor-βand gastric intrinsic factor was restored within 3 d of YWXY administration for the SPEM lesions,speculating that the possible mechanism of YWXY is to inhibit the development and progression of SPEM by regulating vascular endothelial growth factor-βand gastric intrinsic *** miR-7 downregulation is an early event in SPEM through regulation of TFF2 in human gastric *** is able to inhibit the cell proliferation and restore the expression of miR-7 by mediating TFF2 in the SPEM mouse model.

关键词： Spasmolytic polypeptide-expressing metaplasia Yiwei Xiaoyu Granules MicroRNA-7 Chronic atrophic gastritis Trefoil factor 2 Gastric precancerous lesions

“One stone,two birds”solvent system to fabricate microcrystalline cellulose–Ti_(3)C_(2)T_(x)nanocomposite film as a flexible dielectric and thermally conductive material

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Nano Research 2023年第2期16卷 3240-3253页

作者： Yong-Zhu Yan Shuwei Li Sung Soo Park wei-jin zhang Jun Seok Lee Jung Rae Kim Dong Gi Seong Chang-Sik Ha Department of Polymer Science and Engineering School of Chemical EngineeringPusan National UniversityBusan 46241Republic of Korea School of Chemical and Biomolecular Engineering Pusan National UniversityBusan 46241Republic of Korea Division of Advanced Materials Engineering Dong-Eui UniversityBusan 47340Republic of Korea

A strategy for fabricating microcrystalline cellulose–Ti_(3)C_(2)T_(x)(MCC–MXene)nanocomposite films with high relative permittivity,high thermal conductivity,and excellent mechanical properties was *** MCC–MXene nanocomposite film was fabricated by casting a solution containing N,N-dimethylacetamide/lithium chloride(DMAc/LiCl)-soluble MCC and DMAcdispersible MXene nanosheets,followed by humidity control *** MXene nanosheets greatly enhanced the permittivity of the nanocomposite films owing to interfacial ***,the nanocomposite film with 20 wt.%MXene content achieved a desirable permittivity of 71.4 at 102 Hz(a 770%improvement against that of neat cellulose),while the dielectric loss only increased by 1.8 times(from 0.39 to 0.70).The obtained nanocomposite films with 20 wt.%and 30 wt.%MXene exhibited remarkable in-plane thermal conductivities of 8.523 and 9.668 W∙m^(−1)∙K^(−1),respectively,owing to the uniform dispersion and selfalignment of the MXene layered ***,the uniformly dispersed MXene nanosheets in the MCC network with interfacial interaction(hydrogen bonding)and mechanical entanglement endowed the nanocomposite films with excellent mechanical properties and ***,the thermal stability,water resistance,and antibacterial properties of the nanocomposite films were effectively improved with the introduction of ***,using DMAc/LiCl as the solvent system not only improves the compatibility between MCC and MXene but also avoids the problem of easy oxidation of MXene in aqueous *** the high stability of the MCC–MXene solution and enhanced properties of the MCC–MXene films,the proposed strategy manifests great potential for fabricating natural biomass-based dielectric materials.

关键词： Ti_(3)C_(2)T_(x) microcrystalline cellulose flexible dielectric thermally conductive N,N-dimethylacetamide/lithium chloride(DMAc/LiCl) compatibility

Early pirfenidone treatment enhances lung function in idiopathic pulmonary fibrosis patients

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World Journal of Clinical Cases 2024年第28期12卷 6247-6249页

作者： jin-wei zhang Medical School University of ExeterExeter EX44PSUnited Kingdom

This editorial comments on the study by Lei et al investigating the efficacy of early treatment with pirfenidone on the lung function of patients with idiopathic pulmonary fibrosis(IPF)*** study evaluates the efficacy of early treatment with pirfenidone on lung function in patients with *** early and advanced stages of IPF are defined,highlighting the drug's *** prior research indicates pirfenidone's effectiveness in advanced IPF,this study focuses on its advantages in early *** study emphasizes the importance of computed tomography imaging alongside biochemical data and lung function tests for a comprehensive analysis of symptom *** show that early intervention with pirfenidone significantly reduces disease progression and preserves lung function,underscoring its potential as a critical treatment strategy in early IPF.

关键词： Idiopathic pulmonary fibrosis Pirfenidone Early intervention Pulmonary function Inflammatory markers

Lymphangioma of the gallbladder in childhood： a case report and review of the literature

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Chinese Medical Journal 2011年第24期124卷 4359-4360页

作者： HAN wei zhang jin-zhe WANG Huan-min Department of Surgery Beijing Children＇s Hospital Capital Medical University Beijing 100045 China

Lymphangiomas are malformations of the lymphatic system, which is a common disease in children, usually superficial in body, but seldom seen in visceral organs. We present the case of a child with lymphangioma of the gallbladder. Also we reviewed the literatures. A 2-year-6-month-old boy complained of progressing difficulty in walking for 6 months. Cerebral MRI showed abnormal signals in the white matter suggesting leukodystrophy. Ultrasound of abdomen showed a mixed-echoic mass in the site of galJbJadder. CT scan showed an enlarged gaiJbJadder with increased density. Bloodcounting, liver function, and alpha fetal protein were within normal range. Exploratory laparotomy was done in order to rule out malignancy. The liver was found normal at surgery, and the gallbladder looked enlarged and deformed. The gallbladder wall was thick and edematous, and adherent with liver. The gallbladder was excised. Pathological examination gave the diagnosis as lymphangioma of the gallbladder wall. The postoperative recovery was uneventful. There was no evidence of recurrence. Searching in literatures, three cases of lymphangioma of gallbladder in adults were found. According to the pathology of lymphangioma and the anatomy of gallbladder, the outcome of this disease should be benign and may be symptomless throughout the life. No death was reported due to lymphangioma of gall bladder, nor severe complications endangering life at any age. The only indication for surgery in the reported cases was to rule out the risk of being malignancy. If MRI or other means can make a definite preoperative diagnosis of lymphangioma, being a stable lesion, surgery would be unnecessary unless there is a progressive organic obstruction causing repeated infection or persistent abdominal pain.

关键词： childhood lymphangioma

Self-screening of the polarized electric field in wurtzite gallium nitride along[0001]direction

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Chinese Physics B 2022年第4期31卷 589-596页

作者： Qiu-Ling Qiu Shi-Xu Yang Qian-Shu Wu Cheng-Lang Li Qi zhang jin-wei zhang Zhen-Xing Liu Yuan-Tao zhang Yang Liu School of Electronics and Information Technology Sun Yat-Sen UniversityGuangzhou 510275China States Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012China

The strong polarization effect of GaN-based materials is widely used in high-performance devices such as white-lightemitting diodes(white LEDs),high electron mobility transistors(HEMTs),and GaN polarization ***,the current researches on the polarization mechanism of GaN-based materials are not *** this paper,we studied the influence of polarization on electric field and energy band characteristics of Ga-face GaN bulk materials by using a combination of theoretical analysis and semiconductor technology computer-aided design(TCAD) *** selfscreening effect in Ga-face bulk GaN under ideal and non-ideal conditions is studied *** believe that the formation of high-density two-dimensional electron gas(2 DEG) in GaN is the accumulation of screening *** also clarify the source and accumulation of the screening charges caused by the GaN self-screening effect in this paper and aim to guide the design and optimization of high-performance GaN-based devices.

关键词： gallium nitride polarized electric field self-screening effect surface states donor doping intrinsic thermal excitation

Effects of ground-level ozone (O_3) pollution on the yields of rice and winter wheat in the Yangtze River Delta

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Journal of Environmental Sciences 2003年第3期15卷 360-362页

作者： FENG Zong-wei, jin Ming-hong, zhang Fu-zhu, HUANG Yi-zong (Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing\ 100085, China.) Research Center for Eco-Environmental Sciences Chinese Academy of Sciences 北京 100085

Effects of elevated O_3 on the yields of rice and winter wheat were studied by using open-top chambers(OTCs). Results showed that compared to the control treatment, 200 ppb, 100 ppb, 50 ppb treatments caused a 80.4%, 58.6% and 10.5% decrease in grain yields per winter wheat plant and a 49.1%, 26.1% and 8.2% decrease in grain yield per rice plant, respectively. According to the dose-response relation educed from OTCs experiment and the monitor data of O_3 concentrations in spots, it was estimated that the yield losses of rice and winter wheat resulted by O_3 pollution in the Yangtze River Delta region in 1999 were 0.599 million ton and 0.669 million ton, economic losses were 0.539 billion RMB Yuan and 0.936 billion RMB Yuan, respectively.

关键词： rice winter wheat O_3 Yangtze River Delta