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TSPAN1 protein expression:A significant prognostic indicator for patients with colorectal adenocarcinoma

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World Journal of Gastroenterology 2009年第18期15卷 2270-2276页

作者： Li Chen Yuan-Yuan zhu Xiao-Juan Zhang Gui-Lan Wang Xin-Yu Li Song He jian-Bin Zhang jian-wei zhu Department of Pathological Anatomy Nantong University Nantong 226001Jiangsu Province China Biomics (Nantong) Co. Ltd Nantong226016 Jiangsu Province China Department of Pathology The Second Affiliated Hospital Nantong University Nantong 226001Jiangsu Province China Department of Pathology The Affiliated Tumor Hospital Nantong University Nantong226361 Jiangsu Province China Department of General Surgery Affiliated Hospital Nantong University Nantong 226001 Jiangsu Province China

AIM:To determine if TSPAN1 overexpression is associated with clinicopathological and prognostic factors in human colorectal ***:Total RNA was extracted in 20 human adenocarcinoma tissues for TSPAN1 mRNA assay by ***-eight specimens of human colorectal adenocarcinoma were surgically ***1 protein levels in cancer tissues were determined by immunohistochemistry using a polyclonal antibody against self-prepared *** correlation between TSPAN1 expression and the clinicopathological factors and the overall survival rate was analyzed by univariate and multivariate ***:TSPAN1 mRNA was detected in 90.0%(18/20) of cancerous *** light density of TSPAN1 mRNA expression levels was 0.89 ± 0.30 in adenocarcinoma by gel-image ***1 protein expression was detected in 78.41%(69/88) and weakly expressed in 40% normal colorectal *** were significant differences between colorectal adenocarcinoma and normal control epithelium(P < 0.05).TSPAN1 protein expression in colorectal cancerous tissue was significantly correlated with the histological grade,cell expression PCNA,lymph nodal metastasis and TNM staging of the *** with TSPAN1 protein overexpression had a significantly shorter survival period than that in patients with TSPAN1 protein negative or weak expression,respectively(P < 0.05).Furthermore,by multivariate analysis,TSPAN1 protein expression demonstrated an independent prognostic factor for human colorectal cancers(P < 0.05,relative risk 0.755;95% confidence interval 0.302-1.208).CONCLUSION:The expression of TSPAN1 gene is increased in colorectal carcinoma,suggesting that TSPAN1 might serve as an independent prognostic factor for the colorectal adenocarcinoma patients.

关键词： TSPAN1 Colorectal adenocarcinoma Semi-quantitative RT-PCR immunohistochemistry Prognosis

Body distribution and in situ evading of phagocytic uptake by macrophages of long-circulating poly (ethylene glycol) cyanoacrylate-co-nhexadecyl cyanoacrylate nanoparticles

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Acta Pharmacologica Sinica 2005年第12期26卷 1512-1518页

作者： Min HUANG wei WU~2 Jun QIAN Dan-jing WAN Xiu-li wei jian-hua zhu School of Pharmacy,Fudan University,Shanghai 200032,China School of Pharmacy Fudan University Shanghai China

Aim:To investigate the body distribution in mice of[14C]-labeled polymethoxyethyleneglycol cyanoacrylate-co-n-hexadecyl cyanoacrylate(PEG-PHDCA)nanoparticles and in situ evading of phagocytic uptake by mouse peri-toneal ***:PEG-PHDCA copolymers were synthesized bycondensation of methoxypolyethylene glycol cyanoacetate with[14C]-hexadecyl-cyanoacetate.[14C]-nanoparticles were prepared using the nanoprecipitation/solvent diffusion method,while fluorescent nanoparticles were prepared by in-corporating rhodamine *** situ phagocytic uptake was evaluated by *** distribution in mice was evaluated by determining radioactivityin tissues using a scintillation ***:Phagocytic uptake by macroph-ages can be efficiently evaded by fluorescent PEG-PHDCA ***48 h,31% of the radioactivity of the stealth[14C]-PEG-PHDCA nanoparticles afteriv injection was still found in blood,whereas non-stealth PHDCA nanoparticleswere cleaned up from the bloodstream in a short *** distribution of stealthPEG-PHDCA nanoparticles and non-stealth PHDCA nanoparticals in mice waspoor in lung,kidney,and brain,and a little higher in *** accumula-tion was unusually high for both stealth and non-stealth nanoparticles,typical oflymphatic *** accumulation of stealth PEG-PHDCA nanoparticles in thespleen was 1.7 times as much as that of non-stealth PHDCA(P<0.01).But theaccumulation of stealth PEG-PHDCA nanoparticles in the liver was 0.8 times asmuch as that of non-stealth PHDCA(P<0.05).Conclusion:PEGylation leads tolong-circulation of nanoparticles in the bloodstream,and splenotropic accumula-tion opens up the potential for further development of spleen-targeted drug delivery.

关键词： nanotechnology tissue distribution polyethylene glycols cynoacrylates polymers spleen

Allosteric modulation of G protein-coupled receptors as a novel therapeutic strategy in neuropathic pain

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Acta Pharmaceutica Sinica B 2024年第1期14卷 67-86页

作者： Chunhao zhu Xiaobing Lan Zhiqiang wei jianqiang Yu jian Zhang School of Pharmacy Ningxia Medical UniversityYinchuan 750004China Medicinal Chemistry and Bioinformatics Center Shanghai Jiao Tong University School of MedicineShanghai 200025China School of Basic Medical Science Ningxia Medical UniversityYinchuan 750004China Medicinal Chemistry and Bioinformatics Center Ocean University of ChinaQingdao 266100China State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjing 210023China

Neuropathic pain is a debilitating pathological condition that presents significant therapeutic challenges in clinical ***,current pharmacological treatments for neuropathic pain lack clinical efficacy and often lead to harmful adverse *** G protein-coupled receptors(GPCRs)are widely distributed throughout the body,including the pain transmission pathway and descending inhibition pathway,the development of novel neuropathic pain treatments based on GPCRs allosteric modulation theory is gaining *** research has shown that allosteric modulators targeting GPCRs on the pain pathway can effectively alleviate symptoms of neuropathic pain while reducing or eliminating adverse *** review aims to provide a comprehensive summary of the progress made in GPCRs allosteric modulators in the treatment of neuropathic pain,and discuss the potential benefits and adverse factors of this *** will also concentrate on the development of biased agonists of GPCRs,and based on important examples of biased agonist development in recent years,we will describe universal strategies for designing structure-based biased *** is foreseeable that,with the continuous improvement of GPCRs allosteric modulation and biased agonist theory,effective GPCRs allosteric drugs will eventually be available for the treatment of neuropathic pain with acceptable safety.

关键词： Neuropathic pain Allosteric modulators G protein-coupled receptors Analgesia

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Pancreatic panniculitis as the first presentation of pancreatic ductaladenocarcinoma

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 106-108页

作者： wei-Fang zhu Shan Fang jian-Jun Qiao Department of Dermatology the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

To the Editor:Pancreatic panniculitis,also known as pancreatic fat necrosis or enzymatic panniculitis,is a rare type of panniculitis that occurs in 0.3%−3%of patients with pancreatic disease such as acute or chronic pancreatitis and pancreatic carcinoma,especially acinar cell carcinoma[1,2].The clinical manifestations are nonspecific erythema tender nodules.

关键词： Pancreatic acute adenocarcinoma

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Well-controlled Organocatalytic Ring-opening Polymerization of Seven-membered Cyclic Carbonates with Cyclohexyl Fusion

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Chemical Research in Chinese Universities 2024年第5期40卷 856-862页

作者： ZHANG wei SHAN Si-Yi DAI jiang CAI Zhongzheng zhu jian-Bo Tianjin Key Laboratory of Brine Chemical Engineering and Resource Eco-utilization College of Chemical Engineering and Materials ScienceTianjin University of Science and TechnologyTianjin300457P.R.China National Engineering Laboratory of Eco-friendly Polymeric Materials(Sichuan) College of ChemistrySichuan UniversityChengdu610064P.R.China

Developing green and well-controlled polymerization methods is of great significance for the preparation of biomedical polymer *** this contribution,an efficient organocatalytic ring-opening polymerization(ROP)of a class of seven-membered cyclic carbonates(T6DO,T6HDO,C6DO,C6HDO)containing cis-or trans-cyclohexane structure was *** catalyst 1,5,7-triazabicyclo[4.4.0]dec-5-ene(TBD)promoted living polymerization of these cyclic carbonates to deliver polycarbonate and block copolymer products with predictable molecular weights and narrow *** robust TBD-mediated ROP at 90°C showcased turnover frequency(TOF)up to 10^(3)h^(−1).The resulting amorphous polycarbonates displayed good thermal stability.

关键词： CO_(2) Organic catalyst Living ring-opening polymerization Aliphatic polycarbonate

Defect-modulated and heteroatom-functionalized Ti_(3−x)C_(2)T_(y)MXene 3D nanocavities induce growth of MoSe_(2)nanoflakes toward electrocatalytic hydrogen evolution in all pH electrolytes

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Nano Research 2024年第7期17卷 6294-6304页

作者： Ming Du Xianzhi Yang jian Zhang wei Chen Huajie Huang Xinbao zhu Xing’ao Li State Key Laboratory for Organic Electronics and Information Displays and Institute of Advanced Materials(IAM) Jiangsu National Synergetic Innovation Centre for Advanced Materials(SICAM)Nanjing University of Posts and Telecommunications(NJUPT)Nanjing 210023China College of Electronic and Optical Engineering and College of Flexible Electronics Nanjing University of Posts and Telecommunications(NJUPT) Nanjing 210023China New Energy Technology Engineering Lab of jiangsu Province College of ScienceNanjing University of Posts and Telecommunications(NJUPT)Nanjing 210023China College of Pharmaceutical and Chemical Engineering Taizhou UniversityJiaojiang 318000China College of Mechanics and Materials Hohai UniversityNanjing 210098China College of Chemical Engineering Nanjing Forestry UniversityNanjing 210037China

Reducing kinetic energy barriers and developing accessible active sites are critical to deliver high hydrogen evolution reaction(HER)*** this paper,we synthesized defect-modulated and heteroatom(boron)-functionalized three-dimensional(3D)bowl-shaped Ti_(3−x)C_(2)T_(y)MXene(B-TCT)nanocavities coupled with the vertical growth of MoSe_(2)*** B-TCT@MoSe_(2)nanohybrids catalyst delivers the overpotentials of 49.9,52.7,and 67.8 mV to reach a HER current density of 10 mA·cm^(−2)under acidic,alkaline,and neutral conditions,*** outstanding HER activity is predominantly attributed to the heteroatom functionalization,self-adapting Ti vacancy(VTi)defect modulation,and spatial configuration design in the 3D B-TCT nanocavity,which synergistically regulate the electronic structure,activate the basal plane/edge unsaturated sites,and reduce the reaction energy *** and theoretical calculations demonstrate that strong heterogeneous interfacial bonding interactions between B-TCT and MoSe_(2)can dramatically reduce the free energy of hydrogen adsorption and facilitate efficient interfacial charge migration,thus essentially improving the HER *** used this 3D porous nanohybrid system assembled by defectrich lamellar structures to elucidate the advantageous synergistic effects of multiple mechanisms among defect structure,heteroatom functionalization,and interfacial coupling,which provided important insights for the development of efficient hybridtype catalysts.

关键词： electrocatalytic H_(2)evolution three-dimensional(3D)MXene nanocavity MoSe_(2)nanoflake self-adapting Ti vacancy defect heteroatom-functionalized interfacial interaction

Safety and efficacy of omalizumab for antihistamine-resistant chronic urticaria in children:a case series and literature review

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World Journal of Pediatrics 2024年第3期20卷 294-298页

作者： wei-Fang zhu Chen Wang jian-Jun Qiao Lan-Juan Li Department of Dermatology First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Chronic urticaria(CU)is a common skin disease characterized by the occurrence of wheals,with or without angioedema,lasting more than 6 *** prevalence of CU is about 0.7%[1],but higher in children,with an incidence of 1.38%[1].The occurrence of severe pruritus and unpredictable wheals may severely impact patients'quality of life,cause psychological problems,including sleep disorders and depression,and lead to economic burden due to limitation on daily life and work[2,3].

关键词： edema prevalence children

A Second-Order Image Denoising Model for Contrast Preservation

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Communications on Applied Mathematics and Computation 2024年第2期6卷 1406-1427页

作者： wei zhu Department of Mathematics University of AlabamaBox 870350TuscaloosaAL35487USA

In this work,we propose a second-order model for image denoising by employing a novel potential function recently developed in zhu(J Sci Comput 88:46,2021)for the design of a regularization *** to this new second-order derivative based regularizer,the model is able to alleviate the staircase effect and preserve image *** augmented Lagrangian method(ALM)is utilized to minimize the associated functional and convergence analysis is established for the proposed *** experiments are presented to demonstrate the features of the proposed model.

关键词： Image denoising Variational model Image contrast Augmented Lagrangian method(ALM)

Effect of alumina occurrence form on metallurgical properties of hematite and magnetite pellets

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Journal of Iron and Steel Research International 2024年第4期31卷 797-809页

作者： jian Pan Chen-mei Tang Cong-cong Yang De-qing zhu Zheng-qi Guo wei-qun Huang School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083HunanChina Exploration and Development of Geology and Mineral Resources Co. Ltd.Nanchang 330030JiangxiChina

The effect of alumina occurrence form on the metallurgical properties of both hematite and magnetite pellets was investigated at the same Al_(2)O level of 2 wt.%,including reduction index(RI),low-temperature reduction disintegration index(RDI),reduction swelling index(RSI),and high-temperature softening-dripping *** mineralogy of fired pellets was also studied to reveal the influence of alumina occurrence form on the phase composition and *** the results,the alumina occurrence form presents tremendous impacts on the metallurgical perfor-mance of both magnetite and hematite *** of all alumina occurrence forms contributes to inferior reducibility of pellets,especially in the case of gibbsite for magnetite pellets with a RI of 58.4%and kaolinite for hematite pellets with a RI of 56.8%.However,addition of all alumina occurrence forms improves the RDI of magnetite pellets,while there is no significant difference among various alumina occurrence *** contrast,alumina occurrence forms have little influence on the RDI of hematite *** presence of free alumina,gibbsite,and kaolinite tends to improve the RSI of hematite and magnetite pellets,whereas hercynite gives the opposite trend with a RSI of 25.6%.For softening-dripping performance of magnetite pellets,all alumina occurrence forms contribute to narrower softening-melting ***,alumina,gibbsite,and kaolinite give narrower softening-dripping interval,at 229,217,and 88℃,respectively,whereas addition of hercynite results in the largest melting range at 276℃ due to its high melting *** hematite pellets,free alumina,gibbsite,and hercynite tend to enlarge melting range,whereas kaolinite contributes to lower dripping temperature of 1148℃ and narrow softening-dripping interval of 88℃ due to the formation of a greater amount of slag phase at high temperatures.

关键词： Oxidized pellet Magnetite Hematite Alumina occurrence form Metallurgical performance Blast furnace