检索结果-南通市图书馆

Predictive model using four ferroptosis-related genes accurately predicts gastric cancer prognosis

World Journal of Gastrointestinal Oncology 2024年第5期16卷 2018-2037页

作者： Li Wang wei-hua gong Department of Emergency The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Department of Surgery The Second Affiliated Hospital Zhejiang University School of MedicineHangzhou 310052Zhejiang ProvinceChina

BACKGROUND Gastric cancer(GC)is a common malignancy of the digestive *** to global 2018 cancer data,GC has the fifth-highest incidence and the thirdhighest fatality rate among malignant *** than 60%of GC are linked to infection with Helicobacter pylori(***),a gram-negative,active,microaerophilic,and helical *** parasite induces GC by producing toxic factors,such as cytotoxin-related gene A,vacuolar cytotoxin A,and outer membrane ***,or iron-dependent programmed cell death,has been linked to GC,although there has been little research on the link between *** infection-related GC and *** To identify coregulated differentially expressed genes among ferroptosis-related genes(FRGs)in GC patients and develop a ferroptosis-related prognostic model with discrimination *** Gene expression profiles of GC patients and those with ***-associated GC were obtained from The Cancer Genome Atlas and Gene Expression Omnibus(GEO)*** FRGs were acquired from the FerrDb database.A ferroptosis-related gene prognostic index(FRGPI)was created using least absolute shrinkage and selection operator–Cox *** predictive ability of the FRGPI was validated in the GEO ***,we verified the expression of the hub genes and the activity of the ferroptosis inducer FIN56 in GC cell lines and *** Four hub genes were identified(NOX4,MTCH1,GABARAPL2,and SLC2A3)and shown to accurately predict GC and ***-associated *** FRGPI based on the hub genes could independently predict GC patient survival;GC patients in the high-risk group had considerably worse overall survival than did those in the low-risk *** FRGPI was a significant predictor of GC prognosis and was strongly correlated with disease ***,the gene expression levels of common immune checkpoint proteins dramatically increased in the highrisk subgroup of the FRGPI *** hub genes were also conf

关键词： Ferroptosis Gastric cancer Helicobacter pylori infection Immune checkpoint protein Prognostic model Ferroptosis-related gene prognostic index

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

土建工程混凝土施工技术要点探讨

引用

建筑与装饰 2024年第11期 163-165页

作者：韦功华北海综合保税区服务中心广西北海 536000

混凝土是现代化土建工程项目中最为常用的建筑材料之一,性能优越,对提升土建项目整体结构稳定性、延长使用年限,营造舒适居住环境具有重要意义.随着城市化进程的不断加快,高层以及超高层建筑比比皆是,混凝土施工技术以及质量控制对人们... 详细信息

混凝土是现代化土建工程项目中最为常用的建筑材料之一,性能优越,对提升土建项目整体结构稳定性、延长使用年限,营造舒适居住环境具有重要意义.随着城市化进程的不断加快,高层以及超高层建筑比比皆是,混凝土施工技术以及质量控制对人们的生命财产安全以及建筑工程安全管理尤为重要.基于此,本文详细阐述混凝土的优点和缺点,并分析混凝土施工中出现的质量问题由此深入探讨混凝土施工技术要点,望予以借鉴和参考.

关键词：混凝土土建工程使用年限稳定性

来源：博看期刊评论

在线全文

博看期刊

学校读者我要写书评

暂无评论

Epstein-Barr virus infection mimicking acute appendicitis: a case report

引用

World Journal of Emergency Medicine 2023年第2期14卷 148-151页

作者： Li Wang wei-hua gong Department of Emergency Medicine the Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310009China Department of Surgery the Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310052China

Dear editor,Epstein-Barr virus (EBV) infection is common, and more than 90%of adults develop serum EBV antibodies over the course of life.[1]After the first EBV infection, a longterm latent infection develops, which i... 详细信息

关键词： infection acute editor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

土建施工中防水防渗施工技术探讨

引用

建筑与装饰 2024年第12期 163-165页

作者：韦功华李虹瑾北海综合保税区服务中心广西北海 536000 北海市银海区物业管理中心广西北海 536000

土建工程是土木工程和建筑工程的总称,是一门为人类生活、生产、防护等活动建造各类设施与场所的工程学科,在土建施工活动中,防水防渗施工属于非常重要的工作内容.本文针对应用防水防渗施工技术的重要性展开分析,讨论了屋面工程、墙体... 详细信息

土建工程是土木工程和建筑工程的总称,是一门为人类生活、生产、防护等活动建造各类设施与场所的工程学科,在土建施工活动中,防水防渗施工属于非常重要的工作内容.本文针对应用防水防渗施工技术的重要性展开分析,讨论了屋面工程、墙体工程、厨卫工程、地下室工程、门窗工程中防水防渗施工技术应用要点,研究防水防渗材料管理、施工技术工序梳理、加强现场施工管理、组建可靠施工队伍等事项,其目的在于提高土建工程的抗渗性,延长工程项目的使用寿命.

关键词：土建工程防水防渗施工技术墙体工程

来源：博看期刊评论

在线全文

博看期刊

学校读者我要写书评

暂无评论

Design methodology of a mini-missile considering flight performance and guidance precision

引用

Journal of Systems Engineering and Electronics 2024年第1期35卷 195-210页

作者： ZHANG Licong gong Chunlin SU hua ANDREA Da Ronch Shaanxi Aerospace Flight Vehicle Design Key Laboratory School of AstronauticsNorthwestern Polytechnical UniversityXi’an 710072China Faculty of Engineering and Physical Sciences University of SouthamptonSouthampton SO171BJUnited Kingdom

The design of mini-missiles(MMs)presents several novel *** stringent mission requirement to reach a target with a certain precision imposes a high guidance *** miniaturization of the size of MMs makes the design of the guidance,navigation,and control(GNC)have a larger-thanbefore impact on the main-body design(shape,motor,and layout design)and its design objective,i.e.,flight *** a trade-off between flight performance and guidance precision,all the relevant interactions have to be accounted for in the design of the main body and the GNC ***,a multi-objective and multidisciplinary design optimization(MDO)is *** pertinent to motor,aerodynamics,layout,trajectory,flight dynamics,control,and guidance are included in the proposed MDO *** optimization problem seeks to maximize the range and minimize the guidance *** problem is solved by using the nondominated sorting genetic algorithm *** optimum design that balances a longer range with a smaller guidance error is ***,lessons learned about the design of the MM and insights into the trade-off between flight performance and guidance precision are given by comparing the optimum design to a design provided by the traditional approach.

关键词： mini-missiles(MMs) guidance navigation and control(GNC)system multi-objective optimization multidisciplinary design optimization(MDO) flight performance guidance precision

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The Yield and Water Use Efficiency to First Cutting Date of Siberian Wildrye in North China

引用

Agricultural Sciences in China 2011年第11期10卷 1716-1722页

作者： LI Zi-zhong ZHANG wei-hua gong Yuan-shi Department of Soil and Water Sciences China Agricultural University Beijing 100193 P.R.China

A field experiment study was conducted in Bashang Plateau in North China in 2008 to determine the effect of three first cutting dates on the growth and water use efficiency （WUE） of Siberian wildrye （Elymus sibiricus L.） in the agropastoral ecotone of North China （APENC）. The experiment was conducted in a split plot design with three replications with water supply regime as the main plot treatment and first cutting date as the subplot treatment. Two water supply regimes were used, which included rain-fed treatment as control （CK） and a single irrigation and straw mulch treatment （W）. Three first cutting date treatments were conducted at early heading stage on July 1 （E）, at late heading stage on July 12 （L）, and at flowering stage on July 27 （F）, respectively. The results showed that the forage yield and WUE were the lowest at early heading stage harvest, while the highest at flowering stage either in CK or W treatment. Under combined CK and W treatments, average forage yields of the F subplots were 2 900 and 6 703 kg ha-~, and the values of WUE were 0.82 and 2.28 kg m-3, respectively. Under the CK treatment, forage yields of the E and L subplots were 43.8 and 41.9% lower than the F subplots, and their values of WUE were 46.2 and 50.3% lower than F, respectively. Under the W treatment, the forage yields of the E and L subplots were 74.9 and 61.6% lower, and their values of WUE were 78.1 and 63.3% lower, respectively, as compared with F subplots. Therefore, earlier first cutting did not increase the regrowth of Siberian wildrye and improve the mismatch between rainy season and the period of high growth potential of the grass in the semiarid APENC.

关键词： siberian wildrye first cutting date forage yield water use efficiency North China

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The SLEGS beamline of SSRF

引用

Nuclear Science and Techniques 2024年第7期35卷 20-30页

作者： Long-Xiang Liu Hong-wei Wang gong-Tao Fan Hang-hua Xu Yue Zhang Zi-Rui Hao Ai-Guo Li Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai201210China

The Shanghai Laser Electron Gamma Source(SLEGS,located in BL03SSID)beamline at the Shanghai Synchrotron Radiation Facility(SSRF)is a Laser Compton Scattering(LCS)gamma source used for the investigation of nuclear structure,which is in extensive demand in fields such as nulear astrophysics;nulear cdluster structure,polarization physics;and nulear energy The beamline is based on the inverse Compton scattering of 10640 nm photons on 3.5 GeV electrons and a gamma source with va riable energy by changing the scattering angle frorm 20°to 160°.γrays of 0.25-21.1 MeV can be extracted by the scheme consisting of the interaction chamber,coarse collinator,fine collimator,and *** maximum photon flux for 1800 is approximately 10^(7)photons/s at the target at 21.7 MeV,with a 3-mm-diameter *** beamline was equipped with four types of spectrometers for experiments in(Y,Y'),(7,n),(Y,D),and(7,0).At present,Nuclear Resonance Fluorescence(NRF)spectrometry,Flat-Efficiency neutron Detector(FED)spectrometry,neutron Time-OF Flight(TOF)spectrometry,and Light-Charged Particle(LCP)spectrormetry methods have been developed.

关键词： Shanghai Synchrotron Radiation Facility SLEGS Nuclear astrophysics Nuclear structure

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Safflower Yellow Inhibits Progression of Hepatocellular Carcinoma by Modulating Immunological Tolerance via FAK Pathway

引用

Chinese Journal of Integrative Medicine 2024年第4期30卷 339-347页

作者： JI hua-feng YANG Zi-qiang HAN Jun-jun LI He-fang JIN Zhao-qing CHEN wei-qing CHEN Fei-hua gong Mou-chun Department of General Surgery First People's Hospital of Hangzhou Lin'an DistrictHangzhou(311300)China

Objective To explore the anti-tumor effect of safflower yellow(SY)against hepatocellular carcinoma(HCC)and the underlying potential *** An in vitro model was established by mixing Luc-Hepa1-6 cells and CD3^(+)CD8^(+)T cells,followed by adding programmed cell death protein 1(PD-1)antibody(Anti-mPD-1)with or without *** apoptosis was detected by flow cytometry and the level of inflammatory cytokines was determined by enzyme-linked immunosorbent *** protein levels of programmed cell death 1 ligand 1(PD-L1),chemokine ligand(CCL5),C-X-C motif chemokine ligand 10(CXCL10)were measured by Western *** in situ animal model was established in mice followed by treatment with anti-mPD-1 with or without *** imaging was monitored with an AniView 100 imaging *** establish the FAK-overexpressed Luc-Hepa1-6 cells,cells were transfected with adenovirus containing pcDNA3.1-FAK for 48 *** The fluorescence intensity,apoptotic rate,release of inflammatory cytokines,and CCL5/CXCL10 secretion were dramatically facilitated by anti-mPD-1(P<0.01),accompanied by an inactivation of PD-1/PD-L1 axis,which were extremely further enhanced by SY(P<0.05 or P<0.01).Increased fluorescence intensity,elevated percentage of CD3+CD8+T cells,facilitated release of inflammatory cytokines,inactivated PD-1/PD-L1 axis,and increased CCL5/CXCL10 secretion were observed in Anti-mPD-1 treated mice(P<0.01),which were markedly enhanced by SY(P<0.05 or P<0.01).Furthermore,the enhanced effects of SY on inhibiting tumor cell growth,facilitating apoptosis and inflammatory cytokine releasing,suppressing the PD-1/PD-L1 axis,and inducing the CCL5/CXCL10 secretion in Anti-mPD-1 treated mixture of Luc-Hepa1-6 cells and CD3+CD8+T cells were abolished by FAK overexpression(P<0.01).Conclusion SY inhibited the progression of HCC by mediating immunological tolerance through inhibiting FAK.

关键词： hepatocellular carcinoma safflower yellow Chinese medicine tumor microenvironment programmed cell death protein 1 focal adhesion kinase

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

International law obligations for the disposal of Fukushima nuclear-contaminated water under the principles of nuclear safety

引用

Chinese Journal of Population,Resources and Environment 2024年第1期22卷 10-19页

作者： wei gong Law School Southwest UniversityChongqing 400715China

The disposal of contaminated water from Japan’s Fukushima nuclear power plant is a significant international nuclear safety issue with considerable cross-border *** matter requires compliance not only with the law of the sea but also with the principles of nuclear safety under international *** principles serve as the overarching tenet of international and China’s domestic nuclear laws,applicable to nuclear facilities and *** principle of safety in nuclear activities is fully recognized in international and domestic laws,carrying broad legal binding ***’s discharge of nuclear-contaminated water into the sea violates its obligations under the principle of safety in nuclear activities,including commitments to optimum protection,as low as reasonably practicable,and *** Japanese government and the International Atomic Energy Agency(IAEA)have breached the obligation of optimum protection by restricting the scope of assessments,substituting core concepts,and shielding dissenting *** the absence of clear radiation standards,they have acted unilaterally without fulfilling the obligation as low as reasonably practicable *** discharge of Fukushima nuclear-contaminated water poses an imminent and unpredictable risk to all countries worldwide,including Japanese *** and the IAEA should fulfill their obligations under international law regarding disposal,adhering to the principles of nuclear safety,including optimum protection,the obligation as low as reasonably practicable,and prevention through multilateral ***,the obligation to provide optimum protection should be implemented by re-evaluating the most reliable disposal technologies and methods currently available and comprehensively assessing various *** standard of the obligation as low as reasonably practicable requires that the minimization of negative impacts on human health,livelihoods,and the environment should not b

关键词： Principles of nuclear safety Disposal of nuclear-contaminated water Optimum protection Prevention As low as reasonably achievable

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of Mo and cold forging deformation on strength and ductility of cobalt-based alloy L605

引用

Journal of Iron and Steel Research(International) 2024年第7期31卷 1811-1823页

作者： Zhong-lin Wang Zhi-hua gong Quan Li Han-sheng Bao School of Materials and Metallurgy Inner Mongolia University of Science and TechnologyBaotou 014017Inner MongoliaChina Institute of Special Steels Central Iron and Steel Research Institute Co.Ltd.Beijing 100081China

Mo element was added to cobalt-based alloy L605,and cold forging deformation was *** effects of the addition and cold forging deformation on the microstructure and mechanical properties of the alloy were studied by thermodynamic calculation,electron backscatter diffraction,transmission electron microscopy,and X-ray *** stacking fault energy(SFE)of the alloy decreased after the addition,and the formation of stacking faults and intersections were promoted to improve the strength and *** tensile strength of the alloy with Mo increased from 1190 to 1702 MPa after 24%cold deformation,producing significant work *** strengthening mechanism is strain-induced martensitic transformation(SIMT)and deformation *** alloy,combined with Mo and after 24%deformation,had both high strength and ductility in comparison with the original cobalt-based alloy *** is attributed to the lower SFE which caused the increase in stacking fault *** the tensile process,theε-hcp phase was easily generated at the stacking fault to reduce the stress concentration and increase the *** SIMT by adjusting the density of stacking faults can improve the mechanical properties of cobalt-based ***ε-hcp phase,the interaction between deformation twins and dislocations,and the interaction between e-hcp phases during cold forging deformation caused local stress concentration,lowering ductility and toughness.

关键词： Cobalt-based alloy-Stacking fault energy Strain-induced martensitic transformation Deformation twin Cold forging deformation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：