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市场与人口分析 2001年第5期7卷 66-70页

作者：韦宇红广西行政学院经济学部广西南宁530022

金融是现代经济的核心 ,研究老龄产业的发展不能不研究金融对其支持的地位、作用和策略。在论述金融支持老龄产业发展的重要性和迫切性的基础上 ,分析了我国老龄产业发展所面临的主要金融约束 ,并就金融业支持老龄产业发展提出了对策思路。

关键词：老龄产业金融支持中国金融支持银行信贷消费市场

Synthesis and Crystal Structure of 3-Phenyl-10b-benzyl-1,10b-dihydroimdazo[5,1-a]isoquinoline

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有机化学 2004年第Z1期24卷 376-页

作者： HU,Xiang-Nan JIN,hong-wei yu,yu YAN,Shen-He Department of Pharrnaceutics Chongqing Medical University Chongqing 400016 Department of Pharrnaceutics Chongqing Medical University Chongqing 400016 Department of Pharrnaceutics Chongqing Medical University Chongqing 400016 Department of Pharrnaceutics Chongqing Medical University Chongqing 400016

　　Praziquantel, 2-cyclohexylcarbonyl-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one, is a novel antiparasitic drug possessing one chiral center.[1] In the study of structure-activity relationship of praziquantel we were interested in its structural modification. 1-Benzyl Reissert compound of isoquinoline is required as starting materials for the synthesis of praziquantel analogues with modified chiral centers. On the other hand, we want to know what could be obtained when 1-benzyl Reissert compounds were exposed to high pressure catalytic hydrogenation. In this paper we report the results in the hydrogenation of 1-benzyl Reissert compound.……

关键词： structural modification catalytic hydrogenation materials for high pressure

Relationship between longitudinal changes in lipid composition and ischemic stroke among hypertensive patients

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World Journal of Clinical Cases 2025年第4期13卷 18-27页

作者： Cheng-Cheng wei yu-Qing Huang Cheng-hong yu Department of Cardiology Tongxiang First People's HospitalTongxiang 314500Zhejiang ProvinceChina Department of Cardiology Guangdong Cardiovascular InstituteGuangzhou 510080Guangdong ProvinceChina

BACKGROUND Dyslipidemia was strongly linked to stroke,however the relationship between dyslipidemia and its components and ischemic stroke remained *** To investigate the link between longitudinal changes in lipid profiles and dyslipidemia and ischemic stroke in a hypertensive *** Between 2013 and 2014,6094 hypertension individuals were included in this,and ischemic stroke cases were documented to the end of *** changes of lipid were stratified into four groups:(1)Normal was transformed into normal group;(2)Abnormal was transformed into normal group;(3)Normal was transformed into abnormal group;and(4)Abnormal was transformed into abnormal *** examine the link between longitudinal changes in dyslipidemia along with its components and the risk of ischemic stroke,we utilized multivariate Cox proportional hazards models with hazard ratio(HR)and 95%*** The average age of the participants was 62.32 years±13.00 years,with 329 women making up 54.0%of the *** the course of a mean follow-up of 4.8 years,143 ischemic strokes *** normal was transformed into normal group was used as a reference,after full adjustments,the HR for dyslipidemia and ischemic stroke among abnormal was transformed into normal group,normal was transformed into abnormal group and abnormal was transformed into abnormal wei CC et *** changed and ischemic stroke WJCC https://*** 2 February 6,2025 Volume 13 Issue 4 group were 1.089(95%CI:0.598-1.982;P=0.779),2.369(95%CI:1.424-3.941;P<0.001)and 1.448(95%CI:1.002-2.298;P=0.047)(P for trend was 0.233),*** In individuals with hypertension,longitudinal shifts from normal to abnormal in dyslipidemia-particularly in total and low-density lipoprotein cholesterol-were significantly associated with the risk of ischemic stroke.

关键词： Longitudinal change Hypertension Dyslipidemia Lipid profile Ischemic stroke

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基于遗传算法的l_p数据拟合及其应用

计量学报 2005年第3期26卷 284-288页

作者：田社平韦红雨颜德田上海交通大学信息检测技术与仪器系上海200030

在动态测试数据处理中,常常要进行稳健回归分析和最小最大值回归分析。讨论了遗传算法及其在lp数据拟合中的应用。由于遗传算法是用点群进行寻优,而不是用一个单点进行寻优,具有隐含并行算法的特点;群体在每一代的进化过程中执行同样的... 详细信息

在动态测试数据处理中,常常要进行稳健回归分析和最小最大值回归分析。讨论了遗传算法及其在lp数据拟合中的应用。由于遗传算法是用点群进行寻优,而不是用一个单点进行寻优,具有隐含并行算法的特点;群体在每一代的进化过程中执行同样的复制、交叉、变异操作,仅使用问题本身所对应的适应度函数,而不需要任何其它先决条件或辅助信息;遗传算法使用随机转换规则,而不是确定性规则进行运算。从而使得遗传算法是一类全局收敛算法,能够在lp数据拟合中得到很好的应用。给出了应用实例。

关键词：计量学 lp数据拟合遗传算法数据处理

基于ANSYS的盾构机工作井支护结构刚度合理化设计

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建筑技术 2016年第9期47卷 832-835页

作者：魏宇红张宇陕西邮电职业技术学院陕西咸阳712000 武警后勤学院天津300162

以南京过江隧道盾构井工程为例,利用ANSYS软件建立工作井有限元模型,分析连续墙水平位移和围檩、支撑的受力。通过有限元法结果与现场监测结果的对比,说明该有限元方法模拟基坑的开挖过程、探讨基坑墙体变形规律的可行性。通过正交试验... 详细信息

以南京过江隧道盾构井工程为例,利用ANSYS软件建立工作井有限元模型,分析连续墙水平位移和围檩、支撑的受力。通过有限元法结果与现场监测结果的对比,说明该有限元方法模拟基坑的开挖过程、探讨基坑墙体变形规律的可行性。通过正交试验结果的评定,得到各因子对控制指标影响大小,合理化配置了支护结构的刚度。

关键词：过江隧道工作井支护结构刚度数值模拟正交试验

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浅析土地增值税的纳税筹划技巧

中国管理信息化 2008年第20期11卷 28-30页

作者：魏育红常征徐州工程学院江苏徐州221008

房地产开发企业的税费中,土地增值税占有较大的比重,它税率高、税负重,房地产开发企业可以通过合理合法调整收入额和扣除项目金额来减低增值额,采用较低税率等方法进行纳税筹划,从而降低税负。

关键词：土地增值税纳税筹划房地产开发企业

SegHMC:一种基于Segmental HMM模型的顺式调控模块识别算法

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自动化学报 2016年第11期42卷 1718-1731页

作者：郭海涛霍红卫于强西安电子科技大学计算机学院西安710071

顺式调控模块(Cis-regulatory module,CRM)在真核生物基因的转录调控中起着重要作用,识别顺式调控模块是当前计算生物学的一个重要课题.虽然当前有许多计算方法用于识别顺式调控模块,但识别准确率仍有待进一步提高.将顺式调控模块的多... 详细信息

顺式调控模块(Cis-regulatory module,CRM)在真核生物基因的转录调控中起着重要作用,识别顺式调控模块是当前计算生物学的一个重要课题.虽然当前有许多计算方法用于识别顺式调控模块,但识别准确率仍有待进一步提高.将顺式调控模块的多种特征信息结合在一起,有助于提高识别顺式调控模块的准确率.基于此,本文提出了一种识别顺式调控模块的算法Seg HMC(Segmental HMM model for discovery of cis-regulatory module).该算法建立了一种关于顺式调控模块识别问题的Segmental HMM模型,进一步扩展了顺式调控模块调控结构(或调控语法)的表示,不仅将顺式调控模块表示为模体(Motif)的组合,还进一步将模体共同出现的频率、模体顺序偏好以及顺式调控模块中相邻模体间的距离分布等特征引入到顺式调控模块的调控语法中.在模拟数据集和真实生物数据集上的实验结果表明,本文方法识别顺式调控模块的准确率显著优于当前的主要方法.

关键词：基因的转录调控模体 Segmental HMM 顺式调控模块识别

Termination of Missed Abortion in A Combined Procedure: A Randomized Controlled Trial

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Journal of Reproduction and Contraception 2009年第1期20卷 45-50页

作者： Ai-hua FANG Qin-fang CHEN wei ZHENG yu-hong LI Rui-yu CHEN International Peace Maternity & Child Health Hospital Medical College of Shanghai Jiaotong University Shanghai 200030 China

Objective To access an ideal procedure terminating missed abortion within 12 weeks of gestational age. Methods Women with intrauterine fetal death were randomized into 3 groups. Group A （n=30）： vaginal misoprostol （MP） 0.4 mg, 3 h before vacuum aspiration; group B（n=15）： vaginal MP 0.4 mg every 3 h, up to 5 doses; group C（n=30）： oral mifepristone （MF） 200 mg 36-48 h before vaginal MP 0.4 mg, MP was given every 3 h, up to 5 doses. Results Women in group A had the shortest interval of gestation tissue expulsion （3.2± 0.5 h） and the bleeding （3.2 ± 5.7 ml） during medical procedure, which were statistically significant in comparison with the other two groups （P〈0.001, P〈0.01, respectively）. Success rates of groups A, B and C were 100%, 33.3% and 90.0%, respectively. Percentages of women need surgical interventions were similar in group B and group C（80.0%,76.7%, respectively）. Bleeding during operation, pain after medical procedure and satisfaction presented no statistical significance among the 3 groups. Conclusion Vaginal MP followed by vacuum aspiration was valuable in safety, and efficacy, which led to less bleeding and a faster recovery.

关键词： missed abortion mifepristone misoprostol vacuum aspiration

Idiopathic inflammatory demyelinating diseases of the central nervous system in patients following allogeneic hematopoietic stem cell transplantation： a retrospective analysis of incidence, risk factors and survival

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Chinese Medical Journal 2013年第6期126卷 1096-1102页

作者： ZHANG Xiao-hui HUANG Xiao-jun LIU Kai-yan XU Lan-ping LIU Dai-hong CHEN Huan HAN wei CHEN yu-hong WANG Feng-rong WANG Jing-zhi WANG yu ZHAO Ting CHEN Yao FU Hai-xia WANG Min Peking University People's Hospital Peking University Institute of Hematology Beijing 100044 China

Background AIIogeneic hematopoietic stem cell transplantation （allo-HSCT） is a curative therapy for many hematological diseases, but there are many complications following alIo-HSCT, among which neurological complications （NC） are one of the most commonly described ones. However, little is known about idiopathic inflammatory demyelinating diseases （IIDDs） of the central nervous system （CNS） in patients following alIo-HSCT. Methods A nested case-control study was conducted in a large cohort of 1365 patients, who underwent alIo-HSCT at the Institute of Hematology and Peking University People＇s Hospital, between January 2004 and December 2009, 36 patients of whom developed CNS IIDDs. Kaplan-Meier method, univariate and multivariate Cox regression were applied in our statistical analysis using SPSS 16.0. Results The cumulative incidence of all cases of IIDDs at 6 years posttransplantation was 3.6%. Thirty-five patients （97.2%） suffered IIDDs after transplantation, 16 patients （44.4%） between day 0 to day 100 post-transplantation, 10 patients （27.8%） between day 100 to 1 year post-transplantation, and 9 patients （25.0%） 1 year post-transplantation. Multivariate regression analysis identified donor type （P=0.031）, infection （P=0.009）, and acute lymphatic leukemia （P=0.017） as independent risk factors for posttransplantation IIDDs. The median survival time of patients with IIDDs was 514 days after transplantation （95% CI： 223-805）. Survival at 6 years was significantly lower in patients who developed the diseases compared to those who did not （26.6% vs. 73.5%, P 〈0.001）. Of the 36 patients experiencing IIDDs, 58.3% （n=21） died. The causes of death were graft-versus-host disease （GVHD）（n=4）, underlying disease relapse （n=3）, infections （n=12）, and other causes （n=2）. Conclusions IIDDs is an uncommon but serious complication of alIo-HSCT, especially in patients with a primary diagnosis of acute lymphatic leukemia, mismatched transplants, and infections. Our study results in

关键词： hematopoietic stem cell transplantation idiopathic inflammatory demyelinating diseases central nervous system risk factors survival

Association of VCAM-1 overexpression with oncogenesis,tumor angiogenesis and metastasis of gastric carcinoma

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World Journal of Gastroenterology 2003年第7期9卷 1409-1414页

作者： Yong-Bin Ding Guo-yu Chen Jian-Guo Xia Xi-wei Zang hong-yu Yang Li Yang Department of General Surgery,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,Jiangsu Province,China Department of General Surgery the First Affiliated Hospital of Nanjing Medical University Nanjing 210029 Jiangsu Province China. njdyb@***

AIM: To investigate the relationship between the expression of vascular cell adhesion molecule-1 (VCAM-1) and oncogenesis,tumor angiogenesis and metastasis in gastric carcinoma,and to evaluate the clinical significance of serum VCAM-1levels in gastric ***: Specimens from 41 patients with gastric cancer, 8 patients with benign gastric ulcer, and 10 healthy subjects were detected for the expression of VCAM-1 by immunohistochemistry. Microvessel density (MVD) was measured by counting the endothelial cells immunostained with the monoclonal antibody CD34 at x200 *** VCAM-1 concentrations were measured by an enzyme linked immunosorbent assay in the 41 gastric cancer patients before surgery, and at 7 days after surgery as well as in 25 healthy controls. The association between preoperative serum VCAM-1 levels and clinicopathological features, and their changes following surgery was evaluated. Tn addition, serum carcinoembryonic antigen (CEA) was also ***: Of the 41 gastric cancer tissues, 31 (75.6 %)were VCAM-1 positive. The VCAM-1 positive gastric cancers were more invasive and classified in the more advanced stage than the VCAM-1 negative ones. The VCAM-1 positive cancers were associated with more lymph node metastases than VCAM-1-negative ones (P＜0.05). The expression of VCAM-1 was detected in tissues of two of the eight patients with gastric ulcer and two of the 10 healthy controls. The expression of VCAM-1 in gastric cancer patients was significantly more frequent than that in the healthy controls and ulcer group (both P＜0.05). MVD in VCAM-1 expressing tissues was higher than that in VCAM-1 negative tissues (t=2.13,P＜0.05). Serum VCAM-1 levels in gastric cancer patients were significantly higher than those in controls (t=3.4, P＜0.05). There was a significant association between serum VCAM-1 levels and disease stage, as well as invasion depth of the tumor and the presence of distant *** concentrations of serum CEA in g

关键词：血管细胞粘附分子-1 肿瘤形成血管生成肿瘤转移胃癌