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The compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer's disease

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Neural Regeneration Research 2025年第11期20卷 3330-3344页

作者： Xueyan Liu wei wu Xuejuan Li Chengyan Wang Ke Chai Fanru Yuan Huijuan Zheng Yuxing Yao Chenlu Li Zu-Cheng Ye Daijun Zha Department of Medicinal Chemistry School of PharmacyFujian Medical UniversityFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Institute of Laboratory Animal Center Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina Department of Hyperbaric Oxygen National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina

Previous studies have shown that the compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one(D30),a pyromeconic acid derivative,possesses antioxidant and anti-inflammatory properties,inhibits amyloid-β aggregation,and alleviates scopolamine-induced cognitive impairment,similar to the phase Ⅲ clinical drug *** this study,we established a mouse model of Alzheimer's disease via intracerebroventricular injection of fibrillar amyloid-β to investigate the effect of D30 on fibrillar amyloid-β-induced *** results showed that D30 alleviated fibrillar amyloid-β-induced cognitive impairment,promoted fibrillar amyloid-β clearance from the hippocampus and cortex,suppressed oxidative stress,and inhibited activation of microglia and astrocytes.D30 also reversed the fibrillar amyloid-β-induced loss of dendritic spines and synaptic protein ***,we demonstrated that exogenous fibrillar amyloid-βintroduced by intracerebroventricular injection greatly increased galectin-3 expression levels in the brain,and this increase was blocked by *** the role of D30 in clearing amyloid-β,inhibiting neuroinflammation,protecting synapses,and improving cognition,this study highlights the potential of galectin-3 as a promising treatment target for patients with Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β astrocyte cognitive impairment D30 dendritic spines galectin-3 microglia neuroinflammation neuron

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腹腔镜胆总管探查取石术62例临床分析

苏州大学学报（医学版） 2005年第5期25卷 752-754页

作者：王浩炜吴浩荣谷春伟孙亦晖陈伟张楷苏州大学附属二院普外科江苏苏州215004

目的探讨腹腔镜胆总管探查取石术的手术方式、适应证。方法回顾性分析2002年2月至2004年8月62例腹腔镜胆总管探查取石术的临床资料。结果62例均在胆道镜的配合下完成腹腔镜胆总管探查取石术。其中胆总管切开取石后置T管引流20例,胆总管... 详细信息

目的探讨腹腔镜胆总管探查取石术的手术方式、适应证。方法回顾性分析2002年2月至2004年8月62例腹腔镜胆总管探查取石术的临床资料。结果62例均在胆道镜的配合下完成腹腔镜胆总管探查取石术。其中胆总管切开取石后置T管引流20例,胆总管切开取石后一期缝合42例。2例发生术后胆漏。结论对腹腔镜下胆总管探查取石术,不管是采取T管引流还是一期缝合,只要掌握手术方式及适应证,腹腔镜下治疗胆总管结石是可行的,是一种创伤小、恢复快、安全可靠的微创手术。

关键词：腹腔镜胆道镜胆总管结石

Research on Two-stage Voltage and Reactive Power Optimization Coordinated Control Method Considering Flexible On-load Tap Changer

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Dianwang Jishu/Power System Technology 2025年第1期49卷 272-283页

作者： Li, Jiaming Huo, Qunhai Yin, Jingyuan Lu, hao Zhou, Jing Zhu, Meisheng He, wei Dong, Hongwei Institute of Electrical Engineering Chinese Academy of Sciences Haidian District Beijing 100192 China School of Electronic Electrical and Communication Engineering University of Chinese Academy of Sciences Shijingshan District Beijing 100049 China Shanghai Jiguang Polytechnic College Baoshan District Shanghai 201901 China Three Gorges Electric Power Co. Ltd. Hubei Province Wuhan 430000 China

With the large-scale integration of distributed photovoltaic (DPV) in the distribution network, voltage exceeding limits and fluctuations are becoming increasingly severe. The voltage and reactive power optimization and coordination control method considering new power quality management devices needs to be further improved to adapt to the new changes in the power grid. This article considers the power quality regulation effect of the new flexible on-load tap changer (OLTC) and proposes a two-stage voltage and reactive power optimization coordinated control method. The first stage is the day before hour level scheduling stage. Based on distributed photovoltaic and load prediction data, the active output results of DPV and the switching results of flexible OLTC taps and capacitor banks are obtained through power flow calculation and iterative optimization. The second stage is the minute-level reactive power optimization stage. Based on the first stage, considering the reactive power output characteristics of flexible OLTC and DPV, adjusting the reactive power output of the equipment while correcting the capacitor bank switching combination in the first stage, further reducing the maximum voltage deviation of each node and making the distribution network voltage distribution more reasonable. An IEEE33 node distribution system simulation model is built in the paper. The proposed two-stage voltage and reactive power optimization coordination control method considering flexible OLTC can improve the DPV absorption level by 9.29% based on the conventional economic optimal goal of 88.07%, while meeting the requirement that the voltage deviation of the entire node is less than 0.1pu During the entire period, the overall economic efficiency improved by 7.8%. The results demonstrate the rationality and effectiveness of the proposed method. © 2025 Power System Technology Press. All rights reserved.

关键词： Quality management

Adsorption behaviors of strontium using macroporous silica based hexagonal tungsten oxide

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Science China Chemistry 2016年第5期59卷 601-608页

作者： Xiaoxia Zhang Yan wu hao wu Yuezhou wei School of Nuclear Science and Engineering Shanghai Jiao Tong University

A novel macroporous silica-based hexagonal tungsten oxide （h-WO3/SiO2） with exchangeable sodium cations located in hex- agonal tunnel structure was synthesized by a facile hydrothermal treatment of sodium tungstate dihydrate with 1 mol/L HCl solution. Utilization of the h-WO3/SiO2 adsorbent to remove aqueous strontium was investigated under the condition of various pH values, contact time, the initial concentration of metal ions, salt ion concentration, and coexisting ions. According to the experimental data, Sr2＋ adsorption equilibrium was achieved within 15 min in acidic solution, and the maximum removal ca- pacity of Sr2＋ occurred at pH 4. The kinetic adsorption of Sr2＋ on h-WO3/SiO2 was controlled by pseudo second-order model, and the saturated adsorption of Sr2＋ on h-WO3/SiO2 was better described by Langmuir and Redlich-Peterson isotherm models compared with the Freundlich isotherm model. The distribution coefficient of St2＋ was more than 2000 cm3/g in the presence of Ca2＋, Mg2＋, La3＋, and Eu3＋, indicating that the h-WO3/SiO2 showed excellent selectivity towards Sr2＋ in pH 4.

关键词： strontium hexagonal tungsten oxide macroporous silica-based support adsorption equilibrium kinetics

Optimization of Hydrocracking Process for Enhanced BTX Production from Coal Tar-Derived Hydrorefined Products

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China Petroleum Processing & Petrochemical Technology 2024年第1期26卷 139-151页

作者： wu hao wei Hongyuan School of Chemical Engineering and Technology Tianjin UniversityTianjin 300350China SINOPEC Research Institute of Petroleum Processing Co. Ltd.Beijing 100083China

Hydroconversion of coal tar to produce aromatic hydrocarbons(BTX)represents a crucial strategy for the highvalue hierarchical utilization of *** study focused on the hydrocracking of hydrorefined products derived from coal tar to enhance the production of benzene,toluene,and xylene(BTX).Various reaction conditions,including reaction temperature,hydrogen pressure,space velocity,and hydrogen-to-oil volume ratio,were systematically explored to optimize BTX yields while also considering the process’s economic *** results indicate that increasing the reaction temperature from 360℃ to 390℃ significantly favors the production of BTX,with yields increasing from 21.42%to 41.14%.Similarly,an increase in hydrogen pressure from 4 MPa to 6 MPa boosts BTX production,with yields rising from 36.31%to 41.14%.Reducing the space velocity from 2 h^(-1) to 0.5 h^(-1) also favors the BTX production process,with yields increasing from 37.96%to 45.13%.Furthermore,raising the hydrogen-to-oil volume ratio from 750 to 1500 improves BTX yields from 41.61%to 45.44%.Through economic analysis,the optimal conditions for BTX production were identified as a reaction temperature of 390℃,hydrogen pressure of 5-6 MPa,space velocity of 1 h^(-1),and hydrogen-to-oil volume ratio of 1000,achieving a BTX yield of 43.73%.This investigation highlights the importance of a holistic evaluation of hydrocracking conditions to optimize BTX ***,the findings offer valuable insights for the design and operation of industrial hydrocracking processes aimed at efficiently converting coal tar-derived hydrorefined feedstock into BTX.

关键词： coal tar hydrocracking BTX process optimization economic assessment

Ultra-deep Removal of Metal Ions from Coal Tar by Complexation:Experimental Studies and Density Functional Theory Simulations

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China Petroleum Processing & Petrochemical Technology 2023年第3期25卷 127-135页

作者： wu hao wei Hongyuan Li Wangliang School of Chemical Engineering and Technology Tianjin UniversityTianjin 300350China SINOPEC Research Institute of Petroleum Processing Co. Ltd.Beijing 100083China CAS Key Laboratory of Green Process and Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China

As one of the important aspects of upgrading coal tar,the ultra-deep removal of metal ions via the complexation method was investigated by screening four complexing agents and performing density functional theory(DFT)*** of the compositions and contents of the metallic compounds in the coal tar revealed that the main components were iron and calcium *** filtration reduced the mechanical impurity content from 0.24%to 0.0752%,indicating that most of the large particles could be easily *** the four complexing agents,namely,acetic acid,oxalic acid,citric acid,and ethylenediaminetetraacetic acid,oxalic acid exhibited the best demetallization *** DFT simulations suggested that the high performance of oxalic acid originated from its 1:1 coordination mode,rigid dicarboxyl structure,and greater binding energy.

关键词： complexation metallic compounds coal tar upgrading density functional theory

Homologous CoS2 interface with directed electron transfer and strong chloridion repulsion for efficient seawater oxidation

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Science China Chemistry 2025年

作者： Yuan Tian Jiang-Bo Chen Jie Ying Ge Tian Yu-Xuan Xiao Yi Lu Si-Ming wu wei Geng Ling Shen Xiao-Yu Yang State Key Laboratory of Advanced Technology for Materials Synthesis and Processing and School of Materials Science and Engineering and Shenzhen Research Institute & Laoshan Laboratory Wuhan University of Technology School of Chemical Engineering and Technology Sun Yat-Sen University National Energy Key Laboratory for New Hydrogen-Ammonia Energy Technologies Foshan Xianhu Laboratory

Seawater electrolysis is a highly promising method to produce high energy density hydrogen,especially in dry areas that have scarce freshwater ***,application of seawater electrolysis is confronted by two major problems associated with catalysts employed for the anodic oxygen evolution reaction （OER） including the competitive hypochlorite evolution reaction（HCER） and strong chloridion （Cl–） triggered *** studies aimed at overcoming these problems,a facile method has been developed to synthesize a homologous CoS2heterojunction as an OER *** to a difference in work functions at the interface and increased electron density,this material has directed electron transfer and strong chloridion repulsion properties,*** have shown that CoS2achieves low overpotentials of 289 and 322 mV at 10 mA cm-2current density in respective alkaline （1 M KOH） and alkaline simulated seawater ***,the outstanding stability of CoS2is reflected in a negligible decline in activity during promotion of the OER for 100 *** of density functional theory calculations reveal that the homologous CoS2heterojunction promotes directed electron transport for optimizing adsorption/desorption of reactive species and heightens the Cl-adsorption energy for strongly repulsing Cl-,phenomena that enhance OER performance in alkaline simulated seawater.

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Two-dimensional Conductive Metal-Organic Framework Nanowire Arrays for Highly Performed Soft Electrochemical Actuators

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材料导报 2021年第9期35卷 9001-9002页

作者： Zhao Ruoqing wu hao wei Yuan WANG Xuewen Frontiers Science Center for Flexible Electronics(FSCFE)&Shaanxi Institute of Flexible Electronics(SIFE) Northwestern Polytechnical UniversityXi’an 710072China

Fig.1(a)Schematic illustration of the fabrication of a Ni-CAT NWAs/CNF hybrid membrane by the in situ hydrothermal growth of Ni-CAT NWAs on CNF;SEM images of(b)the pristine CNF nanomembrane and(c)Ni-CAT NWAs/CNF,and(d)size distribution statistics of the diameter of Ni-CAT NWAs/CNF;schematic illustrations of(e)the fabrication procedure for the Ni-CAT NWAs/CNF-based actuator,(f)Ni-CAT NWAs/CNF electrode surfaces and Ni-CAT along the c-axis(Color codes:O,red spheres;C,gray spheres;and Ni,blue spheres);(g)actuation performance of the Ni-CAT NWAs/CNF based actuator The demand for high-performance low-voltage driven electromechanical actuators is growing because of their potential applications,such as in soft robotics,artificial muscles,biomimetic flying insects,and micro/nano-electromechanical systems[1].Among these actuators,ionic-polymer metal composite actuators(IPMCs)are promising as they are capable of large actuation deformation under low operation voltages(only a few volts),and they operate best in a humid environment[2].However,although extensive efforts have been made in past decades,developing high-capacitance electrode materials that improve the performance of IPMCs is challenging.

关键词： composite illustration spheres

Normal Forms for Periodic Orbits of Real Vector Fields

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Acta Mathematica Sinica,English Series 2008年第5期24卷 797-808页

作者： Ping WANG hao wu wei Gu LI School of Mathematical Sciences Peking University Beijing 100871 P. R. China

We consider normal forms of real vector fields near periodic orbits and provide sufficient conditions for their smooth linearization. In addition, the main results also assert the existence of vertical local foliation... 详细信息

关键词： normal form Homotopy method foliation