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Optimal decision-making in relieving global high temperature-related disease burden by data-driven simulation

Infectious Disease Modelling 2024年第2期9卷 618-633页

作者： Xin-Chen Li Hao-Ran Qian Yan-Yan Zhang Qi-Yu Zhang Jing-Shu Liu Hong-Yu Lai wei-guo zheng Jian Sun Bo Fu Xiao-Nong Zhou Xiao-Xi Zhang School of Global Health Chinese Center for Tropical Diseases ResearchShanghai Jiao Tong University School of MedicineShanghaiPeople's Republic of China Institute of One Health Shanghai Jiao Tong UniversityShanghaiPeople's Republic of China School of Public Health Shanghai Jiao Tong University School of MedicineShanghaiPeople's Republic of China School of Data Science Fudan UniversityShanghaiPeople's Republic of China

The rapid acceleration of global warming has led to an increased burden of high temperature-related diseases(HTDs),highlighting the need for advanced evidence-based management *** have developed a conceptual framework aimed at alleviating the global burden of HTDs,grounded in the One Health *** framework refines the impact pathway and establishes systematic data-driven models to inform the adoption of evidence-based decision-making,tailored to distinct *** collected extensive national-level data from authoritative public databases for the years 2010–*** burdens of five categories of disease causes–cardiovascular diseases,infectious respiratory diseases,injuries,metabolic diseases,and non-infectious respiratory diseases–were designated as intermediate outcome *** cumulative burden of these five categories,referred to as the total HTD burden,was the final outcome *** evaluated the predictive performance of eight models and subsequently introduced twelve intervention measures,allowing us to explore optimal decision-making strategies and assess their corresponding *** model selection results demonstrated the superior performance of the Graph Neural Network(GNN)model across various *** simulations driven by the GNN model,we identified a set of optimal intervention strategies for reducing disease burden,specifically tailored to the seven major regions:East Asia and Pacific,Europe and Central Asia,Latin America and the Caribbean,Middle East and North Africa,North America,South Asia,and Sub-Saharan *** mitigation and adaptation measures,acting upon our categories of Infrastructure&Community,Ecosystem Resilience,and Health System Capacity,exhibited particularly strong performance for various regions and *** out of twelve interventions were included in the optimal intervention package for each region,including raising low-carbon energy use,increasing energy intensity,improving

关键词： High temperature-related diseases Data-driven simulation Optimal intervention Disease burden Graph neural network Global warming

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UHPC全包裹S690高强型钢短柱轴压性能研究

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武汉理工大学学报 2024年第3期46卷 63-69页

作者：魏国正王振亥李涛武汉理工大学土木工程与建筑学院武汉430070

以高强型钢超高性能混凝土短柱(型钢强度为S690,UHPC强度为C130)的轴压试验为基础,利用有限元软件对试件进行了非线性有限元分析,有限元分析结果和试验荷载-位移曲线吻合较好,破坏模态相同,峰值荷载偏差值为8.9%,有限元模拟型钢荷载-竖... 详细信息

以高强型钢超高性能混凝土短柱(型钢强度为S690,UHPC强度为C130)的轴压试验为基础,利用有限元软件对试件进行了非线性有限元分析,有限元分析结果和试验荷载-位移曲线吻合较好,破坏模态相同,峰值荷载偏差值为8.9%,有限元模拟型钢荷载-竖直应变曲线和荷载-水平应变的峰值应变偏差为4.3%,验证了建模方法的可靠性,表明该有限元模型可以准确预测其轴压性能。基于试验和数值模拟分析了试件的受力机理。最后利用该有限元模型探究了箍筋间距参数、混凝土保护层内布置钢丝网参数对轴压性能的影响。结果表明:箍筋间距增加,试件轴压峰值承载能力变化不大,剩余承载能力减小;设置钢丝网以后,试件的峰值承载能力和剩余承载能力提高。

关键词：超高性能混凝土型钢混凝土组合短柱轴压性能非线性有限元分析

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Artificial Sun synchronous frozen orbit control scheme design based on J_2 perturbation

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Acta Mechanica Sinica 2011年第5期27卷 809-816页

作者： Gong-Bo Wang Yun-He Meng wei zheng guo-Jian Tang College of Aerospace and Material Engineering National University of Defense Technology410073 Changsha China

Sun synchronous orbit and frozen orbit formed due to J 2 perturbation have very strict constraints on orbital parameters,which have restricted the application a *** this paper,several control strategies were illustrated to realize Sun synchronous frozen orbit with arbitrary orbital elements using continuous ***,according to mean element method,the averaged rate of change of the orbital elements,originating from disturbing constant accelerations over one orbital period,was derived from Gauss＇ variation of parameters ***,we proposed that binormal acceleration could be used to realize Sun synchronous orbit,and radial or transverse acceleration could be adopted to eliminate the rotation of the argument of the ***,amending methods on the control strategies mentioned above were presented to eliminate the residual secular *** results showed that the control strategies illustrated in this paper could realize Sun synchronous frozen orbit with arbitrary orbital elements,and can save much more energy than the schemes presented in previous studies,and have no side effect on other orbital parameters＇ secular motion.

关键词： Continuous low-thrust Artificial Sun synchronous orbit Artificial frozen orbit Gauss' variation of parameters equations Mean element method

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Survivability of Components Assembly in Architecture

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Wuhan University Journal of Natural Sciences 2008年第5期13卷 533-538页

作者： guo wei zheng Yanyan XU Renzuo School of Computer Wuhan University Wuhan 430072Wuhan China

Based on the in-depth analysis of the interaction patterns between the components of software system in architecture, this paper illustrates that the association among them is complex and usually changeable during the running period. So we assume the interactions between two adjacency components are grouped into a single connector, which can be used to analyze the influence of components assembly on the survivability for software architecture. The survivability of the components assembly is mapped into the connectivity of graph model. We also bring forward a simplicity method to calculate and quantify the survivability of architecture that could provide a more usable model for designers to evaluate the architecture.

关键词： survivability software architecture component-based software graph connectivity

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Synthesis and cercaricidal activities of a serial of novel self-diffused cercaricides derived from niphensamide

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Chinese Chemical Letters 2008年第4期19卷 406-408页

作者： wei guo Lv Yin zheng Yong Quan Wu Xiao Lin Fan Key Laboratory of Organo-pharmaceutical Chemistry of Jiangxi Province Gannan Normal UniversityGanzhou 341000China

A serial of novel cercaricides that can self-diffuse on the water surface were designed and synthesized according to the special habit of cercariae *** compounds were derived from *** the compounds were dropped on the surface of water,the liquor diffused along the air-water interface and formed thin membranes floating on the water surface *** strong cercaricidal activities against the cereariae larvae of Schistosome japonicum of these compounds have been revealed by further experiments.

关键词： Niphensamide Self-diffused cercaricide Cercariae larvae

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Germplasm resources of three wood plant species enriched with nervonic acid

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Plant Diversity 2022年第3期44卷 308-315页

作者： Xing He Tian-Quan Lu Jiang-Ying Li Ping Mao Li Zhang guo-wei zheng Bo Tian Key Laboratory of Sustainable Utilization of Tropical Plant Resources Xishuangbanna Tropical Botanical GardenChinese Academy of Sciences88 Xuefu RoadKunming650223China University of Chinese Academy of Sciences Beijing100049China Xinping Branch Yuxi Tobacco CompanyXinping653400China d Guangnan Forestry and Grassland Bureau Guangnan663300China Traditional Chinese Medicine College Yunnan University of Chinese MedicineKunming650500China Center of Economic Botany Core Botanical GardensChinese Academy of SciencesMenglunMenglaYunnan666303China

Nervonic acid(NA)is a very-long-chain monounsaturated fatty acid with pharmaceutical and nutraceutical functions that plays an important role in treating several neurological *** major source of NA is plant seed *** we report fatty acid profiles of seeds and germplasm diversity of six plant species,including three woody plants with high amounts of NA-enriched seed oil,Malania oleifera,Macaranga adenantha,and *** had the largest seed(average 7.40 g single seed),highest oil content(58.71%),and highest NA level(42.22%).The germplasm diversity of *** is associated with its habitat but not *** of *** contained higher NA levels(28.41%)than ***(21.77%),but *** contained a significantly higher oil content(29.22%)and seed *** germplasm varied among populations,with one population having seeds with high oil content(22.63%)and NA level(37.78%).Although *** grow naturally at a range of elevations,no significant differences were detected between *** *** results suggest that *** and *** have greater potential as a source of NA,which will contribute to constructing a germplasm resource nursery and establishing a selection and breeding program to improve the development of NA-enriched plants.

关键词： Nervonic acid Germplasm resource Malania oleifera Macaranga adenantha Macaranga indica Diversity

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Nanomedicine Disrupts Stromal Barriers to Augment Drug Penetration for Improved Cancer Therapy

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Chinese Journal of Chemistry 2024年第10期42卷 1175-1189页

作者： guo-Feng Luo wei-Hai Chen Xian-zheng Zhang state Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei KeyLaboratory of StomatologySchool&Hospital of StomatologyWuhan UniversityWuhanHubei 430079China Key Laboratoryof Biomedical Polymers of Ministry of Education&Departmentof Chemistry Wuhan UniversityWuhanHubei 430072China

Tumor stroma composing diverse extracellular matrixes(ECM)and stromal cells shapes a condensed physical barrier,which severely hampers the efficient accessibility of nanomedicine to tumor cells,especially these deep-seated in the core of *** barrier significantly compromises the antitumor effects of drug-loaded nanomedicine,revealing the remarkable importance of disrupting stromal barrier for improved tumor therapy with deep penetration *** achieve this goal,various nanoparticle-based strategies have been developed,including direct depleting ECM components via delivering anti-fibrotic agents or targeting stromal cells to suppress ECM expression,dynamic regulation of nanoparticles’physicochemical properties(i.e.,size,surface charge,and morphology),mechanical force-driven deep penetration,natural/biomimetic self-driven nanomedicine,and transcytosis-inducing *** these nanostrategies were systemically summarized in this review,and the design principles for obtaining admirable nanomedicine were *** the rapid development of nanotechnology,elaborate design of multifunctional nanomedicine provides new opportunities for overcoming the critical stromal barriers to maximize the therapeutic index of various therapies,such as chemotherapy,photodynamic therapy,and immunotherapy.

关键词： Nanomedicine Tumor stroma Deep penetration Enhanced drug perfusion Cancer therapy Drug carriers Biomaterials Nanotechnology

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Effects of air damping on quality factors of different probes in tapping mode atomic force microscopy

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Chinese Physics B 2024年第9期33卷 506-519页

作者： Yu Zeng guo-Lin Liu Jin-Hao Liu zheng wei School of Mechanical and Electrical Engineering Beijing University of Chemical TechnologyBeijing 100029China

The AFM probe in tapping mode is a continuous process of energy dissipation,from moving away from to intermittent contact with the sample *** present,studies regarding the energy dissipation mechanism of this continuous process have only been reported sporadically,and there are no systematic explanations or experimental verifications of the energy dissipation mechanism in each stage of the continuous *** quality factors can be used to characterize the energy dissipation in TM-AFM *** this study,the vibration model of the microcantilever beam was established,coupling the vibration and damping effects of the microcantilever *** quality factor of the vibrating microcantilever beam under damping was derived,and the air viscous damping when the probe is away from the sample and the air squeeze film damping when the probe is close to the sample were *** addition,the mechanism of the damping effects of different shapes of probes at different tip–sample distances was *** accuracy of the theoretical simplified model was verified using both experimental and simulation methods.A clearer understanding of the kinetic characteristics and damping mechanism of the TM-AFM was achieved by examining the air damping dissipation mechanism of AFM probes in the tapping mode,which was very important for improving both the quality factor and the imaging quality of the TM-AFM *** study’s research findings also provided theoretical references and experimental methods for the future study of the energy dissipation mechanism of micro-nano-electromechanical systems.

关键词： TM-AFM quality factors air viscous damping air squeeze film damping

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Macroscopic polarization enhancement boosting piezo-photocatalytic performance via Nb-doping on B-site of Bi_(4)Ti_(3)O_(12)nanosheets

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Journal of Advanced Ceramics 2024年第4期13卷 437-446页

作者： Hongjian Yu Xindong wei Min Wang Yan Zhang zheng Wu Fan guo Jie Han School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002China Engineering Research Center of Ministry of Education for Geological Carbon Storage and Low Carbon Utilization of Resources Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid WastesNational Laboratory of Mineral MaterialsSchool of Material Sciences and TechnologyChina University of Geosciences(Beijing)Beijing 100083China School of Environmental and Chemical Engineering Xi’an Key Laboratory of Textile Chemical Engineering AuxiliariesXi'an Polytechnic UniversityXi'an 710048China

The development of a high-performance ferroelectric piezo-photocatalyst is an efficient strategy for advancing sustainability within the environmental and energy ***,a major challenge lies in the creation of a strong polarized electric field that can effectively hinder charge recombination,both within the bulk and on the surface of ***,we synthesize a series of Nb-doped Bi_(4)Ti_(3)O_(12)nanosheets via a facile one-pot hydrothermal method to achieve synergistically enhanced piezo-photocatalytic performance in CO_(2)reduction and pollutant *** optimized doped Bi_(4)Ti_(3)O_(12)demonstrates remarkable efficiency in the conversion of CO_(2)into CO,with a high production rate of 72.7μmol∙g−1∙h−1 without using co-catalysts or any sacrificial agent,surpassing the performance of unmodified Bi_(4)Ti_(3)O_(12)by up to 4.69 ***,our catalyst demonstrates ultra-fast piezo-photocatalytic degradation of organic pollutant Rhodamine B(RhB)at low concentrations and exceptional piezo-photocatalytic activity at high concentrations,outperforming most previously reported state-of-the-art *** systematic corroboration of catalyst characterization and experimental analysis reveals that the synergistic effect arises from the amplified macroscopic polarization induced by lattice distortion caused by the larger Nb ions,thereby improving piezo-photocatalytic *** research thus offers valuable insights into the direct design and fabrication of versatile catalytic systems,with applications spanning CO_(2)valorization and beyond.

关键词： CO_(2)reduction dye degradation piezo-photocatalysis Nb-doped Bi_(4)Ti_(3)O_(12) macroscopic polarization regulation

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A Study on Artificial Hatching of Chinese Bombyx mandarina Moore

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Agricultural Sciences in China 2008年第4期7卷 502-506页

作者： ZHAO Hua-qiang XU Ya-xiang WANG Dong LI Bing wei zheng-guo CHEN Yu-hua SHEN wei-de College of Life Sciences Soochow University Suzhou 215123 P.R.China Sericultural Institute Soochow University Suzhou 215123 P.R.China

Diapause eggs of Bombyx mandarina Moore from Wujiang, Jiangsu Province, China, were used to study the artificial hatching of B. mandarina Moore. The results showed that the highest hatchability was obtained by instant treatment with hydrochloric acid （HC1, specific gravity 1.065-1.075） for 5 rain under 46℃. After the B. mandarina eggs were cold stored at 5℃ for 40 days, the highest hatchability was obtained by treatment with HC1 （specific gravity 1.092） for 6 minutes under 47.8℃. For the B. mandarina eggs that were stored at 25℃ for 28 d and then cold-stored at 5℃ for 0-100 days, the highest hatchability was obtained by treatment with HCI （specific gravity 1.092） for 6 rain at 47.8℃. The longer the cold storage period, the higher was the hatchability. Acid treatment on diapause eggs of B. mandarina for 6 rains at 47.8℃ with hydrochloric acid （specific gravity 1.092） before hatching in spring could obviously shorten the hatching stage and increase the hatchability.

关键词： Bombyx mandarina Moore artificial hatching instant acid treatment acid treatment after chilling acidtreatment on diapause eggs after chilling

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