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Mechanism of action of linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-lin Li Xin-Ran Song Qian-Qian Wan Yu-Ming Wang Han-Zhou Li wei-Quan Xu Jia-Bao Liao wei-Bo Wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

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磁共振扩散加权成像在急性脑梗死诊断中的应用

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武警医学院学报 2007年第4期16卷 357-361页

作者：冯凯琳董少义顾欣袁滨付维林袁飞武警医学院附属医院放射科天津300162

【目的】评价磁共振扩散加权成像（DWI）在急性脑梗死诊断中的临床价值。【方法】选取呈卒中样发病的患者66例。行头颅CT检查排除脑出血后,经临床和MRI确诊为急性脑梗死的患者56例,根据行MR检查距发病时间长短将患者分成6 h内,6～24 h,2... 详细信息

【目的】评价磁共振扩散加权成像（DWI）在急性脑梗死诊断中的临床价值。【方法】选取呈卒中样发病的患者66例。行头颅CT检查排除脑出血后,经临床和MRI确诊为急性脑梗死的患者56例,根据行MR检查距发病时间长短将患者分成6 h内,6～24 h,24～48 h,48～72 h 4个组。选取病灶中心和健侧相应部位5×5像素大小区域为各自的感兴趣区,测定各自的ADC值,并计算rADC值。【结果】56例患者均在DWI上显示与临床症状、体征相符的病灶。病灶在DWI上具有较高的信号强度和清晰度。36例患者经DWI证实在T2WI上显示的部分高信号病灶为陈旧性。10例呈卒中样发病的非急性脑梗死患者DWI上均未显示典型高信号影。56例患者病灶中心的ADC值均低于健侧相应部位（配对t检验,P〈0.01）;不同时间段的rADC差别无统计学意义（单因素方差分析,F=2.055,P=0.118）。【结论】DWI在脑梗死超急性期和急性期均具有很高的敏感性,在对呈卒中样发病的患者鉴别诊断方面具有较高的应用价值。

关键词：扩散加权成像脑梗死表观扩散系数

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Improved fault location method for AT traction power network based on EMU load test

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Railway Engineering Science 2022年第4期30卷 532-540页

作者： Guosong lin Xuguo fu wei Quan Bin Hong School of Electrical Engineering Southwest Jiaotong UniversityChengdu 611756China

The autotransformer(AT)neutral current ratio method is widely used for fault location in the AT traction power *** the development of high-speed electrified railways,a large number of data show that the relation between the AT neutral current ratio and the distance from the beginning of the fault AT section to the fault point(Q-L relation)is mostly ***,the linear Q-L relation in the traditional fault location method always leads to large *** solve this problem,a large number of load-related current data that can be used to describe the Q-L relation are obtained through the load test of the electric multiple unit(EMU).Thus,an improved fault location method based on the back propagation(BP)neural network is proposed in this *** this basis,a comparison between the improved method and the traditional method shows that the maximum absolute error and the average absolute error of the improved method are 0.651 km and 0.334 km lower than those of the traditional method,respectively,which demonstrates that the improved method can effectively eliminate the influence of nonlinear factors and greatly improve the accuracy of fault location for the AT traction power ***,combined with a shortcircuit test,the accuracy of the improved method is verified.

关键词： Fault location EMU load test BP neural network AT traction power network High-speed electrified railway

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Citrate-promoted dissolution of nanostructured manganese oxides:Implications for nano-enabled sustainable agriculture

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Journal of Environmental Sciences 2023年第3期125卷 492-498页

作者： Di fu lin Duan Xiaoyan Li Chuanjia Jiang Tong Zhang wei Chen Ministry of Education Key Laboratory of Pollution Processes and Environmental Criteria Tianjin Key Laboratory of Environmental Remediation and Pollution ControlCollege of Environmental Science and EngineeringNankai UniversityTianjin 300350China

Nanostructured manganese oxides (nano-MnO_(x)) have shown great promises as versatile agrochemicals in nano-enabled sustainable agriculture,owing to the coupled benefits of controlled release of dissolved Mn2+,an essential nutrient needed by plants,and oxidative destruction of environmental organic ***,we show that three δ-MnO_(2)nanomaterials consisting of nanosheet-assembled flower-like nanospheres not only exhibit greater kinetics in citrate-promoted dissolution,but also are less prone to passivation,compared with three α-MnO_(2)nanowire *** better performance of the δ-MnO_(2)nanomaterials can be attributed to their higher abundance of surface unsaturated Mn atoms–particularly Mn(Ⅲ)–that is originated from their specific exposed facets and higher abundance of surface defects *** results underline the great potential of modulating nanomaterial surface atomic configuration to improve their performance in sustainable agricultural applications.

关键词： Nano-enabled sustainable agriculture Nanostructured manganese oxides Controlled release Unsaturated Mn atoms Mn(III)

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A phenomenological model for plastic flow behavior of rotating band material with a large temperature range

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Defence Technology（防务技术） 2023年第7期25卷 121-133页

作者： Yi-cheng Zhu Jia-wei fu lin-fang Qian Jing-hua Cao School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing210094JiangsuChina Northwest Institute of Mechanical and Electrical Engineering Xianyang712099ShaanxiChina School of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing210094China

The plastic flow behavior of the rotating band material is investigated in this paper. The rotating band material is processed from H96 brass alloy, which is hardened to a much higher yield strength compared to the annealed one. The dynamically uniaxial compression behavior of the material is tested using the split Hopkinson pressure bar(SHPB) with temperature and strain rate ranging from 297 to 1073 K and500 to 3000 s^(-1), respectively, and a phenomenological plastic flow stress model is developed to describe the mechanical behavior of the material. The material is found to present noticeable temperature sensitivity and weak strain-rate sensitivity. The construction of the plastic flow stress model has two steps. Firstly, three univariate stress functions, taking plastic strain, plastic strain rate and temperature as independent variable, respectively, are proposed by fixing the other two variables. Then, as the three univariate functions describe the special cases of flow stress behavior under various conditions, the principle of stress compatibility is adopted to obtain the complete flow stress function. The numerical results show that the proposed plastic flow stress model is more suitable for the rotating band material than the existing well-known models.

关键词： Rotating band Plastic flow behavior Large temperature range Phenomenological model

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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： lin-Yan Huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li Hai-wei Pu Xin-Yian Guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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Phenomenon of the sediment deposition in a hydraulic jump region of open channels

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Journal of Mountain Science 2022年第7期19卷 1874-1885页

作者： XU wei-lin WANG Guo-guang fu Shi-hao wei Wang-ru State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan UniversityChengdu610065China

The hydraulic jump is a typical sudden change for mountain river *** effects of local hydraulic jumps on the particle transport capacity decrease and local flow resistance increase cannot be ignored as the sediment deposition disaster can amplify the flash flood *** present research investigates the influences of a hydraulic jump on the individual particle movement and sediment deposition in a laboratory *** overall processes of a single particle movement are captured by a high-speed *** distribution of sediment deposition along the hydraulic jump is obtained *** results show that both the particle size and the ratio of the upstream and downstream Froude numbers affect the particle motion process.A single particle coming from upstream gradually decelerates and finally stops at the hydraulic jump section because of hydraulic jump *** particle acceleration first increases and then decreases during the time-domain process,and the attenuation trends are fast with the increase of ratio of upstream and downstream of Froude *** increase of the maximum acceleration with sediment flows follows a linear trend approximately,which indicates that the kinetic features of the single sand particle are determined by the coupling effects of the hydraulic jump resistance and the sand dynamic *** the increase of sediment rate and sand particle size,the resistance effect of hydraulic jump on sediment deposition rate along the flow direction gets strong and the sediment deposition area is mainly located upstream of the hydraulic jump *** present study shows that the possible sediment supply upstream must be obtained for identifying the disaster risk combined with the local hydraulic jump *** researches about the detailed critical condition deduced from the relationship between the water flow and sediment deposition are required to confirm and extrapolate present results to other applications.

关键词： Ratio of upstream and downstream Froude

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Influence of Fe on electrocatalytic activity of iron-nitrogendoped carbon materials toward oxygen reduction reaction

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Frontiers in Energy 2022年第5期16卷 812-821页

作者： lin LI Cehuang fu Shuiyun SHEN Fangling JIANG Guanghua wei Junliang ZHANG Institute of fuel Cells School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China SJTU-ParisTech Elite Institute of Technology Shanghai Jiao Tong UniversityShanghai 200240China

The development of highly active nitrogendoped carbon-based transition metal(M-N-C)compounds for the oxygen reduction reaction(ORR)in proton exchange membrane fuel cells(PEMFCs)greatly helps reduce fuel cell cost,thus rapidly promoting their commercial *** different M-N-C electrocatalysts,the series of Fe-N-C materials are highly favored because of their high ORR ***,there remains a debate on the effect of Fe,and rare investigations focus on the influence of Fe addition in the second heat treatment usually performed after acid leaching in the catalyst *** is thus very critical to explore the influences of Fe on the ORR electrocatalytic activity,which will,in turn,guide the design of Fe-N-C materials with enhanced ***,a series of Fe-N-C electrocatalysts are synthesize and the influence of Fe on the ORR activity are speculated both experimentally and *** is deduced that the active site lies in the structure of Fe-N4,accompanied with the addition of appropriate Fe,and the number of active sites increases without the occurrence of agglomeration ***,it is speculated that Fe plays an important role in stabilizing N as well as constituting active sites in the second pyrolyzing process.

关键词： oxygen reduction reaction Fe-N-C active sites Fe addition second heat treatment

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膝关节军事训练性骨挫伤的MRI表现及临床意义

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武警医学院学报 2009年第10期18卷 845-848页

作者：李祖贵冯凯琳顾欣袁飞付维林董少义武警医学院附属医院放射科天津300162

【目的】初步探讨膝关节军事训练性骨挫伤的MRI影像学表现及其临床意义。【方法】对87例X线或CT检查结果为阴性的军事训练性膝关节损伤患者进行MRI检查。根据骨挫伤的分布及其损伤机制,将81例确诊为膝关节骨挫伤的患者分为轴移型损伤、... 详细信息

【目的】初步探讨膝关节军事训练性骨挫伤的MRI影像学表现及其临床意义。【方法】对87例X线或CT检查结果为阴性的军事训练性膝关节损伤患者进行MRI检查。根据骨挫伤的分布及其损伤机制,将81例确诊为膝关节骨挫伤的患者分为轴移型损伤、仪表盘型损伤、过伸型损伤、夹击型损伤及髌骨外侧脱位等五型。【结果】骨挫伤的MRI表现为片状地图样异常信号影,边界不清。PDWI上表现为低信号、T2WI上表现为高信号;在PDWI或T2WI脂肪抑制序列上表现为高信号。81例MRI确诊为骨挫伤的患者中轴移性损伤32例,仪表盘式损伤18例,过伸型损伤11例,夹击式损伤13例,髌骨外侧脱位7例。【结论】MRI能够准确显示膝关节军事训练性骨挫伤的部位、范围及其附属结构的损伤。通过对骨挫伤进行分类,可以推断其损伤机制,并且能够为推测其附属结构损伤提供线索。

关键词：膝关节骨挫伤军事训练磁共振成像

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SARS患者恢复期胸部CT表现的动态变化

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武警医学院学报 2004年第6期13卷 434-436,F002页

作者：冯凯琳付维林董少义赵军刘银社武警医学院附属医院放射科天津300162

[目的]分析SARS患者恢复期胸部后遗病变的CT表现,评价CT在SARS恢复期复查的诊断价值.[方法]对75例恢复期SARS患者进行追踪随访,为期1 a,分4次(于出院后30～40 d、90～100 d、240～250d、350～360 d),行胸部CT检查,并对其影像结果进行分... 详细信息

[目的]分析SARS患者恢复期胸部后遗病变的CT表现,评价CT在SARS恢复期复查的诊断价值.[方法]对75例恢复期SARS患者进行追踪随访,为期1 a,分4次(于出院后30～40 d、90～100 d、240～250d、350～360 d),行胸部CT检查,并对其影像结果进行分析.[结果]75例患者随访观察最后胸部CT正常的59例占78.66%;散在磨玻璃样影未完全吸收的5例占6.66%;部分纤维化的6例占8%;部分纤维化伴细支气管囊状扩张的3例占4%;支气管扩张伴感染1例占1.33%;结核1例占1.33%.[结论]高分率CT是恢复期SARS患者胸部检查最佳方法,能清晰地显示胸部病变的细微改变,指导临床医师采取较积极的治疗措施,以减少病人遗留肺部病变的损害.

关键词：严重急性呼吸综合征放射摄影术 X线计算机随访研究

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