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Can patients with mild non-neoplastic lesions diagnosed at baseline screening be safely exempt from surveillance: evidence from multicenter community-based cohorts

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Science China Life Sciences 2025年第1期68卷 263-271页

作者： Siyi He Zhiyi Zhang Guohui song Zhenhai Wang Chunyun Dai Shipeng Yan Kun Jiang Bingbing song He Li Maomao Cao Dianqin Sun Fan Yang Xinxin Yan Shaoli Zhang Yi Teng Qianru Li Changfa Xia Wanqing Chen Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Department of Gastroenterology Gansu Wuwei Tumor Hospital Cixian Cancer Institute Linzhou Cancer Hospital Center for Disease Control and Prevention of Sheyang County Department of Cancer Prevention and Control Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South University Luoshan Center for Disease Control and Prevention Office for Cancer Control and Research Affiliated Cancer Hospital of Harbin Medical University

Surveillance recommendations for gastric cancer（GC） in current guidelines focused on advanced precancerous lesions and were based on precise diagnosis of severity/extent of baseline lesions. We aimed to develop a less endoscopy-related equipment-dependent risk-stratification tool, and assessed whether mild-precursor-lesion patients can be safely exempt from surveillance. In the multicenter communitybased cohort, 75,051 participants receiving baseline endoscopy were enrolled during 2015–2017 and followed-up until 2021. Cumulative incidence rates（CIRs） of GC for precancerous-conditions were calculated by Kaplan-Meier method and compared by Log-rank tests. Mixedeffects Cox regression models were used to detect potential factors for progression towards GC. A risk score was calculated as counts of selected factors. An independent cohort, including 26,586 participants was used for external validation. During a median follow-up of 6.25 years, CIRs of GC were 0.302%, 0.436%, and 4.756% for normal group, non-neoplastic（atrophic gastritis/intestinal metaplasia） and neoplastic lesions（low-grade/high-grade dysplasia）, respectively(Ptrend<0.001). Four predictors, including male, ≥60 years, smoking, and limited vegetable consumption, were selected for risk-stratification. High-risk patients（≥3 risk factors） with non-neoplastic lesions showed higher GC risks（adjusted HR=7.73, 95%CI: 4.29–13.92）, and their four-year CIR reached the one-year CIR of neoplastic lesions. Further categorizing non-neoplastic lesions by histological grade, both patients with moderate-to-severe lesions（aHR=3.07, 95%CI: 1.67–5.64） and high-risk patients with mild lesions（aHR=7.29, 95%CI: 3.58–14.86） showed higher risks. Consistent trends were observed in validation cohort. High-risk mild-precursor-lesion patients should receive surveillance within 3–5 years after baseline screening. Our study provides evidence on supplementing current guideline recommendations.

关键词： stomach neoplasms precancerous conditions cancer screening cumulative incidence risk stratification

Thermoluminescence of Al_2O_3 crystals grown by temperature gradient techniques

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Chinese Science Bulletin 2013年第16期58卷 1964-1968页

作者： CHEN wei song PingXin dong YongJun ZHANG YingJiu HUA wei College of Physical Science and Engineering Zhengzhou University State Key Laboratory of High Field Laser Physics Shanghai Institute of Optics and Fine Mechanics Chinese Academy of Sciences

Color center concentrations of the Al2O3 crystal grown by temperature gradient techniques were calculated from Gaussian fits to absorption spectra. The concentrations for F- and F + -centers at 204, 232, and 255 nm were determined to be 1.361×10 17 , 0.098×10 17 , and 0.325×10 17cm-3 , respectively. Studies have shown that the thermoluminescence (TL) glow curve exhibits a prominent 450 K peak that matches well the first-order fitting curve. The thermal activation energy E and frequency factor s of the trap were determined to be 0.94456±0.00545 eV and 5.8703×10 11 s-1 . With this theoretical analysis, a simple one-trap/one-center TL model is presented to provide a theoretical explanation of the TL process.

关键词：梯度技术晶体生长生长温度热释光色心浓度吸收光谱拟合曲线频率因子

Synergistically enhanced ORR and HER performance on Co-N-C coupled in-situ generated PtCo intermetallic

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Journal of Energy Chemistry 2025年第1期100卷 721-729页

作者： Guanyu Luo Min song Lulu An Xiao Huang Qian Zhang Chenhao Zhang Tao Shen Shuang Wang Deli Wang Key Laboratory of Material Chemistry for Energy Conversion and Storage (Huazhong University of Science and Technology) Ministry of Education School of Chemistry and Chemical Engineering Huazhong University of Science and Technology

Integrating multi-scale sites in a composite catalyst is vital to realize efficient ***,a synergistic composite catalyst consisting of Co atomic sites and in-situ generated PtCo intermetallic compounds （IMCs）(o-PtCo@CoNC) is proposed through Co pre-anchoring and subsequent impregnation-reduction *** loading of Co atoms provides a chance for in-situ generating PtCo ordered intermetallic *** remaining Co single atoms and PtCo IMCs construct synergistic electrocatalytic *** from the ordered structure,synergistic effect of Pt Co IMCs and Co single atoms,o-PtCo@CoNC exhibits excellent electrocatalytic performance for oxygen reduction reaction （ORR） and hydrogen evolution reaction （HER） with mass activity of 1.21 A mgPt-1（at 0.9 V） and5.70 A mgPt-1（at an overpotential of 100 mV）,***,o-PtCo@CoNC delivers negligible loss of half-wave potential and overpotential during long-term stability test in acid solutions,with 13 mV decay after 50,000 potential cycles for ORR and a 2.7 mV decay after 20,000 potential cycles for *** integration strategy of single-atomic sites coupled IMCs paves the way for enhancing the activity and durability of Pt-based electrocatalysts.

关键词： Synergistic effect Intermetallics Single atomic sites Oxygen reduction reaction Hydrogen evolution reaction

Thickness and sp3 bond modulation of（Ti/tetrahedral amorphous carbon）_n multilayer coatings

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Tungsten 2025年第1期7卷 152-160页

作者： Zhi-Jun Xie Jia-Lin Li Ling Gong Xiang-Li Zhong Hong-Jia song Jin-Bin Wang National-Provincial Laboratory of Special Function Thin Film Materials School of Materials Science and Engineering Xiangtan University

The durability of wear-resistant tetrahedral amorphous carbon（ta-C） coatings is intimately linked to their thickness and the concentration of *** enhance the lifespan of the coatings,we have prepared a multilayer coating consisting of alternating layers of Ti and ta-C,denoted as（Ti/ta-C）_n,using arc ion plating.A multi-layer structure in conjunction with stage cooling is employed to enhance the thickness and promote *** results indicate that the ID/IGvalue,representing the ratio of the intensity of the D peak to that of the G peak in Raman spectroscopy,decreases from 0.85 when no stage cooling is applied to 0.35 when stage cooling is employed,suggesting an enhancement in the fraction of sp3bonds within the *** obtained（Ti/ta-C）_n multilayer coating without peeling off has a maximum thickness of 1.14 μm,which is almost double that of the ta-C coating single layer *** the same time,the coating has a low coefficient of friction,down to 0.069,and maintains excellent friction properties with a wear rate of 3.4×10-6mm3·N-1·*** results conclusively show that the preparation technology can enhance both thickness and sp3bonding in ta-C coatings,significantly expanding their utility across tools,molds,and precision engineering components.

关键词： Arc ion plating Multilayer structure sp3 bond Ta-C coating Wear resistance

2-divisibility of Some Odd Hole Free Graphs

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Acta Mathematicae Applicatae Sinica 2022年第3期38卷 710-718页

作者： wei dong Jia-lei song Bao-gang XU School of Information and Engineering Nanjing Xiaozhuang UniversityNanjing 211171China Institute of Mathematics School of Mathematical SciencesNanjing Normal UniversityNanjing 210023China

Let G be a *** say that G is 2-divisible if for each induced subgraph H of G,either V(H)is a stable set,or V(H)can be partitioned into two sets A and B such thatω(H[A])<ω(H)andω(H[B])<ω(H).A hole is an induced cycle of length at least 4,a bull is a graph consisting of a triangle with two disjoint pendant edges,a diamond is the graph obtained from K4 by removing an edge,a dart denotes the graph obtained from a diamond by adding a pendant edge to one vertex of degree 3,and a racket denotes the graph obtained from a diamond by adding a pendant edge to one vertex of degree *** this paper,we prove that every{odd hole,H}-free graph is 2-divisible,where H is a dart,or a racket,or a *** corollaries,X(G)≤min{2ω^(G)-1,(ω^(G)/2+1)}if G is{odd hole,dart}-free,or{odd hole,racket}-free,or{odd hole,bull}-free.

关键词： hole odd hole 2-divisibility

Effect of Cr2O3 addition on oxidation induration and reduction swelling behavior of chromium-bearing vanadium titanomagnetite pellets with simulated coke oven gas

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International Journal of Minerals,Metallurgy and Materials 2019年第8期26卷 963-972页

作者： wei-dong Tang song-tao Yang Xiang-xin Xue School of Metallurgy Northeastern UniversityShenyang 110819China School of Materials and Metallurgy University of Science and Technology LiaoningAnshan 114051China

The oxidation induration and reduction swelling behavior of chromium-bearing vanadium titanomagnetite pellets(CVTP)with Cr2O3 addition were studied,and the reduction swelling index(RSI)and compressive strength(CS)of the reduced CVTP with simulated coke oven gas(COG)injection were *** results showed that the CS of the CVTP decreases and the porosity of the CVTP increases with increasing amount of Cr2O3 *** Cr2O3 mainly exists in the form of(Cr,Fe)2O3 solid solution in the CVTP and as Fe-Cr in the reduced *** CS of the reduced CVTP increases and the RSI of the reduced CVTP decreases with increasing amount of Cr2O3 *** limited aggregation and diffusion of metallic iron contribute to the formation of dense lamellar crystals,which leads to the slight decrease for reduction swelling behavior of reduced *** work provides a theoretical and technical basis for the utilization of CVTP and other Cr-bearing ores such as chromite with COG recycling technology.

关键词： chromium oxide oxidation induration reduction swellability coke oven gas chromium-bearing vanadium titanomagnetite pellets

实时三维超声技术评价左心室心肌致密化不全患者左心房管道及助力泵功能

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生物医学工程与临床 2017年第3期21卷 262-266页

作者：李方方任卫东宋光吴丹刘开薇中国医科大学附属盛京医院超声科辽宁沈阳110004

目的应用实时三维超声技术对左心室心肌致密化不全(LVNC)患者左心房管道功能和助力泵功能进行研究,并探讨其在LVNC诊断的价值。方法选择有典型LVNC超声表现的患者(LVNC组)20例,其中男性7例,女性13例,年龄4~55岁,平均年龄32.8岁。4~16岁3... 详细信息

目的应用实时三维超声技术对左心室心肌致密化不全(LVNC)患者左心房管道功能和助力泵功能进行研究,并探讨其在LVNC诊断的价值。方法选择有典型LVNC超声表现的患者(LVNC组)20例,其中男性7例,女性13例,年龄4~55岁,平均年龄32.8岁。4~16岁3例,17~35岁9例,36~55岁8例。以20例年龄相匹配的健康人作为正常对照组。应用Philips iE33彩色多普勒超声诊断仪,采集二维左心测量值及三维左心心尖四腔切面full-volume图像,应用Qlab软件进行脱机分析。结果二维测量得出LVNC组与正常对照组在室间隔厚度、左心室舒张末内径及左心室收缩功能差异均无统计学意义(P>0.05)。管道功能:LVNC组左心房被动排空容积/体表面积(BSA)、左心房管道容积/BSA及左心房被动排空指数差异无统计学意义(P>0.05),表明LVNC组与正常对照组左心房管道功能无明显差异。助力泵功能:LVNC组左心房主动排空容积/BSA为(8.73±3.92)mL/m^2,明显高于正常对照组[(5.53±2.93)mL/m^2](P<0.01);LVNC组左心房主动排空指数为(51.27±9.68)%,明显高于对照组[(36.25±12.47)%](P<0.01)。结论 LVNC患者左心房助力泵功能增加,间接反映LVNC患者左心室舒张功能减低。应用实时三维超声技术可以对LVNC患者心脏功能进行评估。

关键词：心肌致密化不全实时三维超声左心房管道功能左心房助力泵功能

Data and Model Driven Task Offloading Strategy in the Dynamic Mobile Edge Computing System

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Journal of Systems Science & Complexity 2024年第1期37卷 351-368页

作者： dong Hairong WU wei song Haifeng LIU Zhen ZHANG Zixuan School of Electronic and Information Engineering Beijing Jiaotong UniversityBeijing 100044China School of Electronic and Information Engineering BeiHang UniversityBeijing 100191China CRSC Research&Design Institute Group Co. Ltd.Beijing 100070China

Mobile Edge Computing(MEC)provides communication and computational capabilities for the industrial Internet,meeting the demands of latency-sensitive ***,traditional model-driven task offloading strategies face challenges in adapting to situations with unknown network communication status and computational *** limitation becomes notably significant in complex industrial networks of high-speed *** by these considerations,a data and model-driven task offloading problem is proposed in this paper.A redundant communication network is designed to adapt to anomalous channel states when tasks are offloaded to edge *** link switching mechanism is executed by the train according to the attributes of the completed *** task offloading optimization problem is formulated by introducing data-driven prediction of communication states into the traditional ***,the optimal strategy is achieved by employing the informer-based prediction algorithm and the quantum particle swarm optimization method,which effectively tackle real-time optimization problems due to their low time *** simulations illustrate that the data and model-driven task offloading strategy can predict the communication state in advance,thus reducing the cost of the system and improving its robustness.

关键词： Data driven model informer mobile edge computing quantum particle swarm optimization task offloading.

Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-Lin Li Xin-Ran song Qian-Qian Wan Yu-Ming Wang Han-Zhou Li wei-Quan Xu Jia-Bao Liao wei-Bo Wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle