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Oriented cellulose hydrogel:Directed tissue regeneration for reducing corneal leukoplakia and managing fungal corneal ulcers

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Bioactive Materials 2024年第11期41卷 15-29页

作者： Lina dong Zixin Fan Bixing Fang Xiaoyu Zhao Hongyi Yao Gangpei Cai Shuo Yang Guoming Zhang Xiaoqi Cheng Yun Feng Shengli mi wei Sun Tsinghua Shenzhen International Graduate School Tsinghua UniversityShenzhen518055China Department of Burns The Second Affiliated HospitalZhejiang University School of MedicineZhejiangChina Shenzhen Eye Hospital Jinan UniversityShenzhen Eye InstituteShenzhenGuangdong518040China Department of Otolaryngology The Second Affiliated HospitalZhejiang University School of MedicineZhejiangChina Department of Mechanical Engineering Biomanufacturing CenterTsinghua UniversityBeijingChina Department of Mechanical Engineering Drexel UniversityPhiladelphiaPAUSA Department of Ophthalmology Peking University Third HospitalBeijing100191China

Fungal corneal ulcer is one of the leading causes of corneal blindness in developing *** scars such as leukoplakia are formed due to inflammation,oxidative stress and non-directed repair,which seriously affect the patients'subsequent visual and life *** this study,drawing inspiration from the oriented structure of collagen fibers within the corneal stroma,we first proposed the directional arrangement of CuTA-CMHT hydrogel system at micro and macro scales based on the 3D printing extrusion method combined with secondary *** played an antifungal role and induced oriented repair in therapy of fungal corneal *** results showed that it effectively inhibited Candida albicans,Aspergillus Niger,Fusarium sapropelum,which mainly affects TNF,NF-kappa B,and HIF-1 signaling pathways,achieving effective antifungal *** importantly,the fibroblasts interacted with extracellular matrix(ECM)of corneal stroma through formation of focal adhesions,promoted the proliferation and directional migration of cells in vitro,induced the directional alignment of collagen fibers and corneal stromal orthogonally oriented repair in *** process is mainly associated with MYLK,MYL9,and ITGA3 ***,the downregulation the growth factors TGF-βand PDGF-βinhibits myofibroblast development and reduces scar-type ECM production,thereby reducing corneal *** also activates the PI3K-AKT signaling pathway,promoting corneal *** conclusion,the oriented CuTA-CMHT hydrogel system mimics the orthogonal arrangement of collagen fibers,inhibits inflammation,eliminates reactive oxygen species,and reduces corneal leukoplakia,which is of great significance in the treatment of fungal corneal ulcer and is expected to write a new chapter in corneal tissue engineering.

关键词： Corneal leukoplakia Fungal corneal ulcers Oriented tissue regeneration Nanozyme Cellulose hydrogel

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Effect of SMAD7 gene overexpression on TGF-β1-induced profibrotic responses in fibroblasts derived from Peyronie＇s plaque

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Asian Journal of Andrology 2015年第3期17卷 487-492页

作者： min Ji Choi Kang-Moon Song Jin-mi Park mi-Hye Kwon Ki-dong Kwon Soo-Hwan Park dong-Soo Ryu Ji-Kan Ryu Jun-Kyu Suh Department of Urology National Research Center for Sexual Medicine Inha University School of Medicine Incheon 400-711 Korea Department of Urology Changwon Samsung Medical Center Changwon 630-522 Korea Inha Research Institute for Medical Sciences Inha University School of Medicine Incheon 400-711 Korea

Transforming growth factor-β1 （TGF-β1） has been identified as one of the most important fibrogenic cytokines associated with Peyronie＇s disease （PD）. The mothers against decapentaplegic homolog 7 （SMAD7） is an inhibitory Smad protein that blocks TGF-J3 signaling pathway. The aim of this study was to examine the anti-fibrotic effect of the SMAD7 gene in primary fibroblasts derived from human PD plaques. PD fibroblasts were pretreated with the SMAD7 gene and then stimulated with TGF-β1. Treated fibroblasts were used for Western blotting, fluorescent immunocytochemistry, hydroxyproline determination, and terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling assays. Overexpression of the SMAD7 gene inhibited TGF-β1-induced phosphorylation and nuclear translocation of SMAD2 and SMAD3, transdifferentiation of fibroblasts into myofibroblasts, and quashed TGF-β1-induced production of extracellular matrix protein and hydroxyproline. Overexpression of the SMAD7 gene decreased the expression of cyclin D1 （a positive cell cycle regulator） and induced the expression of poly （ADP-ribose） polymerase 1, which is known to terminate Smad-mediated transcription, in PD fibroblasts. These findings suggest that the blocking of the TGF-β pathway by use of SMAD7 may be a promising therapeutic strategy for the treatment of PD.

关键词： cell culture decapentaplegic homolog 7 fibrosis Peyronie's disease transforming growth factor-beta

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Stereotactic body radiotherapy for isolated paraaortic lymph node recurrence from colorectal cancer

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World Journal of Gastroenterology 2009年第48期15卷 6091-6095页

作者： mi-Sook Kim Chul Koo Cho Kwang Mo Yang dong Han Lee Sun mi Moon Young Joo Shin Department of RadiationOncology and Surgery Korea Institute of Radiological & Medical Sciences

AIM： To evaluate the efficacy and complications of stereotactic body radiotherapy in localized paraaortic lymph node recurrence from colorectal cancer. METHODS： From 2003 to 2009, 7 patients with paraaortic lymph node recurrence （1-3 lesions） from colorectal cancer were treated with stereotactic body radiotherapy. Total gross tumor volumes ranged from 4 to 40 mL. The doses were escalated from 36 Gy/patient to 51 Gy/patient and were delivered in 3 fractions. RESULTS： One and 3 year overall survival rates were 100% and 71.4%, respectively, and median survival was 37 mo. Grade IV intestinal obstruction was reported in 1 of 7 patients. This patient received 48 Gy in 3 fractions with a maximum point dose to the intestine of 53 Gy and V45Gy = 3.6 mL. However, 6 patients received an intestinal maximum point dose of 〈 51 Gy and V45Gy of 〈 1 mL, and did not develop any severe complications. CONCLUSION： This pilot study suggests selected paraaortic lymph node recurrence （1-3 closed lesions） that failed to respond to chemotherapy can be potentially salvaged by stereotactic body radiotherapy.

关键词： Stereotactic body radiotherapy Paraaortic lymph node recurrence Colorectal cancer

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Phosphorus speciation and colloidal phosphorus responses to short-term cessation of fertilization in a lime concretion black soil

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Pedosphere 2023年第6期33卷 948-959页

作者： Shanshan BAI Jinfang TAN Zeyuan ZHANG mi wei Huimin ZHANG Xiaoqian JIANG School of Agriculture Sun Yat-sen UniversityGuangzhou 510275China Shenzhen Campus of Sun Yat-sen University Shenzhen 518107China Modern Agricultural Innovation Center Henan Institute of Sun Yat-sen UniversityZhumadian 463400China Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural Sciences/National Engineering Laboratory for Improving Quality of Arable LandBeijing 100081China

Long-term excessive application of mineral fertilizer has led to soil acidification and phosphorus(P) accumulation, increasing the risk of P loss and environmental pollution, and cessation of fertilization is widely considered as a cost-effective management strategy to relieve this situation;however, how such cessation influences P speciation and concentrations in a bulk soil and colloidal fractions and whether decreasing P concentration might maintain soil fertility remain unclear. In this study, the effects of long-term fertilization(ca. 40 years) and short-term cessation of fertilization(ca. 16 months) on inorganic, organic,and colloidal P in lime concretion black soil were investigated using P sequential fractionation and31P nuclear magnetic resonance spectroscopy. After long-term fertilization, available P, dicalcium phosphate, iron-bound P, orthophosphate monoesters, and orthophosphate diesters increased significantly, but soil p H decreased by ca. 2.8 units, indicating that long-term fertilization caused soil acidification and P accumulation and changed P speciation markedly. In contrast, short-term fertilization cessation increased soil p H by ca. 0.8 units and slightly reduced available and inorganic P. Available P after fertilization cessation was 22.9–29.8 mg kg-1, which was still sufficient to satisfy crop growth requirements. Additionally, fertilization cessation increased the proportions of fine colloids(100–450 nm, including nontronite and some amorphous iron oxides) and drove a significant release of iron/aluminum oxide nanoparticles(1–100 nm) and associated P with orthophosphate and pyrophosphate species. In summary, short-term fertilization cessation effectively alleviated soil acidification and inorganic P accumulation, while concomitantly maintaining soil P fertility and improving the potential mobilization of P associated with microparticles.

关键词： Fe/Al oxide nanoparticles fine colloids P accumulation 31pP nuclear magnetic resonance P sequential fractionation soil acidification

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Characterization of the Convoluted 3D Internetallic Phases in a Recycled Al Alloy by Synchrotron X-ray Tomography and Machine Learning

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Acta Metallurgica Sinica(English Letters) 2022年第1期35卷 115-123页

作者： Zhenhao Li Ling Qin Baisong Guo Junping Yuan Zhiguo Zhang wei Li Jiawei mi Institute of Advanced Wear Resistant and Functional Materials Jinan UniversityGuangzhou510632China Jewelry Institute Guangzhou Panyu PolytechnicGuangzhou511487China Department of Engineering University of HullEast YorkshireHullHU67RXUK

Fe-rich intermetallic phases in recycled Al alloys often exhibit complex and 3D convoluted structures and *** are the common detrimental intermetallic phases to the mechanical properties of recycled Al *** this study,we used synchrotron X-ray tomography to study the true 3D morphologies of the Ferich phases,Al_(2)Cu phases and casting defects in an ascast Al-5Cu-1.5Fe-1Si *** learning-based image processing approach was used to recognize and segment the diff erent phases in the 3D tomography image *** the studied condition,theβ-Al_(9)Fe_(2)Si_(2)andω-Al_(7)Cu_(2)Fe are found to be the main Fe-rich intermetallic ***β-Al_(9)Fe_(2)Si_(2)phases exhibit a spatially connected 3D network structure and morphology which in turn control the 3D spatial distribution of the Al_(2)Cu phases and the shrinkage *** Al_(3)Fe phases formed at the early stage of solidification aff ect to a large extent the structure and morphology of the subsequently formed Fe-rich intermetallic *** machine learning method has been demonstrated as a powerful tool for processing big datasets in multidimensional imaging-based materials characterization work.

关键词： Recycled Alalloy Solidifi cation Synchrotron X-ray tomography Machine learning Fe-rich intermetallic phases

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Remediation of Ni^(2+)-contaminated water using iron powder and steel manufacturing byproducts

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Journal of Environmental Sciences 2006年第3期18卷 464-467页

作者： JIN Jian ZHAO wei-rong XU Xin-hua HAO Zhi-wei LIU Yong HE Ping ZHOU mi Department of Environment Engineering Zhejiang University Hangzhou 310027 China

Steel manufacturing byproducts and commercial iron powders were tested in the treatment of Ni^2＋-contaminated water. Ni^2＋ is a priority pollutant of some soils and groundwater. The use of zero-valent iron, which can reduce Ni^2＋ to its neural form appears to be an alternative approach for the remediation of Ni^2＋-contaminated sites. Our experimental data show that the removal efficiencies of Ni^2＋ were 95.15% and 94.68% at a metal to solution ratio of 20 g/L for commercial iron powders and the steel manufacturing byproducts in 60 min at room temperature, respectively. The removal efficiency reached 98.20% when the metal to solution ratio was 40 g/L for commercial iron powders. Furthermore, we found that the removal efficiency was also largely affected by other factors such as the pHs of the treated water, the length of time for the metal to be in contact with the Ni^2＋-contaminated water, initial concentrations of metal solutions, particle sizes and the amount of iron powders. Surprisingly, the reaction temperature appeared to have little effect on the removal efficiency. Our study opens the way to further optimize the reaction conditions of in situ remediation of Ni^2＋ or other heavy metals on contaminated sites.

关键词： zero-valent iron reduction remediation Ni^2+

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Novel Ni_(3)S_(4)/NiS/NC composite with multiple heterojunctions synthesized through space-confined effect for high-performance supercapacitors

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International Journal of Extreme Manufacturing 2023年第1期5卷 318-329页

作者： Wutao wei Zijie Guo Jiaqiang Xu Zhe Fang Jiujun Zhang Yu Jia Liwei mi Institute for Sustainable Energy College of SciencesShanghai UniversityShanghai 200444People’s Republic of China Henan Key Laboratory of Functional Salt Materials Center for Advanced Materials ResearchZhongyuan University of TechnologyZhengzhou 450007HenanPeople’s Republic of China International Laboratory for Quantum Functional Materials of Henan&School of Physics and Engineering Zhengzhou UniversityZhengzhou 450001HenanPeople’s Republic of China

The construction of heterojunctions in composite materials to optimize the electronic structures and active sites of energy materials is considered to be the promising strategy for the fabrication of high-performance electrochemical energy *** this paper,a one-step,easy processing and cost-effective technique for generating composite materials with heterojunctions was successfully *** composite containing Ni_(3)S_(4),NiS,and N-doped amorphous carbon(abbreviated as Ni_(3)S_(4)/NiS/NC)with multiple heterojunction nanosheets are synthesized via the space-confined effect of molten salt interface of recrystallized *** lattice matching forms of Ni_(3)S_(4)with cubic structure and NiS with hexagonal structure are confirmed by the detailed characterization of heterogeneous *** C–S bonds are the key factor in realizing the chemical coupling between nickel sulfide and NC and constructing the stable *** functional theory calculations further revealed that the electronic interaction on the heterogeneous interface of Ni_(3)S_(4)/NiS can contribute to high electronic *** heterogeneous interfaces are identified to be the good electroactive region with excellent electrochemical *** synergistic effect of abundant active sites,the enhanced kinetic process and valid interface charge transfer channels of Ni_(3)S_(4)/NiS/NC multiple heterojunction can guarantee high reversible redox activity and high structural stability,resulting in both high specific capacitance and energy/power densities when it is used as the electrode for *** work offers a new avenue for the rational design of the heterojunction materials with improved electrochemical performance through space-confined effect of NaCl.

关键词： multiple heterojunction space-confined effect electronic interaction supercapacitors

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论灾害事故预防应对的调查评估问题

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灾害学 2025年第1期40卷 1-7,85页

作者：刘传正米文忠黄帅应急管理部国家自然灾害防治研究院北京100085 清华大学合肥公共安全研究院灾害事故调查评估应急管理部重点实验室北京100084

为了推动我国灾害事故预防应对调查评估工作的科学化与规范化发展,该文通过界定灾害事故类型,探讨了灾害事故预防应对调查评估的目的任务、工作原则、工作方法、工作组织和成果应用方面的基本问题。灾害事故被划分为灾害、事故、灾害事... 详细信息

为了推动我国灾害事故预防应对调查评估工作的科学化与规范化发展,该文通过界定灾害事故类型,探讨了灾害事故预防应对调查评估的目的任务、工作原则、工作方法、工作组织和成果应用方面的基本问题。灾害事故被划分为灾害、事故、灾害事故(链)和事故灾害(链)四类。调查评估目的任务明确为认定事实、查找问题、分析原因并提出对策措施。在工作原则上,强调了6个方面:事实依据、法规准绳、认知判断、沟通协调、良知底线和素质保障。工作方法涵盖了现场勘查、档案查阅、访谈问询、检测试验、分析计算、模拟仿真、成因论证和性质界定等8个环节。工作组织或调查机构组成包括综合协调组、法规管理组、技术工作组和专家顾问组。成果应用范畴包括即时政策制定、法规标准制修订、管理体制改革以及工作机制完善等领域。

关键词：灾害事故预防应对调查评估工作原则工作方法

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Annual Energy Production Estimation for Variable-speed Wind Turbine at High-altitude Site

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Journal of Modern Power Systems and Clean Energy 2021年第3期9卷 684-687页

作者： dongran Song Songyue Zheng Sheng Yang Jian Yang mi dong Mei Su Young Hoon Joo the School of Automation Central South UniversityChangsha 410083China the School of Energy Science and Engineering Central South UniversityChangsha 410083China the School of IT Information and Control Engineering Kunsan National UniversityKunsan 573701Korea

This letter presents a systematic approach to estimate the annual energy production(AEP) of variable-speed wind turbines erected at high-altitude sites. Compared with the existing empirical-model based approaches, the proposed approach models the influence of the air density on the power production while employing the theoretical power curve. Consequently, the proposed approach provides a precise estimation of AEP, which can serve as a foundation of the optimum turbinesite matching design at different-altitude sites.

关键词： Variable-speed wind turbine annual energy production high-altitude site turbine-site matching

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Three-dimensional printed talar prosthesis with biological function for giant cell tumor of the talus:A case report and review of the literature

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World Journal of Clinical Cases 2021年第13期9卷 3147-3156页

作者： Qian-dong Yang mi-Duo Mu Xu Tao Kang-Lai Tang Sports Medicine Center The First Affiliated Hospital of Army Medical UniversityChongqing 400038China

BACKGROUND Giant cell tumors(GCT)are most commonly seen in the distal *** tumors are uncommon in the small bones of the hand and feet,and a very few cases have been reported.A giant cell tumor of the talus is rarely seen clinically and could be a challenge to *** SUMMARY We report a rare case of GCT of the talus in one patient who underwent a new reconstructive surgery technique using a three-dimensional(3D)printing talar *** prosthesis shape was designed by tomographic image processing and segmentation using technology to match the intact side by mirror symmetry with 3D post-processing *** patient recovered nearly full range of motion of the ankle after 6 *** visual analogue scale and American Orthopaedic Foot and Ankle Society scores were 1 and 89 points,*** We demonstrated that 3D printing of a talar prosthesis is a beneficial option for GCT of the talus.

关键词： Three-dimensional printing technology Giant cell tumor Talar prosthesis Case report

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